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| 1 | Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop显示文摘The inflammatory response is induced by the overexpression of inflammatory cytokines, mainly interleukin(IL)-1β, and is one of the main causes of intervertebral disc degeneration(IVDD). NLR pyrin domain containing 3(NLRP3) inflammasome activation is an important source of IL-1β. As an anti-inflammatory neuroendocrine hormone, melatonin plays various roles in different pathophysiological conditions. However, its roles in IVDD are still not well understood and require more examination. First, we demonstrated that melatonin delayed the progression of IVDD and relieved IVDD-related low back pain in a rat needle puncture IVDD model;moreover, NLRP3 inflammasome activation(NLRP3, p20, and IL-1β levels) was significantly upregulated in severely degenerated human discs and a rat IVDD model. Subsequently, an IL-1β/NF-κB-NLRP3 inflammasome activation positive feedback loop was found in nucleus pulposus(NP) cells that were treated with IL-1β. In these cells, expression of NLRP3 and p20 was significantly increased, NF-κB signaling was involved in this regulation, and mitochondrial reactive oxygen species(mt ROS)production increased. Furthermore, we found that melatonin disrupted the IL-1β/NF-κB-NLRP3 inflammasome activation positive feedback loop in vitro and in vivo. Melatonin treatment decreased NLRP3, p20, and IL-1β levels by inhibiting NF-κB signaling and downregulating mt ROS production. Finally, we showed that melatonin mediated the disruption of the positive feedback loop of IL-1β in vivo. In this study, we showed for the first time that IL-1β promotes its own expression by upregulating NLRP3 inflammasome activation. Furthermore, melatonin disrupts the IL-1β positive feedback loop and may be a potential therapeutic agent for IVDD. | Fan Chen Guowei Jiang Hui Liu Zemin Li Yuxin Pei Hua Wang Hehai Pan Haowen Cui Jun Long Jianru Wang Zhaomin Zheng | 2020 | Bone Research2020，8，2： | 18 |
| 2 | Deep seismic sounding data reveal the crustal structures beneath Zoigê basin and its surrounding folded orogenic belts显示文摘Songpan-Garze massif is located at the turning position of tectonics from the nearly west-east direction to the nearly north-south direction in the northeastern margin of Tibetan Plateau,with Zoigê basin in the centre of the massif.In this paper,we build a crustal structure model of Zoigê basin and its surrounding folded orogenic belts using the deep seismic sounding data in this region.We also discuss structures and properties of the basement in Zoigê basin,tectonic relations between Zoigê upland basin and its surrounding folded orogenic belts,crustal deformation and thickening in the northeastern margin of Tibetan Plateau,and decoupling and relaxing processes in the crust.The results indicate that a special 'Mesozoic basement' is formed of Triassic rocks with high density (2.65-2.75 g/cm3) and high velocity (5.6 km/s) in Zoigê basin.Songpan-Garze tectonic massif was transformed into two types of tectonic units with different crustal structures,i.e.,relatively stable Zoigê upland basin and active folded orogenic belts around the basin,in the course of the crustal material of Tibetan Plateau flowing eastward and obstructed by surrounding stable blocks.The thickening of the crust in the northeastern margin of Tibetan Plateau mainly occurred in the mid and lower crust,and the structure characterized by low velocities and multiple reflectors obviously appears in the folded orogenic belts around Zoigê basin.It implies that the mid and lower crust underwent a strong tectonic deformation in the folded orogenic areas.The thickness of the crust is about 50 km in Zoigê basin and the folded orogenic belts at the both southern and northern sides of Zoigê basin.The 'Mountain root' cannot be identified.It is inferred that during the later orogenic period the eastwards flowing deep materials moved clockwise along the relatively relaxing southern side around the eastern tectonic knot under the obstructing of surrounding rigid massifs,and it resulted in the strong stretching action of the folded orogenic belts around Zoigê basin. | JIA ShiXu,ZHANG XianKang,ZHAO JinRen,WANG FuYun,ZHANG ChengKe,XU ZhaoFan,PAN JiShun,LIU Zhi,PAN SuZhen & SUN GuoWei Geophysical Exploration Center,China Earthquake Administration,Zhengzhou 450002,China | 2010 | Science China Earth Sciences2010，53，2： | 11 |
