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| 1 | A new cytotoxic 2-(2-phenylethyl)chromone from Chinese eaglewood显示文摘新复合 8-chloro-5,6,7-trihydroxy-2-(3-hydroxy-4-methoxyphenethyl )-5,6,7,8-tetrahydro-4H-chromen-4-one (1 ) 从中国沉香被孤立[Aquilaria sinensis (愁相) Gilg ] 。它的结构被阐明根据光谱数据。与 14.6 渭 g /mL 的 IC50 价值由 MTT 方法在 vitro 对人的胃的癌症房间线(SGC-7901 ) 加重 1 显示出的 cytotoxicity。 | Jun Liu Jiao Wu You Xing Zhao Yuan Yuan Deng Wen Li Mei Hao Fu Dai | 2008 | Chinese Chemical Letters2008，19，8： | 25 |
| 2 | Long-term effects of alendronate on fracture healing and bone remodeling of femoral shaft in ovariectomized rats显示文摘 | Ling-jie FU Ting-ting TANG Yong-qiang HAO Ke-rong DAI | 2013 | Acta Pharmacologica Sinica2013，34，3： | 10 |
| 3 | Two new epimeric pairs of iridoid from mangrove plant Scyphiphora hydrophyllacea显示文摘iridoid scyphiphin A1 (1a ) 的二新 epimeric 对, A2 (1b ) 和 scyphiphin B1 (2a ) , B2 (2b ) 从 Scyphiphora hydrophyllacea Gaertn 被孤立。F。他们的结构被分光镜的方法阐明。scyphiphin B1 和 scyphiphin B2 的混合由 MTT 方法在 vitro 对人的 hepatoma SMMC-7721 房间线显示出中等 cytotoxicity。 | Yan Bo Zeng Wen Li Mei You Xing Zhao Ling Zhuang Kui Hong Hao Fu Dai | 2007 | Chinese Chemical Letters2007，18，12： | 8 |
| 4 | Broadband perovskite quantum dot spectrometer beyond human visual resolution显示文摘The quantum dot spectrometer,fabricated by integrating different quantum dots with an image sensor to reconstruct the target spectrum from spectral-coupled measurements,is an emerging and promising hyperspectrometry technology with high resolution and a compact size.The spectral resolution and spectral range of quantum dot spectrometers have been limited by the spectral variety of the available quantum dots and the robustness of algorithmic reconstruction.Moreover,the spectrometer integration of quantum dots also suffers from inherent photoluminescence emission and poor batch-to-batch repeatability.In this work,we developed nonemissive in situ fabricated MA_(3)Bi_(2)X_(9) and Cs_(2)SnX_(6)(MA=CH_(3)NH_(3);X=Cl,Br,I)perovskite-quantum-dot-embedded films(PQDFs)with precisely tunable transmittance spectra for quantum dot spectrometer applications.The resulting PQDFs contain in situ fabricated perovskite nanocrystals with homogenous dispersion in a polymeric matrix,giving them advantageous features such as high transmittance efficiency and good batch-to-batch repeatability.By integrating a filter array of 361 kinds of PQDFs with a silicon-based photodetector array,we successfully demonstrated the construction of a perovskite quantum dot spectrometer combined with a compressive-sensing-based total-variation optimization algorithm.A spectral resolution of ~1.6 nm was achieved in the broadband of 250-1000 nm.The performance of the perovskite quantum dot spectrometer is well beyond that of human eyes in terms of both the spectral range and spectral resolution.This advancement will not only pave the way for using quantum dot spectrometers for practical applications but also significantly impact the development of artificial intelligence products,clinical treatment equipment,scientific instruments,etc. | Xiaoxiu Zhu Liheng Bian Hao Fu Lingxue Wang Bingsuo Zou Qionghai Dai Jun Zhang Haizheng Zhong | 2020 | Light(Science & Applications)2020，9，1： | 5 |
