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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Rasl CA overexpression in the posterior silk gland improves silk yield显示文摘 | Li Ma Hanfu Xu Jinqi Zhu Sanyuan Ma Yan Liu Rong-Jing Jiang Qingyou Xia Sheng Li | 2011 | Cell Research2011，21，6： | 19 |
| 3 | A detailed procedure for CRISPR/Cas9-mediated gene editing in Arabidopsis thaliana显示文摘The newly developed CRISPR(Clustered Regularly Interspaced Short Palindromic Repeats)/Cas(CRISPR-associated) system has emerged as an efficient tool for genome-editing, providing an alternative to classical mutagenesis and transgenic methods to study gene function and improve crop traits. CRISPR/Cas facilitates targeted gene editing through RNA-guided DNA cleavage followed by cellular DNA repair mechanisms that introduce sequence changes at the site of cleavage. Here we describe a detailed procedure for our previously developed and highly efficient CRISPR/Cas9 method that allows the generation of heritable-targeted gene mutations andcorrections in Arabidopsis. This protocol describes the strategies and steps for the selection of targets, design of single-guide RNA(sg RNA), vector construction and analysis of transgenic lines. We also offer a method to target two loci simultaneously using vectors containing two different sg RNAs. The principles described in this protocol can be applied to other plant species to generate stably inherited DNA modifications. | Wenshan Liu Xiaohong Zhu Mingguang Lei Qingyou Xia Jose Ramon Botella Jian-Kang Zhu Yanfei Mao | 2015 | Science Bulletin2015，60，15： | 18 |
| 4 | Clinical features and management of postural tachycardia syndrome in children: a single-center experience显示文摘 | Li Jiawei Zhang Qingyou Hao Hongjun Jin Hongfang Du Junbao | 2014 | Chinese Medical Journal2014，，21： | 11 |
| 5 | Experimental measurement of the electrical conductivity of single crystal olivine at high temperature and high pressure under different oxygen fugacities显示文摘At 1.0-4.0 GPa and 1123-1473 K and under oxygen fugacity-controlled conditions (Ni + NiO, Fe + Fe3O4, Fe + FeO and Mo+ M0O2 buffers), a YJ-3000t Model six-anvil solid high-pressure apparatus and a Sarltron-1260 Impedance/Gain-Phase analyzer were employed to conduct an in situ measurement of the electrical conductivity of single crystal olivine. Experimental results showed that: (1) within the range of experimentally selected frequencies (103-106 Hz), the electrical conductivity of the sample is of great dependence on the frequency; (2) with the rise of temperature ( T), the electrical conductivity (σ) will increase, and the Arrenhius linear relationship is established between lgσ and 1/T; (3) under the control of oxygen buffer Fe+ Fe3O4, with the rise of pressure, the electrical conductivity tends to decrease whereas the activation enthalpy and independent-of-temperature preexponential factor tend to increase, with the activation energy and activation volume of the sample estimated at (1. 25 ± 0.08) eV and (0.105 ±0.025) cm3/mol, respectively; (4) under given pressure and temperature conditions, the electrical conductivity tends to increase whereas the activation energy tends to decrease with increasing oxygen fugacity; and ( 5) the mechanism of electrical conduction of small polarons can provide insight into the behavior of electrical conduction of olivine under high pressure and high temperature. | DAI Lidong LI Heping LIU Congqiang CUI Tongdi SHAN Shuangming YANG Changjun LIU Qingyou DENG Heming | 2006 | Progress in Natural Science:Materials International2006，16，4： | 9 |
| 6 | Analysis of cytochrome P450 genes in silkworm genome (Bombyx mori)显示文摘We have searched the Bombyx mori genome for members of the major enzyme family, the Cytochrome P450s, which carry out multiple reactions to enable organisms to rid themselves of foreign compounds. As a result, 86 putative P450s were discovered in silkworm genome, which are thought to belong to 32 subfamilies. A comparative genomic analysis with Drosophila melanogaster reveals that the two insects have some similar P450 distribution pat-terns but still have some obvious differences. Especially, the diverse distribution exists in 7 p450 subfamilies, which are CYP4A, CYP4C, CYP4D, CYP6A, CYP6AE, CYP6B and CYP9A. Fur-thermore, we collected expression sequence tag (EST) evidence for 49 putative P450s genes, which are expressed at the transcriptional level and more likely to be true P450s. | LI Bin XIA Qingyou LU Cheng ZHOU Zeyang XIANG Zhonghuai | 2005 | Science China(Life Sciences)2005，48，4： | 7 |