| 3 | Static Corrosion Rates of Fused-cast AZS Refractory Materials by Molten Glass显示文摘In order to investigate corrosive phenomena of fused-cast Al_2O_3-ZrO_2-SiO_2(AZS) refractory materials by molten glass,two types of fused-cast AZS refractory bricks were taken as the interests of the research to study static corrosion rates(mm/d) of the two type materials by molten soda-lime-silica glass at different temperatures(1400,1450 and 1500 *C) and for different isothermal periods(0.5,1.0 and 1.5 d).It was shown that static corrosion rate of each AZS material by molten glass at the triple point developed with raising temperature but slightly decreased with enhancing isothermal period.Based on chemical compositions,microstructures,and corrosive morphologies of AZS refractory materials,the relation between them and static corrosion rates of AZS refractory materials by molten glass was analyzed. | LI Kunming SHI Xinyong XUE Fei XIE Jinli LIN Guowei PAN Chuancai LIU Yueqiang ZHANG Hang | 2016 | Journal of the Chinese Ceramic Society2016，，4： | 2 |
| 4 | Effects of Chemical Composition and Microstructure on Exudation of Fused Cast AZS Refractory Materials显示文摘The fused cast alumina-zirconia-silica(AZS)refractory is an indispensable material of the glass melting furnace,because of its outstanding corrosion resistance and low pollution to glass production.The exudation is one important index to evaluate the performance of fused cast AZS refractory products.In order to study the effects of chemical composition and microstructure on the exudation of fused cast AZS refractory materials,three types of fused-cast AZS refractory bricks(AZS33#,AZS36#and AZS41#)were selected from several companies as the research object,and their composition,bulk density,apparent porosity,the value of exudation,static corrosion rate and microstructure were discussed.The results show that the chemical composition,especially the content of SiO2 and Na2O,and the distribution of zirconia would greatly affect the content and viscosity of glass phase,thus affecting the glass exudation.This work will provide technical reference for the development of low exudation AZS refractories. | YI Shuai DENG Lina ZENG Luju XUE Fei PAN Chuancai LIN Guowei LIU Yueqiang ZHANG Hang XIE Jinli | 2019 | China's Refractories2019，28，2： | 1 |
| 5 | Fine particulate air pollution and daily mortality in Sheny ang, China 显示文摘 | Ma Yanjun Chen Renjie Pan Guowei | 2011 | Science of the Total Environment2011，409，13： | 1 |
| 6 | Decreased serum free testosterone in workers ex- posed to high levels of di-n-butyl phthalate (DBP) and di-2-eth- ylhexyl phthalate (DEHP) : a cross-sectional study in China显示文摘 | PAN GUOWEI HANAOKA TOMOYUKI YOSHIMURA MARIKO | 2006 | Environ Health Perspect2006，114，11： | 1 |
| 7 | Air pollution and children’s respiratory symptoms in six cities of Northern China显示文摘 | Guowei Pan Shujuan Zhang Yiping Feng Ken Takahashi Jun Kagawa Lianzheng Yu Ping Wang Meijuan Liu Qinan Liu Shuwen Hou Bailing Pan Jianping Li | 2010 | Respiratory Medicine2010，，12： | 1 |
| 8 | Space-time correlations of passive scalar in Kraichnan model显示文摘We consider the two-point,two-time(space-time)correlation of passive scalar R(r,τ)in the Kraichnan model under the assumption of homogeneity and isotropy.Using the fine-gird PDF method,we find that R(r,τ)satisfies a diffusion equation with constant diffusion coefficient determined by velocity variance and molecular diffusion.Itssolution can be expressed in terms of the two-point,one time correlation of passive scalar,i.e.,R(r,0).Moreover,the decorrelation o R(k,τ),which is the Fourier transform of R(r,τ),is determined byR(k,0)and a diffusion kernal. | Ping-Fan Yang Liubin Pan Guowei He | 2023 | Theoretical & Applied Mechanics Letters2023，13，5： | 0 |
