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| 1 | Co-delivery of resveratrol and docetaxel via polymeric micelles to improve the treatment of drug-resistant tumors显示文摘Co-delivery of anti-cancer drugs is promising to improve the efficacy of cancer treatment.This study was aiming to investigate the potential of concurrent delivery of resveratrol(RES)and docetaxel(DTX)via polymeric nanocarriers to treat breast cancer.To this end,methoxyl poly(ethylene glycol)-poly(D,L-lactide)copolymer(mPEG-PDLA)was prepared and characterized using FTIR and 1H NMR,and their molecular weights were determined by GPC.Isobologram analysis and combination index calculation were performed to find the optimal ratio between RES and DTX to against human breast adenocarcinoma cell line(MCF-7 cells).Subsequently,RES and DTX were loaded in the mPEG-PDLA micelles simultaneously,and the morphology,particle size distribution,in vitro release,pharmacokinetic profiles,as well as cytotoxicity to the MCF-7 cells were characterized.IC50 of RES and DTX in MCF-7 cells were determined to be 23.0μg/ml and 10.4μg/ml,respectively,while a lower IC50 of 4.8μg/ml of the combination of RES and DTX was obtained.The combination of RES and DTX at a ratio of 1:1(w/w)generated stronger synergistic effect than other ratios in the MCF-7 cells.RES and DTX loaded mPEG-PDLA micelles exhibited prolonged release profiles,and enhanced cytotoxicity in vitro against MCF-7 cells.The AUC(0→t)of DTX and RES in mPEG-PDLA micelles after i.v.administration to rats were 3.0-fold and 1.6-fold higher than that of i.v.injections of the individual drugs.These findings indicated that the co-delivery of RES and DTX using mPEG-PDLA micelles could have better treatment of tumors. | Xiong Guo Zhiyue Zhao Dawei Chen Mingxi Qiao Feng Wan Dongmei Cun Yi Sun Mingshi Yang | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，1： | 4 |
| 2 | Prophylactic effects of alkaloids from Ba lotus seeds on L-NNA-induced hypertension in mice显示文摘Alkaloids from Ba lotus seeds(ABLS) are a kind of important functional compounds in lotus seeds. The present study was designed to determine its hypertension prophylactic effects in the L-NNA-induced mouse hypertension model. The mice were treated with ABLS, the serum and tissues levels of NO, MDA, ET-1, VEGF, and CGRP were determined using the experimental kits, the mRNA levels of various genes in the heart muscle and blood vessel tissues were further determined by RT-PCR assay. ABLS could reduce the systolic blood pressure(SBP), mean blood pressure(MBP), and diastolic blood pressure(DBP), compared to that of the model control group. After ABLS treatment, the NO(nitric oxide) contents in serum, heart, liver, kidney and stomach of the mice were higher than that of the control mice, but the MDA(malonaldehyde) contents were lower than that of the control mice. The serum levels of ET-1(endothelin-1), VEGF(vascular endothelial growth factor) were decreased after ABLS treatment, but CGRP(calcium gene related peptide) level was increased. The ABLS treated mice had higher mRNA expressions of HO-1, nNOS, and eNOS and lower expressions of ADM, RAMP2, IL-1β, TNF-α, and iNOS than the control mice. Higher concentration of ABLS had greater prophylactic effects, which were close to that of the hypertension drug captopril. These results indicated the hypertension prophylactic effects of ABLS could be further explored as novel medicine or functional food in the future. | SUN Peng ZHU Kai WANG Cun LIU Wei-Wei PENG De-Guang ZHAO Xin | 2016 | Chinese Journal of Natural Medicines2016，14，11： | 3 |
