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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Progress of gene targeting in mouse显示文摘Gene targeting is a powerful approach of studying the gene function in vivo. Specific genetic modifications, including simple gene disruption, point mutations, large chromosomal deletions and rearrangements, targeted incorporation of foreign genes, could be introduced into the mouse genome by gene targeting. Recent studies make it possible to do the gene targeting with temporal and spatial control. | Xiao Yang Peitang Huang Cuifen Huang | 2001 | Chinese Science Bulletin2001，46，4： | 5 |
| 3 | Human pescadillo induces large-scale chromatin unfolding显示文摘The human pescadillo gene encodes a protein with a BRCT domain. Pescadillo plays an important role in DNA synthesis, cell proliferation and transformation. Since BRCT do- mains have been shown to induce chromatin large-scale unfolding, we tested the role of Pesca- dillo in regulation of large-scale chromatin unfolding. To this end, we isolated the coding region of Pescadillo from human mammary MCF10A cells. Compared with the reported sequence, the isolated Pescadillo contains in-frame deletion from amino acid 580 to 582. Targeting the Pesca- dillo to an amplified, lac operator-containing chromosome region in the mammalian genome re- sults in large-scale chromatin decondensation. This unfolding activity maps to the BRCT domain of Pescadillo. These data provide a new clue to understanding the vital role of Pescadillo. | ZHANG Hao FANG Yan HUANG Cuifen YANG Xiao YE Qinong | 2005 | Science China(Life Sciences)2005，48，3： | 4 |
| 4 | Cancer Immunotherapy Targeting the Telomerase Reverse Transcriptase显示文摘人的 telomerase 颠倒 transcriptase (hTERT ) 在超过 85% 肿瘤房间被表示,但是通常没在正常房间被发现,它作为理想的肿瘤伙伴抗原(TAA ) 做 hTERT 开发没有在人的癌症免疫疗法损害正常纸巾,明确地破坏癌症的潜在的疫苗。这被考察 hTERT 或它的肽和早临床的 trials using 的 immunogenicity 上的研究的基本进展在最后十年的 hTERT 疫苗途径。 | Longfei Huo Janice WS Tang Junjian Huang Peitang Huang Cuifen Huang Hsiang-fu Kung Marie C. Lin | 2006 | Cellular & Molecular Immunology2006，3，1： | 4 |
| 5 | Interleukin-25 in sputum as a marker of airway inflammation in children asthma显示文摘Dear Editor,Interleukin-25(IL-25,also called IL-17E)is an important IL-17 family member that helps initialize and regulate type 2 immunity,exerting an important influence on the pathogenesis of asthma(Corrigan et al.,2011;Barlow et al.,2012).Furthermore,it plays a vital role in initiating type 2 innate lymphoid cell activation and maintenance(Tong and Li,2018)and inducing Th2-type cytokine-mediated allergic airway eosinophilia(Morita et al.,2015).IL-25 expression increases in patients with asthma in different types of lung cells,including lung structural cells(such as endothelium and airway epithelium),eosinophils,T-cells,and mast cells.Following allergen exposure,cells in the bronchial submucosa increase and secrete or respond to IL-25(Corrigan et al.,2011).Plasma IL-25 levels increase in patients with asthma and correlate with lung function(Cheng et al.,2014).The association between IL-25 cells and pulmonary function indicates that IL-25 could be used to monitor asthma severity.In some mouse models,epithelial IL-25 cytokines are closely related with a range of airway inflammation modalities,including type 2 cytokine production,airway eosinophil inflammation,mucinous epithelial metaplasia,and airway hyperresponsiveness(AHR)(Suzukawa et al.,2012). | Yun Zhang Cuifen Zhao Xiuxia Zhao Qingyu Kong Mingjie Dingi Yuling Han Xiang Ma Lu Cheng | 2019 | Science China(Life Sciences)2019，62，12： | 3 |
| 6 | Molecular mapping of leaf rust resistance gene LrNJ97 in Chinese wheat line Neijiang 977671显示文摘 | Huixin Zhou Xianchun Xia Zhonghu He Xing Li Cuifen Wang Zaifeng Li Daqun Liu | 2013 | Theoretical and Applied Genetics2013，，8： | 2 |
| 7 | Prognostic Nomogram for Patients with Hepatitis E Virus-related Acute Liver Failure:A Multicenter Study in China显示文摘Background and Aims:Timely and effective assessment scoring systems for predicting the mortality of patients with hepatitis E virus-related acute liver failure(HEV-ALF)are urgently needed.The present study aimed to establish an effective nomogram for predicting the mortality of HEV-ALF patients.Methods:The nomogram was based on a cross-sectional set of 404 HEV-ALF patients who were identified and enrolled from a cohort of 650 patients with liver failure.To compare the performance with that of the model for end-stage liver disease(MELD)scoring and CLIF-Consortiumacute-on-chronic liver failure score(CLIF-C-ACLFs)models,we assessed the predictive accuracy of the nomogram using the concordance index(C-index),and its discriminative ability using time-dependent receiver operating