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| 1 | Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells显示文摘体的房间能由定义因素是进导致的 pluripotent 干细胞(iPSCs ) 的 reprogrammed。reprogramming 的低效率和 oncogenes 和病毒的向量的 genomic 集成限制了 iPSCs 的潜在的申请。这里,我们报导那锂(李) ,药过去常对待心情混乱,极大地从老鼠提高 iPSC 产生胚胎的成纤维细胞和人的脐的静脉 endothelial 房间。李与(Oct4 ) 或二个因素(OS 或好) 便于 iPSC 产生。支持 reprogramming 上的李的效果仅仅部分取决于它的主要目标 GSK3β。不同于另外的 GSK3β禁止者,李不仅增加 Nanog 的表示,而且提高 Nanog 的 transcriptional 活动。我们也发现李由经由 LSD1 的 downregulation 支持 epigenetic 修正施加它的效果, H3K4 特定的 histone demethylase。将 LSD1 击倒部分在提高 reprogramming 模仿李的效果。我们的结果不仅提供一个直接方法改进 iPSC 产生效率,而且为体的房间 reprogramming 作为一个批评调节的人识别了 histone demethylase。 | Quan Wang Xinxiu Xu Jun Li Jing Liu Haifeng Gu Ru Zhang Jiekai Chen Yin Kuang Jian Fei Cong Jiang Ping Wang Duanqing Pei Sheng Ding Xin Xie | 2011 | Cell Research2011，21，10： | 23 |
| 2 | Successful generation of cloned mice using nuclear transfer from induced pluripotent stem cells显示文摘 | Shuya Zhou Chenhui Ding Xiaoyang Zhao Eryao Wang Xiangpeng Dai Lei Liu Wei Li Zichuan Liu Haifeng Wan Chunjing Feng Tang Hai Liu Wang Qi Zhou | 2010 | Cell Research2010，20，7： | 10 |
| 3 | Trend and Development of Semi-Solid Metal Processing显示文摘This paper reviewed the trend and development of semi-solid metal technique. The processes and mechanisms for producing slurry of SSM and its industrial applications have been summarized and discussed. Discussions on the basic rheological theory are presented for more applications. Further consideration of the development and application of SSM technique is also proposed. | Xianfeng PAN, Haifeng ZHANG, Aimin WANG, Bingzhe DING, Keqiang QIU and Zhuangqi HU (State Key Laboratory of Rapidly Solidified Nonequilibrium Alloys, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110015, China) | 2000 | Journal of Materials Science & Technology2000，16，5： | 7 |
| 4 | Sedimentary environment of Ediacaran glacigenic diamictite in Guozigou of Xinjiang, China显示文摘The Talisayi Formation found in the Guozigou region on the southern side of Sayram Lake of Xinjiang, China is a Neoproterozoic glacigenic diamictite succession that has not been adequately researched. According to its isotopic geochronology and regional stratigraphic correlation, the Talisayi Formation is equivalent to the Ediacaran glacial sediments. The present paper provides the geochemical data of the Talisayi Formation that reveals the tectonic setting and sedimentary environment in this area during the Ediacaran period. The oxides of Si, K, Na and Al and their ratios of matrix materials from glacigenic diamictites and bulk rock of siltstone and argillaceous siltstones indicate that the sedimentary environment of this formation evolved from a tectonically active region to a passive continental margin. Values of CIA (carbonate-corrected Chemical Index of Alteration) ranging from 54 to 74 show a low-middle weathering action under a glacial environment. Total organic carbon (TOC), V/Cr, Ni/Co and U/Th ratios suggest that the sediments deposited in shallow water with an oxic and weak hydrodynamic condition. There is an abrupt rise in TOC, V/Cr, Ni/Co and U/Th ratios respectively in the overlying Lower Cambrian dolomitic limestones and in the bottom of Talisayi Formation, indicating a rapidl increase in biologic productivity and a variation in redox conditions, which was probably caused by seawater mixing of deep anoxic water and surface oxic water. | DING HaiFeng MA DongSheng YAO ChunYan SHU LiangShu | 2009 | Chinese Science Bulletin2009，54，18： | 7 |
