|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis显示文摘Iron has been shown to trigger oxidative stress by elevating reactive oxygen species (ROS) and to participate in different modes of cell death,such as ferroptosis,apoptosis and necroptosis. However,whether iron-elevated ROS is also linked to pyroptosis has not been reported. Here,we demonstrate that iron-activated ROS can induce pyroptosis via a Tom20-Bax-caspase-GSDME pathway. In melanoma cells,iron enhanced ROS signaling initiated by CCCP,causing the oxidation and oligomerization of the mitochondrial outer membrane protein Tom20. Bax is recruited to mitochondria by oxidized Tom20,which facilitates cytochrome c release to cytosol to activate caspase-3;eventually triggering pyroptotic death by inducing GSDME cleavage. Therefore,ROS acts as a causative factor and Tom20 senses ROS signaling for iron-driven pyroptotic death of melanoma cells. Since iron activates ROS for GSDME-dependent pyroptosis induction and melanoma cells specifically express a high level of GSDME,iron may be a potential candidate for melanoma therapy. Based on the functional mechanism of iron shown above,we further demonstrate that iron supplementation at a dosage used in iron-deficient patients is sufficient to maximize the anti-tumor effect of clinical ROS-inducing drugs to inhibit xenograft tumor growth and metastasis of melanoma cells through GSDME-dependent pyroptosis. Moreover,no obvious side effects are observed in the normal tissues and organs of mice during the combined treatment of clinical drugs and iron. This study not only identifies iron as a sensitizer amplifying ROS signaling to drive pyroptosis,but also implicates a novel iron-based intervention strategy for melanoma therapy. | Bo Zhou Jia-yuan Zhang Xian-shuo Liu Hang-zi Chen Yuan-li Ai Kang Cheng Ru-yue Sun Dawang Zhou Jiahuai Han Qiao Wu | 2018 | Cell Research2018，28，12： | 52 |
| 2 | The Hippo signaling pathway in liver regeneration and tumorigenesis显示文摘表明小径的河马是在肝尺寸控制和 tumorigenesis 起关键作用的一个 evolutionarily 保存的发信号的模块。河马小径由在的核心 kinase 串联组成哺乳动物的象 Ste20 一样 kinases (Mst1/2,果蝇河马的 orthologs ) 并且他们的余因子萨尔瓦多(Sav1 ) 形成建筑群到 phosphorylate 并且激活大肿瘤 suppressor (Lats1/2 ) 。Lats1/2 kinases 接着 phosphorylate 并且与 PDZ 有约束力的主题(TAZ ) 禁止抄写激活剂,联系是的蛋白质(笨蛋) 和 transcriptional 激活剂,河马小径的二个主要下游的受动器。河马小径部件的损失导致异常肝肿大和 tumorigenesis,笨蛋在协调房间增长和 apoptosis 的规定并且起一个必要作用。这评论总结在肝新生和 tumorigenesis 发信号的河马的规定的当前的调查结果,集中河马小径的肿瘤 suppressor 部件的损失怎么导致肝癌症并且讨论调整它在肝 tumorigenesis 的下游的受动器笨蛋的表示和激活的分子的机制。 | Lixin Hong Yabo Cai Mingting Jiang Dawang Zhou Lanfen Chen | 2015 | Acta Biochimica et Biophysica Sinica2015，47，1： | 12 |
| 3 | A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis显示文摘 | Shuying Shen Xiaocan Guo Huan Yan Yi Lu Xinyan Ji Li Li Tingbo Liang Dawang Zhou Xin-Hua Feng Jonathan C Zhao Jindan Yu Xing-Guo Gong Lei Zhang Bin Zhao | 2015 | Cell Research2015，25，9： | 10 |
| 4 | The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8显示文摘Pyroptosis is a form of regulated cell death mediated by gasdermin family members,among which the function of GSDMC has not been clearly described.Herein,we demonstrate that the metabolite a-ketoglutarate(α-KG)induces pyroptosis through caspase-8-mediated cleavage of GSDMC Treatment with DM-αKG,a cell-permeable derivative of α-KG,elevates ROS levels,which leads to oxidation of the plasma membrane-localized death receptor DR6. | Jia-yuan Zhang Bo Zhou Ru-yue Sun Yuan-li Ai Kang Cheng Fu-nan Li Bao-rui Wang Fan-jian Liu Zhi-hong Jiang Wei-jia Wang Dawang Zhou Hang-zi Chen Qiao Wu | 2021 | Cell Research2021，31，9： | 10 |