| 5 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 6 | Two New Steroidal Glycosides from Ophiopogon japonicus显示文摘Two new C27 steroidal glycosides, named ophiopojaponin A (1) and B (2), were isolated from the tubers of famous traditional Chinese herb(Ophiopogon japonicus. The spectroscopic and chemical evidences revealed their structures to be Pennogenin 3-O-[2’-O-acetyl-(-L-rhamnopyranosyl (1?2)]-(-D-xylopyranosyl (1?3)-(-D-glucopyranoside (1) and 26-O-(-D-glucopyranosyl-(22(, 25R)-3(, 14(, 22(, 26-tetrahydroxyfurost-5-ene 3-O-(-L-rhamnopyranosyl (1?2)-(-D-glucopyranoside (2), respectively. | Hao Fu DAI Jun ZHOU Zhong Tao DING Jiang XIONG Ning Hua TAN | 2000 | Chinese Chemical Letters2000，11，10： | 4 |
| 7 | Design of a C-band polarization rotator-splitter based on a mode-evolution structure and an asymmetric directional coupler显示文摘A C-band polarization rotator-splitter based on a mode-evolution structure and an asymmetric directional coupler is proposed. The mode-evolution structure is designed in a bi-level taper through which the TM_0 mode can evolve into the TE_1 mode. Then the TE_1 mode is coupled to the TE_0 mode at the cross port using the asymmetric directional coupler. The input TE_0 mode propagates along the waveguide without mode conversion and output at the through port. From the experimental results, the extinction ratio is lower than 30 dB and the excess loss is less than 1 dB for input TE_0 mode at the whole C-band. For input TM_0 mode, the ER and the EL are, respectively,lower than-10 and 1.5 dB. | Chen Yuan Jincheng Dai Hao Jia Jianfeng Ding Lei Zhang Xin Fu Lin Yang | 2018 | Journal of Semiconductors2018，39，12： | 4 |
| 8 | eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses显示文摘It has become increasingly challenging for researchers to analyze the exponentially expanding amount of multi-omic data.Here,we describe multi-functional software named evolutionary GenotypePhenotype Systems(eGPS)that enables users to perform comprehensive multiomic and evolutionary analyses.The eGPS combines the power of cloud computing and the advantage of desktop application,has a user-friendly graphic interface and is highly interactive. | Dalang Yu Lili Dong Fangqi Yan Hailong Mu Bixia Tang Xiao Yang Tao Zeng Qing Zhou Feng Gao Zhonghuang Wang Ziqian Hao Hongen Kang Yi Zheng Hongwei Huang Yuzhang Wei Wei Pan Yaochen Xu Junwei Zhu Shilei Zhao Ciran Wang Pengyu Wang Long Dai Mushan Li Li Lan Yiwei Wang Hua Chen Yi-Xue Li Yun-Xin Fu Zhen Shao Yiming Bao Fangqing Zhao Luo-Nan Chen Guo-Qing Zhang Wenming Zhao Haipeng Li | 2019 | National Science Review2019，6，5： | 4 |
| 9 | A New Triterpene from Cephalomappa sinensis显示文摘A new triterpene 1, 1(, 2(, 3(-trihydroxylup-20 (29) -ene was isolated from Cepha-lomappa sinensis. The structure was elucidated mainly on the basis of 1D and 2D NMR spectral means. | Wen Li MEI, Yun Bao MA, Shao Hua WU, Hao Fu DAI, Da Gang WU* Laboratory of Phytochemistry, Kunming Institute of Botany, Academia Sinica, Kunming 650204 | 2001 | Chinese Chemical Letters2001，12，6： | 4 |
| 10 | Blocking the JAK2/STAT3 and ERK pathways suppresses the proliferation of gastrointestinal cancers by inducing apoptosis显示文摘Dysregulated crosstalk between different signaling pathways contributes to tumor development,including resistance to cancer therapy.In the present study,we found that the mitogen-activated extracellular signal-regulated kinase(MEK)inhibitor trametinib failed to suppress the proliferation of PANC-1 and MGC803 cells by activating the Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3)signaling pathway,while the JAK2 inhibitor fedratinib failed to inhibit the growth of the PANC-1 cells upon stimulation of