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| 1 | Apoptosis and non-alcoholic fatty liver diseases显示文摘The number of patients with nonalcoholic fatty liver diseases(NAFLD) including nonalcoholic steatohepatitis(NASH), has been increasing. NASH causes cirrhosis and hepatocellular carcinoma(HCC) and is one of the most serious health problems in the world. The mechanism through which NASH progresses is still largely unknown. Activation of caspases, Bcl-2 family proteins, and c-Jun N-terminal kinase-induced hepatocyte apoptosis plays a role in the activation of NAFLD/NASH. Apoptotic hepatocytes stimulate immune cells and hepatic stellate cells toward the progression of fibrosis in the liver through the production of inflammasomes and cytokines. Abnormalities in glucose and lipid metabolism as well as microbiota accelerate these processes. The production of reactive oxygen species, oxidative stress, and endoplasmic reticulum stress is also involved. Cell death, including apoptosis, seems very important in the progression of NAFLD and NASH. Recently, inhibitors of apoptosis have been developed as drugs for the treatment of NASH and may prevent cirrhosis and HCC. Increased hepatocyte apoptosis may distinguish NASH from NAFLD, and the improvement of apoptosis could play a role in controlling the development of NASH. In this review, the association between apoptosis and NAFLD/NASH are discussed. This review could provide their knowledge, which plays a role in seeing the patients with NAFLD/NASH in daily clinical practice. | Tatsuo Kanda Shunichi Matsuoka Motomi Yamazaki Toshikatsu Shibata Kazushige Nirei Hiroshi Takahashi Tomohiro Kaneko Mariko Fujisawa Teruhisa Higuchi Hitomi Nakamura Naoki Matsumoto Hiroaki Yamagami Masahiro Ogawa Hiroo Imazu Kazumichi Kuroda Mitsuhiko Moriyama | 2018 | World Journal of Gastroenterology2018，24，25： | 32 |
| 2 | 求解最优潮流问题的内点半定规划法显示文摘基于内点半定规划(semi-definite programming,SDP),提出一种求解最优潮流(optimal power flow,OPF)的新方法——SDP-OPF法。该方法将非凸OPF问题等价转换为半定规划问题,然后应用原始–对偶内点法求解。根据OPF半定规划模型的特点,采用基于半定规划的稀疏技术,使存储效率和计算性能得以大幅度提高。以4节点的简单电力系统为例,展示模型等价转换的过程及如何获取原OPF问题的解。IEEE-300节点等6个标准系统的仿真计算表明:所提算法具有超线性收敛性,其计算结果与内点非线性规划的结果一致,且能保证解的全局最优性,可在多项式时间内完成,是一种应用前景广阔的方法。 | 白晓清 韦化 Katsuki Fujisawa | 2008 | 中国电机工程学报2008，28，19： | 25 |
| 3 | Is endoscopic papillary balloon dilatation really a risk factor for post-ERCP pancreatitis?显示文摘Endoscopic papillary balloon dilatation(EPBD) is useful for decreasing early complications of endoscopic retrograde cholangio-pancreatography(ERCP), including bleeding, biliary infection, and perforation, but it is generally avoided in Western countries because of a relatively high reported incidence of post-ERCP pancreatitis(PEP). However, as the efficacy of endoscopic papillary largeballoon dilatation(EPLBD) becomes widely recognized, EPBD is attracting attention. Here we investigate whether EPBD is truly a risk factor for PEP, and seek safer and more effective EPBD procedures by reviewing past studies. We reviewed thirteen randomised control trials comparing EPBD and endoscopic sphincterotomy(EST) and ten studies comparing direct EPLBD and EST. Three randomized controlled trials of EPBD showed significantly higher incidence of PEP than EST, but no study of EPLBD did. Careful analysis of these studies suggested that longer and higher-pressure inflation of balloons might decrease PEP incidence. The paradoxical result that EPBD with small-calibre balloons increases PEP incidence while EPLBD does not may be due to insufficient papillary dilatation in the former. Insufficient dilatation could cause the high incidence of PEP through the use of mechanical lithotripsy and stress on the papilla at the time of stone removal. Sufficient dilation of the papilla may be useful in preventing PEP. | Toshio Fujisawa Koichi Kagawa Kantaro Hisatomi Kensuke Kubota Atsushi Nakajima Nobuyuki Matsuhashi | 2016 | World Journal of Gastroenterology2016，22，26： | 23 |
