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| 1 | 急性脑卒中综合性治疗模式的优越性显示文摘目的 探讨综合性治疗 [卒中单元 ,(strokeunit) ]模式对急性脑卒中治疗的优越性。方法 选择在澳大利亚卒中单元治疗的 2 0 7例急性脑卒中病人为A组 ,同期在我科常规治疗的 32 6例为B组。入选标准统一为经CT或MRI确诊发病 48h内的急性脑卒中 ,比较两组主要临床指标。结果 A组 1 4d内病死率为 5 3 % ,其中死于非脑内原因占 2 7 3 % ,感染发生率 1 7 9% ,而B组分别为1 0 4%、64 7%、47 9% ,差异具有显著性 (P <0 0 1 )。 2 1d神经功能评分和随访 90dRankin积分差异也有显著性 (P <0 0 1 )。结论 在综合性治疗模式下急性脑卒中患者的预后 。 | 王少石 Daniel Kam Yin CHAN David Gillies | 2002 | 中华内科杂志2002，41，11： | 47 |
| 2 | Acupuncture's Role in Solving the Opioid Epidemic: Evidence, Cost-Effectiveness, and Care Availability for Acupuncture as a Primary, Non-Pharmacologic Method for Pain Relief and Management-White Paper 2017显示文摘The United States(U.S.) is facing a national opioid epidemic, and medical systems are in need of nonpharmacologic strategies that can be employed to decrease the public's opioid dependence. Acupuncture has emerged as a powerful, evidence-based, safe, cost-effective, and available treatment modality suitable to meeting this need. Acupuncture has been shown to be effective for the management of numerous types of pain conditions, and mechanisms of action for acupuncture have been described and are understandable from biomedical, physiologic perspectives. Further, acupuncture's cost-effectiveness can dramatically decrease health care expenditures, both from the standpoint of treating acute pain and through avoiding addiction to opioids that requires costly care, destroys quality of life, and can lead to fatal overdose. Numerous federal regulatory agencies have advised or mandated that healthcare systems and providers offer non-pharmacologic treatment options for pain. Acupuncture stands out as the most evidence-based, immediately available choice to fulfil these calls. Acupuncture can safely, easily, and cost-effectively be incorporated into hospital settings as diverse as the emergency department, labor and delivery suites, andneonatal intensive care units to treat a variety of commonly seen pain conditions. Acupuncture is already being successful y and meaningfully utilized by the Veterans Administration and various branches of the U.S. Military, in some studies demonstrably decreasing the volume of opioids prescribed when included in care. | arthur yin fan david w.miller bonnie bolash matthew bauer john mcdonald sarah faggert hongjian he yong ming li amy matecki lindy camardella mel hopper koppelman jennifer a.m.stone lindsay meade john pang | 2017 | Journal of Integrative Medicine2017，15，6： | 29 |
| 3 | Out of southern East Asia: the natural history of domestic dogs across the world显示文摘 | Guo-Dong Wang Weiwei Zhai He-Chuan Yang Lu Wang LioZhong Yan-Hu Liu Ruo-Xi Fan Ting-Ting Yin Chun-Ling Zhu Andrei D Poyarkov David M Irwin Marjo K Hytonen Hannes Lohi Chung-I Wu Peter Savolainen Ya-Ping Zhang | 2016 | Cell Research2016，26，1： | 16 |
| 4 | Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells显示文摘有各种各样的长度的 telomeres 的返老还童在导致的 pluripotent 干细胞(iPSCs ) 被发现了。telomere 长度规定的机制在 iPSCs 的正式就职和增长期间留下逃犯。我们证明 telomere 动力学在 reprogramming 和经过期间在鼠标 iPSCs 是可变的,并且建议这些差别多半源于多重潜在的因素,包括包括外长的 reprogramming 因素的表示的 telomerase 机械, telomerase 独立的机制和同种细胞的影响。用一个基因模型 telomerase 缺乏(为 iPSCs 的推导和段落的 Terc −/− 和 Terc +/−) 房间,我们发现 telomerase 在 iPSCs 的 reprogramming 和自强起一个关键作用。进一步,当由再结合的延伸和维护的其他的小径也被要求时, telomeres 的 telomerase 维护为真 pluripotency 的正式就职是必要的,然而并非足够。一起, telomere 生物学的几个方面可以在 iPSCs 说明可变 telomere 动力学。尤其是,采用在 iPSC reprogramming 期间维持 telomeres 的机制很类似于胚胎的干细胞的那些。这些调查结果可以也联系到这些机制能为在由体的房间的原子 reprogramming 以后的 telomere 异质负责的克隆的地原子转移。 | Fang Wang Yu Yin Xiaoying Ye Kai Liu Haiying Zhu Lingling Wang Maria Chiourea Maja Okuka Guangzhen Ji Jiameng Dan Bingfeng Zuo Minshu Li Qian Zhang Na Liu Lingyi Chen Xinghua Pan Sarantis Gagos David L Keefe Lin Liu | 2012 | Cell Research2012，22，4： | 7 |
