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| 1 | Seasonal variations and sources of mass and chemical composition for PM_(10) aerosol in Hangzhou,China显示文摘Aerosol observation was conducted for four seasons from September 2001 to August 2002 at five sampling sites in Hangzhou, South China, on PM10 mass, 22 elements (Na, Mg, Al, Si, P, S, K, Ca, Ti, V, Cr, Mn, Fe, Ni, Cu, Zn, As, Se, Br, Cd, Ba, and Pb), 5 major ions (F-, Cl-, NO3-, SO42-, and NH4+), and organic and elemental carbon (OC and EC), showing that PM10 mass ranged from 46.7 to 270.8 g/m3, with an annual average of 119.2 g/m3. Na, Al, Si, S, K, Ca, and Fe were the most abundant elements in PM10, most of S being in the form of SO42-. SO42-, NO3-, and NH4+ were the major ions, which contributed to about 20% of the PM10 mass. The mean seasonal concentrations for SO42-, averaged over all sites, were found to be 18.0, 18.5, 24.7, and 21.4 g/m3, for spring, summer, autumn, and winter, respectively, while the corresponding loadings for NO3- were 7.2, 4.7, 7.1, and 11.2 g/m3, and for NH4+ were 6.0, 5.9, 8.2, and 9.3 g/m3, in the form mostly of NH4NO3 in spring, autumn, and winter, and mostly of (NH4)2SO4 in summer. The low NO3-/SO42-ratio found indicates coal combustion as the major source throughout the year. The mean annual concentrations of OC and EC in PM10 were found to be 21.4, and 4.1 g/m3, respectively. Material balance calculation indicated that fugitive dust, the secondary aerosol, and carbonaceous matter were the most abundant species in PM10 for the four seasons, as is characteristic for cities in South China. | Junji Cao Zhenxing Shen Judith C. Chow Guowei Qi John G. Watson | 2009 | Particuology2009，7，3： | 58 |
| 2 | Structure and deformation around the Gyirong basin, north Himalaya, and onset of the south Tibetan detachment system显示文摘Gyirong basin and its adjacent area are located at a special position in the Himalayan orogen, where the south Tibetan detachment system (STDS) and N-S trending rift converged. The north Himalayan orogen here can be divided into five petrologic-tectonic units successively from south to north: 1) the Greater Himalayan crystalline complex (GHC); 2) the STDS shear zone; 3) the Tethyan Himalayan sedimentary sequence (THS); 4) the late Cenozoic sedimentary basins, such as Gyirong and Oma basins; and 5) the Malashan gneiss dome. Structural studies show that this area experienced four stages of deformation: 1) the earlier south-directed thrusting, preserved both in the GHC and THS; 2) top-down-to-north slip along the STDS, normal faults related to this slip formed the early controlling structures of the Cenozoic basins,and the tilted pattern of the blocks between the basins indicated a north-directed slip; 3) east-west extension, the resultant N-S trending normal fault formed the eastern boundary of the basins; and 4) late gravitational collapse. Zircon SHRIMP U-Pb dating on the syn-deformational (leuco-) granite along the STDS indicates that the major activity of the STDS occurred at ca. 26 Ma, but its onset may have begun as early as ca. 36 Ma. | YANG XiongYing ZHANG JinJiang QI GuoWei WANG DeChao GUO Lei LI PengYuan LIU Jiang | 2009 | Science China Earth Sciences2009，52，8： | 33 |
| 3 | Corrosion behavior of bulk metallic glasses in different aqueous solutions显示文摘The corrosion behavior of as-cast fully amorphous, structural relaxed amorphous and crystallized Fe65.5Cr4Mo4Ga4P12C5B5.5 bulk metallic glasses (BMGs) in NaCl, HCl and NaOH solutions was investigated by electrochemical polarization and immersion methods. X-ray photoelectron spectroscopy measurements was used to analyze the changes of the elements on the alloy surface before and after immersion in various solutions. The corrosion resistance of the Fe65.5Cr4Mo4Ga4P12C5B5.5 BMG was better than its structural relaxation/crystallization counterparts and common alloys (such as stainless steel, carbonized steel, and steel) in the selected aqueous solutions. The high corrosion resistance of this alloy in corrosive solutions leads to the formation of Fe-, Cr- and Mo-enriched protective thin surface films. | LI Gong, HUANG Lei, DONG YanGuo, HE GuoWei, QI Li, JING Qin, MA MingZhen & LIU RiPing State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，3： | 6 |
