|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Analogic China map constructed by DNA显示文摘In this research,a nanoscale DNA structure of analogic China map is created. The nanostructure of roughly 150 nm in diameter with a spatial resolution of 6 nm is purely constructed by folding DNA. The picture observed by atomic force microscopy (AFM) is almost identical with the de-signed shape. The DNA origami technology invented by Rothemund in 2006 is employed in the construc-tion of this shape,which has proved the capability of constructing almost any complicated shape enabled by DNA origami,and provides new bottom-up method for constructing nanostructures. | QIAN Lulu WANG Ying ZHANG Zhao ZHAO Jian PAN Dun ZHANG Yi LIU Qiang FAN Chunhai HU Jun HE Lin | 2006 | Chinese Science Bulletin2006，51，24： | 20 |
| 2 | Saponins from Panax japonicus attenuate age-related neuroinflammation via regulation of the mitogen-activated protein kinase and nuclear factor kappa B signaling pathways显示文摘Neuroinflammation is recognized as an important pathogenic factor for aging and related cognitive disorders. Mitogen-activated protein kinase and nuclear factor kappa B signaling pathways may mediate neuroinflammation. Saponins from Panax japonicus are the most abundant and bioactive members in rhizomes of Panax japonicus, and show anti-inflammatory activity. However, it is not known whether saponin from Panax japonicus has an anti-inflammatory effect in the aging brain, and likewise its underlying mechanisms. Sprague-Dawley rats were divided into control groups(3-, 9-, 15-, and 24-month-old groups) and saponins from Panax japonicus-treated groups. Saponins from Panax japonicus-treated groups were orally administrated saponins from Panax japonicus at three doses of 10, 30, and 60 mg/kg once daily for 6 months until the rats were 24 months old. Immunohistochemical staining and western blot assay results demonstrated that many microglia were activated in 24-month-old rats compared with 3-and 9-month-old rats. Expression of interleukin-1β, tumor necrosis factor-α, cyclooxygenase-2, and inducible nitric oxide synthase increased. Each dose of saponins from Panax japonicus visibly suppressed microglial activation in the aging rat brain, and inhibited expression levels of the above factors. Each dose of saponins from Panax japonicus markedly diminished levels of nuclear factor kappa B, IκBα, extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38. These results confirm that saponins from Panax japonicus can mitigate neuroinflammation in the aging rat brain by inhibition of the mitogen-activated protein kinase and nuclear factor kappa B signaling pathways. | Li-li Deng Ding Yuan Zhi-yong Zhou Jing-zhi Wan Chang-cheng Zhang Chao-qi Liu Yao-yan Dun Hai-xia Zhao Bo Zhao Yuan-jian Yang Ting Wang | 2017 | Neural Regeneration Research2017，12，11： | 17 |
| 3 | Genetic analysis and molecular mapping of a presenescing leaf gene psll in rice (Oryza sativa L.)显示文摘A rice psl1 (presenescing leaf) mutant was obtained from a japonica variety Zhonghua 11 via radiation of 60Co-γ in M2 generation. Every leaf of the mutant began to wither after it reached the big-gest length,while the leaves of the wild variety could keep green for 25―35 d. In this study,genetic analysis and gene mapping were carried out for the mutant identified. The SSR marker analysis showed that the mutant was controlled by a single recessive gene (psl1) located on chromosome 2. Fine mapping of the psl1 locus was conducted with 34 new STS markers developed around psl1 anchored region based on the sequence diversity between Nippon-bare and 93-11. The psl1 was further mapped be-tween two STS markers,STS2-19 and STS2-26,with genetic distances of 0.43 and 0.11 cM,respectively,while cosegregated with STS2-25. A BAC contig was found to span the psl1 locus,the region being delim-ited to 48 kb. This result was very useful for cloning of the psl1 gene. | WANG dun WU Shujun ZHOU Yong ZHOU Lihui XU Jiefen HU Jing FANG Yunxia GU Minghong LIANG Guohua | 2006 | Chinese Science Bulletin2006，51，24： | 16 |