| 4 | Treatment strategies for advanced hepatocellular carcinoma:Sorafenib vs hepatic arterial infusion chemotherapy显示文摘Sorafenib is used worldwide as a first-line standardsystemic agent for advanced hepatocellular carcinoma(HCC) on the basis of the results of two large-scale Phase Ⅲ trials. Conversely,hepatic arterial infusion chemotherapy(HAIC) is one of the most recommended treatments in Japan. Although there have been no randomized controlled trials comparing sorafenib with HAIC,several retrospective analyses have shown no significant differences in survival between the two therapies. Outcomes are favorable for HCC patients exhibiting macroscopic vascular invasion when treated with HAIC rather than sorafenib,whereas in HCC patients exhibiting extrahepatic spread or resistance to transcatheter arterial chemoembolization,good outcomes are achieved by treatment with sorafenib rather than HAIC. Additionally,sorafenib is generally used to treat patients with Child-Pugh A,while HAIC is indicated for those with either Child-Pugh A or B. Based on these findings,we reviewed treatment strategies for advanced HCC. We propose that sorafenib might be used as a first-line treatment for advanced HCC patients without macroscopic vascular invasion or Child-Pugh A,while HAIC is recommended for those with macroscopic vascular invasion or Child-Pugh A or B. Additional research is required to determine the best second-line treatment for HAIC non-responders with Child-Pugh B through future clinical trials. | Issei Saeki Takahiro Yamasaki Masaki Maeda Takuro Hisanaga Takuya Iwamoto Koichi Fujisawa Toshihiko Matsumoto Isao Hidaka Yoshio Marumoto Tsuyoshi Ishikawa Naoki Yamamoto Yutaka Suehiro Taro Takami Isao Sakaida | 2018 | World Journal of Hepatology2018，10，9： | 10 |
| 5 | Long-term effect of Helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic resection of early gastric cancer显示文摘 | Yuji Maehata Shotaro Nakamura Kiyoshi Fujisawa Motohiro Esaki Tomohiko Moriyama Kouichi Asano Yuta Fuyuno Kan Yamaguchi Issei Egashira Hyonji Kim Motonobu Kanda Minako Hirahashi Takayuki Matsumoto | 2012 | Gastrointestinal Endoscopy2012，，1： | 10 |
| 6 | Unsteady Behavior of Leading-edge Vortex and Diffuser Stall in a Centrifugal Compressor with Vaned Diffuser显示文摘The characteristics of a rotating stall of an impeller and diffuser and the evolution of a vortex generated at the diffuser leading-edge(i.e., the leading-edge vortex(LEV)) in a centrifugal compressor were investigated by experiments and numerical analysis. The results of the experiments revealed that both the impeller and diffuser rotating stalls occurred at 55 and 25 Hz during off-design flow operation. For both, stall cells existed only on the shroud side of the flow passages, which is very close to the source location of the LEV. According to the CFD results, the LEV is made up of multiple vortices. The LEV is a combination of a separated vortex near the leading-edge and a longitudinal vortex generated by the extended tip-leakage flow from the impeller. Therefore, the LEV is generated by the accumulation of vorticity caused by the velocity gradient of the impeller discharge flow. In partial-flow operation, the spanwise extent and the position of the LEV origin are temporarily transmuted. The LEV develops with a drop in the velocity in the diffuser passage and forms a significant blockage within the diffuser passage. Therefore, the LEV may be regarded as being one of the causes of a diffuser stall in a centrifugal compressor. | Nobumichi FUJISAWA Shotaro HARA Yutaka OHTA | 2016 | Journal of Thermal Science2016，25，1： | 8 |