| 4 | Mesozoic thrusts and extensional structures in the Daqingshan orogen, Inner Mongolia, and their temporal and spatial relationship显示文摘三大规模戳在 Daqingshan orogen 发展了,内部蒙古,与东北东方,到 Suletu 的从 Louhuashan 的 trending 在这篇论文被描述。这些指导西北的戳,和四条构造的带(或构造的表) 由这些差错分开了,形成了一个典型推进系统。原来定义的 Hohhot 变形核心建筑群可以是一张构造的表,做推进的系统的最高的构造联合起来并且在顶上由 Daqingshan 分开差错截断了。存在 tectono 按年代先后的研究证明可能推进这个区域沿着最高的分开差错发生在象延期的一样的时间。这在 Daqingshan orogen 的收缩和延期可能是同时的礼品。Daqingshan orogen 的结构的模式能为同时的推进被相关到喜玛拉雅的 orogen,和模型,在 Himalaya 的分开可以为解释 Daqingshan orogen 的发展给一个提示。 | QI Guowei ZHANG Jinjiang WANG Xinshe GUO Lei | 2007 | Progress in Natural Science:Materials International2007，17，2： | 6 |
| 5 | SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation显示文摘Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is the ongoing global pandemic that poses substantial challenges to public health worldwide.A subset of COVID-19 patients experience systemic inflammatory response,known as cytokine storm,which may lead to death.Receptor-interacting serine/threonine-protein kinase 1(RIPK1)is an important mediator of inflammation and cell death.Here,we examined the interaction of RIPK1-mediated innate immunity with SARS-CoV-2 infection.We found evidence of RIPK1 activation in human COVID-19 lung pathological samples,and cultured human lung organoids and ACE2 transgenic mice infected by SARS-CoV-2.Inhibition of RIPK1 using multiple smallmolecule inhibitors reduced the viral load of SARS-CoV-2 in human lung organoids.Furthermore,therapeutic dosing of the RIPK1 inhibitor Nec-1s reduced mortality and lung viral load,and blocked the CNS manifestation of SARS-CoV-2 in ACE2 transgenic mice.Mechanistically,we found that the RNA-dependent RNA polymerase of SARS-CoV-2,NSP12,a highly conserved central component of coronaviral replication and transcription machinery,promoted the activation of RIPK1.Furthermore,NSP12323L variant,encoded by the SARS-CoV-2 C14408T variant first detected in Lombardy,Italy,that carries a Pro323Leu amino acid substitution in NSP12,showed increased ability to activate RIPK1.Inhibition of RIPK1 downregulated the transcriptional induction of proinflammatory cytokines and host factors including ACE2 and EGFR that promote viral entry into cells.Our results suggest that SARS-CoV-2 may have an unexpected and unusual ability to hijack the RIPK1-mediated host defense response to promote its own propagation and that inhibition of RIPK1 may provide a therapeutic option for the treatment of COVID-19. | Gang Xu Ying Li Shengyuan Zhang Haoran Peng Yunyun Wang Dekang Li Taijie Jin Zhuohao He Yilun Tong Chunting Qi Guowei Wu Kangyun Dong Jizhou Gou Yang Liu Tongyang Xiao Jing Qu Liang Li Liang Liu Ping Zhao Zheng Zhang Junying Yuan | 2021 | Cell Research2021，31，12： | 6 |
| 6 | Reduced turnover rate of topsoil organic carbon in old-growth forests:a case study in subtropical China显示文摘Background:Old-growth forests are irreplaceable with respect to climate change mitigation and have considerable carbon(C)sink potential in soils.However,the relationship between the soil organic carbon(SOC)turnover rate and forest development is poorly understood,which hinders our ability to assess the C sequestration capacity of soil in old-growth forests.Methods:In this study,we evaluated the SOC turnover rate by calculating the isotopic enrichment factor β(defined as the slope of the regression between ^(13)C natural abundance and log-transformed C concentrations)along 0-30 cm soil profiles in three successional forests in subtropical China.A lower β(steeper slope)is associated with a higher turnover rate.The three forests were a 60-year-old P.massoniana forest(PF),a 100-year-old coniferous and broadleaved mixed forest(MF),and a 400-year-old monsoon evergreen broadleaved forest(BF).We also analyzed the soil physicochemical properties in these forests to examine the dynamics of SOC turnover during forest succession and the main regulators.Results:The β value for the upper 30-cm soils in the BF was significantly(p<0.05)higher than that in the PF,in addition to the SOC