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| 1 | Empirical estimates of regional carbon budgets imply reduced global soil heterotrophic respiration显示文摘Resolving regional carbon budgets is critical for informing land-based mitigation policy.For nine regions covering nearly the whole globe,we collected inventory estimates of carbon-stock changes complemented by satellite estimates of biomass changes where inventory data are missing.The net land–atmospheric carbon exchange(NEE)was calculated by taking the sum of the carbon-stock change and lateral carbon fluxes from crop and wood trade,and riverine-carbon export to the ocean.Summing up NEE from all regions,we obtained a global‘bottom-up'NEE for net land anthropogenic CO_(2)uptake of–2.2±0.6 Pg C yr^(-1)consistent with the independent top-down NEE from the global atmospheric carbon budget during 2000–2009.This estimate is so far the most comprehensive global bottom-up carbon budget accounting,which set up an important milestone for global carbon-cycle studies.By decomposing NEE into component fluxes,we found that global soil heterotrophic respiration amounts to a source of CO_(2)of 39 Pg C yr^(-1)with an interquartile of 33–46 Pg C yr^(-1)—a much smaller portion of net primary productivity than previously reported. | Philippe Ciais Yitong Yao Thomas Gasser Alessandro Baccini Yilong Wang Ronny Lauerwald Shushi Peng Ana Bastos Wei Li Peter A.Raymond Josep G.Canadell Glen P.Peters Rob J.Andres Jinfeng Chang Chao Yue A.Johannes Dolman Vanessa Haverd Jens Hartmann Goulven Laruelle Alexandra G.Konings Anthony W.King Yi Liu Sebastiaan Luyssaert Fabienne Maignan Prabir K.Patra Anna Peregon Pierre Regnier Julia Pongratz Benjamin Poulter Anatoly Shvidenko Riccardo Valentini Rong Wang Grégoire Broquet Yi Yin Jakob Zscheischler Bertrand Guenet Daniel SGoll Ashley-P.Ballantyne Hui Yang Chunjing Qiu Dan Zhu | 2021 | National Science Review2021，8，2： | 3 |
| 2 | 25 Gbps low-voltage hetero-structured silicongermanium waveguide pin photodetectors for monolithic on-chip nanophotonic architectures显示文摘Near-infrared germanium(Ge) photodetectors monolithically integrated on top of silicon-on-insulator substrates are universally regarded as key enablers towards chip-scale nanophotonics, with applications ranging from sensing and health monitoring to object recognition and optical communications. In this work, we report on the highdata-rate performance pin waveguide photodetectors made of a lateral hetero-structured silicon-Ge-silicon(Si-Ge-Si) junction operating under low reverse bias at 1.55 μm. The pin photodetector integration scheme considerably eases device manufacturing and is fully compatible with complementary metal-oxide-semiconductor technology. In particular, the hetero-structured Si-Ge-Si photodetectors show efficiency-bandwidth products of^9 GHz at-1 V and ~30 GHz at-3 V, with a leakage dark current as low as ~150 nA, allowing superior signal detection of high-speed data traffic. A bit-error rate of 10-9 is achieved for conventional 10 Gbps, 20 Gbps, and25 Gbps data rates, yielding optical power sensitivities of-13.85 dBm,-12.70 dBm, and-11.25 dBm, respectively. This demonstration opens up new horizons towards cost-effective Ge pin waveguide photodetectors that combine fast device operation at low voltages with standard semiconductor fabrication processes, as desired for reliable on-chip architectures in next-generation nanophotonics integrated circuits. | DANIEL BENEDIKOVIC LéOPOLD VIROT GUY AUBIN FARAH AMAR BERTRAND SZELAG BAYRAM KARAKUS JEAN-MICHEL HARTMANN CARLOS ALONSO-RAMOS XAVIER LE ROUX PAUL CROZAT ERIC CASSAN DELPHINE MARRIS-MORINI CHARLES BAUDOT FRéDéRIC BOEUF JEAN-MARC FéDéLI CHRISTOPHE KOPP LAURENT VIVIEN | 2019 | Photonics Research2019，7，4： | 2 |
| 3 | Differential equation based constraned reinitialization for level set methods显示文摘 | Daniel Hartmann Matthias Meinke Wolfgang Schroder | 2008 | Journal of Computational Physics2008，227，： | 1 |