| 3 | Tonoplast-associated calcium signaling regulates manganese homeostasis in Arabidopsis显示文摘Manganese(Mn)is an essential micronutrient in plants.However,excessive Mn absorption in acidic and waterlogged soils can lead to Mn toxicity.Despite their essential roles in Mn homeostasis,transcriptional and post-transcriptional modifications of Mn transporters remain poorly understood.Here,we demonstrated that high-Mn stress induces an obvious Ca^(2+) signature in Arabidopsis.We identified four calcium-dependent protein kinases,CPK4/5/6/11,that interact with the tonoplast-localized Mn and iron(Fe)transporter MTP8 in vitro and in vivo.The cpk4/5/6/11 quadruple mutant displayed a dramatic high-Mn-sensitive phenotype similar to that of the mtp8 mutant.CPKs phosphorylated the N-terminal domain of MTP8 primarily at the Ser31 and Ser32 residues.Transport assays combined with multiple physiological experiments on phospho-dead variant MTP8^(S31/32A)and phospho-mimetic variant MTP8^(S31/32D)plants under different Mn and Fe conditions suggested that Ser31 and Ser32 are crucial for MTP8 function.In addition,genetic analysis showed that CPKs functioned upstream of MTP8.In summary,we identified a tonoplast-associated calcium signaling cascade that orchestrates Mn homeostasis and links Mn toxicity,Ca^(2+) signaling,and Mn transporters.These findings provide new insight into Mn homeostasis mechanisms and Ca^(2+) signaling pathways in plants,providing potential targets for engineering heavy metal toxicity-tolerant plants. | Zhenqian Zhang Dali Fu Zhihui Sun Chuanfeng Ju Cuicui Miao Zhangqing Wang Dixiang Xie Liang Ma Zhizhong Gong Cun Wang | 2021 | Molecular Plant2021，14，5： | 2 |
| 4 | Temperature-dependent photoluminescence of highly luminescent water-soluble CdTe quantum dots显示文摘高度光的水溶性的 CdTe 量点(QD ) 与一位 electrogener ated 先锋被综合了。获得的 CdTe QD 能拥有好可结晶性,高量收益(QY ) 和有利稳定性。而且,一个察觉系统为 QD 的温度依赖者 PL 的调查第一被设计。 | Ji Wei Liu Yu Zhang Cun Wang Ge Yong Long Jin Sun Ling Hu Ning Gu | 2009 | Chinese Chemical Letters2009，20，8： | 2 |
| 5 | Erratum to Simultaneous inhibition of PI3Kα and CDK4/6synergistically suppresses KRAS-mutated non-small cell lung cancer显示文摘In the published Figure 11,errors appeared in Figure 1B on page 69.In Figure 1B,bands for p-Akt S473,Akt,and Actin in H1355 cells were mistakenly placed.Here,we have updated Figure 1B to correct the mistake above.The errors do not impact the conclusions of this article.We apologize for the errors and for any confusion it may have caused. | Yuxiang Wang Xian Li Xueling Liu Yi Chen Chunhao Yang Cun Tan Bobo Wang Yiming Sun Xi Zhang Yinglei Gao Jian Ding Linghua Meng | 2019 | Cancer Biology & Medicine2019，16，4： | 1 |
| 6 | Cytochalasin B loaded nano/microparticles:preparation and in vitro drug release evaluation显示文摘Cytochalasin B (cytoB) loaded nanoparticles (NPs) and microspheres (MSs) were formed using an emulsification / solvent evaporation technique.Biodegradable poly(lactic co glycolic acid)(PLGA) and poly(L lactic acid)(PLLA)were used as carrier and were compared in terms of drug release rate and initial burst.The PLGA nanoparticles and microparticles of graded diameter,150 nm,500 nm,1 μm,5 μm,10 μm and 20 μm,is formulated.Nanoparticles of 150 500 nm diameter were obtained by high energy sonication,whereas larger size particles were obtained by normal homogenization.The degree of initial burst release varied depending on particle size and polymer matrix.For the PLGA matrix,about 50% of the entrapped drug released from the 150 nm nanoparticles,whereas only 10% released from the 20 μm particles within the first 24 hours.On the other hand,cytoB release from 150 nm PLLA nanoparticles was much slower and showed less burst effect than the PLGA ones with same size.The results suggest that desired release profile can be achieved by properly selecting the matrix material and particle size. | SONG Cun xian SUN Hong fan YANG Jin ZHU Zhen feng WANG Peng yan Robert Levy | 2000 | Chinese Journal of Biomedical Engineering(English Edition)2000，9，1： | 1 |
| 7 | Temporal and spatial variability of soil organic matter and total nitrogen in an agricultural ecosystem as affected by fanning practices 显示文摘 | Huang Biao Sun Wei xia Zhao Yong cun | 2007 | Geodenna2007，139，34： | 1 |