characteristics(td-ROC)analysis,respectively.Results:Multivariate logistic regression analysis of the development set carried out to predict mortality revealed that γ-glutamyl transpeptidase,albumin,total bilirubin,urea nitrogen,creatinine,international normalized ratio,and neutrophil-to-lymphocyte ratio were independent factors,all of which were incorporated into the new nomogram to predict the mortality of HEV-ALF patients.The area under the curve of this nomogram for mortality prediction was 0.671(95%confidence interval:0.602-0.740),which was higher than that of the MELD and CLIF-C-ACLFs models.Moreover,the td-ROC and decision curves analysis showed that both discriminative ability and threshold probabilities of the nomogram were superior to those of the MELD and CLIF-C-ACLFs models.A similar trend was observed in the validation set.Conclusions:The novel nomogram is an accurate and efficient mortality prediction method for HEV-ALF patients. | Jian Wu Cuifen Shi Xinyu Sheng Yanping Xu Jinrong Zhang Xinguo Zhao Jiong Yu Xinhui Shi Gongqi Li Hongcui Cao Lanjuan Li | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 2 |
| 8 | Molecular mapping of leaf rust resistance gene LrFun in Romanian wheat line Fundulea 900显示文摘 | Lifang Xing Cuifen Wang Xianchun Xia Zhonghu He Wanquan Chen Taiguo Liu Zaifeng Li Daqun Liu | 2014 | Molecular Breeding2014，，4： | 1 |
| 9 | Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-[beta]-like signaling pathway显示文摘 | Ding Lihua Wang Zhaoyun Yan Jinghua Yang Xiao Liu Aijun Qiu Weiyi Zhu Jianhua Han Juqiang Zhang Hao Lin Jing Cheng Long Qin Xi Niu Chang Yuan Bin Wang Xiaohui Zhu Cui Zhou Yan Li Jiezhi Song Haifeng Huang Cuifen Ye Qinong | 2009 | Journal of Clinical Investigation2009，，2： | 1 |
| 10 | Substituted dipiperidine alcohols as potent CCR2 antagonists 显示文摘 | Xia M D Cuifen H Duane D M | 2008 | Bioor Med Chem Lett2008，18，12： | 1 |
| 11 | The Influence of Transmutation Conditions on the Adulteration Performance of Nano-scale Nickel Hydroxide显示文摘Spherical Nano-scale nickel hydroxide was prepared through precipitation transmutation method by controlling the transmutation conditions in this paper. The measurement results of XRD and TEM indicate that the crystallization of the nano-scale nickel hydroxide isβ-style and its shape is spherical with a diameter of 40~70 nanometer. The adulteration experiment shows that the adulteration ratio of nano- scale Ni(OH) 2 in common spherical micrometer-scale Ni(OH) 2 exists a optimal value (1∶9). And at this point, the utilization ratio of Ni(OH) 2 in electrodes can be raised by 10%, and the nano-scale nickel hydroxide with sphericity shape shows a better adulteration performance than that with needle shape. | 赵力 ZHANG Cuifen Zhou Derui | 2002 | High Technology Letters2002，8，1： | 1 |
| 12 | Heat stabilitystudy on ginsenoside liquor显示文摘 | Yu Xiaoling Miao Qing Fang Cuifen | 2011 | China Modem ApplicationPharmacy2011，28，12： | 1 |
| 13 | Electrochemical properties of rechargeable lithium batteries with sulfur-containing composite cathode materials显示文摘 | Zheng Wei Hu Xinguo Zhang Cuifen | 2006 | Electrochemical and Solid-State Letters2006，9，7： | 1 |
| 14 | Composite corrosion inhibitors for secondary alkaline zinc anodes 显示文摘 | JIA Zheng ZHOU Derui ZHANG Cuifen | 2005 | Trans Nonferrous Met Soc China2005，15，1： | 1 |
| 15 | Synthesis and Applications of Tetra- functional Branched Poly(ethylene glycol) Derivative for the Decellularized Valve Leaflets Cross-linking显示文摘To investigate the effects of polyethylene glycol cross-linking on the mechanical properties, 80 porcine aortic valves were harvested, decellularized, and introduced with sulfhydryl. Then the valves were randomly assigned into 5 experimental groups and 1 control group(n=16). For the valves in those experimental groups, branched polyethylene glycol diacrylate(PEG) of 5 different molecular weights(3.4, 8, 12, 20, 40 k Da) were synthesized and cross-linked with them respectively. The efficiency of the cross-linking was determined by measuring the amount of residual thiol group and the mechanical properties of the cross-linked valve leaflets were assessed by uni-axial planar tensile testing. The efficiency of the PEG 20 k Da group was 70.72±2.33%, obviously superior to that of the other groups(p<0.05). Tensile test proved that branched PEG cross-linking can significantly enhance the mechanical behaviors of the decellularized valve leaflet and the Young's modulus of each group was positively correlated with the molecular weight of PEG. It was concluded that branched PEG with the molecular weight of 20 k Da can effectively cross-link the decellularized porcine aortic valves and improve their mechanical properties, which makes it a promising cross-linker that can be used in the modification of decellularized tissue engineering valves. | 胡行健 董念国 SHI Jiawei LI Huadong DENG Cheng LU Cuifen | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，1： | 1 |
