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| 1 | 冠状动脉内影像学临床应用专家共识(第一部分):对冠状动脉介入治疗的指导与优化显示文摘欧洲心血管介入协会(EAPCI)专家组系统总结了血管内超声(IVUS)和光学相干断层成像(OCT)这两种血管内影像学检查临床应用指征的现有证据,提供了关于IVUS和OCT指导经皮冠状动脉介入治疗(PCI)的应用价值,并明确了最可能从腔内影像学指导的介入治疗中获得临床收益的患者或病变类型,同时详细论述了PCI前如何使用IVUS或OCT优化支架尺寸(支架长度和直径)和手术策略的选择。此外,专家推荐对支架失败(支架内再狭窄或支架内血栓形成)的患者应常规进行冠状动脉内影像学检查,并首选OCT。最后,重点论述了IVUS和OCT在指导PCI和评估支架失败两个方面的优势和局限性,并对未来需要深入研究的领域进行了展望。 | Lorenz Raber Gary S Mintz Konstantinos C Koskinas Thomas W Johnson Niels R Holm Yoshinubo Onuma Maria D Radu Michael Joner Bo Yu Haibo Jia Nicolas Meneveau Jose M.de la Torre Hemandez Javier Escaned Jonathan Hill Francesco Prati Antonio Colombo Carlo di Mario Evelyn Regar Davide Capodanno William Wijns Robert A Byme Giulio Guagliumi | 2019 | 中华心血管病杂志2019，47，1： | 17 |
| 2 | Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease显示文摘AIM: To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide poly- morphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007fi nsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy. METHODS: Allele and genotype frequencies of NOD2/ CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD pa-tients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESULTS: NOD2/CARD15 R702W mutation was sig-nificantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03). No sig-nificant difference was found between UC patients and control group (P > 0.05). In CD and UC patients, no signifi cant association with G908R variant was found. L1007f insC SNP showed an association with CD (9.8%) compared with controls (2.9%, P = 0.002) and UC patients (2.3%, P = 0.01). Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05). CONCLUSION: These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/ CARD15, but not TLR4 SNPs, are associated with in-creased risk of CD. | Luciana Rigoli Claudio Romano Rosario Alberto Caruso Maria A Lo Presti Chiara Di Bella Vincenzo Procopio Giuseppina Lo Giudice Maria Amorini Giuseppe Costantino Maria D Sergi Caterina Cuppari Giovanna Elisa Calabrò Romina Gallizzi Carmelo Damiano Salpietro Walter Fries | 2008 | World Journal of Gastroenterology2008，14，28： | 8 |
| 3 | Intraoperative use of indocyanine green fluorescence imaging in rectal cancer surgery: The state of the art显示文摘Indocyanine green(ICG)fluorescence imaging is widely used in abdominal surgery.The implementation of minimally invasive rectal surgery using new methods like robotics or a transanal approach required improvement of optical systems.In that setting,ICG fluorescence optimizes intraoperative vision of anatomical structures by improving blood and lymphatic flow.The purpose of this review was to summarize all potential applications of this upcoming technology in rectal cancer surgery.Each type of use has been separately addressed and the evidence was investigated.During rectal resection,ICG fluorescence angiography is mainly used to evaluate the perfusion of the colonic stump in order to reduce the risk of anastomotic leaks.In addition,ICG fluorescence imaging allows easy visualization of organs such as the ureter or urethra to protect them from injury.This intraoperative technology is a valuable tool for conducting lymph node dissection along the iliac lymphatic chain or to better identifying the rectal dissection planes when a transanal approach is performed.This is an overview of the applications of ICG fluorescence imaging in current surgical practice and a synthesis of the results obtained from the literature.Although further studies are need to investigate the real clinical benefits,these findings may enhance use of ICG fluorescence in current clinical practice and stimulate future research on new applications. | Roberto Peltrini Mauro Podda Simone Castiglioni Maria Michela Di Nuzzo Michele D'Ambra Ruggero Lionetti Maurizio Sodo Gaetano Luglio Felice Mucilli Salomone Di Saverio Umberto Bracale Francesco Corcione | 2021 | World Journal of Gastroenterology2021，27，38： | 3 |