| 7 | Polymorphisms of chemokine receptors and its ligand alleles influencing genetic suscepti-bity to HIV-1 infection in eight ethnic groups in Chinese mainland显示文摘Limited genetic information is available concerning the polymorphisms of HIV-1 resistant genes in indigenous Chinese populations. The aim of this study is to identify the allelic frequencies of the chemokine and chemokine receptor genes in the Chinese mainland. Genomic DNA samples extracted from whole blood of 2318 subjects were analyzed by using PCR or PCR/restriction fragment length polymorphism (RFLP) assays, and further confirmed by direct DNA sequencing. Higher frequencies of mutant CCR2-64I (19.15%-28.79%) and SDF1-3’A (19.10% -29.86%) alleles were found in subjects of 8 ethnic groups in the Chinese mainland. In contrast, the △32 mutation in CCRS gene occurs at a very low frequency (0.0016, n=1287) in Han population. A relatively high frequency of CCR5-wt/△32 heterozygotes was observed in Uygurian and Mongolian populations. No A32 mutation allele was detected in Tibetan and other 4 ethnic groups in Yunnan Province. There was no CCR5-m303 mutation in subjects of any ethnic group in the Chinese | WANG Fusheng JIN lei LIU Mingxu HONG Weiguo SHI Hong LEI Zhouyun WANG Jiming DU Qingyou HOU Jing ZHANG Bing JIANG Jiandong WANG Yue LI Yueqi XU Anlong HUANG Honglian LIU Fajun | 2001 | Chinese Science Bulletin2001，46，12： | 6 |
| 8 | Review of grain ref inement methods for as-cast microstructure of magnesium alloy显示文摘As the lightest structural metal,Mg and Mg-based alloys have great potential applications in the aerospace,automotive and nuclear industries.However,such applications have been limited by low ductility and strength.Theoretically,small grain sized structure can synchronously improve its ductility and strength.Yet,universally reliable grain ref inement techniques for the magnesium alloys are still under investigation and some are in strong debating.This paper presents a brief review of development of grain ref inement methods for magnesium alloys,which would contribute to a better understanding of the factors controlling grain ref inement and provide an outlook of future research in this fi eld. | Song Changjiang Han Qingyou Zhai Qijie | 2009 | China Foundry2009，6，2： | 6 |
| 9 | The role of solutes in grain refinement of hypoeutectic magnesium and aluminum alloys显示文摘The effect of solutes on grain formation has been studied over a century but is still under debating,simply because it is a very complex topic.This article focuses on the effect of dissolved solute on the growth,fragmentation of a dendrite and the resultant grain size.Experimental data on grain size in magnesium and aluminum alloys with various solute concentrations are collected and analyzed using phase diagram variables including Q,P,andΔT.The physical meaning of each phase diagram variable is discussed.Curve fitting of the recently proposed two-parameter models with experimental data suggests that there is a clear correlation between the measured grain size and the solidification range of the alloy over the entire range of the hypoeutectic composition.Such a trend of grain size vs.ΔT is closely related to the grain refining mechanisms operating under relevant experimental conditions.A critical review of the grain refining mechanisms indicates that the mechanisms associated with the dendrite fragmentation are operating under the conditions where convection is substantial in the melt during its solidification. | Qingyou Han | 2022 | Journal of Magnesium and Alloys2022，10，7： | 3 |
| 10 | Latest Development and Application of High Strength and Heavy Gauge Pipeline Steel in China显示文摘 | Zhang Yongqing Guo Aimin Shang Chengjia Liu Qingyou J. Malcolm Gray Frank Barbaro | 2016 | Journal of Mechanics Engineering and Automation2016，6，1： | 3 |