| 16 | Changes and distributions of peptidesderived from proadrenomedullin in left - to - right shunt pulmonary hy-pertension of rats显示文摘 | Cuifen Z Lijuan W Li G | 2008 | Circ 12008，72，3： | 1 |
| 17 | Emodin induces apoptosis through caspase 3-dependent pathway in HK-2 cells显示文摘 | Cuifen W Xudong W Min C | 2007 | Toxicology2007，231，23： | 1 |
| 18 | Fast-response fluorescent probe with favorable water solubility for highly sensitive imaging of endogenous tyrosinase in living cells and zebrafish model显示文摘Tyrosinase(TYR) is an important polyphenolic oxidase enzyme and usually regards as a biomarker of melano ma cancer.Highly effective tracking TYR activity in vivo will help to study the mechanism of TYR in living organisms and forecasts related diseases.In this study,we present a novel TYR-activatable fluo rescent probe(CHMC-DOPA) for tracking TYR activity in vitro and in vivo.CHMC-DOPA is constructed by incorporating dopamine(DOPA) moiety into a fluorescent chloro-hydroxyl-merocyanine(CHMC)scaffold.Upon exposure to TYR,the dopamine unit in CHMC-DOPA is oxidized to a dopaquinone derivative,and an intramolecular photo-induced electron transfer(PET) process between CHMC fluorophore and o-dopaquinone will take place,the fluorescence of CHMC-DOPA is quenched rapidly.Therefore,the evaluation of TYR activity is established in terms of the relationship between fluorescence quenching efficiency and TYR activity.In our experiments,CHMC-DOPA shows various advantages,such as fast response(8 min),low concentration of TYR activation(0.5 U/mL),good water-solubility,as well as the lowest detection limit(0.003 U/mL) compared with previously reported works.Furthermore,CHMCDO PA also exhibits excellent cell membrane permeability and low cytotoxicity,which is successfully used to monitor endogenous TYR activity in living cancer cells and zebrafish models.CHMC-DOPA performs well,and we anticipate that this newly designed novel platform will provide an alternative for high effective monitoring TYR activity in biosystems. | Zheng Li Xiaofeng Xia Yu You Cuifen Lu Guichun Yang Chao Ma Junqi Nie Qi Sun Shuilin Wu Jun Ren Feiyi Wang | 2021 | Chinese Chemical Letters2021，32，5： | 1 |
| 19 | Screening and identification of Shigella flexneri 2a virulence-related genes induced after invasion of epithelial cells显示文摘An in vivo expression technology (IVET) was applied to screen s.flexneri 2a genes induced after invasion of epithelial cells, and virulence-related genes were further identified by mutational analysis. Thirteen intracellular induced genes were identified with a HeLa cell infection model. Of these, two were identified as alkylation-related genes; one was related to metabolism; one encoded a transcriptional regulator; three were identified as insertion elements; three ap- peared to be antisense to genes involved in the transmethylation,biosyntheseis, and phos- photransferase system;and three were predicted to encode polypeptides with unknown functions. Intracellular survival assavs showed that the mutants of alkA,citC and wcaJ genes had lower capability of intracellular replication or survival than the the wild-type strain.The results indicated that alkA, citC and wcaJ genes could take part in the intracellular survival or replication of S. flexneri 2a and the capability of intracellular survival or replication could be one of the major virulence elements. However, the yaiC mutant was able to survive in the murine infection assay but almost not in HeLa cell infection assay. Very possibly, yaiC gene was involved in the other mechanism of S. flexneri virulence. This study might lead to a better understanding of the intra- cellular survival or proliferation process of S. flexneri 2a and perhaps provide insights into the pathogenicity of this pathogen. | SHI Zhaoxing WANG Hengliang HU Kun FENG Erling YAO Xiao HUANG Liuyu SU Guofu HUNAG Peitang HUANG Cuifen | 2004 | Science China(Life Sciences)2004，47，6： | 0 |
| 20 | With Brand Enterprises Releasing Male Cosmetics, Has the Spring of Male Beauty Products Arrived?显示文摘Recently, the advanced male beauty care brand HOUSE 99 jointly developed by L’Oreal Group and David Beckham formally entered China and Jingdong beauty Makeup on the same day. At the same time, L’Oreal Group and Tmall jointly released White Paper about China’s Male Beauty Care Market (hereafter called White Paper). | Huang Cuifen | 2019 | China Detergent & Cosmetics2019，4，1： | 0 |
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