| 5 | Prevalence and Risk Factors of Atrial Fibrillation in Chinese Elderly: Results from the Chinese Longitudinal Healthy Longevity Survey显示文摘 | Choy-Lye Chei Prassanna Raman Chi Keong Chino Zhao-Xue Yin Xiao-Ming Shi Yi Zeng David B Matchar | 2015 | Chinese Medical Journal2015，，18： | 7 |
| 6 | 中国地方政府性债务规模估算显示文摘中央政府决意遏制政府性债务规模,但道德风险问题尚未得到解决本文列出未来5年政府可能采取的解决措施我们估计地方政府性债务规模可能达到21.9-24.4万亿元(约合3.6-4.0万亿美元),占GDP的38-42%,表1显示了我们对地方政府性债务规模的估算过程。对于这样一个规模,市场应该不会感到吃惊,我们在此前发布的亚洲债务报告中估算中国地方政府债务规模为20万亿元~①。我们预计,相关部门公布对地方政府性债务规模的估算将为2014年财政体制改革创造动力,同时也为更全面解决地方投融资平台债务问题寻找路径。 | 王志浩 申岚 李炜 Dorris Chen David Yin Jennifer Law | 2013 | 金融发展评论2013，，12： | 6 |
| 7 | Neuroprotectants attenuate hypobaric hypoxia-induced brain injuries in cynomolgus monkeys显示文摘Hypobaric hypoxia (HH) exposure can cause serious brain injury as well as life-threatening cerebral edema in severe cases. Previous studies on the mechanisms of HH-induced brain injury have been conducted primarily using non-primate animal models that are genetically distant to humans, thus hindering the development of disease treatment. Here, we report that cynomolgus monkeys (Macaca fascicularis) exposed to acute HH developed human-like HH syndrome involving severe brain injury and abnormal behavior. Transcriptome profiling of white blood cells and brain tissue from monkeys exposed to increasing altitude revealed the central role of the HIF-1 and other novel signaling pathways, such as the vitamin D receptor (VDR) signaling pathway, in co-regulating HH-induced inflammation processes. We also observed profound transcriptomic alterations in brains after exposure to acute HH, including the activation of angiogenesis and impairment of aerobic respiration and protein folding processes, which likely underlie the pathological effects of HH-induced brain injury. Administration of progesterone (PROG) and steroid neuroprotectant 5α-androst-3β,5,6β-triol (TRIOL) significantly attenuated brain injuries and rescued the transcriptomic changes induced by acute HH. Functional investigation of the affected genes suggested that these two neuroprotectants protect the brain by targeting different pathways, with PROG enhancing erythropoiesis and TRIOL suppressing glutamate-induced excitotoxicity. Thus, this study advances our understanding of the pathology induced by acute HH and provides potential compounds for the development of neuroprotectant drugs for therapeutic treatment. | Pei Zhang Jie-Si Chen Qi-Ye Li Long-Xiang Sheng Yi-Xing Gao Bing-Zheng Lu Wen-Bo Zhu Xiao-Yu Zhan Yuan Li Zhi-Bing Yuan Gang Xu Bi-Tao Qiu Min Yan Chun-Xue Guo You-Qiong Wang Yi-Jun Huang Jing-Xia Zhang Fu-Yu Liu Zhong-Wei Tang Sui-Zhen Lin David NCooper Huan-Ming Yang Jian Wang Yu-Qi Gao Wei Yin Guo-Jie Zhang Guang-Mei Yan | 2020 | Zoological Research2020，41，1： | 6 |