| 4 | An automated, 0.5 Hz nano-foil target positioning system for intense laser plasma experiments显示文摘We report on a target system supporting automated positioning of nano-targets with a precision resolution of 4 μm in three dimensions. It relies on a confocal distance sensor and a microscope. The system has been commissioned to position nanometer targets with 1 Hz repetition rate. Integrating our prototype into the table-top ATLAS 300 TW-laser system at the Laboratory for Extreme Photonics in Garching, we demonstrate the operation of a 0.5 Hz laser-driven proton source with a shot-to-shot variation of the maximum energy about 27% for a level of confidence of 0.95. The reason of laser shooting experiments operated at 0.5 Hz rather than 1 Hz is because the synchronization between the nano-foil target positioning system and the laser trigger needs to improve. | Ying Gao Jianhui Bin Daniel Haffa Christian Kreuzer Jens Hartmann Martin Speicher Florian H.Lindner Tobias M.Ostermayr Peter Hilz Thomas F.Rsch Sebastian Lehrack Franz Englbrecht Sebastian Seuferling Max Gilljohann Hao Ding Wenjun Ma Katia Parodi Jorg Schreiber | 2017 | High Power Laser Science and Engineering2017，5，2： | 1 |
| 5 | Supply risk management: model development and empirical analysis 显示文摘 | Daniel Kern Roger Moser Evi Hartmann Marco Mod- er | 2012 | International Journal of Physical Distribution & Logistics Management2012，42，1： | 1 |
| 6 | Flat epithelial atypia and risk of breast cancer: A Mayo cohort study显示文摘 | Samar M. Said Daniel W. Visscher Aziza Nassar Ryan D. Frank Robert A. Vierkant Marlene H. Frost Karthik Ghosh Derek C. Radisky Lynn C. Hartmann Amy C. Degnim | 2015 | Cancer2015，，： | 1 |
| 7 | Ki67: a time-varying biomarker of risk of breast cancer in atypical hyperplasia显示文摘 | Marta Santisteban Carol Reynolds Emily G. Barr Fritcher Marlene H. Frost Robert A. Vierkant Stephanie S. Anderson Amy C. Degnim Daniel W. Visscher V. Shane Pankratz Lynn C. Hartmann | 2010 | Breast Cancer Research and Treatment2010，，2： | 1 |
| 8 | Organophosphate flame retardants and plasticizers in indoor air显示文摘 | Paul C. Hartmann Daniel Bürgi Walter Giger | 2004 | Chemosphere2004，，8： | 1 |
| 9 | Improving ITS sequence data for identification of plant pathogenic fungi显示文摘Plant pathogenic fungi are a large and diverse assemblage of eukaryotes with substantial impacts on natural ecosystems and human endeavours.These taxa often have complex and poorly understood life cycles,lack observable,discriminatory morphological characters,and may not be amenable to in vitro culturing.As a result,species identification is frequently difficult.Molecular(DNA sequence)data have emerged as crucial information for the taxonomic identification of plant pathogenic fungi,with the nuclear ribosomal internal transcribed spacer(ITS)region being the most popular marker.However,international nucleotide sequence databases are accumulating numerous sequences of compromised or low-resolution taxonomic annotations and substandard technical quality,making their use in the molecular identification of plant pathogenic fungi problematic.Here we report on a concerted effort to identify high-quality reference sequences for various plant pathogenic fungi and to re-annotate incorrectly or insufficiently annotated public ITS sequences from these fungal lineages.A third objective was to enrich the sequences with geographical and ecological metadata.The results-a total of 31,954 changes-are incorporated in and made available through the UNITE database for molecular identification of fungi(http://gffzz7cc2bea597fa4d6chnnqf6bwxbkk56vnq.ffgz.tsg.suse.edu.cn),including standalone FASTA files of sequence data for local BLAST searches,use in the next-generation sequencing analysis platforms QIIME and mothur,and related applications.The present initiative is just a beginning to cover the wide spectrum of plant pathogenic fungi,and we invite all researchers with pertinent expertise to join the annotation effort. | R.Henrik Nilsson Kevin D.Hyde Julia Pawlowska Martin Ryberg Leho Tedersoo Anders Bjornsgard Aas Siti A.Alias Artur Alves Cajsa Lisa Anderson Alexandre Antonelli A.Elizabeth Arnold Barbara Bahnmann Mohammad Bahram Johan Bengtsson-Palme Anna Berlin Sara Branco Putarak Chomnunti Asha Dissanayake Rein Drenkhan Hanna Friberg Tobias Guldberg Froslev Bettina Halwachs Martin Hartmann Beatrice Henricot Ruvishika Jayawardena Ari Jumpponen Havard Kauserud Sonja Koskela Tomasz Kulik Kare Liimatainen Bjorn D.Lindahl Daniel Lindner Jian-Kui Liu Sajeewa Maharachchikumbura Dimuthu Manamgoda Svante Martinsson Maria Alice Neves Tuula Niskanen Stephan Nylinder Olinto Liparini Pereira Danilo Batista Pinho Teresita M.Porter Valentin Queloz Taavi Riit Marisol Sánchez-García Filipe de Sousa Emil Stefańczyk Mariusz Tadych Susumu Takamatsu Qing Tian Dhanushka Udayanga Martin Unterseher Zheng Wang Saowanee Wikee Jiye Yan Ellen Larsson Karl-Henrik Larsson Urmas Koljalg Kessy Abarenkov | 2014 | Fungal Diversity2014，，4： | 1 |