| 5 | Trace elements and stable isotopic geochemistry of an Early Cambrian chert-phosphorite unit from the lower Yurtus Formation of the Sugetbrak section in the Tarim Basin显示文摘A chert-phosphorite unit from the Sugetbrak section in the Tarim Basin was analyzed for rare earth elements(Ce,Eu),redox sensitive proxies,and carbon isotopic compositions(??13C carb and??13C org)in the lower Yurtus Formation of the Early Cambrian period.Redox sensitive element ratios(Th/U,V/Cr,Ni/Co,and V/Sc)were employed to determine the palaeoenvironmental conditions during this period.The ratios indicated that the depositional environment of the chert-phosphorite-black shale unit ranged from suboxic to anoxic.Negative Ce and positive Eu anomalies in the chert-phosphorite assemblages of the studied Yurtus Formation indicated the existence of a redox-stratified ocean,similar to that of South China.Overturn or upward expansion of the deep water-mass probably reached the shallow marine zone after the formation of the Yurtus phosphorites.The characteristics of the negative Ce anomaly may be due to phosphoritic inheritance from the Ce-depleted signature of the overlying water column.Subsequent hydrothermal inputs and reduced detrital supplies of the deep water caused by the upwelling affected certain redox sensitive elements in the sedimentary basin.??13C carb and??13C org negative excursions in the Yurtus chert-phosphorite unit may be related to a transgression phase when episodic basinal upwelling moved12C-and P-rich waters from the pelagic basin floor to the continental shelf.Although carbon isotopic compositions in the Yurtus chert-phosphorite assemblages may have suffered from diagenetic alteration,they can be used to probe diagenetic conditions.Multi-proxy geochemical studies indicated that the??13C carb values of the Yurtus chert-phosphorite assemblages might be considered reflections of a predominantly suboxic environment that was subsequently affected by hydrothermal inputs due to the upwelling. | YAO ChunYan MA DongSheng DING HaiFeng ZHANG XiaoYong HUANG Hui | 2014 | Science China Earth Sciences2014，57，3： | 7 |
| 6 | Nonlinear health evaluation for lithium-ion battery within full-lifespan显示文摘Lithium-ion batteries(LIBs), as the first choice for green batteries, have been widely used in energy storage, electric vehicles, 3C devices, and other related fields, and will have greater application prospects in the future. However, one of the obstacles hindering the future development of battery technology is how to accurately evaluate and monitor battery health, which affects the entire lifespan of battery use. It is not enough to assess battery health comprehensively through the state of health(SoH) alone, especially when nonlinear aging occurs in onboard applications. Here, for the first time, we propose a brand-new health evaluation indicator—state of nonlinear aging(SoNA) to explain the nonlinear aging phenomenon that occurs during the battery use, and also design a knee-point identification method and two SoNA quantitative methods. We apply our health evaluation indicator to build a complete LIB full-lifespan grading evaluation system and a ground-to-cloud service framework, which integrates multi-scenario data collection, multi-dimensional data-based grading evaluation, and cloud management functions. Our works fill the gap in the LIBs’ health evaluation of nonlinear aging, which is of great significance for the health and safety evaluation of LIBs in the field of echelon utilization such as vehicles and energy storage. In addition, this comprehensive evaluation system and service framework are expected to be extended to other battery material systems other than LIBs, yet guiding the design of new energy ecosystem. | Heze You Jiangong Zhu Xueyuan Wang Bo Jiang Hao Sun Xinhua Liu Xuezhe Wei Guangshuai Han Shicong Ding Hanqing Yu Weihan Li Dirk Uwe Sauer Haifeng Dai | 2022 | Journal of Energy Chemistry2022，31，9： | 4 |
