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| 1 | Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development显示文摘cytosine 的 Methylation 是与基因压抑联系的 DNA 修正。最近,新奇 cytosine 修正, 5-hydroxymethylcytosine (5-hmC ) 被发现了。这里,我们在哺乳动物的开发期间并且在细胞的系统检验 5-hmC 分发,并且证明 5-hmC 的发展动力学与 5-methylcytosine (5-mC ) 的那些不同;特别地 5-hmC 与成年纸巾相比在胚胎的上下文被充实。一个可检测的 5-hmC 信号在在父亲的染色体受到 5-mC 的染色体宽的 hydroxylation 的地方,在接合子阶段开始的培植前开发出现,它精确在父亲的前核与 5-mC 信号的损失与一致。5-hmC 的层次与在老鼠的表示 nestin 房间人口在在胚囊,和修正 colocalises 的内部房间团的房间高培植以后的胚胎。比作另外的成年哺乳动物的机关, 5-hmC 强烈在骨头髓和大脑被充实, 5-hmC 内容在那里高是 neuronal 祖先和 mitotic 以后神经原的一个特征。我们证明 5-hmC 的那高水平是在老鼠和人的胚胎的干细胞(转换字符) 的不仅现在并且,在区别期间输以前被报导了,而且在导致的 pluripotent 干细胞的产生期间重现;因此, 5-hmC 丰富与一个 pluripotent 房间状态相关。我们的调查结果建议除了 neuronal 系的房间, genomic 5-hmC 的高水平是胚胎的房间人口和细胞的 pluri 系和多系力量的一个 epigenetic 特征。到我们的知识, 5-hmC 那么代表其丰富是的发现的 DNA 的第一 epigenetic 修正房间类型特定。 | Alexey Ruzov Yanina Tsenkina Andrea Serio Tatiana Dudnakova Judy Fletcher Yu Bai Tatiana Chebotareva Steve Pells Zara Hannoun Gareth Sullivan Siddharthan Chandran David C Hay Mark Bradley Ian Wilmut Paul De Sousa | 2011 | Cell Research2011，21，9： | 4 |
| 2 | Hepatitis C Virus Infects the Endothelial Cells of the Blood-Brain Barrier显示文摘 | Nicola F. Fletcher Garrick K. Wilson Jacinta Murray Ke Hu Andrew Lewis Gary M. Reynolds Zania Stamataki Luke W. Meredith Ian A. Rowe Guangxiang Luo Miguel A. Lopez–Ramirez Thomas F. Baumert Babette Weksler Pierre–Olivier Couraud Kwang Sik Kim Ignacio A. R | 2012 | Gastroenterology2012，，3： | 2 |
| 3 | Sensitivity of transvaginal ultrasound screening for endometrial cancer in postmenopausal women: a case-control study within the UKCTOCS cohort显示文摘 | Ian Jacobs Aleksandra Gentry-Maharaj Matthew Burnell Ranjit Manchanda Naveena Singh Aarti Sharma Andy Ryan Mourad W Seif Nazar N Amso Gillian Turner Carol Brunell Gwendolen Fletcher Rani Rangar Kathy Ford Keith Godfrey Alberto Lopes David Oram Jonathan He | 2011 | Lancet Oncology2011，，1： | 2 |
| 4 | Origin of carbonatites in the South Qinling orogen: Implications for crustal recycling and timing of collision between the South and North China Blocks显示文摘 | Cheng Xu Anton R. Chakhmouradian Rex N. Taylor Jindrich Kynicky Wenbo Li Wenlei Song Ian R. Fletcher | 2014 | Geochimica et Cosmochimica Acta2014，，： | 1 |
| 5 | Modified Thiele massage as therapeutic intervention for female patients with interstitial cystitis and high-tone pelvic floor dysfunction显示文摘 | Ian A. Oyama Amy Rejba James C. Lukban Erica Fletcher Susan Kellogg-Spadt Adam S. Holzberg Kristene E. Whitmore | 2004 | Urology2004，，5： | 1 |
| 6 | Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial显示文摘 | George D Demetri Allan T van Oosterom Christopher R Garrett Martin E Blackstein Manisha H Shah Jaap Verweij Grant McArthur Ian R Judson Michael C Heinrich Jeffrey A Morgan Jayesh Desai Christopher D Fletcher Suzanne George Carlo L Bello Xin Huang Charles | 2006 | The Lancet2006，，9544： | 1 |