| 10 | Disruption of Trp53 in Livers of Mice Induces Formation of Carcinomas With Bilineal Differentiation显示文摘 | Sarah–Fee Katz André Lechel Anna C. Obenauf Yvonne Begus–Nahrmann Johann M. Kraus Eva M. Hoffmann Johanna Duda Parisa Eshraghi Daniel Hartmann Birgit Liss Peter Schirmacher Hans A. Kestler Michael R. Speicher K. Lenhard Rudolph | 2012 | Gastroenterology2012，，5： | 1 |
| 11 | Mass Spectrometric Noncovalent Probing of Amino Acids in Peptides and Proteins显示文摘 | Friess SD Daniel JM Hartmann R | 2002 | Int J Mass Spectrom2002，219，： | 1 |
| 12 | Aberrant methylation of DAPK in long-standing ulcerative colitis and ulcerative colitis-associated carcinoma显示文摘 | Doerthe Kuester Thomas Guenther Susanne Biesold Arndt Hartmann Frauke Bataille Petra Ruemmele Brigitte Peters Frank Meyer Daniel Schubert Ulrich R. Bohr Peter Malfertheiner Hans Lippert Andrew R.J. Silver Albert Roessner Regine Schneider-Stock | 2010 | Pathology - Research and Practice2010，，9： | 1 |
| 13 | Sorafenib perpetuates cellular anticancer effector functions by modulating the crosstalk between macrophages and natural killer cells显示文摘 | Martin Franz Sprinzl Florian Reisinger Andreas Puschnik Marc Ringelhan Kerstin Ackermann Daniel Hartmann Matthias Schiemann Arndt Weinmann Peter Robert Galle Marcus Schuchmann Helmut Friess Gerd Otto Mathias Heikenwalder Ulrike Protzer | 2013 | Hepatology2013，，： | 1 |
| 14 | Observation of a single protein by ultrafast X-ray diffraction显示文摘The idea of using ultrashort X-ray pulses to obtain images of single proteins frozen in time has fascinated and inspired many.It was one of the arguments for building X-ray free-electron lasers.According to theory,the extremely intense pulses provide sufficient signal to dispense with using crystals as an amplifier,and the ultrashort pulse duration permits capturing the diffraction data before the sample inevitably explodes.This was first demonstrated on biological samples a decade ago on the giant mimivirus.Since then,a large collaboration has been pushing the limit of the smallest sample that can be imaged.The ability to capture snapshots on the timescale of atomic vibrations,while keeping the sample at room temperature,may allow probing the entire conformational phase space of macromolecules.Here we show the first observation of an X-ray diffraction pattern from a single protein,that of Escherichia coli GroEL which at 14 nm in diameter is the smallest biological sample ever imaged by X-rays,and demonstrate that the concept of diffraction before destruction extends to single proteins.From the pattern,it is possible to determine the approximate orientation of the protein.Our experiment demonstrates the feasibility of ultrafast imaging of single proteins,opening the way to single-molecule time-resolved studies on the femtosecond timescale. | Tomas Ekeberg Dameli Assalauova Johan Bielecki Rebecca Boll Benedikt J.Daurer Lutz A.Eichacker Linda E.Franken Davide E.Galli Luca Gelisio Lars Gumprecht Laura H.Gunn Janos Hajdu Robert Hartmann Dirk Hasse Alexandr Ignatenko Jayanath Koliyadu Olena Kulyk Ruslan Kurta Markus Kuster Wolfgang Lugmayr Jannik Lübke Adrian P.Mancuso Tommaso Mazza Carl Nettelblad Yevheniy Ovcharenko Daniel E.Rivas Max Rose Amit K.Samanta Philipp Schmidt Egor Sobolev Nicusor Timneanu Sergey Usenko Daniel Westphal Tamme Wollweber Lena Worbs Paul Lourdu Xavier Hazem Yousef Kartik Ayyer Henry N.Chapman Jonas A.Sellberg Carolin Seuring Ivan A.Vartanyants Jochen Küpper Michael Meyer Filipe R.N.C.Maia | 2024 | Light(Science & Applications)2024，13，1： | 0 |
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