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| 1 | Review of the diagnosis,classification and management of autoimmune pancreatitis显示文摘Autoimmune pancreatitis(AIP)is a rare form of chronic pancreatitis,with as yet undetermined incidence and prevalence in the general population.Our understanding of it continues to evolve.In the last few years,2separate subtypes have been identified:type 1 AIP has been recognised as the pancreatic manifestation of a multiorgan disease,named immunoglobulin G4(IgG4)-related disease while type 2 AIP is a pancreas specific disorder not associated with IgG4.International criteria for the diagnosis of AIP have been defined:the HISORt criteria from the Mayo clinic,the Japan consensus criteria and,most recently,the international association of pancreatology'International Consensus Diagnostic Criteria'.Despite this,in clinical practice it can still be very difficult to confirm the diagnosis and differenti-ate AIP from a pancreatic cancer.There are no large studies into the long-term prognosis and management of relapses of AIP,and there is even less information at present regarding the Type 2 AIP subtype.Further studies are necessary to clarify the pathogenesis,treatment and long-term outcomes of this disease.Critically for clinicians,making the correct diagnosis and differentiating the disease from pancreatic cancer is of the utmost importance and the greatest challenge. | Derek A O'Reilly Deep J Malde Trish Duncan Madhu Rao Rafik Filobbos | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，2： | 14 |
| 2 | 复杂并发症产生在简单并且 polycystic 肝包囊显示文摘 Liver cysts are common,affecting 5%-10% of the population.Most are asymptomatic,however 5% of patients develop symptoms,sometimes due to complications and will require intervention.There is no consensus on their management because complications are so uncommon.The aim of this study was to perform a collected review of how a series of complications were managed at our institutions.Six different patients presenting with rare complications of liver cysts were obtained from Hepatobiliary Units in the United Kingdom and The Netherlands.History and radiological imaging were obtained from case notes and computerised radiology.As a result,1 patient admitted with inferior vena cava obstruction was managed by cyst aspiration and lanreotide;1 patient with common bile duct obstruction was first managed by endoscopic retrograde cholangiopancreatography and stenting,followed by open fenestration;1 patient with ruptured cysts and significant medical co-morbidities was managed by percutaneous drainage;1 patient with portal vein occlusion and varices was managed by open liver resection;1 patient with infected cysts was treated with intravenous antibiotics and is awaiting liver transplantation.The final patient with a simple liver cyst mimicking a hydatid was managed by open liver resection.In conclusion,complications of cystic liver disease are rare,and we have demonstrated in this series that both operative and non-operative strategies have defined roles in management.The mainstays of treatment are either aspiration/sclerotherapy or,alternatively laparoscopic fenestration.Medical management with somatostatin analogues is a potentially new and exciting treatment option but requires further study. | Christian Macutkiewicz Ricci Plastow Melissa Chrispijn Rafik Filobbos Basil A Ammori David J Sherlock Joost PH Drenth Derek A O’Reilly | 2012 | World Journal of Hepatology2012，4，12： | 10 |
| 3 | The Clinical Course of Acute Pancreatitis and the Inflammatory Mediators That Drive It显示文摘 | Leena Kyl?np?? Zoltán Rakonczay Derek A. O’Reilly David A. Hart | 2012 | International Journal of Inflammation2012，，： | 2 |
| 4 | Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis: the New EPOC randomised controlled trial显示文摘 | John Primrose Stephen Falk Meg Finch-Jones Juan Valle Derek O’Reilly Ajith Siriwardena Joanne Hornbuckle Mark Peterson Myrddin Rees Tim Iveson Tamas Hickish Rachel Butler Louise Stanton Elizabeth Dixon Louisa Little Megan Bowers Sian Pugh O James Garden D | 2014 | Lancet Oncology2014，，6： | 2 |
| 5 | Multidisciplinary approach for multifocal, bilobar hepatocellular carcinoma: A case report and literature review显示文摘BACKGROUND Hepatocellular carcinoma(HCC) is the second most lethal malignancy worldwide. There has been virtually no change in the survivability of HCC in spite of improvement in therapies. Surgery is considered the ideal first, curative intervention, however most patients present in advanced stages with unresectable disease. Therefore, systemic and liver-directed non-operative therapies are initially offered to downstage the disease. To ensure optimal management, a multidisciplinary team approach is often warranted. Our case highlights the benefits of a multidisciplinary approach in a young woman with multifocal, bilobar HCC.CASE SUMMARY A 36-year-old Chinese woman with untreated hepatitis B was found to have large bilobar HCC during work up for abdominal