|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Live cell screening platform identifies PPAR6 as a regulator of cardiomyocyte proliferation and cardiac repair显示文摘Zebrafish 能高效地通过 cardiomyocyte 增长改革他们的心。相反,哺乳动物的 cardiomyocytes 站立即在出生以后增殖,限制出生后的哺乳动物的心的再生能力。因此,如果出生后的 cardiomyocyte 增长的内长的潜力能被提高,它能为心失败病人提供有希望的未来治疗。这里,我们开始系统地识别触发出生后的 cardiomyocyte 增长的小分子。由屏蔽为估计房间周期阶段利用一个基于 Fucci 的系统的化学复合图书馆,我们作为出生后的 cardiomyocyte 增长的 inducer 识别了 carbacyclin。在 vitro, carbacyclin 经由 peroxisome 导致了新生、成年的 mononuclear 老鼠 cardiomyocytes 的增长激活 proliferator 的受体(PPAR )/PDK1/p308Akt/GSK3/-catenin 小径。PPAR 的抑制在 zebrafish 心新生期间减少了 cardiomyocyte 增长。尤其是,象有在在老鼠的心肌的梗塞以后的 PPAR 收缩筋的治疗一样的组成地活跃的 PPAR 的可诱导的 cardiomyocyte 特定的 overexpression 在 cardiomyocytes 导致了房间周期前进,减少了结疤,并且改进了心脏的功能。一起,我们建立了屏蔽系统和礼品的 cardiomyocyte 增长有为心脏的病理的治疗的诺言的一个新 drugable 目标由 cardiomyocyte 损失引起了。 | Ajit Magadum Yishu Ding Lan He Teayoun Kim Mohankrishna Dalvoy Vasudevarao Qinqiang Long Kevin Yang Nadeera Wickramasinghe Harsha V Renikunta Nicole Dubois Gilbert Weidinger Qinglin Yang Felix B Engel | 2017 | Cell Research2017，27，8： | 6 |
| 2 | Sedation-risk-free colonoscopy for minimizing the burden of colorectal cancer screening显示文摘Unsedated colonoscopy is available worldwide,but is not a routine option in the United States(US).We conducted a literature review supplemented by our experience and expert commentaries to provide data to support the use of unsedated colonoscopy for colorectal cancer screening.Medline data from 1966 to 2009 were searched to identify relevant articles on the subject.Data were summarized and co-authors provided critiques as well as accounts of unsedated colonoscopy for screening and surveillance.Diagnostic colonoscopy was initially dev eloped as an unsedated procedure.Procedure-re lated discomfort led to wide adoption of sedation in the US,although unsedated colonoscopy remains the usual practice elsewhere.The increased use of colonoscopy for colorectal cancer screening in healthy,asymptomatic individuals suggests a reass-essment of the burden of sedation in colonoscopy for screening is appropriate in the US for lowering costs and minimizing complications for patients.A water method developed to minimize discomfort has shown promise to enhance outcomes of unsedated colonoscopy.The use of scheduled,unsedated colono scopy in the US appears to be feasible for colorectal cancer screening.Studies to assess its applicability in diverse practice settings deserve to be conducted and supported. | Felix W Leung Abdulrahman M Aljebreen Emilio Brocchi Eugene B Chang Wei-Chih Liao Takeshi Mizukami Melvin Schapiro Konstantinos Triantafyllou | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，3： | 3 |
| 3 | Molecular phenotypes of human parvovirus B19 in patients with myocarditis显示文摘AIM:To investigate molecular phenotypes of myocardial B19V-infection to determine the role of B19V in myocarditis and dilated cardiomyopathy(DCM).METHODS:Endomyocardial biopsies(EMBs) from 498 B19V-positive patients with myocarditis and DCMwere analyzed using molecular methods and functional experiments.EMBs were obtained from the University Hospitals of Greifswald and Tuebingen and additionally from 36 German cardiology centers.Control tissues were obtained at autopsy from 34 victims of accidents,crime or suicide.Identification of mononuclear cell infiltrates in EMBs was performed using immunohistological staining.Anti-B19V-IgM and anti-B19V-IgG were analyzed by enzyme-linked immunosorbent assay(ELISA).B19V viral loads were determined using in-house quantitative real-time polymerase chain reaction(PCR).For B19V-genotyping a new B19V-genotype-specific restriction fragment length polymorphism(RFLP)-PCR was established.B19V-genotyping was verified by direct DNAsequencing and sequences were aligned using BLAST and BioEdit software.B19V P6-promoter and HHV6-U94-transactivator constructs were generated for cell culture experiments.Transfection experiments were conducted using human endothelial cells 1.Luciferase reporter assays were performed to determine B19Vreplication activity.Statistical analysis and graphical representation were calculated using SPSS and Prism5 software.RESULTS:The prevalence of B19V was significantly more likely to be associated with inflammatory cardiomyopathy(iCMP) compared to uninflamed DCM(59.6% vs 35.3%)(P < 0.0001).The detection of B19V-mRNA replication intermediates proved that replication of B19V was present.RFLP-PCR assays showed that B19V-genotype 1(57.4%) and B19V-genotype 2(36.7%) were the most prevalent viral genotypes.B19V-genotype 2 was observed more frequently in EMBs with iCMP(65.0%) compared to DCM(35%)(P = 0.049).Although there was no significant difference in gender-specific