stock,although there were nonsignificant differences between the BF and MF.The β value was significantly(p<0.05)positively correlated with the soil recalcitrance index,total nitrogen,and available nitrogen contents but was significantly(p<0.01)negatively correlated with soil pH.Conclusions:Our results demonstrate that SOC has lower turnover rates in old-growth forests,accompanied by higher soil chemical recalcitrance,nitrogen status,and lower soil pH.This finding helps to elucidate the mechanism underlying C sequestration in old-growth forest soils,and emphasizes the important value of old-growth forests among global C sinks. | Xin Xiong Juxiu Liu Guoyi Zhou Qi Deng Huiling Zhang Guowei Chu Ze Meng Deqiang Zhang | 2021 | Forest Ecosystems2021，8，4： | 4 |
| 7 | Ductile deformation and its geological implications for retrograded eclogites from the Hongqiyingzi Complex in Chicheng,northern Hebei,China显示文摘The rheology of rocks at depth remains a key point in earth sciences. Deformation of high-temperature–highpressure rocks from the subduction zone has not been fully studied; in particular, the deformation behavior of eclogites remains poorly understood. This research is focused on the microstructure and fabric of retrograded eclogites from the Hongqiyingzi Complex in Chicheng, north Hebei, China, based on photomicrography, scanning electron microscopy(SEM) and electron backscattered diffraction(EBSD) analysis. The analytical results show that plastic deformation occurred in the garnets during exhumation, but they do not show an obvious lattice preferred orientation(LPO). This can be interpreted as being caused by the simultaneous activation of multiple slip systems in the garnets during deformation by dislocation creep. The plagioclases have a special fabric; the(001) LPO presents a maximum in Z direction which can be correlated with a new [100](001) slip system. The misorientation angle distribution(MAD) of the plagioclases in the deformed retrograded garnet augens shows a special bimodal distribution with peaks in both a low-angle range(<40?) and a high-angle range(>140?). In the retrograded garnet augens(i.e. 'white eye socket' garnets) the maximum peak moves from a high-angle range to a low-angle range when we analyze only those plagioclases surrounding the residual garnet porphyroclast. Deformation behavior is controlled by the crystallographic orientation of the host grain and the grain boundary sliding process. Hornblendes in different layers and the retrograded garnet augens show almost the same strong LPO patterns, which are correlated with the [001](010) slip system; and MAD diagrams show a peak in a low-angle range(<40?). Integrating recent studies on metamorphism and geochronology, we argue that ductile deformation occurred during the exhumation periods together with retrograded metamorphism. | LIU ShiRan ZHANG JinJiang QI GuoWei WANG Meng | 2016 | Science China Earth Sciences2016，59，8： | 2 |
| 8 | Enhanced phosphorus biological removal from wastewater-effect of microorganism acclimatization with different ratios of short-chain fatty acids mixture显示文摘 | Yinguang Chen Yan Liu Qi Zhou Guowei Gu | 2005 | Biochemical Engineering Journal2005，27，： | 1 |
| 9 | Complete DNA sequence and gene analysis of the virulence plasmid pCP301 of Shigella flexneri 2a显示文摘 | Jiyu Zhang Hong Liu Xiaobing Zhang Jian Yang Fan Yang Guowei Yang Yan Shen Yunde Hou Qi Jin | 2003 | Science in China Series C: Life Sciences2003，，5： | 1 |
| 10 | Granitoid emplacement during syn-convergent transtension:An example from the Huamenlou pluton in North Qinling,central China显示文摘The Huamenlou pluton,is an elongated granite intrusion with high aspect ratio,emplaced within the southern margin of the North Qinling(central China).Here we investigate this pluton through multiple techniques including the fabric study,microstructural observation and zircon geochronology.Our zircon U-Pb data confirm that the granite crystallized at ca.462 Ma which is consistent with the ages of other linear plutons in North Qinling.Microstructural observations of the Huamenlou granites illustrate that the pluton has undergone superimposed deformation during