| 8 | Machine-learning informed prediction of high-entropy solid solution formation:Beyond the Hume-Rothery rules显示文摘The empirical rules for the prediction of solid solution formation proposed so far in the literature usually have very compromised predictability.Some rules with seemingly good predictability were,however,tested using small data sets.Based on an unprecedented large dataset containing 1252 multicomponent alloys,machine-learning methods showed that the formation of solid solutions can be very accurately predicted(93%).The machine-learning results help identify the most important features,such as molar volume,bulk modulus,and melting temperature. | Zongrui Pei Junqi Yin Jeffrey A.Hawk David E.Alman Michael C.Gao | 2020 | npj Computational Materials2020，，1： | 6 |
| 9 | A literature survey on smart cities显示文摘Rapid urbanization creates new challenges and issues, and the smart city concept offers opportunities to rise to these challenges, solve urban problems and provide citizens with a better living environment. This paper presents an exhaustive literature survey of smart cities. First, it introduces the origin and main issues facing the smart city concept, and then presents the fundamentals of a smart city by analyzing its definition and application domains. Second, a data-centric view of smart city architectures and key enabling technologies is provided. Finally, a survey of recent smart city research is presented. This paper provides a reference to researchers who intend to contribute to smart city research and implementation. | YIN ChuanTao XIONG Zhang CHEN Hui WANG JingYuan COOPER Daven DAVID Bertrand | 2015 | Science China(Information Sciences)2015，58，10： | 5 |
| 10 | Discussions on real-world acupuncture treatments for chroni clow-back pain in older adults显示文摘Chronic low-back pain(CLBP) is one of the most common pain conditions. Current clinical guidelines for low-back pain recommend acupuncture for CLBP. However, there are very few high-quality acupuncture studies on CLBP in older adults. Clinical acupuncture experts in the American Traditional Chinese Medicine Association(ATCMA) were interested in the recent grant on CLBP research announced by the National Center for Complementary and Integrative Health. The ATCMA experts held an online discussion on the subject of real-world acupuncture treatments for CLBP in older adults. Seven participants, each with more than 20 years of acupuncture practice, discussed their own unique clinical experience while another participant talked about the potential mechanism of acupuncture in pain management. As a result of the discussion, a picture of a similar treatment strategy emerged across the participants for CLBP in older adults. This discussion shows that acupuncture may have complicated mechanisms in pain management, yet it is effective for the treatment of chronic pain involving maladaptive neuroplasticity;therefore, it should be effective for CLBP in older adults. | Arthur Yin Fan Hui Ouyang Xinru Qian Hui Wei David Dehui Wang Deguang He Haihe Tian Changzhen Gong Amy Matecki Sarah Faggert Alemi | 2019 | Journal of Integrative Medicine2019，17，2： | 5 |