| 7 | Early Cambrian carbon isotope stratigraphy in the Tarim Basin and a correlation with the Yangtze Platform显示文摘Carbon isotope chemostratigraphy has been used worldwide for stratigraphic correlation.In this study,δ13Ccarb values are estimated for the Early Cambrian Sugaitebulake section in the Tarim Basin,Xinjiang Autonomous Region,China.As a result,one positive and two negative carbon isotope excursions in the studied section were iden-tified.The δ13Ccarb values reached the maximum negative excursion(N1:-12.39‰) at the basal of the Yuertusi For-mation,and then increased to P1.After P1,δ13Ccarb values sharply decreased to about-7.06‰(N2) in the studied section.The pattern of δ13Ccarb in the Early Cambrian is comparable to the synchronous records of other sections,such as the Laolin section,the Xiaotan section and the Anjiahe section of the Yangtze Platform.It is concluded that the Early Cambrian Yuertusi Formation from the Tarim Basin is within the Nemakit-Daldynian stage,and the lower strata of the Yuertusi Formation may belong to the Zhujiaqing Formation(Meishucun Formation) of the Yangtze Platform.The Ediacaran/Cambrian boundary of the Tarim Block should be located in cherts and phosphorites suc-cessions at the basal of the Yuertusi Formation.The δ13Ccarb negative excursion N1 is just across the PC/C boundary,and may be related to certain biomass extinction due to anoxic sedimentary environment,transgression and/or the oceanic overturn.The second δ13Ccarb negative excursion N2 may account for the sea-level falling in the Early Cam-brian. | YAO Chunyan MA Dongsheng DING Haifeng ZHANG Xiaoyong | 2011 | Chinese Journal Of Geochemistry2011，30，3： | 3 |
| 8 | In vivo degradation and endothelialization of an iron bioresorbable scaffold显示文摘Detection of in vivo biodegradation is critical for development of next-generation medical devices such as bioresorbable stents or scaffolds(BRSs).In particular,it is urgent to establish a nondestructive approach to examine in vivo degradation of a new-generation coronary stent for interventional treatment based on mammal experiments;otherwise it is not available to semi-quantitatively monitor biodegradation in any clinical trial.Herein,we put forward a semi-quantitative approach to measure degradation of a sirolimus-eluting iron bioresorbable scaffold(IBS)based on optical coherence tomography(OCT)images;this approach was confirmed to be consistent with the present weight-loss measurements,which is,however,a destructive approach.The IBS was fabricated by a metal-polymer composite technique with a polylactide coating on an iron stent.The efficacy as a coronary stent of this new bioresorbable scaffold was compared with that of a permanent metal stent with the name of trade mark Xience,which has been widely used in clinic.The endothelial coverage on IBS was found to be greater than on Xience after implantation in a rabbit model;and our well-designed ultrathin stent exhibited less individual variation.We further examined degradation of the IBSs in both minipig coronary artery and rabbit abdominal aorta models.The present result indicated much faster iron degradation of IBS in the rabbit model than in the porcine model.The semi-quantitative approach to detect biodegradation of IBS and the finding of the species difference might be stimulating for fundamental investigation of biodegradable implants and clinical translation of the next-generation coronary stents. | Wenjiao Lin Hongjie Zhang Wanqian Zhang Haiping Qi Gui Zhang Jie Qian Xin Li Li Qin Haifeng Li Xiang Wang Hong Qiu Xiaoli Shi Wei Zheng Deyuan Zhang Runlin Gao Jiandong Ding | 2021 | Bioactive Materials2021，6，4： | 3 |
| 9 | Carbon Isotope Features of the Sugetbrak Section in the Aksu-Wushi Area, Northwest China: Implications for the Precambrian/Cambrian Stratigraphic Correlations显示文摘The upper Qigeblaq Formation(Fm) dolostones and the Yurtus Fm phosphatic cherts, black shales, limestones, and dolostones are widely distributed in the Precambrian/Cambrian transitional succession of the Aksu-Wushi area. Negative δ13C excursion above the Yurtus Fm/Qigeblaq Fm boundary was determined in this study. The pronounced negative carbon isotope excursion occurs in the phosphatic chert layers at the bottom of the Cambrian Yurtus Fm, below which the first appearance of the Asteridium- Heliosphaeridium-Comasphaeridium(AHC) acritarch