| 4 | Rapid report of the 8 January 2022 M_(S)6.9 Menyuan earthquake,Qinghai,China显示文摘The M_(S)6.9 Menyuan earthquake in Qinghai Province,west China is the largest earthquake by far in 2022.The earthquake occurs in a tectonically active region,with a background b-value of 0.87 within 100 km of the epicenter that we derived from the unified catalog produced by China Earthquake Networks Center since late 2008.Field surveys have revealed surface ruptures extending 22 km along strike,with a maximum ground displacement of 2.1 m.We construct a finite fault model with constraints from In SAR observations,which showed multiple fault segments during the Menyuan earthquake.The major slip asperity is confined within 10 km at depth,with the maximum slip of 3.5 m.Near real-time back-projection results of coseismic radiation indicate a northwest propagating rupture that lasted for~10 s.Intensity estimates from the back-projection results show up to a Mercalli scale of IX near the ruptured area,consistent with instrumental measurements and the observations from the field surveys.Aftershock locations(up to January 21,2022)exhibit two segments,extending to~20 km in depth.The largest one reaches M_(S)5.3,locating near the eastern end of the aftershock zone.Although the location and the approximate magnitude of the mainshock had been indicated by previous studies based on paleoearthquake records and seismic gap,as well as estimated stressing rate on faults,significant surfacebreaching rupture leads to severe damage of the high-speed railway system,which poses a challenge in accurately assessing earthquake hazards and risks,and thus demands further investigations of the rupture behaviors for crustal earthquakes. | Hongfeng Yang Dun Wang Rumeng Guo Mengyu Xie Yang Zang Yue Wang Qiang Yao Chuang Cheng Yanru An Yingying Zhang | 2022 | Earthquake Research Advances2022，2，1： | 14 |
| 5 | The effect of hematoma puncture drainage before decompressive craniectomy on the prognosis of hypertensive intracerebral hemorrhage with cerebral hernia at a high altitude显示文摘Purpose:Rapid decompressive craniectomy(DC)was the most effective method for the treatment of hypertensive intracerebral hemorrhage(HICH)with cerebral hernia,but the mortality and disability rate is still high.We suspected that hematoma puncture drainage(PD)+DC may improve the therapeutic effect and thus compared the combined surgery with DC alone.Methods:From December 2013 to July 2019,patients with HICH from Linzhi,Tibet and Honghe,Yunnan Province were retrospectively analyzed.The selection criteria were as follows:(1)altitude≥1500 m;(2)HICH patients with cerebral hernia;(3)Glascow coma scale score of 4-8 and time from onset to admission≤3 h;(4)good liver and kidney function;and(5)complete case data.The included patients were divided into DC group and PD+DC group.The patients were followed up for 6 months.The outcome was assessed by Glasgow outcome scale(GOS)score,Kaplan-Meier survival curve and correlation between time from admission to operation and prognosis.A good outcome was defined as independent(GOS score,4-5)and poor outcome defined as dependent(GOS score,3-1).All data analyses were performed using SPSS 19,and comparison between two groups was conducted using separatet-tests or Chi-square tests.Results:A total of 65 patients was included.The age ranged 34-90 years(mean,63.00±14.04 years).Among them,31 patients had the operation of PD+DC,whereas 34 patients underwent DC.The two groups had no significant difference in the basic characteristics.After 6 months of follow-up,in the PD+DC group there were 8 death,4 vegetative state,4 severe disability(GOS score 1-3,poor outcome 51.6%);8 moderate