| 8 | Specific Regulation of m^(6)A by SRSF7 Promotes the Progression of Glioblastoma显示文摘Serine/arginine-rich splicing factor 7(SRSF7),a known splicing factor,has been revealed to play oncogenic roles in multiple cancers.However,the mechanisms underlying its oncogenic roles have not been well addressed.Here,based on N6-methyladenosine(m^(6)A)co-methylation network analysis across diverse cell lines,we find that the gene expression of SRSF7 is positively correlated with glioblastoma(GBM)cell-specific m^(6)A methylation.We then indicate that SRSF7 is a novel m^(6)A regulator,which specifically facilitates the m^(6)A methylation near its binding sites on the mRNAs involved in cell proliferation and migration,through recruiting the methyltransferase complex.Moreover,SRSF7 promotes the proliferation and migration of GBM cells largely dependent on the presence of the m^(6)A methyltransferase.The two m^(6)A sites on the mRNA for PDZ-binding kinase(PBK)are regulated by SRSF7 and partially mediate the effects of SRSF7 in GBM cells through recognition by insulin-like growth factor 2 mRNA-binding protein 2(IGF2BP2).Together,our discovery reveals a novel role of SRSF7 in regulating m^(6)A and validates the presence and functional importance of temporal-and spatial-specific regulation of m^(6)A mediated by RNA-binding proteins(RBPs). | Yixian Cun Sanqi An Haiqing Zheng Jing Lan Wenfang Chen Wanjun Luo Chengguo Yao Xincheng Li Xiang Huang Xiang Sun Zehong Wu Yameng Hu Ziwen Li Shuxia Zhang Geyan Wu Meisongzhu Yang Miaoling Tang Ruyuan Yu Xinyi Liao Guicheng Gao Wei Zhao Jinkai Wang Jun Li | 2023 | Genomics, Proteomics & Bioinformatics2023，21，4： | 1 |
| 9 | Genetic variations of mTORC1 genes and risk of gastric cancer in an eastern chinese population显示文摘 | Jing He Meng‐Yun Wang Li‐Xin Qiu Mei‐Ling Zhu Ting‐Yan Shi Xiao‐Yan Zhou Meng‐Hong Sun Ya‐Jun Yang Jiu‐Cun Wang Li Jin Ya‐Nong Wang Jin Li Hong‐Ping Yu Qing‐Yi Wei | 2013 | Carcinog2013，，1： | 1 |
| 10 | Tumor-derived secretory clusterin induces epithelial–mesenchymal transition and facilitates hepatocellular carcinoma metastasis显示文摘 | Cun Wang Kai Jiang Xiaonan Kang Dongmei Gao Chun Sun Yan Li Lu Sun Shu Zhang Xiaohui Liu Weizhong Wu Pengyuan Yang Kun Guo Yinkun Liu | 2012 | International Journal of Biochemistry and Cell Biology2012，，12： | 1 |
| 11 | Formulation and in vitro / in vivo correlation of a drug‐in‐adhesive transdermal patch containing azasetron显示文摘 | Lin Sun Dongmei Cun Bo Yuan Hongxia Cui Honglei Xi Liwei Mu Yang Chen Chao Liu Zhongyan Wang Liang Fang | 2012 | J. Pharm. Sci2012，，： | 1 |
| 12 | Warp Degree Optimization of Automobile Bumper in Sequential Injection Molding显示文摘 | Shi Xian Sun Yao Shun Zhu Cun Yu Cai Yong Mei Li Rui Tao Rong Sun | 2013 | Applied Mechanics and Materials . 2013 (329)2013，，： | 1 |
| 13 | Characteristic strength and acoustic emission properties of weakly cemented sandstone at different depths under uniaxial compression显示文摘As coal mining is extended from shallow to deep areas along the western coalfield,it is of great significance to study weakly cemented sandstone at different depths for underground mining engineering.Sandstones from depths of 101.5,203.2,317.3,406.9,509.9 and 589.8 m at the Buertai Coal Mine were collected.The characteristic strength,acoustic emission(AE),and energy evolution of sandstone during uniaxial compression tests were analyzed.The results show that the intermediate frequency(125-275 kHz)of shallow rock mainly occurs in the postpeak stage,while deep rock occurs in the prepeak stage.The initiation strength and damage strength of the sandstone at different depths range from 0.23 to 0.50 and 0.63 to 0.84 of peak strength(σ_(c)),respectively,decrease exponentially and are a power function with depth.The precursor strength ranges from 0.88σ_(c)to 0.99σ_(c),increases with depth before reaching a depth of 300 m,and tends to stabilize after 300 m.The ratio of the initiation strength to the damage strength(k)ranges from 0.25 to 0.62 and decreases exponentially with depth.The failure modes of sandstone at different depths are tension-dominated mixed tensile-shear failure.Shear failure mainly occurs at the unstable crack propagation stage.The count of the shear failure bands before the peak strength increases gradually,and increases first and then decreases after the peak strength with burial depth.The cumulative input energy,released elastic energy and dissipated energy increase with depth.The elastic release rate ranges from 0.46×10^(-3)to 198.57×10^(-3)J/(cm^(3)s)and increases exponentially with depth. | Bin Liu Yixin Zhao Cun Zhang Jinlong Zhou Yutao Li Zhuang Sun | 2021 | International Journal of Coal Science & Technology2021，8，6： | 1 |