assemblage zone. The δ13C curve of the lower part of the Yurtus Fm in the Aksu-Wushi area was found to be correlated with the early Cambrian δ13C curves of the Zhujiaqing Fm(Daibu Member), the lower part of the Yanjiahe Fm on the Yangtze Platform in China, the lower Tal Fm in India, the Sukharikha Fm in Siberia, and the upper part of the Tsagaan Oloom Fm in Mongolia through biostigraphy. The lower part of the Yurtus Fm in the Tarim Basin is at the Nemakit-Daldynian stage, and the Precambrian/Cambrian boundary of the Aksu-Wushi area may be located in the phosphatic chert unit which just below the first appearance AHC acritarch assemblage zone. The negative δ13C excursion(N1) across the Precambrian/ Cambrian boundary in the studied section may have resulted from oceanic overturning and sea level rise. | YAO Chunyan DING Haifeng MA Dongsheng LI Guoxiang | 2014 | Acta Geologica Sinica(English Edition)2014，88，5： | 3 |
| 10 | CCAR1 5' UTR as a natural miRancer of miR-1254 overrides tamoxifen resistance显示文摘 | Gaopeng Li Xiaoli Wu Wenchang Qian Huayong Cai Xinbao Sun Weijie Zhang Sheng Tan Zhengsheng Wu Pengxu Qian Keshuo Ding Xuefei Lu Xiao Zhang Hong Yan Haifeng Song Shouhong Guang Qingfa Wu Peter E Lobie Ge Shan Tao Zhu | 2016 | Cell Research2016，26，6： | 3 |
| 11 | Progress and prospects of horizontal well fracturing technology for shale oil and gas reservoirs显示文摘By systematically summarizing horizontal well fracturing technology abroad for shale oil and gas reservoirs since the “13th Five-Year Plan”, this article elaborates new horizontal well fracturing features in 3D development of stacked shale reservoirs, small well spacing and dense well pattern, horizontal well re-fracturing, fracturing parameters optimization and cost control. In light of requirements on horizontal well fracturing technology in China, we have summarized the technological progress in simulation of multi-fracture propagation, horizontal well frac-design, electric-drive fracturing equipment, soluble tools and low-cost downhole materials and factory-like operation. On this basis, combined with the demand analysis of horizontal well fracturing technology in the “14th Five-Year Plan” for unconventional shale oil and gas, we suggest strengthening the research and development in the following 7 aspects:(1) geology-engineering integration;(2) basic theory and design optimization of fracturing for shale oil and gas reservoirs;(3) development of high-power electric-drive fracturing equipment;(4) fracturing tool and supporting equipment for long horizontal section;(5) horizontal well flexible-sidetracking drilling technology for tapping remaining oil;(6) post-frac workover technology for long horizontal well;(7) intelligent fracturing technology. | LEI Qun XU Yun CAI Bo GUAN Baoshan WANG Xin BI Guoqiang LI Hui LI Shuai DING Bin FU Haifeng TONG Zheng LI Tao ZHANG Haoyu | 2022 | Petroleum Exploration and Development2022，49，1： | 3 |
| 12 | High-temperature tribological behaviors of a Cr-Si co-alloyed layer on TA15 alloy显示文摘A Cr-Si co-alloyed layer was successfully deposited on TA15 alloy by the double glow plasma surface technology to improve its poor wear resistance at elevated temperature.The microstructure,composition,and phase structure of the layer were investigated by SEM,EDS,and XRD.The tribological behaviors of the Cr-Si co-alloyed layer at 20 ℃ and 500 ℃ were analyzed in details.The results indicated that the friction coefficient and wear rate of the Cr-Si coalloyed layer at 20 ℃ and 500 ℃ were much lower than those of the substrate,which was due to higher hardness and superior elastic modulus.This layer may become an approach to effectively improving the wear resistance of TA15 alloy at elevated temperature. | Lu Haifeng Miao Qiang Liang Wenping Wang Fang Ding Zheng Xia Jinjiao | 2017 | Chinese Journal of Aeronautics2017，30，2： | 2 |