disability,and 7 good recovery(GOS score 4-5,good outcome 48.4%);while in the DC group the result was 15 death,6 vegetative state,5 severe disability(poor outcome 76.5%),4 moderate disability and 4 good recovery(good outcome 23.5%).The GOS score and good outcome were significantly less in DC group than in PD+DC group(Z=-1.993,p=0.046;χ2=4.38,p=0.043).However,there was no significant difference regarding the survival curve between PD+DC group and DC group.The correlation between the time from admission to operation and GOS at 6 months(r=-0.41,R2=0.002,p=0.829)was not significant in the PD+DC group,but significant in the DC group(r=-0.357,R2=0.128,p=0.038).Conclusion:PD+DC treatment can improve the good outcomes better than DC treatment for HICH with cerebral hernia at a high altitude. | Lin-Jie Wei Chi Lin Xing-Sen Xue Guo-Dong Dun Jian-Bo Zhang Yan-Xiang Tong Jia-Xiong Wang Shi-Ji Yang Ling Wang Zhi Chen Hua Feng Gang Zhu | 2021 | Chinese Journal of Traumatology2021，24，6： | 11 |
| 6 | Advances in BeiDou Navigation Satellite System(BDS)and satellite navigation augmentation technologies显示文摘Several noteworthy breakthroughs have been made with the BeiDou Navigation Satellite System(BDS)and other global navigation satellite systems as well as the associated augmentation systems,such as the commissioning of the BDS-3 preliminary system and the successful launch of the first BDS-3 GEO satellite which carries the satellite-based augmentation payload.Presently,BDS can provide basic services globally,and its augmentation system is also being tested.This paper gives an overview of BDS and satellite navigation augmentation technologies.This overview is divided into four parts,which include the system segment technologies,satellite segment technologies,propagation segment technologies,and user segment technologies.In each part,these technologies are described from the perspectives of preliminary information,research progress,and summary.Moreover,the significance and progress of the BeiDou Satellite-based Augmentation System(BDSBAS),low earth orbit augmentation,and the national BeiDou ground-based augmentation system are presented,along with the airborne-based augmentation system.Furthermore,the conclusions and discussions covering popular topics for research,frontiers in research and development,achievements,and suggestions are listed for future research. | Rui Li Shuaiyong Zheng Ershen Wang Jinping Chen Shaojun Feng Dun Wang Liwen Dai | 2020 | Satellite Navigation2020，1，1： | 9 |
| 7 | EMTP-type Program Realization of Krylov Subspace Based Model Reduction Methods for Large-Scale Active Distribution Network显示文摘Effective model reduction methods are required to deal with new challenges in active distribution network simulations that are on a large scale and have complicated structures.In the development of advanced electromagnetic transient simulation programs,automated model reduction plays an important role.This paper proposes an automated realization algorithm for the Krylov subspace based model reduction methods of an active distribution network with which the reduced model can be automatically established according to a given threshold of reduction error.The combined state-space nodal analysis framework is employed to apply the automated model reduction algorithm in popular EMTP-type simulation programs.Simulations are performed using PSCAD and a self-developed program to show the feasibility and validity of the proposed methods. | Chengshan Wang Hao Yu Peng Li Jianzhong Wu Chengdi Ding Guanyu Song Dun Lin Feng Xing | 2015 | CSEE Journal of Power and Energy Systems2015，1，1： | 8 |