its emplacement,from magmatic to hightemperature solid state conditions.The internal fabric obtained by anisotropy of magnetic susceptibility(AMS)and shape preferred orientation(SPO)show similar results.The fabrics are relatively concordant and generally vary from NE-SW to NEE-SWW which are roughly oblique to the trend of the pluton elongation and the regional structures.Meanwhile,scalar parameters reflect two completely different strain regimes for the pluton and its host rocks,i.e.,the fabrics within host rocks are mainly oblate while the central part of the intrusion displays mainly prolate fabrics.It is inferred that the structural pattern recorded in this pluton was caused by local dextral transtension in consequence of oblique convergence between the South and North China Blocks.We propose that the local transtension in convergence setting probably evolved from vertical extrusion tectonics that provided room for the magma emplacement and imparted prolate fabrics in the Huamenlou pluton. | Yang Li Wentian Liang Guowei Zhang Yazhou Ran Qi Shen Jingli Wang Chunsheng Jin | 2018 | Geoscience Frontiers2018，9，1： | 1 |
| 11 | Synthesis and Antitumor Activity of Sorafenib Analogs Containing a Tetrazole Moiety显示文摘A novel series of diaryl biuret derivatives containing a tetrazole moiety was designed and synthesized.All the target compounds were evaluated for their in vitro antitumor activity against HT-29,HepG2,MCF-7 and A549 cells by MTT assay.Most of them exhibited obvious antitumor activity,and four of them(4a,4c,4h and 7a)were superior to sorafenib in general.Among them,Compound 4h displayed more potent activity than sorafenib in all tested cancer cells.Compound 4c exhibited the most outstanding activity in inhibition of growth of HepG2 cells(IC50=0.55 μmol/L).Further,they both revealed favorable metabolic stability in in vitro assay.Compounds 4c and 4h are promising candidates for further development. | TIAN Ye YU Simiao CAI Lude GONG Guowei WU Guodong QI Hongxia ZHAO Yanfang QIN Mingze | 2019 | Chemical Research in Chinese Universities2019，35，1： | 0 |
| 12 | Methylation of PLK1 by SET7/9 ensures accurate kinetochore–microtubule dynamics显示文摘Faithful segregation of mitotic chromosomes requires bi-orientation of sister chromatids, which relies on the sensing of correct attachments between spindle microtubules and kinetochores. Although the mechanisms underlying PLK1 activation have been extensively studied, the regulatory mechanisms that couple PLK1 activity to accurate chromosome segregation are not well understood. In particular, PLK1 is implicated in stabilizing kinetochore–microtubule attachments, but how kinetochore PLK1 activity is regulated to avoid hyperstabilized kinetochore–microtubules in mitosis remains elusive. Here, we show that kinetochore PLK1 kinase activity is modulated by SET7/9 via lysine methylation during early mitosis. The SET7/9-elicited dimethylation occurs at the Lys191 of PLK1, which tunes down its activity by limiting ATP utilization. Overexpression of the non-methylatable PLK1 mutant or chemical inhibition of SET7/9 methyltransferase activity resulted in mitotic arrest due to destabilized kinetochore–microtubule attachments. These data suggest that kinetochore PLK1 is essential for stable kinetochore–microtubule attachments and methylation by SET7/9 promotes dynamic kinetochore–microtubule attachments for accurate error correction. Our findings define a novel homeostatic regulation at the kinetochore that integrates protein phosphorylation and methylation with accurate chromosome segregation for maintenance of genomic stability. | Ruoying Yu Huihui Wu Hazrat Ismail Shihao Du Jun Cao Jianyu Wang Tarsha Ward Fengrui Yang Ping Gui Mahboob Ali Lingluo Chu Fei Mo Qi Wang Youjun Chu Jianye Zang Yun Zhao Mingliang Ye Guowei Fang Peng RChen Zhen Dou Xinjiao Gao Wenwen Wang Xing Liu Xuebiao Yao | 2020 | Journal of Molecular Cell Biology2020，12，6： | 0 |
| 13 | Radically distributed value and normal families of meromorphic functions显示文摘 | Jianming QI Guowei ZHANG Weniun YUAN | 2014 | Frontiers of Mathematics in China2014，9，2： | 0 |
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