| 11 | Formation of hypereutectic silicon particles in hypoeutectic Al-Si alloys under the influence of high-intensity ultrasonic vibration显示文摘The modification of eutectic silicon is of general interest since fine eutectic silicon along with fine primary aluminum grains improves mechanical properties and ductilities. In this study, high intensity ultrasonic vibration was used to modify the complex microstructure of aluminum hypoeutectic alloys. The ultrasonic vibrator was placed at the bottom of a copper mold with molten aluminum. Hypoeutectic Al-Si alloy specimens with a unique in-depth profile of microstructure distribution were obtained. Polyhedral silicon particles, which should form in a hypereutectic alloy, were obtained in a hypoeutectic Al-Si alloy near the ultrasonic radiator where the silicon concentration was higher than the eutectic composition. The formation of hypereutectic silicon near the radiator surface indicates that high-intensity ultrasonic vibration can be used to influence the phase transformation process of metals and alloys. The size and morphology of both the silicon phase and the aluminum phase varies with increasing distance from the ultrasonic probe/radiator. Silicon morphology develops into three zones. Polyhedral primary silicon particles present in zoneⅠ, within 15 mm from the ultrasonic probe/radiator. Transition from hypereutectic silicon to eutectic silicon occurs in zoneⅡ about 15 to 20 μm from the ultrasonic probe/radiator. The bulk of the ingot is in zoneⅢ and is hypoeutectic Al-Si alloy containing fine lamellar and fibrous eutectic silicon. The grain size is about 15 to 25 μm in zoneⅠ, 25 to 35 μm in zoneⅡ, and 25 to 55 μm in zoneⅢ. The morphology of the primary α-Al phase is also changed from dendritic (in untreated samples) to globular. Phase evolution during the solidification process of the alloy subjected to ultrasonic vibration is described. | Xiaogang Jian Qingyou Han | 2013 | China Foundry2013，10，2： | 3 |
| 12 | The tribological behavior of a surface-nanocrystallized magnesium alloy AZ31 sheet after ultrasonic shot peening treatment显示文摘A magnesium alloy AZ31 sheet was processed by ultrasonic shot peening treatment to fabricate a surface nanocrystalline,and a ball-on-disk dry sliding wear test was performed to evaluate the tribological behavior after treatment.The microstructure observation indicated a gradient nanocrystalline structure was formed after USSP treatment.The microhardness at the top surface was improved from 60 HV to 145 HV after treatment.The formed nanocrystalline resulted in an easy formation of MgO patches on the surface and reduced the coefficient of friction.Moreover,the formed nanocrystalline leaded to a retard of delamination with increasing the sliding speed and applied load,which was due to its stronger sub-surface.Under high sliding speed(0.5 m/s)and high applied load(50 N),it was firstly found that the formed nanocrystalline prevented the happening of thermal softening and melting.The possible reasons accounting for the prevention of thennal softening and melting were discussed accordingly. | Jianyue Zhang Yongxin Jian Xuzhe Zhao Dean Meng Fusheng Pan Qingyou Han | 2021 | Journal of Magnesium and Alloys2021，9，4： | 3 |
| 13 | Understanding divergent domestication traits from the whole-genome sequencing of swamp-and river-buffalo populations显示文摘Domesticated buffaloes have been integral to rice-paddy agro-ecosystems formillennia,yet relatively little is known about the buffalo genomics.Here,we sequenced and assembled reference genomes for both swamp and river buffaloes and we re-sequenced 230 individuals(132 swamp buffaloes and 98 river buffaloes)sampled from across Asia and Europe.Beyond the many actionable insights that our study revealed about the domestication,basic physiology and breeding of buffalo,we made the striking discovery that the divergent domestication traits between swamp and river buffaloes can be explained with recent selections of genes on social behavior,digestion metabolism,strengths and milk production. | Xier Luo Yu Zhou Bing Zhang Yi Zhang Xiaobo Wang Tong Feng Zhipeng Li Kuiqing Cui Zhiqiang Wang Chan Luo Hui Li Yanfei Deng Fenghua Lu Jianlin Han Yongwang Miao Huaming Mao Xiaoyan Yi Cheng Ai Shigang Wu Alun Li Zhichao Wu Zijun Zhuo Do Da Giang Bikash Mitra Mohammad Farhad Vahidi Shahid Mansoor Sahar Ahmed Al-Bayatti Eka Meutia Sari Neena Amatya Gorkhali Sigit Prastowo Laiba Shafique Guoyou Ye Qian Qian Baoshan Chen Deshun Shi Jue Ruan Qingyou Liu | 2020 | National Science Review2020，7，3： | 3 |
| 14 | Atomic resolution scanning tunneling microscope imaging up to 27 T in a water-cooled magnet显示文摘我们在一个 water-cooled 磁铁(WM ) 报导第一原子地解决的扫描通道显微镜(STM ) 成像,为哪个极其严厉的颤动和噪音是主要挑战。这特定的 WM-STM 展示粗糙的途径被我们的最新设计的 TunaDrive 压电的马达在驾驶的一个极端僵硬、紧缩的扫描头。挂系统的一个三水平的弹簧被用于颤动隔离。有优秀原子分辨率的石墨的房间温度未加工数据的图象面对很强壮的磁场被获得,与直到 27 T 的领域力量,在有在 10 MW 的一个力量等级的 27.5 T 的最大的领域力量的 32-mm-diameter 讨厌的人 WM ,由原子磁性的回声( NMR )校准了。27 T 的这记录地力量超过常规超导的磁铁完成的最大的地力量。而且,我们的 WM-STM 用 45 T 铺平了道路到 STM 成像, 32-mm-diameter 讨厌的人混血儿磁铁,是世界旗舰磁铁,生产最强壮的稳定的磁场。 | Wenjie Meng Ying Guo Yubin Hou Qingyou Lu | 2015 | Nano Research2015，8，12： | 2 |