| 8 | Morphological changes of blood spleen barrier in portal hypertensive spleen显示文摘背景:脾机能亢进和免疫者的致病与门静脉高血压(PH ) 在病人怒气工作仍然保持阴暗。这研究试图由于 PH 与脾机能亢进在怒气评估血怒气障碍的词法变化并且为怒气的有免疫力的功能的深入的调查向证据提供脾机能亢进和脾机能亢进的机制。方法:从有怒气的创伤的破裂的 12 个门 hypertensive 病人和 4 个病人的怒气样品被检验。怒气的样品被转变为病理学的节,与马森一起染色了三色的污点, Gomori 污点,和 CD68, CD34 免疫组织化学,并且是为在骨胶原纤维,网状纤维,巨噬细胞,和脉管的 endothelial 的分发的变化的检验用显微镜。在在缘带的巨噬细胞和 endothelial 的超微结构的变化被传播电子显微镜学也评估。结果:作为与正常怒气相比,在 PH 怒气的巨噬细胞的密度被减少,但是巨噬细胞主要位于缘带并且在脾小结附近散布了,与房间表面上的许多绒毛和像伪足的伸出。骨胶原纤维的增生在脾小结和中央动脉附近是明显的。增加的 reticulate 纤维环绕了有在纤维之间的更多的连接的脾小结。脉管的 endothelial 在传播分发,没有在 PH 怒气的任何 regionality,但是有扩大的腔的容器在红髓增加了。结论:血怒气障碍的词法变化能是为有免疫力的功能的反常和与 PH 位于病人的怒气的血细胞的增加的破坏的病理学的臀部之一。然而,这仍然必要澄清。 | LI Zong-fang ZHANG Shu HUANG Ying XIA Xian-ming LI Ai-min PAN Dun ZHANG Wei WANG Juan | 2008 | Chinese Medical Journal2008，，6： | 7 |
| 9 | 使用欧洲、中国、日本和澳大利亚4个台阵由反投影方法确定的2015年4月25日尼泊尔M_W7.8地震的短周期能量显示文摘应用反投影(backprojection)分析方法确定了2015年尼泊尔地震产生的短周期(0.5~5s)能量的震源位置和时间。使用欧洲、中国、日本和澳大利亚不同方位的不同台阵的数据,这些数据在破裂传播方面表现出一致的特性。发震后的25~55s,强短周期能量震源分布在震中以东10~100km内。前20s破裂速度约1.0km/s,而在其后的30~40s加速到~3.0km/s。短周期能量震源位置接近于断层下倾边缘,它补充了更靠上发生的大断裂滑动区域。尼泊尔地震可能是大断层滑动区域与短周期能量震源区域不一致的另一个实例,这可能与破坏性强地震动有关。在线材料:使用4个不同台阵对尼泊尔地震进行反投影的动画演示。 | Dun Wang Jim Mori 杨国栋 | 2016 | 国际地震动态2016，0，5： | 5 |
| 10 | Development of highly glyphosate-tolerant tobacco by coexpression of glyphosate acetyltransferase gat and EPSPS G2-aroA genes显示文摘The widely used herbicide glyphosate targets 5-enolpyruvylshikimate-3-phosphate synthase(EPSPS).Glyphosate acetyltransferase(GAT)effectively detoxifies glyphosate by N-acetylation.With the aim of identifying a new strategy for development of glyphosate-tolerant crops,the plant expression vector pG2-GAT harboring gat and G2-aroA(encoding EPSPS)has been transformed into tobacco(Nicotiana tabacum)to develop novel plants with higher tolerance to glyphosate.Results from Southern and Western blotting analyses indicated that the target genes were integrated into tobacco chromosomes and expressed effectively at the protein level.Glyphosate tolerance was compared among transgenic tobacco plants containing gat,G2-aroA,or both genes.Plants containing both gat and G2-aroA genes were the most glyphosate-tolerant.This study has shown that a combination of different strategies may result in higher tolerance in transgenic crops,providing a new approach for development of glyphosate-tolerant crops. | Baoqing Dun Xujing Wang Wei Lu Ming Chen Wei Zhang Shuzhen Ping Zhixing Wang Baoming Zhang Min Lin | 2014 | The Crop Journal2014，2，Z1： | 4 |
| 11 | Mitochondrial DNA T7719G in tRNA-Lys gene affects litter size in Small-tailed Han sheep显示文摘Background: In farm animals, mitochondrial DNA(mtDNA) effect on economic performance remains hot-topic for breeding and genetic selection. Here, 53 maternal lineages of Small-tailed Han sheep were used to investigate the association of mitochondrial DNA variations and the lambing litter size.Results: Sequence sweeping of the mitochondrial coding regions discovered 31 non-synonymous mutations, and the association study revealed that T7719G in mt DNA t RNA-Lys gene was associated with litter size(P < 0.05),manifesting 0.29 lambs per litter between the G and T carriers. Furthermore, using the mixed linear model, we assayed the potential association of the ovine litter size and haplogroups and multiple-level mtDNA haplotypes,including general haplotypes, assembled haplotypes of electron transport chain contained sequences(H-ETC),mitochondrial respiratory complex contained sequences(H-MRC) and mitochondrial genes(H-gene, including polypeptide-coding genes, rRNA genes and tRNA genes). The strategy for assembled mitochondrial haplotypes was proposed for the first time in mtDNA association analyses on economic traits, although none of the significant relations could be concluded(P > 0.05). In addition, the nuclear major gene BMPR1B was significantly correlated with litter size in the flock(P < 0.05), however, did not interact with mtDNA T7719G mutation(P > 0.05).Conclusions: Our results highlight mutations of ovine mitochondrial coding genes, suggesting T7719G in tRNA-Lys gene be a potentially useful marker for selection of sheep litter size. | Xiaoyong Chen Dan Wang Hai Xiang Weitao Dun Dave O.H.Brahi Tao Yin Xingbo Zhao | 2017 | Journal of Animal Science and Biotechnology2017，8，3： | 4 |