extracellular signal-regulated kinase(ERK)signaling.In particular,the most prominent enhancement of the anti-proliferative effect resulted from the concurrent blockage of the JAK2/STAT3 and ERK signaling pathways.Furthermore,the combination of the two inhibitors resulted in a reduced tumor burden in mice.Our evidence suggests novel crosstalk between JAK2/STAT3 and ERK signaling in gastric cancer(GC)and pancreatic ductal adenocarcinoma(PDAC)cells and provides a therapeutic strategy to overcome potential resistance in gastrointestinal cancer. | Xi WANG Chunyan DAI Yifei YIN Lin WU Weiyang JIN Yufei FU Zhe CHEN Ke HAO Bin LU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，6： | 4 |
| 11 | A New Degraded Sesquiterpene from Marine Actinomycete Streptomyces sp. 0616208显示文摘A new degraded sesquiterpene was isolated from the marine actinomycete Streptomyces sp. 0616208. Its structure was elucidated as (1α,4aα,5α, 7β, 8aβ)-5, 8a-dimethyl-decahydronaphthalene -1, 4a, 7-triol on the basis of spectroscopic data. | Xiu Chao XIE Wen Li MEI You Xing ZHAO Kui HONG Hao Fu DAI | 2006 | Chinese Chemical Letters2006，17，11： | 3 |
| 12 | Deletion of SMARCA4 impairs alveolar epithelial type II cells proliferation and aggravates pulmonary fibrosis in mice显示文摘Alveolar epithelial cells(AECs)injury and failed reconstitution of the AECs barrier are both integral to alveolar flooding and subsequent pulmonary fibrosis(PF).Nevertheless,the exact mechanisms regulating the regeneration of AECs post-injury still remain unclear.SMARCA4 is a part of the large ATP-dependent chromatin remodelling complex SWI/SNF,which is essential for kidney and heart fibrosis.We investigates SMARCA4 function in lung fibrosis by establishing PF mice model with bleomycin firstly and found that the expression of SMARCA4 was mainly enhanced in alveolar type II(ATII)cells.Moreover,we established an alveolar epithelium-specific SMARCA4-deleted SP-C-rtTA/(tetO)7-Cre/SMARCA4f/f mice(SOSM4D/D)model,as well as a new SMARCA4-deleted alveolar type II(ATII)-like mle-12 cell line.We found that the bleomycin-induced PF was more aggressive in SOSM4D/D mice.Also,the proliferation of ATII cells was decreased with the loss of SMARCA4 in vivo and in vitro.In addition,we observed increased proliferation of ATII cells accompanied by abnormally high expression of SMARCA4 in human PF lung sections.These data uncovered the indispensable role of SMARCA4 in the proliferation of ATII cells,which might affect the progression of PF. | Danyi Peng Daozhu Si Rong Zhang Jiang Liu Hao Gou Yunqiu Xia Daiyin Tian Jihong Dai Ke Yang Enmei Liu Yujun Shi Q.Richard Lu Lin Zou Zhou Fu | 2017 | Genes & Diseases2017，4，4： | 3 |
| 13 | Hypoxia confers protection against apoptosis via the PI3K/Akt pathway in endothelial progenitor cells显示文摘瞄准:到局部缺血的 endothelial 祖先房间(EPC ) 的招募最近作为织物修理的重要机制被建议了。尽管织物局部缺血能在 hypoxic 地点便于 EPC 动员,招募,和保留, EPC 幸存上的组织缺氧的效果不是众所周知的。在现在的学习,我们检验了是否组织缺氧(2% O 2) 将压制浆液退却导致的 apoptosis 并且幸存是否发信号,例如 phosphatidylinositol 3-kinase (PI3K )/Akt 和细胞外的调整信号的蛋白质 kinase (英皇家空军之阶级最低之兵) 小径,涉及这进程。方法:在为 24 h 是浆液饥饿的以后, EPC 在 normoxic 或 hypoxic 条件下面是有教养的(为 24 h 的 2% O 2) 。房间幸存被 3-(4,5-dimethylthiazol-2-yl ) 估计 -2,5-diphenyltetrazolium 溴化物试金,在 V propidium 碘化物附加双颜色的流动 cytometry,和终端 deoxynucleotidyl 调停 transferase 的 digoxigenin-dUTP 刻痕结束标记试金。表明蛋白质的表达式被西方的污点分析计算。结果:在 hypoxic 条件下面, EPC 对浆液饥饿导致的 apoptosis 抵抗。用 LY294002 禁止者的 PI3K/Akt 小径的抑制在 EPC 阻止了禁止组织缺氧的 apoptosis 并且改变了肝糖 synthase kinase-3β 的 phosphorylation 状态,涉及 EPC apoptosis 的规定的受动器蛋白质。然而,英皇家空军之阶级最低之兵禁止者 PD98059 没在房间幸存上有重要效果。结论:我们表明的数据组织缺氧禁止了浆液在 EPC 的导致退却的 apoptosis,它可能与 PI3K/Akt 小径的激活被联系。 | Tao DAI Hao ZHENG Guo-sheng FU | 2008 | Acta Pharmacologica Sinica2008，29，12： | 3 |