| 11 | p53 isoform △113p53/△133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage显示文摘在 DNA 双海滨的 p53 的禁止的角色裂缝(DSB ) 修理对它的压制肿瘤的性质似乎矛盾。p53 isoform Δ 113p53/Δ 133p53 是反对 p53 apoptotic 的 p53 目标基因活动。然而,它在 DNA 损坏修理的功能的信息正在缺乏。这里,我们报导那 Δ 113p53 表示被 γ 强烈导致; -irradiation, 然而并非由紫外照耀或热电震疗法。惊人地, Δ 113p53 支持 DNA DSB 修理小径包括相应再结合,非相应的结束加入并且单个海滨的退火。学习 Δ 的生物意义;在支持 DNA DSB 修理的 113p53,我们产生了 zebrafish Δ 113p53 经由抄写的 M/M 异种像使活跃之物的受动器核酸酶技术并且发现异种对 γ 更敏感;照耀。人的 ortholog, Δ 133p53,被 γ 仅仅也导致;照耀和功能修理支持 DNA DSB。Δ 133p53-knockdown 房间响应 γ 在以后的阶段在 G2 阶段被逮捕;照耀由于 unrepaired DNA DSB 的高水平,它最后导致了房间老朽。而且, Δ 113p53/Δ 133p53 经由 upregulating 支持 DNA DSB 修理由到在他们的倡导者的 p53 应答的元素的一种新奇类型的绑定的修理基因 rad51, lig4 和 rad52 的抄写。我们的结果表明那 Δ 113p53/Δ 133p53 是为由阻止 apoptosis 并且支持 DNA DSB 修理禁止房间老朽的 DNA 损坏应力的一个进化地保存的支持幸存的因素。我们的数据也建议 Δ 的正式就职;在正常房间或纸巾的 133p53 表示为癌症病人提供一个重要忍耐标记给放射疗法。 | Lu Gong Hongjian Gong Xiao Pan Changqing Chang Zhao Ou Shengfan Ye Le Yin Lina Yang Ting Tao Zhenhai Zhang Cong Liu David P Lane Jinrong Peng Jun Chen | 2015 | Cell Research2015，25，3： | 4 |
| 12 | Exposure to blast shock waves via the ear canal induces deficits in vestibular afferent function in rats显示文摘The ears are air-filled structures that are directly impacted during blast exposure.In addition to hearing loss and tinnitus,blast victims often complain of vertigo,dizziness and unsteady posture,suggesting that blast exposure induces damage to the vestibular end organs in the inner ear.However,the underlying mechanisms remain to be elucidated.In this report,single vestibular afferent activity and the vestibuloocular reflex(VOR)were investigated before and after exposure to blast shock waves(~20 PSI)delivered into the left external ear canals of anesthetized rats.Single vestibular afferent activity was recorded from the superior branch of the left vestibular nerves of the blast-treated and control rats one day after blast exposure.Blast exposure reduced the spontaneous discharge rates of the otolith and canal afferents.Blast exposure also reduced the sensitivity of irregular canal afferents to sinusoidal head rotation at 0.5e2Hz.Blast exposure,however,resulted in few changes in the VOR responses to sinusoidal head rotation and translation.To the best of our knowledge,this is the first study that reports blast exposure-induced damage to vestibular afferents in an animal model.These results provide insights that may be helpful in developing biomarkers for early diagnosis of blast-induced vestibular deficits in military and civilian populations. | Yue Yu Jun Huang Xuehui Tang Jerome Allison David Sandlin Dalian Ding Yi Pang Chunming Zhang Tianwen Chen Nathan Yin Lan Chen William Mustain Wu Zhou Hong Zhu | 2020 | Journal of Otology2020，15，3： | 3 |
| 13 | Factors influencing the diagnosis and treatment of chronic prostatitis among urologists in China显示文摘瞄准:识别在中国泌尿科医师之中影响长期的前列腺炎(CP ) 的诊断和处理的因素。方法:从中国的 29 个省的 656 个泌尿科医师的一件样品被要求完成在 CP 的管理向 CP 以及诊断和治疗模式探索了态度的一张问询表。univariate 并且多,逻辑回归分析策划的变量被用来决定影响 CP 的诊断和处理的因素。结果:656 张问询表的一个总数被给出。所有被归还, 410 那些在最后的 univariate 并且多被包括变量分析。Multivariate 逻辑回归分析在 CP 的病原学显示了细菌的感染的那个信仰(机会比率[或] , 2.544;95% 信心间隔[CI ] , 1.650-3.923;P <
0.001 ) 是影响细菌的文化测试的平淡的性能的最重要的因素。用一样的模型,医院的类型(或, 2.799;95% CI, 1.719-4.559;P <
0.001 ) 并且 4- 或 2 眼镜的平淡的使用测试(或, 3.194;95% CI, 2.069-4.931;P <
0.001 ) 被决定是影响健康(NIH ) 的国家研究所的使用的重要因素新分类系统。根据一样的模型的意见,在 CP 的病原学的细菌的感染的信仰(或, 3.415;95% CI, 2.024-5.762;P <
0.001 ) 并且细菌的文化的平淡的使用测试(或, 2.261;95% CI, 1.364-3.749;P <
0.01 ) 是影响抗菌素的平淡的药方的重要因素。结论:我们的调查结果建议对 CP 的态度,和单个泌尿科医师的惯例的特征可以在中国泌尿科医师之中影响 CP 的诊断和处理。 | Long-Fei Liu Jin-Rui Yang David A.Ginsberg Hui-Wen Xie Jian-Ming Rao Long Wang Zhuo Yin Qian He Tu-Bao Yang | 2008 | Asian Journal of Andrology2008，10，4： | 3 |