| 13 | A Novel Fully Homomorphic Encryption Scheme Bsed on LWE显示文摘Although the learning with errors(LWE)-based full homomorphic encryption scheme was the first example of deviation from the original Gentry's blueprint, the scheme did not give detailed conversion process of circuit layer structure, and must rely on bootstrapping technique to achieve full homomorphism.Therefore, through modifying the re-linearization technique proposed by the above scheme, a technique called non-matrix key switching is presented, which includes key switching with re-linearization and pure key switching. The complex matrix operations of existing key switching technique are removed. Combining this technique with modulus switching, a(leveled) fully homomorphic encryption scheme without bootstrapping from LWE is constructed. In order to make circuit layer structure clear, the scheme gives detailed refresh door operation. Finally, we use bootstrapping to upgrade arithmetic circuit to any layer, and make the homomorphic computing capability of the scheme have nothing to circuit depth. | DING Yong LI Xiumin Lü Haifeng LI Xinguo | 2016 | Wuhan University Journal of Natural Sciences2016，21，1： | 2 |
| 14 | Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-[beta]-like signaling pathway显示文摘 | Ding Lihua Wang Zhaoyun Yan Jinghua Yang Xiao Liu Aijun Qiu Weiyi Zhu Jianhua Han Juqiang Zhang Hao Lin Jing Cheng Long Qin Xi Niu Chang Yuan Bin Wang Xiaohui Zhu Cui Zhou Yan Li Jiezhi Song Haifeng Huang Cuifen Ye Qinong | 2009 | Journal of Clinical Investigation2009，，2： | 1 |
| 15 | One-step Synthesis of Shape-controllable Gold Nanoparticles and Their Application in Surface-enhanced Raman Scattering显示文摘Gold nanoparticles(NPs) of various shapes were synthesized by a one-step method at ambient temperature in the presence of NaCI.2-mercaptosuccinic acid(MSA) was used as both reducing agent and stabilizing agent.The shapes of gold NPs were controllable by simply tuning S/Au ratio(S is from MSA molecule,and S/Au ratio is controlled by tuning the volume of added MSA solution),and triangle,polygonal and spherical nanoparticles were obtained.This result suggested a new way to consider the effects of MSA on the growth of nanoparticles,which showed that MSA is a strong capping agent and facilitates more uniform growth of nanoparticles in every dimension.And other important factors on nanoparticles growth including NaCI and temperature were discussed.Furthermore,a typical probe molecule,4-aminothiophenol(4-ATP) was used to test the surface-enhanced Raman scattering(SERS) activity of these gold NPs and the results indicated good Raman activity on these substrates.And the enhancement factor(EF) at 1078 cm^(-1)(a_1) was estimated to be as large as 6.3×10~4 and 5.5×10~4 for triangular plates and truncated particles,respectively. | Lanlan Sun Dongxu Zhao Meng Ding Haifeng Zhao Zhenzhong Zhang Binghui Li Dezhen Shen | 2013 | Journal of Materials Science & Technology2013，29，7： | 1 |
| 16 | Effect of warming moxibustion Tianshu(ST 25, bilateral) and Qihai(CV 6) for the treatment of diarrhea-dominant irritable bowel syndrome: a patient-blinded pilot trial with orthogonal design显示文摘OBJECTIVE: To investigate the effects of warming moxibustion Tianshu(ST 25, bilateral) and Qihai(CV6) in patients with diarrhea-dominant irritable bowel syndrome(D-IBS) by assessing predominant factors, and determining the best factor combinations and their interactions. To identify the optimal quantity of warming moxibustion Tianshu(ST 25, bilateral) and Qihai(CV 6) to achieve optimal efficacy.METHODS: An L9(3~4) orthogonal design was applied to 233 confirmed subjects based on the three most influential factors and the three most frequently used levels. Nine programs were designed.Subjects were assigned to four subgroups according to age and gender; each subject underwent one of the nine programs randomly. We selected Tianshu(ST 25, bilateral) and Qihai(CV 6). The scores of symptoms and the IBS Quality of Life(IBS-QOL) were evaluated after the