pain. Her initial serum alphafetoprotein was significantly elevated to 311136 ng/mL. Computed tomography scan demonstrated bulky bilobar liver masses, consistent with intermediate stage HCC, Barcelona Clinic Liver Cancer Stage B. Her case was discussed and a personalized care plan was developed at the Multidisciplinary Center for Advanced Minimally Invasive Liver Oncologic Therapies at the University of Washington. She initially underwent bilobar transarterial chemoembolization with partial response of the left lobar tumor. Salvage hypofractionated proton beam radiation therapy was delivered to the right lobe followed by two additional transarterial chemoembolizations to the left lobe with good response.Finally, to remove left lobar residual disease, she was taken to the operating roomfor a left hepatectomy eleven months after her initial presentation. She continues to be without evidence of disease.CONCLUSION Coordinating the multiple HCC treatment modalities is complex and our case highlights the benefits of a multidisciplinary approach. | Kevin P Labadie Stephanie K Schaub Derek Khorsand Guy Johnson Smith Apisarnthanarax James O Park | 2019 | World Journal of Hepatology2019，11，1： | 2 |
| 6 | The Preparation and Characterization of Poly(lactide-co-glycolide) Microparticles. II. The Entrapment of a Model Protein Using a (Water-in-Oil)-in-Water Emulsion Solvent Evaporation Technique显示文摘 | Hayley Jeffery Stanley S. Davis Derek T. O’Hagan | 1993 | Pharmaceutical Research1993，，3： | 2 |
| 7 | Biological activity of cryopreserved bovine spermatogonial stem cells during in vitro culture显示文摘 | Jon M O Jerry J R Derek J M | 2004 | Biology of Reproduction2004，71，： | 1 |
| 8 | Distinct subpopulations of γδ T cells are present in normal and tumor-bearing human liver显示文摘 | Tony Kenna Lucy Golden-Mason Suzanne Norris John E. Hegarty Cliona O'Farrelly Derek G. Doherty | 2004 | Clinical Immunology2004，，1： | 1 |
| 9 | Salaried Defenders and the Access to Justice Act 1999 显示文摘 | Derek O'Brien & John Arnold Epp | 2000 | Modern Law Review2000，，3： | 1 |
| 10 | Mucoepidermoid Carcinoma of the Parotid Gland:The Mayo Clinic Experience显示文摘 | Derek Kofi O Boahene Kerry D | 2004 | Arch Otolaryngol Head NeckSurg2004，130，： | 1 |
| 11 | Reduction in Mortality as a Result of Direct Transport From the Field to a Receiving Center for Primary Percutaneous Coronary Intervention显示文摘 | Michel R. Le May George A. Wells Derek Y. So Chris A. Glover Michael Froeschl Justin Maloney Richard Dionne Jean-Fran?ois Marquis Edward R. O’Brien Alexander Dick Heather L. Sherrard John Trickett Pierre Poirier Melissa Blondeau Jordan Bernick Marino Labi | 2012 | Journal of the American College of Cardiology2012，，14： | 1 |
| 12 | Usefulness of Mean Platelet Volume as a Biomarker for Long-Term Outcomes After Percutaneous Coronary Intervention显示文摘 | Sandro Cadaval Goncalves Marino Labinaz Michel Le May Chris Glover Michael Froeschl Jean-Francois Marquis Edward O’Brien Dino Shukla Peter Ruchin Dharmendra Sookur Andrew Ha Derek So | 2011 | The American Journal of Cardiology2011，，2： | 1 |
| 13 | Mucoepidermoid Carcinoma of the Parotid Gland:The Mayo Clinic Experience显示文摘 | Derek Kofi O Boahene Kerry D | 2004 | Arch Otolaryngol Head Neck Surg2004，130，： | 1 |
| 14 | Bone Marrow‐Derived Mesenchymal Stem Cells Have Innate Procoagulant Activity and Cause Microvascular Obstruction Following Intracoronary Delivery: Amelioration by Antithrombin Therapy显示文摘 | Birgitta M. Gleeson Kenneth Martin Mohammed T. Ali Arun H. S. Kumar M. Gopala‐Krishnan Pillai Sujith P. G. Kumar John F. O’Sullivan Derek Whelan Alessia Stocca Wisam Khider Frank P. Barry Timothy O’Brien Noel M. Caplice | 2015 | Stem Cells2015，，9： | 1 |
| 15 | Investigating text input methods for mobile phones显示文摘 | Kevin Curran Derek Woods Barry O R | 2006 | Telematics and Informatics2006，23，1： | 1 |
| 16 | Acute Pancreatitis显示文摘 | Andrew K Derek O'Reilly | 2006 | BMJ2006，332，： | 1 |
| 17 | Changes in accommo- dative and vergence responses when viewing through near addi- tion lenses显示文摘 | Baichuan Jiang Tea YC Derek O'Donnell | 2007 | Optometry2007，78，3： | 1 |
| 18 | Resident human hepatitis lymphocytes are phenotypically different from circulating lymphocytes显示文摘 | Suzanne Norris Clive Collins Derek G. Doherty Fiona Smith Gerry McEntee Oscar Traynor Niamh Nolan John Hegarty Cliona O’Farrelly | 1998 | Journal of Hepatology1998，，1： | 1 |
| 19 | Circulating tumour cells, their role in metastasis and their clinical utility in lung cancer显示文摘 | John D. O’Flaherty Steven Gray Derek Richard Dean Fennell John J. O’Leary Fiona H. Blackhall Kenneth J. O’Byrne | 2012 | Lung Cancer2012，，1： | 1 |
| 20 | The Preparation and Characterization of Poly(lactide-co-glycolide) Microparticles. II. The Entrapment of a Model Protein Using a (Water-in-Oil)-in-Water Emulsion Solvent Evaporation Technique显示文摘 | Hayley Jeffery Stanley S. Davis Derek T. O’Hagan | 1993 | Pharmaceutical Research1993，，3： | 1 |
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