| 12 | Ratiometric delivery of doxorubicin and berberine by liposome enables superior therapeutic index than Doxil?显示文摘Although the appearance of Doxil alleviated the cardiotoxicity of DOX, the progression-free survival of patients was not prolonged compared with traditional medication regimens, and side effects such as hand-foot syndrome has occurred. In order to solve this dilemma, we have designed a novel co-delivery strategy to construct a co-loaded liposome of berberine(BER) and doxorubicin(DOX), which was called Lipo Be Do. The optimal synergistic ratio of the two drugs was screened by cell cytotoxicity experiments in vitro, and the optimal attenuation ratio was further determined by in vivo cardiac H&E staining pathological sections. The optimal combination treatment caused a robust increase in apoptotic cells of 4T1, as compared to drug alone treatment. The prepared co-loaded liposome, Lipo Be Do, had high encapsulation efficiency and good stability. The nanoliposome carrier controlled the biological fate of the drugs and maintained a pre-defined optimal ratio in vivo. The Lipo Be Do significantly inhibited tumor growth in 4T1 murine mammary carcinoma model compared with Doxil(P < 0.05), and completely overcame the myocardial rupture toxicity caused by Doxil in mice. Our co-loaded liposome delivery platform technology provided a new direction for the clinical treatment of triple-negative breast cancer and the safe application of DOX. | Ruoshi Zhang Yingxi Zhang Yue Zhang Xin Wang Xuanming Gao Yuyan Liu Xuanbo Zhang Zhonggui He Dun Wang Yongjun Wang | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，3： | 4 |
| 13 | EFFECT OF CATALYST PRETREATMENT ON THE OXIDATION OF CARBON MONOXIDE OVER Au/NiO CATALYST显示文摘EFFECTOFCATALYSTPRETREATMENTONTHEOXIDATIONOFCARBONMONOXIDEOVERAu/NiOCATALYSTEFFECTOFCATALYSTPRETREATMENTONTHEOXIDATIONOFCARBO... | Zheng Ping HAO Li Dun AN Jun Ling Zhou Hong Li WANG(Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000) | 1995 | Chinese Chemical Letters1995，6，4： | 3 |
| 14 | Campus Vibration in Nanwangshan Campus,China University of Geosciences at Wuhan Monitored by Short-Period Seismometers显示文摘Continuous seismic observations can record seismic waveforms, and ambient noise, for the purposes of earthquake researches and other applications. Here we deploy three digital seismometers(EPS-2) in and around the Nanwangshan Campus of the China University of Geosciences(Wuhan). This network was running from April 9 to May 9 of 2018. During this period, the seismometers recorded the May 4, 2018 M6.9 Hawaii earthquake. From the recorded waveforms, we could observe clearly the P and S arrivals, and the corresponding particle motions. Analysis of continuous observations of ambient noise shows obvious fluctuation of vibration intensity inside of the campus. The campus is quietest from 0 to 5 am. From 5 am on, the vibration intensity increases, and reaches the peak of entire day at 12 am. The amplitude then decreases to a very low level at 19:30 to 20:00 pm, and reaches another strong noisy time at 21:00 to 21:30 pm. After 21:30 pm, the intensity goes down slowly. We also observed seismic signals that were generated by the interaction of speed-control hump cars and ground. By taking the envelope and smooth operations, we observe different characteristics for different car speeds, which suggests that seismic monitoring approaches can be used for speed measurement of cars. This kind of small seismic network running in a real time fashion, would greatly help understanding of the sources of ambient noise at high frequency bands in interested areas. Analysis of a long-term observed dataset, and real time illustration will help to strengthen campus security and high-precision laboratory deployments, and also contribute to research atmosphere in earthquake science. | Lihui Wu Dun Wang Ziguang Lei Jing Fu Shuai Min Xianbing Xu Sarina Bao | 2020 | Journal of Earth Science2020，31，5： | 3 |