| 9 | Expert consensus on blood pressure management in critically ill patients显示文摘Introduction For critically ill patients with unstable hemodynamics,goal‑directed therapy for arterial blood pressure is needed with continuous daily bedside monitoring.The prevalence of hypertension in Chinese adults is 25.2%,of which 1–2%of patients may experience a hypertensive emergency,with a mortality rate of 6.9%in the acute phase.The mortality and readmission rates within 90 days of onset are as high as 11%.[1]Furthermore,the mortality rate for patients who experience hypertensive emergencies can reach 50%within 12 months of the incident.[2]The incidence of perioperative hypertension in patients undergoing cardiac surgery is approximately 50%,with this figure dropping to 25%for non-cardiac surgery.Surgery may increase the incidence of perioperative cardio-cerebrovascular adverse events by 3–5%.[3] | Yuetian Yu Ye Gong Bo Hu Bin Ouyang Aijun Pan Jinglun Liu Fen Liu Xiu-Ling Shang Xiang-Hong Yang Guowei Tu Changsong Wang Shaolin Ma Wei Fang Ling Liu Jiao Liu Dechang Chen | 2023 | Journal of Intensive Medicine2023，3，3： | 0 |
| 10 | Enhancement of a recombinase-aided amplification assay using betaine and pullulan显示文摘Background:Nucleic acid amplification enhancers suitable for use in a recombinase-aided amplification(RAA)assay were studied for the first time,and amplification of a long-fragment(509 bp)was initially explored.Methods:Using recombinant plasmids and clinical samples,RAA fluorescence and basic methods were used to evaluate the efficacy.The fluorescence method was evaluated by threshold time and fluorescence value,and the basic method was characterized by 2%agarose gel electrophoresis.Results:Taking a previously established RAA assay for HPV18 as an example,we demonstrated that the addition of 0.2 M,0.4 M,and 0.6 M betaine and 10%pullulan could enhance the RAA.The new RAA assays with betaine and pullulan were named B-RAA and P-RAA,respectively.Using the B-RAA and P-RAA fluorescence methods,the threshold time values could be shortened by 1.72-2.32 minutes and 2.60 minutes,respectively,and the fluorescence values could be enhanced by 8847.25-9094.37 mv and 5250 mv,respectively.Using the basic method,the sensitivity could be increased 10-fold.We successfully amplified a long-fragment of 509 bp using a P-RAA assay with a sensitivity of 102 copies/μL(compared with 103 copies/μL in the RAA assay).Conclusions:Thus,we concluded that betaine and pullulan are effective additives to enhance the sensitivity of RAA assays. | Jinrong Wang Guowei Song Yue Ming Jing Pan Ruiqing Zhang Guohao Fan Xinxin Shen Xuejun Ma Lixin Li | 2022 | Infectious Medicine2022，1，2： | 0 |
| 11 | Pan-cancer immunogenic death analysis identifies key roles of CXCR3 and CCL18 in hepatocellular carcinoma显示文摘Immunogenic death is a form of programmed cell death that is common in the development and progression of cancer.However,its impact on tumor progression differs depending on the location of the tumor.Meanwhile,it also plays an important role in antitumor immunity because the process of immunogenic death can release substances that activate immunity.1 Therefore,in this study,the key mechanism of mediating immunogenic death in hepatocellular carcinoma(HCC)was found from the excavation of the immunogenic death characteristics of pan-cancer and the in-depth investigation of its effects on different tumor types(Fig.1A). | Jia Guo Xin Sun Guowei Pan Ce Li Xin He Xiaofang Che Zan Teng Xiujuan Qu Yunpeng Liu Bowen Yang | 2024 | Genes & Diseases2024，11，2： | 0 |
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