B19V-loads,women were more frequently infected with B19V-genotype 2(44.6%) than men(36.0%)(P = 0.0448).Coinfection with B19V and other cardiotropic viruses was found in 19.2% of tissuesamples and was associated with higher B19V viral load compared to B19V-monoinfected tissue(P = 0.0012).The most frequent coinfecting virus was human herpes virus 6(HHV6,16.5%).B19V-coinfection with HHV6 showed higher B19V-loads compared to B19V-monoinfected EMBs(P = 0.0033),suggesting that HHV6 had transactivated B19V.In vitro experiments confirmed a 2.4-fold increased B19V P6-promoter activity by the HHV6 U94-transactivator.CONCLUSION:The finding of significantly increased B19V loads in patients with histologically proven cardiac inflammation suggests a crucial role of B19V-genotypes and reactivation of B19V-infection by HHV6-coinfection in B19V-associated iCMP.Our findings suggest that B19V-infection of the human heart can be a causative event for the development of an endothelial cell-mediated inflammatory disease and that this is related to both viral load and genotype. | C-Thomas Bock Anja Düchting Friederike Utta Eva Brunner Bui Tien Sy Karin Klingel Florian Lang Meinrad Gawaz Stephan B Felix Reinhard Kandolf | 2014 | World Journal of Cardiology2014，6，4： | 3 |
| 4 | Hyperthermia in combined treatment of cancer显示文摘 | P Wust B Hildebrandt G Sreenivasa B Rau J Gellermann H Riess R Felix PM Schlag | 2002 | Lancet Oncology2002，，8： | 2 |
| 5 | Gastric Bypass Leads to Improvement of Diabetic Neuropathy Independent of Glucose Normalization—Results of a Prospective Cohort Study (DiaSurg 1 Study)显示文摘 | Beat P. Müller-Stich Lars Fischer Hannes G. Kenngott Matthias Gondan Jonas Senft Gabriella Clemens Felix Nickel Thomas Fleming Peter P. Nawroth Markus W. Büchler | 2013 | Annals of Surgery2013，，5： | 2 |
| 6 | Parallcl ization of the Scatter Search for the p median Problem 显示文摘 | FELIX G L BELEN M B JOSE A M P | 2003 | Parallel Computing2003，29，5： | 1 |
| 7 | Enforceable security policies revisited 显示文摘 | David B Vincent J Felix K | 2013 | ACM Transactions on Information and System Se- curity2013，16，1： | 1 |
| 8 | Peripheral osteoma of the mandibular condyle显示文摘 | J C M A Mancini M Woltmann V B Felix | 2005 | Journal of the Chinese Medical Association2005，34，1： | 1 |
| 9 | Network reconfiguration in distribution systems for loss reduction and load balancing显示文摘 | Mesut E B Wu Felix F | 1989 | IEEE Trans on Power Delivery1989，4，2： | 1 |
| 10 | Real-time image guidance in laparoscopic liver surgery: first clinical experience with a guidance system based on intraoperative CT imaging显示文摘 | Hannes G. Kenngott Martin Wagner Matthias Gondan Felix Nickel Marco Nolden Andreas Fetzer Jürgen Weitz Lars Fischer Stefanie Speidel Hans-Peter Meinzer Dittmar B?ckler Markus W. Büchler Beat P. Müller-Stich | 2014 | Surgical Endoscopy2014，，3： | 1 |
| 11 | The effect of distance from light source on light intensity from curing lights 显示文摘 | Felix C A Price R B | 2003 | J Adhes Dent2003，5，4： | 1 |
| 12 | Comparison of accelerated solvent extraction with conventional solvent extraction for organophosphorus pesticides and herbicides显示文摘 | Ezzell J L Richter B E Felix W D | 1995 | LC/GC1995，13，5： | 1 |
| 13 | Physical and biological properties of barium cross-linked alginate membranes 显示文摘 | HEIKO Z FELIX W CLAUDIA B | 2006 | Biomaterials2006，28，7： | 1 |
| 14 | Causes of recurrence after lapar-oscopic hernioplasty显示文摘 | Felix E Scott S Crafton B | 1998 | Surg Endosc1998，12，3： | 1 |
| 15 | Utilization of Nigerian Natural Gas Resources: Potentials and Opportunities显示文摘 | Anthony O Adegbulugbe | 1988 | Energy Policy1988，16，2： | 1 |
| 16 | Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats显示文摘 | Simonides Warner S Mulcahey Michelle A Redout Everaldo M Muller Alice Zuidwijk Marian J Visser Theo J Wassen Frank W J S Crescenzi Alessandra da-Silva Wagner S Harney John Engel Felix B Obregon Maria-Jesús Larsen P Reed Bianco Antonio C Huan | 2008 | Journal of Clinical Investigation2008，，3： | 1 |
| 17 | Prognostic role of the initial portal pressure gradient reduction after TIPS in patients with cirrhosis显示文摘 | Erwin B Felix R Jorg H | 2007 | European Journal Gastroenterol & Hepatol2007，19，10： | 1 |
| 18 | New perspectives on endothelin-1 in atherosclerosis and diabetes mellitus 显示文摘 | JOHN P ALEXEY S FELIX B | 2012 | Life Sci2012，91，1314： | 1 |
| 19 | Optimal capacitor placement on radial distribution systems 显示文摘 | Felix F W | 1989 | IEEE Trans on Power Delivery1989，4，1： | 1 |
| 20 | p21cip controls proliferating cell nuclear antigen level in adult cardiomyocytes显示文摘 | Felix B Engel Ludger H | 2003 | Mol Cell Biol2003，23，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员