| 7 | Safety and utility of capsule endoscopy for infants and young children显示文摘AIM:To assess the safety and utility of capsule endoscopy(CE)for children who are unable to swallow the capsule endoscope.METHODS:The medical records of all of the children who underwent CE between 2010 and 2012 were retrospectively reviewed.The patients were divided into 2groups:group A included patients who were unable to swallow the capsule endoscope,and group B included patients who were able to swallow it.For the patients who were unable to swallow the capsule endoscope,it was placed in the duodenum endoscopically.The small bowel transit time,endoscopic diagnosis and complications of the 2 groups were compared.RESULTS:During the study period,28 CE procedures were performed in 26 patients.Group A included 11patients with a median age of 2 years(range 10 mo-9years),and group B included 15 patients with a median age of 12 years(range 8 years-16 years).The lightest child in the study weighed 7.9 kg.The detection rates did not differ between the 2 groups.The median small bowel transit time was 401 min(range 264-734 min)in group A and 227 min(range 56-512 min)in group B(P=0.0078).No serious complications,including capsule retention,occurred.No significant mucosal trauma occurred in the pharynx,esophagus,stomach or duodenum when the capsule was introduced using an endoscope.CONCLUSION:CE is a safe and useful procedure for infants and young children who are unable to swallow the capsule endoscope. | Manari Oikawa-Kawamoto Tsuyoshi Sogo Takeshi Yamaguchi Tomoyuki Tsunoda Takeo Kondo Haruki Komatsu Ayano Inui Tomoo Fujisawa | 2013 | World Journal of Gastroenterology2013，19，45： | 7 |
| 8 | Unsteady Behavior and Control of Vortices in Centrifugal Compressor显示文摘Two examples of the use of vortex control to reduce noise and enhance the stable operating range of a centrifugal compressor are presented in this paper.In the case of high-flow operation of a centrifugal compressor with a vaned diffuser,a discrete frequency noise induced by interaction between the impeller-discharge flow and the diffuser vane,which appears most notably in the power spectra of the radiated noise,can be reduced using a tapered diffuser vane(TDV) without affecting the performance of the compressor.Twin longitudinal vortices produced by leakage flow passing through the tapered portion of the diffuser vane induce secondary flow in the direction of the blade surface and prevent flow separation from the leading edge of the diffuser.The use of a TDV can effectively reduce both the discrete frequency noise generated by the interaction between the impeller-discharge flow and the diffuser surface and the broadband turbulent noise component.In the case of low-flow operation,a leading-edge vortex(LEV) that forms on the shroud side of the suction surface near the leading edge of the diffuser increases significantly in size and blocks flow in the diffuser passage.The formation of an LEV may adversely affect the performance of the compressor and may cause the diffuser to stall.Using a one-side tapered diffuser vane to suppress the evolution of an LEV,the stable operating range of the compressor can be increased by more than 12 percent,and the pressure-rise characteristics of the compressor can be improved.The results of a supplementary examination of the structure and unsteady behavior of LEVs,conducted by means of detailed numerical simulations,are also presented. | Yutaka Ohta Nobumichi Fujisawa | 2014 | Journal of Thermal Science2014，23，5： | 5 |
| 9 | Levovist ultrasonography imaging in intracystic hemorrhage of simple liver cyst显示文摘The differential diagnosis between intracystic hemorrhage and cystadenocarcinoma of the liver is often difficult even with the use of various imaging modalities. A 73-year-old woman was admitted to our hospital with the complaint of right upper quadrant pain. Ultrasonography (US) demonstrated a heterogeneous echogenic cyst measuring 11 cm × 8 cm in size in S2 of the liver, indicated intracystic hemorrhage of simple liver cyst or cystadenocarcinoma, but the differential diagnosis was considerably difficult. Levovist (Schering, Berlin, Germany) US revealed no enhancement of the intracystic structures, suggesting a clot in the case of intracystic hemorrhage. An operation was performed and the resected lesion showed a solitary benign liver cyst, measuring 5.5 cm × 4.7 cm × 8.5 cm containing a large blood clot. The patient had an uneventful recovery after the surgery. Levovist US may play an important role in discrimination between intracystic hemorrhage of simple hepatic cysts and cystadenocarcinoma of the liver. | Tomoyuki Akiyama Masahiko Inamori Satoru Saito Hirokazu Takahashi Masato Yoneda Koji Fujita Toshio Fujisawa Yasunobu Abe Hiroyuki Kirikoshi Kensuke Kubota Michio Ueda Kuniya Tanaka Shinji Togo Norio Ueno Hiroshi Shimada Atsushi Nakajima | 2008 | World Journal of Gastroenterology2008，14，5： | 4 |