| 5 | Role of Hippo signaling in regulating immunity显示文摘The Hippo signaling pathway has been established as a key regulator of organ size control,tumor suppression,and tissue regeneration in multiple organisms.Recently,emerging evidence has indicated that Hippo signaling might play an important role in regulating the immune system in both Drosophila and mammals.In particular,patients bearing a loss-of-function mutation of MST1 are reported to have an autosomal recessive primary immunodeficiency syndrome.MST1/2 kinases,the mammalian orthologs of Drosophila Hippo,may activate the non-canonical Hippo signaling pathway via MOB1A/B and/or NDR1/2 or cross-talk with other essential signaling pathways to regulate both innate and adaptive immunity.In this review,we present and discuss recent findings of cellular mechanisms/functions of Hippo signaling in the innate immunity in Drosophila and in mammals,T cell immunity,as well as the implications of Hippo signaling for tumor immunity. | Lixin Hong Xun Li Dawang Zhou Jing Geng Lanfen Chen | 2018 | Cellular & Molecular Immunology2018，15，12： | 5 |
| 6 | Hippo pathway in intestinal homeostasis and tumorigenesis显示文摘The Hippo pathway plays a crucial role in controlling organ size by inhibiting cell proliferation and promoting cell death.Recent findings implicate that this pathway is involved in the process of intestinal regeneration and tumorigenesis.Here we summarize current studies for the function of the Hippo signaling pathway in intestinal homeostasis,regeneration and tumorigenesis,and the crosstalk between the Hippo signaling pathway and other major signaling pathways,i.e.Wnt,Notch and Jak/Stat signaling pathways in intestinal compartment. | Lanfen Chen Funiu Qin Xianming Deng Joseph Avruch Dawang Zhou | 2012 | Protein & Cell2012，3，4： | 4 |
| 7 | Facile Li-Al layered double hydroxide films on Al alloy for enhanced hydrophobicity, anti-biofouling and anti-corrosion performance显示文摘In this work,lithium(Li)-aluminum(Al)layered double hydroxide(LDH)films modified by 4-amino-2-((hydrazine methylene)amino)-4-oxobutanoic acid(denoted as AOA acid)and/or 1H,1H,2H,2H-perfluorooctyltriethoxysilane were prepared on 6N01 Al alloy by a facile,in-situ growth method with enhanced hydrophobicity,anti-biofouling and anti-corrosion performance.The preparation is low energy consumptive and environment friendly,relying on self-assembly at ambient temperature.The structure,molecular weight and functional groups of the synthesized AOA acid were characterized by NMR spectrometer,ESI-MS spectrometer and Fourier transform infrared(FT-IR)spectroscopy.And the compositions,structure and morphology of the films were characterized by Fourier transform infrared(FT-IR)spectroscopy,glancing-angle X-ray diffraction(GA-XRD),X-ray photoelectron spectroscopy(XPS),field emission scanning electron microscopy(FE-SEM)and energy-dispersive x-ray spectrum(EDS).Water contact angle measurements(CA)and atomic force microscopy(AFM)characterization show that the films possess a micro/nanostructure with an improved hydrophobicity.Immersion test,neutral salt tests(NSS)and electrochemical impedance spectroscopy(EIS)conducted in 3.5 wt.%NaCl solutions demonstrate the improved corrosion resistance of the films over bare Al alloy.Meanwhile,the films also possess an excellent anti-bacterial property toEscherichia coli,Bacillus subtilis and sulfate-reducing bacteria. | Ji Li Tianci Yuan Chengliang Zhou Bo Chen Yi Shuai Dawang Wu Dongchu Chen Xiaohu Luo Y.Frank Cheng Yali Liu | 2021 | Journal of Materials Science & Technology2021，，20： | 2 |
| 8 | Impeded Nedd4-1-Mediated Ras Degradation Underlies Ras-Driven Tumorigenesis显示文摘 | Taoling Zeng Qun Wang Jieying Fu Qi Lin Jing Bi Weichao Ding Yikai Qiao Sheng Zhang Wenxiu Zhao Huayue Lin Meilin Wang Binfeng Lu Xianming Deng Dawang Zhou Zhenyu Yin Hong-Rui Wang | 2014 | Cell Reports2014，，3： | 1 |