| 14 | Enhanced Learning Resource Recommendation Based on Online Learning Style Model显示文摘Smart learning systems provide relevant learning resources as a personalized bespoke package for learners based on their pedagogical needs and individual preferences.This paper introduces a learning style model to represent features of online learners.It also presents an enhanced recommendation method named Adaptive Recommendation based on Online Learning Style(AROLS),which implements learning resource adaptation by mining learners’behavioral data.First,AROLS creates learner clusters according to their online learning styles.Second,it applies Collaborative Filtering(CF)and association rule mining to extract the preferences and behavioral patterns of each cluster.Finally,it generates a personalized recommendation set of variable size.A real-world dataset is employed for some experiments.Results show that our online learning style model is conducive to the learners’data mining,and AROLS evidently outperforms the traditional CF method. | Hui Chen Chuantao Yin Rumei Li Wenge Rong Zhang Xiong Bertrand David | 2020 | Tsinghua Science and Technology2020，25，3： | 3 |
| 15 | M0S2 dual-gate transistors with electrostatically doped contacts显示文摘Two-dimensional(2D)transition metal dichalcogenides(TMDs)such as molybdenum disulfide(M0S2)have been intensively investigated because of their exclusive physical properties for advaneed electronics and optoelectronics.In the present work,we study the M0S2 transistor based on a novel tri-gate device architecture,with dual-gate(Dual-G)in the channel and the buried side-gate(Side-G)for the source/drain regi ons.All gates can be in depe ndently con trolled without in terfere nee.For a MoS2 sheet with a thick ness of 3.6 nm,the Schottky barrier(SB)and non-overlapped channel region can be effectively tuned by electrostatically doping the source/drain regions with Side-G.Thus,the extri nsic resista nee can be effectively lowered,and a boost of the ON-state cur re nt can be achieved.Mean while,the cha nn el c ontrol remai ns efficient under the Dual-G mode,with an ON-OFF current ratio of 3 x 107 and subthreshold swing of 83 mV/decade.The corresponding band diagram is also discussed to illustrate the device operati on mechanism.This no vel device structure ope ns up a new way toward fabricati on of high-performance devices based on 2D-TMDs. | Fuyou Liao Yaocheng Sheng Zhongxun Guo Hongwei Tang Yin Wang Lingyi Zong Xinyu Chen Antoine Riaud Jiahe Zhu Yufeng Xie Lin Chen Hao Zhu Qingqing Sun Peng Zhou Xiangwei Jiang Jing Wan Wenzhong Bao David Wei Zhang | 2019 | Nano Research2019，12，10： | 2 |
| 16 | Hologenomic insights into mammalian adaptations to myrmecophagy显示文摘Highly specialized myrmecophagy(ant-and termite-eating)has independently evolved multiple times in species of various mammalian orders and represents a textbook example of phenotypic evolutionary convergence.We explored the mechanisms involved in this unique dietary adaptation and convergence through multi-omic analyses,including analyses of host genomes and transcriptomes,as well as gut metagenomes,in combination with validating assays of key enzymes'activities,in the species of three mammalian orders(anteaters,echidnas and pangolins