| 15 | PHYTOCHROME-INTERACTING FACTORS Interact with the ABA Receptors PYL8 and PYL9 to Orchestrate ABA Signaling in Darkness显示文摘PHYTOCHROME-INTERACTING FACTORS(PIFs)are a group of basic helix-loop-helix transcription factors that can physically interact with photoreceptors,including phytochromes and cryptochromes.It was previously demonstrated that PIFs accumulated in darkness and repressed seedling photomorphogenesis,and that PIFs linked different photosensory and hormonal pathways to control plant growth and development.In this study,we show that PIFs positively regulate the ABA signaling pathway during the seedling stage specifically in darkness.We found that PIFs positively regulate ABI5 transcript and protein levels in darkness in response to exogenous ABA treatment by binding directly to the G-box motifs in the ABI5 promoter.Consistently,PIFs and the G-box motifs in the ABI5 promoter determine ABI5 expression in darkness,and overexpression of ABI5 could rescue the ABA-insensitive phenotypes of pifq mutants in the dark.Moreover,we discovered that PIFs can physically interact with the ABA receptors PYL8 and PYL9,and that this interaction is not regulated by ABA.Further analyses showed that PYL8 and PYL9 promote PIF4 protein accumulation in the dark and enhance PIF4 binding to the ABI5 promoter,but negatively regulate PIF4-mediated ABI5 activation.Taken together,our data demonstrate that PIFs interact with ABA receptors to orchestrate ABA signaling in darkness by controlling ABI5 expression,providing new insights into the pivotal roles of PIFs as signal integrators in regulating plant growth and development. | Lijuan Qi Shan Liu Cong Li Jingying Fu Yanjun Jing Jinkui Cheng Hong Li Dun Zhang Xiaoji Wang Xiaojing Dong Run Han Bosheng Li Yu Zhang Zhen Li William Terzaghi Chun-Peng Song Rongcheng Lin Zhizhong Gong Jigang Li | 2020 | Molecular Plant2020，13，3： | 3 |
| 16 | Correction to: Advances in BeiDou Navigation Satellite System (BDS) and satellite navigation augmentation technologies显示文摘Correction to:Satell Navig(2020)1:12 http://gffzzd3cc09b8251d45dfsccqu06fnwnb56uvf.ffgz.tsg.suse.edu.cn/10.1186/s43020-020-00010-2 In the original publication of this article(Li et al.2020),there are several corrections as below:1.In the first paragraph of this article,the sentence“In recent years,China has been actively promoting the con-struction and development of the BeiDou Navigation Sat-ellite System(BDS),and by the end of the year 2000 the construction of BDS-1 was complete and BDS-1 began to provide GPS services for China.”should be changed into“In recent years,China has been actively promoting the construction and development of the BeiDou Navigation Satellite System(BDS),and by the end of the year 2000 the construction of BDS-1 was completed and BDS-1 began to provide services for China.”The word“GPS”should be removed. | Rui Li Shuaiyong Zheng Ershen Wang Jinping Chen Shaojun Feng Dun Wang Liwen Dai | 2020 | Satellite Navigation2020，1，1： | 3 |
| 17 | Early Report of the Source Characteristics,Ground Motions,and Casualty Estimates of the 2023 Mw 7.8 and 7.5 Turkey Earthquakes显示文摘INTRODUCTION,At 01:17 UTC(04:17 on local time)on Feb.6,2023,a devastating earthquake with a moment magnitude(Mw)7.8 occurred in the Gaziantep,southern Turkey.The earthquake was located at 37.174°N and 37.032°E,with a hypocentral depth of 17.9 km as reported by the United States Geological Survey(USGS). | Wenkai Chen Gang Rao Dengjie Kang Zhifan Wan Dun Wang | 2023 | Journal of Earth Science2023，34，2： | 3 |