| 14 | Structural characterization of SiC nanoparticles显示文摘The structure and size of SiC nanoparticles were studied by different characterization methods including small angle X-ray scattering(SAXS),transmission electron microscope(TEM),and X-ray diffraction(XRD).The results showed that particle size distributions determined respectively from SAXS and TEM are comparable and follow the log-normal function.The size distribution of the particles is between 10 to 100nm with most of them being in the range of 20-50nm.The average particle size is around 42nm.XRD identifies the phase of the SiC nanoparticles and suggests the average size of the single crystalline domain to be around 21nm.The combined results from XRD and SAXS suggest the existence of many polycrystals,which is confirmed by the HRTEM observation of particles with twins and stacking faults.The material synthesis methods leading to various particle sizes are also discussed. | Baoxing Sun Ruobing Xie Cun Yu Cheng Li Hongjie Xu | 2017 | Journal of Semiconductors2017，38，10： | 0 |
| 15 | Mechanism of oxide thickness and temperature dependent current conduction in n^+-polySi/SiO_2/p-Si structures—a new analysis显示文摘The conduction mechanism of gate leakage current through thermally grown silicon dioxide(Si02)films on(100) p-type silicon has been investigated in detail under negative bias on the degenerately doped n-type polysilicon(n+-polySi) gate.The analysis utilizes the measured gate current density J_G at high oxide fields E_(ox) in5.4 to 12 nm thick Si02 films between 25 and 300 ℃.The leakage current measured up to 300 ℃ was due to Fowler-Nordheim(FN) tunneling of electrons from the accumulated n+-polySi gate in conjunction with Poole Frenkel(PF) emission of trapped-electrons from the electron traps located at energy levels ranging from 0.6 to 1.12 eV(depending on the oxide thickness) below the Si02 conduction band(CB).It was observed that PF emission current I_(PF) dominates FN electron tunneling current I_(FN) at oxide electric fields E_(OX) between 6 and 10 MV/cm and throughout the temperature range studied here.Understanding of the mechanism of leakage current conduction through Si02 films plays a crucial role in simulation of time-dependent dielectric breakdown(TDDB) of metaloxide-semiconductor(MOS) devices and to precisely predict the normal operating field or applied gate voltage for lifetime projection of the MOS integrated circuits. | Baoxing Sun Ruobing Xie Cun Yu Cheng Li Hongjie Xu Piyas Samanta | 2017 | Journal of Semiconductors2017，38，10： | 0 |
| 16 | Urease inactivation by an unusual GroES chaperonin显示文摘It remains uncovered yet how the common gastric pathogen,Helicobacter pylori,survives through the acidic barrier and the immune response simultaneously in the stomach.Herein we report a unique GroES chaperonin that effectively inactivates Helicobacter pylori urease in Escherichia coli model.Such a function depends on the quaternary structure as well as the metal binding at the C terminus.Surprisingly,the C-terminal metal capacity seems not closely relevant to the apparent urease inactivation.Our findings have possibly revealed a survival strategy of Helicobacter pylori after its gastric localization. | CUN ShuJian SUN HongZhe | 2014 | Science China Chemistry2014，57，6： | 0 |