of the orders Xenarthra,Monotremata and Pholidota,respectively)and their relatives.We demonstrate the complex and diverse interactions between hosts and their symbiotic microbiota that have provided adaptive solutions for nutritional and detoxification challenges associated with high levels of protein and lipid metabolisms,trehalose degradation,and toxic substance detoxification.Interestingly,we also reveal their spatially complementary cooperation involved in degradation of ants'and termites'chitin exoskeletons.This study contributes new insights into the dietary evolution of mammals and the mechanisms involved in the coordination of physiological functions by animal hosts and their gut commensals. | Shao-Chen Cheng Chun-Bing Liu Xue-Qin Yao Jing-Yang Hu Ting-Ting Yin Burton KLim Wu Chen Guo-Dong Wang Cheng-Lin Zhang David MIrwin Zhi-Gang Zhang Ya-Ping Zhang Li Yu | 2023 | National Science Review2023，10，4： | 2 |
| 17 | Functions of autophagy in normal and diseased liver显示文摘 | Mark J. Czaja Wen-Xing Ding Terrence M. Donohue Scott L. Friedman Jae-Sung Kim Masaaki Komatsu John J. Lemasters Antoinette Lemoine Jiandie D. Lin Jing-hsiung James Ou David H. Perlmutter Glenn Randall Ratna B. Ray Allan Tsung Xiao-Ming Yin | 2013 | Autophagy2013，，8： | 2 |
| 18 | Functional Role of Matrix Metalloproteinase-8 in Stem/Progenitor Cell Migration and Their Recruitment Into Atherosclerotic Lesions显示文摘 | Qingzhong Xiao Feng Zhang Luyang Lin Changcun Fang Guanmei Wen Tsung-Neng Tsai Xiangyuan Pu David Sims Zhongyi Zhang Xiaoke Yin Binia Thomaszewski Boris Schmidt Manuel Mayr Ken Suzuki Qingbo Xu Shu Ye | 2013 | Circulation Research2013，，1： | 2 |
| 19 | Hydrogen bonding with adsorbent during storage governs drug dissolution from solid-dispersion grannules显示文摘 | Manish K Gupta Yin - Chao Tseng David Goldman | 2002 | Pharmaceutical Research2002，19，11： | 1 |
| 20 | Low-depth whole genome sequencing reveals copy number variations associated with higher pathologic grading and more aggressive subtypes of lung non-mucinous adenocarcinoma显示文摘Objective:Histology grade,subtypes and TNM stage of lung adenocarcinomas are useful predictors of prognosis and survival.The aim of the study was to investigate the relationship between chromosomal instability,morphological subtypes and the grading system used in lung non-mucinous adenocarcinoma(LNMA).Methods:We developed a whole genome copy number variation(WGCNV)scoring system and applied next generation sequencing to evaluate CNVs present in 91 LNMA tumor samples.Results:Higher histological grades,aggressive subtypes and more advanced TNM staging were associated with an increased WGCNV score,particularly in CNV regions enriched for tumor suppressor genes and oncogenes.In addition,we demonstrate that 24-chromosome CNV profiling can be performed reliably from specific cell types(<100 cells)isolated by sample laser capture microdissection.Conclusions:Our findings suggest that the WGCNV scoring system we developed may have potential value as an adjunct test for predicting the prognosis of patients diagnosed with LNMA. | Zheng Wang Lin Zhang Lei He Di Cui Chenglong Liu Liangyu Yin Min Zhang Lei Jiang Yuyan Gong Wang Wu Bi Liu Xiaoyu Li David S Cram Dongge Liu | 2020 | Chinese Journal of Cancer Research2020，32，3： | 1 |
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