| 14 | First light for the sodium laser guide star adaptive optics system on the Lijiang 1.8 m telescope显示文摘A first generation sodium Laser Guide Star Adaptive Optics System(LGS-AOS) was developed and integrated into the Lijiang 1.8 m telescope in 2013. The LGS-AOS has three sub-systems:(1) a 20 W long pulsed sodium laser,(2) a 300-millimeter-diameter laser launch telescope, and(3) a 37-element compact adaptive optics system. On 2014 January 25, we obtained high resolution images of an mV8.18 star,HIP 43963, during the first light of the LGS-AOS. In this paper, the sodium laser, the laser launch telescope,the compact adaptive optics system and the first light results will be presented. | Kai Wei Min Li Shan-Qiu Chen Yong Bo Feng Chen Jun-Wei Zuo Qi Bian Ji Yao Lu-Chun Zhou Lin Wei Dong-Hong Chen Yang Gao KaiJin Xiao-Lin Dai Han-Chu Fu Chang Xu Zhi-Chao Wang Xiang-Hui Xue Xue-Wu Chen Xian-Mei Qian Yu Zhou Hao Xian Qin-Jun Peng Chang-Hui Rao Zu-Yan Xu Yu-Dong Zhang | 2016 | Research in Astronomy and Astrophysics2016，16，12： | 2 |
| 15 | SDF-1α/CXCR4 decreases endothelial progenitor cells apoptosis under serum deprivation by PI3K/Akt/eNOS pathway显示文摘 | Hao Zheng Tao Dai Binquan Zhou Junhui Zhu He Huang Min Wang Guosheng Fu | 2008 | Atherosclerosis2008，，1： | 1 |
| 16 | Recent advances in interfacial modification of zinc anode for aqueous rechargeable zinc ion batteries显示文摘To tackle energy crisis and achieve sustainable development, aqueous rechargeable zinc ion batteries have gained widespread attention in large-scale energy storage for their low cost, high safety, high theoretical capacity, and environmental compatibility in recent years. However, zinc anode in aqueous zinc ion batteries is still facing several challenges such as dendrite growth and side reactions(e.g., hydrogen evolution), which cause poor reversibility and the failure of batteries. To address these issues, interfacial modification of Zn anodes has received great attention by tuning the interaction between the anode and the electrolyte. Herein, we present recent advances in the interfacial modification of zinc anode in this review. Besides, the challenges of reported approaches of interfacial modification are also discussed.Finally, we provide an outlook for the exploration of novel zinc anode for aqueous zinc ion batteries.We hope that this review will be helpful in designing and fabricating dendrite-free and hydrogenevolution-free Zn anodes and promoting the practical application of aqueous rechargeable zinc ion batteries. | Qing Wen Hao Fu Ru-de Cui He-Zhang Chen Rui-Han Ji Lin-Bo Tang Cheng Yan Jing Mao Ke-Hua Dai Xia-Hui Zhang Jun-Chao Zheng | 2023 | Journal of Energy Chemistry2023，，8： | 1 |
| 17 | A new cytotoxic cardenolide from the latex of Antiaris toxicaria显示文摘新 cardenolide, toxicarioside E (1 ) ,从 Antiaris 的乳胶被孤立有毒的唱腔(Pers.) Lesch (Moraceae ) 。它的结构被阐明根据光谱数据和化学证据。对 K562 和 SGC-7901 房间的化合物 1 显示出的重要 cytotoxicity 与 0.026 和 0.027 μ 的 IC 50 价值由 MTT 方法在 vitro 排队; g/mL 分别地。 | Yu Juan Gan Wen Li Mei You Xing Zhao Hao Fu Dai | 2009 | Chinese Chemical Letters2009，20，4： | 1 |