| 10 | Improvement of liver fibrosis by infusion of cultured cells derived from human bone marrow显示文摘 | Haruko Tanimoto Shuji Terai Takami Taro Yasuhiko Murata Kouichi Fujisawa Naoki Yamamoto Isao Sakaida | 2013 | Cell and Tissue Research2013，，3： | 3 |
| 11 | Erythropoietin gene transfer into rat testes by in vivo electropo-ration may reduce the risk of germ cell loss caused by cryptorchidism显示文摘瞄准:由借助于在活体内 electroporation 把老鼠 Epo 基因变成地窟兰花睾丸在精子发生上调查老鼠红细胞生成素(Epo ) 的效果。方法:有通过手术导致的单方的隐睾病的 Sprague-Dawley 老鼠被划分成三个组:第一个组被给 pCAGGS-Epo (pCAGGS-Epo 组) 的睾丸内注射,第二个组被给 pCAGGS (pCAGGS 组) 的睾丸内注射,并且第三个组是给定的睾丸内注射缓冲磷酸盐 saline (PBS 组) 。同时, 30 V 的方形的电的脉搏与 100 ms 的一个时间常数被使用六次。在注射以后的一或二个星期,每个睾丸被称,总数的比率生殖细胞数到 Sertoli 房间(G/S 比率) 的被计算评估精子发生的缺陷。从每三个组拿的十个睾丸被检验在每次指。结果:在 pCAGGS-Epo 或 pCAGGS 控制原生质标志的注射以后的阴囊的重量是(0.85+/-0.08 ) g 并且(0.83+/-0.03 ) g,分别地在星期 1 点(P = 0.788 ) 并且(0.62+/-0.06 ) g 并且(0.52+/-0.02 ) g,分别地在星期 2 点(P = 0.047 ) 。在星期 1 点, spermatids 和精子比在控制睾丸的那些更充满有 pCAGGS-Epo 的睾丸。在星期 2 点, spermatids 和精子几乎没在任何一个组被检测。G/S 比率在星期 1 点是 23.27 +/-6.80 对 18.63+/-5.30 (P = 0.0078 ) 并且在星期 2 点的 7.16+/-3.06 对 6.05+/-1.58 (P = 0.1471 ) 分别地。结论:到由在活体内 electroporation 的老鼠睾丸的 Epo 的转移可以减少隐睾病引起的细菌房间损失的风险。 | Masaki Dobashi Kazumasa Goda Hiroki Maruyama Masato Fujisawa | 2005 | Asian Journal of Andrology2005，7，4： | 3 |
| 12 | Effects of an oral iron chelator, deferasirox, on advanced hepatocellular carcinoma显示文摘AIM To evaluate the inhibitory effects of deferasirox(DFX) against hepatocellular carcinoma(HCC) through basic and clinical studies.METHODS In the basic study, the effect of DFX was investigated in three hepatoma cell lines(Hep G2, Hep3 B, and Huh7), as well as in an N-nitrosodiethylamine-induced murine HCC model. In the clinical study, six advanced HCC patients refractory to chemotherapy were enrolled. The initial dose of DFX was 10 mg/kg per day and was increased by 10 mg/kg per day every week, until the maximum dose of 30 mg/kg per day. The duration of a single course of DFX therapy was 28 consecutive days. In the event of dose-limiting toxicity(according to the Common Terminology Criteria for Adverse Events v.4.0), DFX dose was reduced.RESULTS Administration of DFX inhibited the proliferation of hepatoma cell lines and induced the activation of caspase-3 in a dose-dependent manner in vitro. In the murine model, DFX treatment significantly suppressed the development of liver tumors(P < 0.01), and significantly upregulated the mR NA expression levels of hepcidin(P < 0.05), transferrin receptor 1(P < 0.05), and hypoxia inducible factor-1α(P < 0.05) in both tumor and non-tumor tissues, compared with control mice. In the clinical study, anorexia and elevated serum creatinine were observed in four and all six patients, respectively. However, reduction in DFX dose led to decrease in serum creatinine levels in all patients. After the first course of DFX, one patient discontinued the therapy. We assessed the tumor response in the remaining five patients; one patient exhibited stable disease, while four patients exhibited progressive disease. The one-year survival rate of the six patients was 17%.CONCLUSION We demonstrated that DFX inhibited HCC in the basic study, but not in the clinical study due to dose-limiting toxicities. | Issei Saeki Naoki Yamamoto Takahiro Yamasaki Taro Takami Masaki Maeda Koichi Fujisawa Takuya Iwamoto Toshihiko Matsumoto Isao Hidaka Tsuyoshi Ishikawa Koichi Uchida Kenji Tani Isao Sakaida | 2016 | World Journal of Gastroenterology2016，22，40： | 3 |