| 4 | Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence显示文摘 | Juan C. Acosta Ana O’Loghlen Ana Banito Maria V. Guijarro Arnaud Augert Selina Raguz Marzia Fumagalli Marco Da Costa Celia Brown Nikolay Popov Yoshihiro Takatsu Jonathan Melamed Fabrizio d’Adda di Fagagna David Bernard Eva Hernando Jesús Gil | 2008 | Cell2008，，6： | 2 |
| 5 | Treatment of benign paroxysmal positional ver tigo of posterior semicircular canal by 'Quick Libera- tory Rotation Manoeuvre'显示文摘 | CALIFANO L CAPPARUCCIA P G DI MARIA D | 2003 | Acta Otorhinolaryngol Ital2003，23，： | 1 |
| 6 | Cost-effectiveness of semi-annual surveillance for hepatocellular carcinoma in cirrhotic patients of the Italian Liver Cancer population显示文摘 | Alessandro Cucchetti Franco Trevisani Matteo Cescon Giorgio Ercolani Fabio Farinati Paolo Del Poggio Gianludovico Rapaccini Maria Anna Di Nolfo Luisa Benvegnù Marco Zoli Franco Borzio Edoardo Giovanni Giannini Eugenio Caturelli Maria Chiaramonte Antonio D | 2012 | Journal of Hepatology2012，，5： | 1 |
| 7 | Homozygous C677T Mutation of the 5,10 Methylenetetrahydrofolate Reductase Gene and Hyperhomocysteinemia in Italian Patients With a History of Early-Onset Ischemic Stroke显示文摘 | Lucia Soriente Antonio Coppola Pasquale Madonna Anna Maria Cerbone Giovanni Di Minno Guiseppe Orefice Armando D’Angelo | 1998 | Stroke A Journal of Cerebral Circulation1998，，4： | 1 |
| 8 | Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence显示文摘 | Juan C. Acosta Ana O’Loghlen Ana Banito Maria V. Guijarro Arnaud Augert Selina Raguz Marzia Fumagalli Marco Da Costa Celia Brown Nikolay Popov Yoshihiro Takatsu Jonathan Melamed Fabrizio d’Adda di Fagagna David Bernard Eva Hernando Jesús Gil | 2008 | Cell2008，，6： | 1 |
| 9 | A three month-old infant with severe hyperchylomicronemia: Molecular diagnosis and extracorporeal treatment显示文摘 | Claudia Stefanutti Maria Gozzer Livia Pisciotta Patrizia D’Eufemia Giovanna Bosco Claudia Morozzi Francesco Papadia Manhaz Shafii Serafina Di Giacomo Stefano Bertolini | 2013 | Atherosclerosis (Supplements) (Component)2013，，1： | 1 |
| 10 | Long-term antiviral treatment for recurrent hepatitis C after liver transplantation显示文摘 | Valentina Rosa Bertuzzo Matteo Cescon Maria Cristina Morelli Paolo Di Gioia Mariarosa Tamè Stefania Lorenzini Pietro Andreone Giorgio Ercolani Massimo Del Gaudio Matteo Ravaioli Alessandro Cucchetti Alessandro Dazzi Antonietta D’Errico-Grigioni Antonio Da | 2012 | Digestive and Liver Disease2012，，10： | 1 |
| 11 | Regional variations in the use of complementary and alternative medicines (CAM) for inflammatory bowel disease patients in Italy: An IG-IBD study显示文摘 | Perla Bertomoro Sara Renna Mario Cottone Gabriele Riegler Fabrizio Bossa Licio Giglio Luca Pastorelli Claudio Papi Fabiana Castiglione Erika Angelucci Roberta Pica Maria Carla Di Paolo Renata D’Incà | 2009 | Journal of Crohn’s and Colitis2009，，3： | 1 |
| 12 | Effects of low concentrations of Regorafenib and Sorafenib on human HCC cell AFP, migration, invasion, and growth in vitro显示文摘 | Brian I. Carr Rosalba D’Alessandro Maria G. Refolo Palma A. Iacovazzi Catia Lippolis Caterina Messa Aldo Cavallini Mario Correale Antonio Di Carlo | 2013 | J. Cell. Physiol2013，，6： | 1 |
| 13 | Boceprevir or telaprevir in hepatitis C virus chronic infection:The Italian real life experience显示文摘AIM: To check the safety and efficacy of boceprevir/telaprevir with peginterferon/ribavirin for hepatitis C virus(HCV) genotype 1 in the real-world settings. METHODS: This study was a non-randomized, observational, prospective, multicenter. This study involved 47 centers in Italy. A database was prepared for the homogenous collection of the data, was used by all of the centers for data collection, and was updated continuously. All of the patients enrolled in this study were older than 18 years of age and were diagnosed with chronic infection due to HCV genotype 1. The HCV RNA testing was performed using COBAS-Taq Man2.0(Roche, LLQ 25 IU/m L). RESULTS: All consecutively treated patients were included. Forty-seven centers enrolled 834 patients as follows: Male 64%; median age 57(range 18-78), of whom 18.3% were over 65; mean body mass index 25.6(range 16-39); genotype 1b(79.4%); diagnosis of cirrhosis(38.2%); and fibrosis F3/4(71.2%). The following