| 18 | In-situ chemical conversion film for stabilizing zinc metal anodes显示文摘Zinc metal anodes face several challenges,including the uncontrolled formation of dendrites,hydrogen evolution,and corrosion,which seriously hinder their application in practice.To address the above problems such as dendrite formation and corrosion,we present a simple and applicable immersion method that enables in situ formation of a zinc phytate(PAZ)coating on the surface of commercial Zn flakes via a substitution reaction.This protective coating mitigates corrosion of zinc flakes by the electrolyte,reduces the interfacial impedance,and accelerates the migration kinetics of zinc ions.Besides,this method can preferentially expose the(002)crystal plane with strong atomic bonding,which not only improves the corrosion resistance of the zinc flake,but can also guide the parallel deposition of zinc ions along the(002)crystal plane and reduce the formation of dendrites.Benefiting from the above advantages,the PAZ@Zn‖Cu half-cell has shown over 900 cycles with average coulombic efficiency(CE)of99.81%at 4 mA cm^(-2).Besides,the PAZ@Zn‖PAZ@Zn symmetric cell operate stably for>1000 h at5 mA cm^(-2)and>340 h at 10 mA cm^(-2).Furthermore,we demonstrated that this in situ chemical treatment enables the formation of a robust,well-bound protective coating.This method provides insights for advancing the commercialization of zinc anodes and other metal anodes. | Hao Fu Qing Wen Pei-Yao Li Zhen-yu Wang Zhen-jiang He Cheng Yan Jing Mao Kehua Dai Xia-hui Zhang Jun-chao Zheng | 2022 | Journal of Energy Chemistry2022，31，10： | 1 |
| 19 | Electron-ion collider in China显示文摘Lepton scattering is an established ideal tool for studying inner structure of small particles such as nucleons as well as nuclei.As a future high energy nuclear physics project,an Electron-ion collider in China(EicC)has been proposed.It will be constructed based on an upgraded heavy-ion accelerator,High Intensity heavy-ion Accelerator Facility(HIAF)which is currently under construction,together with a new electron ring.The proposed collider will provide highly polarized electrons(with a po-larization of 80%)and protons(with a polarization of 70%)with variable center of mass energies from 15 to 20 GeV and the luminosity of(2–3)×1033 cm^(−2)·s^(−1).Polarized deuterons and Helium-3,as well as unpolarized ion beams from Carbon to Uranium,will be also available at the EicC.The main foci of the EicC will be precision measurements of the structure of the nucleon in the sea quark region,including 3D tomography of nucleon;the partonic structure of nuclei and the parton interaction with the nuclear environment;the exotic states,especially those with heavy flavor quark contents.In addition,issues fundamental to understanding the origin of mass could be addressed by measurements of heavy quarkonia near-threshold production at the EicC.In order to achieve the above-mentioned physics goals,a hermetical detector system will be constructed with cutting-edge technologies.This document is the result of collective contributions and valuable inputs from experts across the globe.The EicC physics program complements the ongoing scientific programs at the Jefferson Laboratory and the future EIC project in the United States.The success of this project will also advance both nuclear and particle physics as well as accelerator and detector technology in China. | Daniele PAnderle Valerio Bertone Xu Cao Lei Chang Ningbo Chang Gu Chen Xurong Chen Zhuojun Chen Zhufang Cui Lingyun Dai Weitian Deng Minghui Ding Xu Feng Chang Gong Longcheng Gui Feng-Kun Guo Chengdong