| 17 | Speech Encryption with Fractional Watermark显示文摘Research on the feature of speech and image signals are carried out from two perspectives,the time domain and the frequency domain.The speech and image signals are a non-stationary signal,so FT is not used for the non-stationary characteristics of the signal.When short-term stable speech is obtained by windowing and framing the subsequent processing of the signal is completed by the Discrete Fourier Transform(DFT).The Fast Discrete Fourier Transform is a commonly used analysis method for speech and image signal processing in frequency domain.It has the problem of adjusting window size to a for desired resolution.But the Fractional Fourier Transform can have both time domain and frequency domain processing capabilities.This paper performs global processing speech encryption by combining speech with image of Fractional Fourier Transform.The speech signal is embedded watermark image that is processed by fractional transformation,and the embedded watermark has the effect of rotation and superposition,which improves the security of the speech.The paper results show that the proposed speech encryption method has a higher security level by Fractional Fourier Transform.The technology is easy to extend to practical applications. | Yan Sun Cun Zhu Qi Cui | 2022 | Computers, Materials & Continua2022，，10： | 0 |
| 18 | Estimation of Solar Observations with the Five-hundred-meter Aperture Spherical Radio Telescope(FAST)显示文摘We present the estimation of solar observation with the Five-hundred-meter Aperture Spherical radio Telescope(FAST).For both the quiet Sun and the Sun with radio bursts,when pointing directly to the Sun,the total power received by FAST would be out of the safe operational range of the signal chain,even resulting in damage to the receiver.As a conclusion,the Sun should be kept at least~2°away from the main beam during observations at~1.25 GHz.The separation for lower frequency should be larger.For simplicity,the angular separation between the FAST beam and the Sun is suggested to be~5°for observations at 200 MHz or higher bands. | Lei Qian Zhichen Pan Hongfei Liu Hengqian Gan Jinglong Yu Lei Zhao Jiguang Lu Cun Sun Jingye Yan Peng Jiang | 2023 | Research in Astronomy and Astrophysics2023，23，1： | 0 |
| 19 | Mobile MicroRobotin Small Pipe Driven by ElectroMagnetic Force显示文摘It is required to develop micro machine for inspection and maintenance of defects inside small pipe with diameter smaller than one inch. Considering the advantages of electromagnetic actuators with simple mechanism, high response, convenience to control and fabricate, we tried to develop a new micro robot in small pipe based on interaction principle of electromagnetic attraction and spring force. This paper describes its structure and design. The dimension of the prototype is diameter of 15 mm, length of 30 mm and weight of 25 g. It can climb in small pipe of diameter of 20 mm with a speed of 6~8 mm/s in horizontal or in vertical situation. | SUN Lin zhi SUN Ping WANG Cun min QIN Xin jie (School of Mechanical and Electronic Engineering, Shanghai University) | 1999 | Advances in Manufacturing1999，，4： | 0 |
| 20 | Van Hove Singularities as a Result of Quantum Confinement:The Origin of Intriguing Physical Properties in Pb Thin Films显示文摘In situ angle-resolved photoemission spectroscopy(ARPES)and scanning tunneling spectroscopy(STS)have been used to study the electronic structure of Pb thin films grown on a Si(111)substrates.The experiments reveal that the electronic structure near the Fermi energy is dominated by a set of m-shaped subbands because of strong quantum confinement in the films,and the tops of the m-shaped subbands form an intriguing ring-like Van Hove singularity.Combined with theoretical calculations,we show that it is the Van Hove singularity that leads to an extremely high density of states near the Fermi energy and the recently reported strong oscillations(with a period of two monolayers)in various properties of Pb films. | Yu Jie Sun S.Souma Wen Juan Li T.Sato Xie Gang Zhu Guang Wang Xi Chen Xu Cun Ma Qi Kun Xue Jin Feng Jia T.Takahashi T.Sakurai | 2010 | Nano Research2010，3，11： | 0 |
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