drugs were used: Telaprevir(66.2%) and PEG-IFN-alpha2a(67.6%). Patients were na?ve(24.4%), relapsers(30.5%), partial responders(14.8%) and null responders(30.3%). Overall, adverse events(AEs) occurred in 617 patients(73.9%) during the treatment. Anemia was the most frequent AE(52.9% of cases), especially in cirrhotic. The therapy was stopped for 14.6% of the patients because of adverse events or virological failure(15%). Sustained virological response was achieved in 62.7% of the cases, but was 43.8% in cirrhotic patients over 65 years of age. CONCLUSION: In everyday practice, triple therapy is safe but has moderate efficacy, especially for patients over 65 years of age, with advanced fibrosis, nonresponders to peginterferon + ribavirin. | Antonio Ascione Luigi Elio Adinolfi Pietro Amoroso Angelo Andriulli Orlando Armignacco Tiziana Ascione Sergio Babudieri Giorgio Barbarini Michele Brogna Francesco Cesario Vincenzo Citro Ernesto Claar Raffaele Cozzolongo Giuseppe D’Adamo Emilio D’Amico Pellegrino Dattolo Massimo De Luca Vincenzo De Maria Massimo De Siena Giuseppe De Vita Antonio Di Giacomo Rosanna De Marco Giorgio De Stefano Giulio De Stefano Sebastiano Di Salvo Raffaele Di Sarno Nunzia Farella Laura Felicioni Basilio Fimiani Luca Fontanella Giuseppe Foti Caterina Furlan Francesca Giancotti Giancarlo Giolitto Tiziana Gravina Barbara Guerrera Roberto Gulminetti Angelo Iacobellis Michele Imparato Angelo Iodice Vincenzo Iovinella Antonio Izzi Alfonso Liberti Pietro Leo Gennaro Lettieri Ileana Luppino Aldo Marrone Ettore Mazzoni Vincenzo Messina Roberto Monarca Vincenzo Narciso Lorenzo Nosotti Adriano Maria Pellicelli Alessandro Perrella Guido Piai Antonio Picardi Paola Pierri Grazia Pietromatera Francesco Resta Luca Rinaldi Mario Romano Angelo Rossini Maurizio Russello Grazia Russo Rodolfo Sacco Vincenzo Sangiovanni Antonio Schiano Antonio Sciambra Gaetano Scifo Filomena Simeone Annarita Sullo Pierluigi Tarquini Paolo Tundo Alfredo Vallone | 2016 | World Journal of Hepatology2016，8，22： | 1 |
| 14 | Activation of the Amyloidogenic Route by NGF Deprivation Induces Apoptotic Death in PC12 Cells显示文摘 | Carmela Matrone Anna Di Luzio Giovanni Meli Simona D’Aguanno Cinzia Severini Maria Teresa Ciotti Antonino Cattaneo Pietro Calissano | 2008 | Journal of Alzheimer’s Disease2008，，1： | 1 |
| 15 | Estrogen deficiency increases osteoclastogenesis up-regulating T cells activity: A key mechanism in osteoporosis显示文摘 | Patrizia D'Amelio Anastasia Grimaldi Stefania Di Bella Stefano Z.M. Brianza Maria Angela Cristofaro Cristina Tamone Giuliana Giribaldi Daniela Ulliers Gian P. Pescarmona Giancarlo Isaia | 2008 | Bone2008，，1： | 1 |
| 16 | NEUROGLOBIN EXPRESSION AND OXIDANTS/ANTIOXIDANTS BALANCE FOLLOWING GRADED TRAUMATIC BRAIN INJURY IN THE RAT显示文摘 | Valentina Di Pietro Giacomo Lazzarino Angela Maria Amorini Barbara Tavazzi Serafina D’Urso Salvatore Longo Roberto Vagnozzi Stefano Signoretti Elisabetta Clementi Bruno Giardina Giuseppe Lazzarino Antonio Belli | 2014 | Free Radical Biology and Medicine2014，，： | 1 |
| 17 | Advantages of multidisciplinary management of bile duct injuries occurring during cholecystectomy显示文摘 | Gennaro Nuzzo Felice Giuliante Ivo Giovannini Marino Murazio Fabrizio D’Acapito Francesco Ardito Maria Vellone Riccardo Gauzolino Guido Costamagna Carmine Di Stasi | 2008 | The American Journal of Surgery2008，，6： | 1 |
| 18 | Isolation and structure elucidation of four new triterpenoid estersaponins from fruits of Pittosporum tobira显示文摘 | Ilaria D' Acquarica Maria Cristina Di Giovanni Francesco Gasparrini Domenico Misiti | 2002 | AIT2002，，10： | 1 |
| 19 | Isolation and structure elucidation of four new triterpenoid estersaponins from fruits of Pittosporum tobira Ait显示文摘 | Ilaria D'Acquarica Maria Cristina Di Giovanni Francesco Gasparrini | 2002 | Tetrahedron2002，58，10： | 1 |
| 20 | Isolation and structure elucidation of four new triterpenoid estersaponins from fruits of Pittosporum tobira AIT显示文摘 | Ilaria D'Acquarica Maria Cristina Di Giovanni Francesco Gasparrini | 2002 | Tetrahedron2002，，10： | 1 |
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