| 15 | Design and Analysis of an Active Helical Drive Downhole Tractor显示文摘During oil-gas well drilling and completion,downhole tools and apparatus should be conveyed to the destination to complete a series of downhole works.Downhole tractors have been used to convey tools in complex wellbores, however a very large tractive force is needed to carry more downhole tools to accomplish works with high efficiency. A novel serial active helical drive downhole tractor which has significantly improved performance compared with previous work is proposed. All previously reported helical drive downhole tractors need stators to balance the torque generated by the rotator. By contrast, the proposed serial downhole tractor does not need a stator; several rotator-driven units should only be connected to one another to achieve a tractive force multifold higher than that was previously reported. As a result,the length of a single unit is shortened, and the motion flexibility of the downhole tractor is increased. The major performance indicators, namely, gear ratio, velocity, and tractive force, are analyzed. Experimental results show that the maximum tractive force of a single-unit prototype with a length of 900 mm is 165.3 kg or 1620 N. The analysis and experimental results show that the proposed design has considerable potential for downhole works. | Yujia LI Qingyou LIU Yonghua CHEN Tao REN | 2017 | Chinese Journal of Mechanical Engineering2017，30，2： | 2 |
| 16 | Degassing of molten aluminum A356 alloy using ultrasonic vibration显示文摘 | Hanbing Xu Xiaogang Jian Thomas T. Meek Qingyou Han | 2004 | Materials Letters2004，，29： | 2 |
| 17 | Haplotype-resolved genome of diploid ginger (Zingiber officinale) and its unique gingerol biosynthetic pathway显示文摘Ginger(Zingiber officinale),the type species of Zingiberaceae,is one of the most widespread medicinal plants and spices.Here,we report a high-quality,chromosome-scale reference genome of ginger‘Zhugen’,a traditionally cultivated ginger in Southwest China used as a fresh vegetable,assembled from PacBio long reads,Illumina short reads,and high-throughput chromosome conformation capture(Hi-C)reads.The ginger genome was phased into two haplotypes,haplotype 1(1.53 Gb with a contig N50 of 4.68 M)and haplotype 0(1.51 Gb with a contig N50 of 5.28 M).Homologous ginger chromosomes maintained excellent gene pair collinearity.In 17,226 pairs of allelic genes,11.9%exhibited differential expression between alleles.Based on the results of ginger genome sequencing,transcriptome analysis,and metabolomic analysis,we proposed a backbone biosynthetic pathway of gingerol analogs,which consists of 12 enzymatic gene families,PAL,C4H,4CL,CST,C3’H,C3OMT,CCOMT,CSE,PKS,AOR,DHN,and DHT.These analyses also identified the likely transcription factor networks that regulate the synthesis of gingerol analogs.Overall,this study serves as an excellent resource for further research on ginger biology and breeding,lays a foundation for a better understanding of ginger evolution,and presents an intact biosynthetic pathway for species-specific gingerol biosynthesis. | Hong-Lei Li Lin Wu Zhaoming Dong Yusong Jiang Sanjie Jiang Haitao Xing Qiang Li Guocheng Liu Shuming Tian Zhangyan Wu Bin Wu Zhexin Li Ping Zhao Yan Zhang Jianmin Tang Jiabao Xu Ke Huang Xia Liu Wenlin Zhang Qinhong Liao Yun Ren Xinzheng Huang Qingzhi Li Chengyong Li Yi Wang Baskaran Xavier-Ravi Honghai Li Yang Liu Tao Wan Qinhu Liu Yong Zou Jianbo Jian Qingyou Xia Yiqing Liu | 2021 | Horticulture Research2021，8，1： | 2 |
| 18 | A Draft Sequence for the Genome of the Domesticated Silkworm (Bombyx mori)显示文摘 | Xia Qingyou Zhou Zeyang Lu Cheng | 2004 | Science2004，306，： | 1 |
| 19 | Preparation of trichlorosilane from hydrogenation of silicon tetrachloride in thermal plasma显示文摘 | Wu Qingyou Chen Hanbin Li Yuliang | 2010 | Inorganic Materials2010，46，3： | 1 |
| 20 | Association of clinical characteristics of children with unexplained syncope and the outcome of head-up tilt tests显示文摘 | Zhang Qingyou Du Junbao Chen Jianjun | 2004 | Pediatr Cardiol2004，25，4： | 1 |
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