final treatment.RESULTS: After treatment, clinical symptoms of all patients were significantly improved(P = 0.001).Quality of life also improved significantly(P < 0.05).For all the participants, frequency was the dominating factor regarding symptoms(P = 0.01). Duration was the dominating factor for quality of life(P =0.0001). The best combination for improving symptoms in 30-40-year-old male and female patients was two courses of 10 min each once a day, and for41-50-year-old male and female patients it was three courses of 10 min(males) or 30 min(females)twice a day. The best combination for quality of life was three courses of 20 min once a day. No interaction was found between frequency and course, or frequency and duration.CONCLUSION: Warming moxibustion Tianshu(ST25, bilateral) and Qihai(CV 6) is a promising therapy for D-IBS. To acquire optimal efficacy, the three main factors(duration, frequency and treatment course) of the warming moxibustion should reach a specific quantity and be combined appropriately. | Yang Ling Lu Yuan Zhang Haifeng Ma Xiaopeng Bao Chunhui Wu Huangan Zhao Chen Ding Guanghong Qi Li Zhou Shuang | 2017 | Journal of Traditional Chinese Medicine2017，37，4： | 1 |
| 17 | Effect of Pd on GFA and Thermal Stability of Zr-based Bulk Amorphous Alloy显示文摘The effect of Pd addition on the glass-forming ability and thermal stability of the Zr5sAl10Cus0Nis-xPdx (x=0, 1, 3,5 at. Pct) alloys upon copper-mold casting has been investigated. The structure, thermal stability and microstructure were studied by X-ray diffraction (XRD), differential scanning calorimetry (DSC) and transmission electron microscopy (TEM), respectively. It was identified that a new bulk amorphous alloy with the larger supercooled liquid region Atx of 100 K is obtained with substituting Ni by 1 at. Pct Pd. Furthermore, the origins that thermal stability and GFA change with increasing of Pd have also beer discussed. | Fengxiang QIN, Haifeng ZHANG, Aimin WANG, Bingzhe DING and Zhuangqi HUShenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China | 2004 | Journal of Materials Science & Technology2004，20，2： | 1 |
| 18 | Effect of Grain Boundary on the Wettability and Interfacial Morphology in the Molten Bi/Cu System显示文摘The wetting behavior of molten Bi on polycrystalline Cu substrate and single crystal Cu substrate was studied bythe sessile drop method in the temperature range from 673 to 873 K. At low temperature the wetting behaviors ofmolten Bi on both types of Cu substrate were similar. However, at high temperature, the equilibrium contact angleof polycrystalline Cu substrate was lower than that of single crystal Cu substrate, because the preferred dissolutionof grain boundaries leads to a smaller liquid/solid interfacial energy for polycrystalline Cu substrate. The formationmechanism of arrow-shaped Cu grains at the Bi/single crystal Cu interface is also discussed. | Qiangang XU, Haifeng ZHANG, Bingzhe DING Zhuangqi HUShenyang National Lab. for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China | 2003 | Journal of Materials Science & Technology2003，19，3： | 1 |
| 19 | Interfacial morphologies between iron and Ag-Cu-Sn alloy显示文摘A series of experiments have been designed to investigate the effect of different space positions between liquid Ag-Cu-Sn alloy drop and iron substrates on the liquid/solid inter-facial morphologies by a sessile drop method. The results show that Ag-Cu-Sn alloy diffuses into the solid iron substrate, and the amounts are greater and the distances are longer when it dif- | Hong Li Haifeng Zhang Longbao Wang Guangjie Zhai Bingzhe Ding Zhenhong Mai Zhuangqi Hu | 1999 | Chinese Science Bulletin1999，44，16： | 1 |
| 20 | Double porous media model for mass transfer of hemodialyzers显示文摘 | Ding Weiping He Liqun Zhao Gang Zhang Haifeng Shu Zhiquan Gao Dayong | 2004 | International Journal of Heat and Mass Transfer2004，47，22： | 1 |
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