| 9 | Identification of serum metabolites enhancing inflammatory responses in COVID-19显示文摘Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is characterized by a strong production of inflammatory cytokines such as TNF and IL-6,which underlie the severity of the disease.However,the molecular mechanisms responsible for such a strong immune response remains unclear.Here,utilizing targeted tandem mass spectrometry to analyze serum metabolome and lipidome in COVID-19 patients at different temporal stages,we identified that 611 metabolites(of 1,039)were significantly altered in COVID-19 patients.Among them,two metabolites,agmatine and putrescine,were prominently elevated in the serum of patients;and 2-quinolinecarboxylate was changed in a biphasic manner,elevated during early COVID-19 infection but levelled off.When tested in mouse embryonic fibroblasts(MEFs)and macrophages,these 3 metabolites were found to activate the NF-κB pathway that plays a pivotal role in governing cytokine production.Importantly,these metabolites were each able to cause strong increase of TNF and IL-6 levels when administered to wildtype mice,but not in the mice lacking NF-κB.Intriguingly,these metabolites have little effects on the activation of interferon regulatory factors(IRFs)for the production of type I interferons(IFNs)for antiviral defenses.These data suggest that circulating metabolites resulting from COVID-19 infection may act as effectors to elicit the peculiar systemic inflammatory responses,exhibiting severely strong proinflammatory cytokine production with limited induction of the interferons.Our study may provide a rationale for development of drugs to alleviate inflammation in COVID-19 patients. | Chen-Song Zhang Bingchang Zhang Mengqi Li Xiaoyan Wei Kai Gong Zhiyong Li Xiangyang Yao Jianfeng Wu Cixiong Zhang Mingxia Zhu Lei Zhang Xiufeng Sun Yi-Hong Zhan Zhengye Jiang Wenpeng Zhao Wei Zhong Xinguo Zhuang Dawang Zhou Hai-Long Piao Sheng-Cai Lin Zhanxiang Wang | 2022 | Science China(Life Sciences)2022，65，10： | 1 |
| 10 | Efficient Photocatalytic Degradation of the Persistent PET Fiber‑Based Microplastics over Pt Nanoparticles Decorated N‑Doped TiO_(2) Nanoflowers显示文摘Fiber-based microplastics(FMPs)are highly persistent and ubiquitously exist in the wastewater of textile industry and urban sewage.It remains challenging to completely remove such newly emerged organic pollutants by the predominant physical techniques.In this work,we investigated a photocatalytic degradation catalyzed by TiO_(2) catalyst to demonstrate the feasibility of implementing efficient chemical protocol to fast degrading polyethylene terephthalate(PET)-FMPs(a major FMP type existing in environment).The result shows that a hydrothermal pretreatment(180℃/12 h)is necessary to induce the initial rough appearance and molecular weight reduction.With the comprehensive action of the nano-flower shaped N doped-TiO_(2) catalyst(Pt@N-TiO_(2)-1.5%)on the relatively low molecular weight intermediates,an approximate 29%weight loss was induced on the pretreated PET-FMPs,which is about 8 times superior to the untreated sample.This work not only achieves a superior degradation effect of PET-FMPs,but also provides a new inspiration for the proposal of reduction strategies in the field of environmental remediation in the future. | Dawang Zhou Hongxia Luo Fangzhou Zhang Jing Wu Jianping Yang Huaping Wang | 2022 | Advanced Fiber Materials2022，4，5： | 1 |