| 13 | Malignant peritoneal mesothelioma presenting umbilical hernia and Sister Mary Joseph's nodule显示文摘Malignant peritoneal mesothelioma is a rare aggres-sive tumor of the peritoneum. An increasing number of malignant mesothelioma cases have been reported in recent years. We report here a very rare case of malignant peritoneal mesothelioma with both umbilical hernia and umbilical metastasis which is also called Sister Mary Joseph's nodule. We performed laparoscopy which showed specific laparoscopic findings, and the pathological findings of the biopsy specimen led to the diagnosis. This case was associated with umbilical her-nia which could be induced by massive ascites. A newly developed abdominal hernia should be noted as a primary symptom of malignant peritoneal mesothelioma, as shown in the present case. | Kota Tsuruya Masashi Matsushima Takayuki Nakajima Mia Fujisawa Katsuya Shirakura Muneki Igarashi Jun Koike Takayoshi Suzuki Tetsuya Mine | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，8： | 2 |
| 14 | Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways显示文摘 | Claudio Alarcón Alexia-Ileana Zaromytidou Qiaoran Xi Sheng Gao Jianzhong Yu Sho Fujisawa Afsar Barlas Alexandria N. Miller Katia Manova-Todorova Maria J. Macias Gopal Sapkota Duojia Pan Joan Massagué | 2009 | Cell2009，，4： | 2 |
| 15 | Angiosarcoma of the scalp diagnosed by the presence of neck inflammation:a case report显示文摘Angiosarcoma is an uncommon malignancy,which spread out from the endothelial cells of vessels.Scalp angiosarcoma with cervical lymph node metastasis is particularly rare.This article describes a rare case of angiosarcoma of the scalp,presenting as neck inflammation.Imaging procedures such as computed tomography(CT),magnetic resonance image(MRI) and ultrasonography(US) were not sufficient to diagnose this case.A needle biopsy provided an effective and accurate diagnosis of cervical lymph node metastasis.Additional observation and physical examination was required to diagnose the origin of the primary cancerous lesion.Once the angiosarcoma diagnosis was confirmed histologically,sequential weekly and monthly docetaxel(DTX) treatment was effective in preventing reoccurrence.Nonetheless,the optimization of angiosarcoma treatment remains a future goal.Although patients generally describe pain and swelling at the primary lesion site,this patient complained only of painful neck inflammation,without any indication of pain or swelling of the scalp.A revised diagnostic protocol should note that cervical lymph node metastasis of unknown primary origin may result from angiosarcoma of the scalp. | Rei Karube Hiroyoshi Sasaki Keiji Shinozuka Yasuhiro Fujisawa Toru Yanagawa Kenji Yamagata Kojiro Onizawa Fujio Otsuka Hiroki Bukawa | 2012 | International Journal of Oral Science2012，4，3： | 2 |
| 16 | Endoscopic resection of large colorectal polyps using a clipping method显示文摘 | Dr. Yoshiro Iida M.D. Shoji Miura M.D. Yoshinori Munemoto M.D. Yoshio Kasahara M.D. Yasuyuki Asada M.D. Daishu Toya M.D. Masakiyo Fujisawa M.D | 1994 | Diseases of the Colon & Rectum1994，，2： | 2 |
| 17 | Clinical factors associated with shock in bacteremic UTI显示文摘 | Katsumi Shigemura Kazushi Tanaka Kayo Osawa Sochi Arakawa Hideaki Miyake Masato Fujisawa | 2013 | International Urology and Nephrology2013，，3： | 2 |
| 18 | Id1 expression is associated with histological grade and invasive behavior in endometrial earcinoma显示文摘 | Takai N Miyazaki T Fujisawa K | 2001 | Cancer Lett2001，165，2： | 1 |
| 19 | Increased telomerase activity and elevated hTERTmRNA expression during multistage carcinogenesis of squamamous cell carcinoma of lung 显示文摘 | Fujisawa T Hoshino H | 2001 | Cancer2001，92，6： | 1 |
| 20 | Visualization study of the flow in and around a Savonius rotor 显示文摘 | Fujisawa N Gotoh F | 1992 | Experiments in Fluids1992，12，6： | 1 |
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