| 18 | Synthesis of tetrazole containing 1,2,3-thiadiazole derivatives via U-4CR and their anti-TMV activity显示文摘A series of novel tetrazole containing 1,2,3-thiadiazole derivatives were designed and synthesized via Ugi reaction. Their structures were confrmed by melting points, IR,1H NMR, and HRMS(ESI).Preliminary bioassay indicated that most target compounds exhibited very good direct anti-TMV activity at 100 μg/mL, which was equal to or higher than that of ribavirin. Among them, compounds 4b, 4c and 4i also showed equivalent protection effect to ribavirin in vivo at 100μg/mL. | Shou-Xin Wanga Zhen Fang Zhi-Jin Fan Dun Wang Yue-Dong Li Xiao-Tian Ji Xue-Wen Hua Yun Huang Tatiana A.Kalinina Vasiliy A.Bakulev Yury Yu.Morzherin | 2013 | Chinese Chemical Letters2013，24，10： | 3 |
| 19 | Recent advances in chemical durability and mechanical stability of superhydrophobic materials: Multi-strategy design and strengthening显示文摘Inspired by the lotus leaf effect, non-wetting artificial superhydrophobic surfaces demonstrate an enormous potential in numerous fields. However, limited by poor stability and durability, superhydrophobic surfaces are rarely available for practical applications. In this review, based on the wettability mechanisms and failure modes of superhydrophobic surfaces, it is proposed that the construction of highly stable superhydrophobic materials can be approached from four aspects, including structural design, chemical bonding, interfacial-strengthening of hydrophobic materials and substrates, and self-healing. We introduced in detail the design ideas, strengthening approaches, and characterization tools of highly stable superhydrophobic materials from the perspective of multi-strategy design and strengthening, and provided corresponding insights. Eventually, the development, current status, and prospects of highly stable and multifunctional superhydrophobic materials were also presented in detail. Recent advances and development prospects of durable superhydrophobic materials were summarized and discussed in this review,providing certain insights and design guidelines for the fabrication of stable superhydrophobic materials. | Peng Wang Changyang Li Dun Zhang | 2022 | Journal of Materials Science & Technology2022，，34： | 3 |
| 20 | Co-amorphous solid dispersion systems of lacidipine-spironolactone with improved dissolution rate and enhanced physical stability显示文摘Co-amorphous solid dispersion(C-ASD)systems have attracted great attention to improve the solubility of poorly soluble drugs,but the selection of an appropriate stabilizer to stabilize amorphous forms is still a huge challenge.Herein,C-ASD system of two clinical combined used drugs(lacidipine(LCDP)and spironolactone(SPL))as stabilizers to each other,was prepared by solvent evaporation method.The effects of variation in molar ratio of LCDP and SPL(3:1,1:1,1:3,1:6,and 1:9)on the drug release characteristics were explored.Polarized light microscopy(PLM),powder X-ray diffraction(PXRD),differential scanning calorimetry(DSC)and thermogravimetric analysis(TGA)were employed to evaluate the solid states.Prepared C-ASDs were further studied for their stability under the high humidity(RH 92.5%).Further analysis of C-ASDs via Fourier-transform infrared spectroscopy(FTIR)and Raman spectroscopy confirmed that hydrogen bond interactions between the two drugs played a significant role in maintaining the stability of the C-ASDs systems.Moreover,molecular dynamic(MD)simulations provided a clear insight into the stability mechanism at the molecular level.This study demonstrated the novel drug-drug C-ASDs systems is a promising formulation strategy for improved dissolution rate and enhanced physical stability of poorly soluble drugs. | Zhaomeng Wang Mengchi Sun Tian Liu Zisen Gao Qing Ye Xiao Tan Yanxian Hou Jin Sun Dun Wang Zhonggui He | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，1： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员