| 11 | Selective production of acetol or methyl lactate from cellulose over RuSn catalysts显示文摘Designing a catalytic system that could convert cellulose to switchable C3 alcohols or esters with controllable selectivity is highly desired to meet the rapidly changing market demand.Herein,we develop RuSn catalysts with the altering Sn loadings that can achieve acetol formation from cellulose hydrogenation at240℃in presence of H_(2)or yield methyl lactate production from cellulose conversion in methanol and water mixture at 200℃in presence of N_(2).The increased Sn contents from 3%to 6%lead to form different surface sites from Ru_(3)Sn_(7),Ru,and SnO_(x)to Ru_(3)Sn_(7)and SnO_(x).The integrated Ru_(3)Sn_(7),Ru,and SnO_(x)species on 1.5%Ru-3%Sn/SiO_(2)catalyze isomerization,retro-aldol condensation,and hydrogenation individual steps with coordinated reaction rates,resulting in the acetol formation with a high yield of 53.7 C%.Furthermore,the optimum combination of Ru_(3)Sn_(7)and SnO_(x)on 1.5%Ru-6%Sn/SiO_(2)contributes to the isomerization,retro-aldol condensation,dehydration,and 1,2-hydride shift,giving rise to the preferential production of methyl lactate at a 25.1 C%yield.These results illustrate the feasibility of controlling the selective conversion of cellulose to C3 acetol or methyl lactate by devising a tunable catalytic system,which guides the rational design of catalysts for the selective conversion of cellulose. | Dawang Chu Zhicheng Luo Chen Zhao | 2022 | Journal of Energy Chemistry2022，31，10： | 1 |
| 12 | Tannins and other phenolics from Myrica esculenta bark显示文摘 | Zuchun Zhao Herbert Wong | 1988 | Phytochemistry1988，27，2： | 1 |
| 13 | Protein kinases of the Hippo pathway: Regulation and substrates显示文摘 | Joseph Avruch Dawang Zhou Julien Fitamant Nabeel Bardeesy Fan Mou Laura Regué Barrufet | 2012 | Seminars in Cell and Developmental Biology2012，，7： | 1 |
| 14 | Influence of crystal-transforming agent on the performance and mechanism ofα-high-strength gypsum prepared from FGD gypsum显示文摘This paper investigates the impact of flue gas desulfurization(FGD)gypsum's crystal modifier on the characteristics and microcosmic mechanism ofα-high strength gypsum.The results demonstrate that all three crystal modifiers can convert FGD gypsum toα-high-strength gypsum.Citric acid(CA)has the most significant influence onα-high-strength gypsum,and the preparedα-high-strength gypsum is short columnar,with an aspect ratio in the range of 1-3,and has a faster setting time,a larger specific surface area,and a smaller standard consistency,higher compressive strength,greater surface hardness,and smaller crystal particle size.The initial setting time of theα-high-strength gypsum manufactured with CA crystal modifier was decreased by 36%compared to the blank sample,the final setting time was lowered by 37.5%,and the water consumption of the standard consistency was reduced by 8%.The maximum strength is 32 MPa after 2 h,the absolute dry compressive strength is up to 38 MPa,and the surface hardness is improved by 24.43%. | Zhuoyue Xu Xiao Wang Biao Jin Dawang Zhang Hui Li | 2024 | Particuology2024，87，4： | 0 |
| 15 | SET1A催化YAP甲基化修饰调控YAP细胞核转运和促进肿瘤发生显示文摘文章简介YAP作为Hippo信号通路主要效应因子之一,在Hippo通路受抑的条件下,从细胞质转运至细胞核调控基因表达和促进肿瘤发生。虽然YAP锚定在细胞质中的调控机制已经被广泛研究,但是YAP激活后入核在细胞核中持续积累的分子机制并不十分清楚。 | 方兰 滕鸿琦 王益林 廖光红 Linjun Weng Yaxu Li Xinbo Wang Jiali Jin Chenchen Jiao Lei Chen Xiaoping Peng Jiayu Chen Yongzhi Yang Houqin Fang Dongyan Han Cheng Li Xueling Jin Shihao Zhang Zhongchen Liu Min Liu Qing Wei Lujian Liao Xin Ge Bin Zhao Dawang Zhou HuanLong Qin Jun Zhou 王平 | 2019 | 科学新闻2019，0，2： | 0 |
| 16 | STUDIES ON STEPWISE STABILITY CONSTANTS OF COORDINATION COMPOUNDS FROM SULFONATED SHEOAK TANNIN WITH METAL IONS显示文摘The stepwise stability constants of coordination compounds from sulfonatedsheoak tannin with metal ions have been determined by pH potential method with catechol asmodel compounds at 20℃and constant ionic strength. | Huang Jianling Sun Dawang Nanjing Forestry University | 1993 | Journal of Northeast Forestry University1993，4，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员