| 7 | Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial显示文摘 | George D Demetri Allan T van Oosterom Christopher R Garrett Martin E Blackstein Manisha H Shah Jaap Verweij Grant McArthur Ian R Judson Michael C Heinrich Jeffrey A Morgan Jayesh Desai Christopher D Fletcher Suzanne George Carlo L Bello Xin Huang Charles | 2006 | The Lancet . 2006 (9544)2006，，9544： | 1 |
| 8 | Hepatitis C Virus Infects the Endothelial Cells of the Blood-Brain Barrier显示文摘 | Nicola F. Fletcher Garrick K. Wilson Jacinta Murray Ke Hu Andrew Lewis Gary M. Reynolds Zania Stamataki Luke W. Meredith Ian A. Rowe Guangxiang Luo Miguel A. Lopez–Ramirez Thomas F. Baumert Babette Weksler Pierre–Olivier Couraud Kwang Sik Kim Ignacio A. R | 2012 | Gastroenterology2012，，3： | 1 |
| 9 | Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial显示文摘 | George D Demetri Allan T van Oosterom Christopher R Garrett Martin E Blackstein Manisha H Shah Jaap Verweij Grant McArthur Ian R Judson Michael C Heinrich Jeffrey A Morgan Jayesh Desai Christopher D Fletcher Suzanne George Carlo L Bello Xin Huang Charles | 2006 | The Lancet2006，，9544： | 1 |
| 10 | Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial显示文摘 | George D Demetri Allan T van Oosterom Christopher R Garrett Martin E Blackstein Manisha H Shah Jaap Verweij Grant McArthur Ian R Judson Michael C Heinrich Jeffrey A Morgan Jayesh Desai Christopher D Fletcher Suzanne George Carlo L Bello Xin Huang Charles | 2006 | The Lancet2006，，9544： | 1 |
| 11 | Helsing?r statement on poly- and perfluorinated alkyl substances (PFASs)显示文摘 | Martin Scheringer Xenia Trier Ian T. Cousins Pim de Voogt Tony Fletcher Zhanyun Wang Thomas F. Webster | 2014 | Chemosphere2014，，： | 1 |
| 12 | Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial显示文摘 | George D Demetri Allan T van Oosterom Christopher R Garrett Martin E Blackstein Manisha H Shah Jaap Verweij Grant McArthur Ian R Judson Michael C Heinrich Jeffrey A Morgan Jayesh Desai Christopher D Fletcher Suzanne George Carlo L Bello Xin Huang Charles | 2006 | The Lancet2006，，9544： | 1 |
| 13 | Comparing the safety and immunogenicity of a candidate TB vaccine MVA85A administered by intramuscular and intradermal delivery显示文摘 | Joel Meyer Stephanie A. Harris Iman Satti Ian D. Poulton Hazel C. Poyntz Rachel Tanner Rosalind Rowland Kristin L. Griffiths Helen A. Fletcher Helen McShane | 2012 | Vaccine2012，，： | 1 |
| 14 | 悬崖勒马:日本三菱公司起死回生(二)显示文摘2007年10月,三菱公司宣布,连续第七个月在全球的产量增加,销售和利润进一步上升,意义重大,超过了2007/2008全部财政年度的预期。随着数年的剧变,三菱公司发出了明显的信号,最近三年结构重组计划进展良好;不过在全球化的现代汽车工业中是否可行尚属未知。三菱公司的第二个中期计划,由于要到2008年3月才宣布,是否能在未来持续发展呢? | Ian Fletcher | 2008 | 汽车与配件2008，，6： | 0 |
| 15 | 悬崖勒马:日本三菱公司起死回生(一)显示文摘2007年10月,三菱公司宣布,连续第七个月在全球的产量增加,销售和利润进一步上升,意义重大,超过了2007/2008全部财政年度的预期。随着数年的剧变,三菱公司发出了明显的信号,最近三年结构重组计划进展良好;不过在全球化的现代汽车工业中是否可行尚属未知。三菱公司的第二个中期计划,由于要到2008年3月才宣布,是否能在未来持续发展呢? | Ian Fletcher | 2008 | 汽车与配件2008，，2： | 0 |
| 16 | 塔塔需备总资本豢养“虎豹”显示文摘经济状况和未来的排放要求可能对这两个品牌不利,塔塔应为此做好准备,并具有足够的资本,才能安全渡过这场经济风暴。 | Ian Fletcher Rebecca Wright | 2008 | 汽车与配件2008，，15： | 0 |
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