Han Jun He Tie-Jiun Hou Hongxia Huang Yin Huang KrešImir KumeričKi LPKaptari Demin Li Hengne Li Minxiang Li Xueqian Li Yutie Liang Zuotang Liang Chen Liu Chuan Liu Guoming Liu Jie Liu Liuming Liu Xiang Liu Tianbo Liu Xiaofeng Luo Zhun Lyu Boqiang Ma Fu Ma Jianping Ma Yugang Ma Lijun Mao Cédric Mezrag HervéMoutarde Jialun Ping Sixue Qin Hang Ren Craig DRoberts Juan Rojo Guodong Shen Chao Shi Qintao Song Hao Sun PawełSznajder Enke Wang Fan Wang Qian Wang Rong Wang Ruiru Wang Taofeng Wang Wei Wang Xiaoyu Wang Xiaoyun Wang Jiajun Wu Xinggang Wu Lei Xia Bowen Xiao Guoqing Xiao Ju-Jun Xie Yaping Xie Hongxi Xing Hushan Xu Nu Xu Shusheng Xu Mengshi Yan Wenbiao Yan Wencheng Yan Xinhu Yan Jiancheng Yang Yi-Bo Yang Zhi Yang Deliang Yao Zhihong Ye Peilin Yin C-PYuan Wenlong Zhan Jianhui Zhang Jinlong Zhang Pengming Zhang Yifei Zhang Chao-Hsi Chang Zhenyu Zhang Hongwei Zhao Kuang-Ta Chao Qiang Zhao Yuxiang Zhao Zhengguo Zhao Liang Zheng Jian Zhou Xiang Zhou Xiaorong Zhou Bingsong Zou Liping Zou | 2021 | Frontiers of physics2021，16，6： | 1 |
| 20 | Mediating role of resilience in the relationship between COVID-19 related stigma and mental health among COVID-19 survivors:a cross-sectional study显示文摘Background The global coronavirus disease 2019(COVID-19)has caused many negative effects on physical and mental health of patients who have survived COVID-19.Apart from some long-lasting physical sequelae,those COVID-19 survivors are also suffering stigma and discrimination at different levels around the world.The current study aims to assess the role resilience played in stigma and mental disorders among COVID-19 survivors.Methods The cross-sectional study was carried out among former COVID-19 patients in Jianghan District(Wuhan,China)from June 10 to July 25,2021.The demographic questions,the Impact of Events Scale-Revised,the Generalized Anxiety Disorder Questionnaire,the Patient Health Questionnaire,the Resilience Style Questionnaire and the Short Version of COVID-19 Stigma Scale of 12 items were used to collect relevant information of the participants.Descriptive analyses,Pearson correlation analysis and Structural Equation Modeling were used to make data description and analysis.Results A total of 1541 out of 1601 COVID-19 survivors(887 females and 654 males)were included in the analysis.Perceived stigma of those COVID-19 survivors correlates significantly with anxiety(r=0.335,P<0.001),depression(r=0.325,P<0.001)and post-traumatic stress disorder(PTSD)(r=0.384,P<0.001).It has a direct effect on COVID-19 survivors’anxiety(β=0.326,P<0.001),depression(β=0.314,P<0.001),PTSD(β=0.385,P<0.001)and their resilience(β=−0.114,P<0.01).Resilience partially mediated the association between perceived stigma and anxiety(β=0.020,P<0.01),depression(β=0.020,P<0.01),and PTSD(β=0.014,P<0.01)among COVID-19 survivors.Conclusion Stigma has a significant negative impact on mental health,while resilience plays a mediator role in the relationship between stigma and mental health among COVID-19 survivors.Based on our study,we suggested that when designing psychological interventions for COVID-19 survivors,consideration should be taken into account to reduce stigma and improve resilience. | Weijun Xiao Xiaoyang Liu Hao Wang Yiman Huang Zhenwei Dai Mingyu Si Jiaqi Fu Xu Chen Mengmeng Jia Zhiwei Leng Dan Cui Winnie W.S.Mak Liming Dong Xiaoyou Su | 2023 | Infectious Diseases of Poverty2023，12，2： | 0 |
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