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| 1 | Role of the HLA-DQ locus in the development of chronic gastritis and gastric carcinoma in Mexican patients显示文摘AIM: To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma. METHODS: Oligotyping for HLA-DQ locus was performed in 45 Mexican patients with chronic gastritis and 13 Mexican patients with diffuse-type gastric adenocarcinoma, and was then compared with 99 clinically healthy unrelated individuals. H pylori infection and CagA status were assessed in patients by enzyme-linked immunosor-bent assay (ELISA) method. RESULTS: We found a significant increased frequency of HLA-DQB1*0401 allele in H pylori-positive patients with chronic gastritis when compared with healthy subjects [19 vs 0%, P= 1 × 10-7, odds ratio (OR) = 4.96; 95% confidence interval (95% CI), 3.87-6.35]. We also found a significant increased frequency of HLA-DQB1*0501 in patients with diffuse-type gastric carcinoma in comparison with healthy individuals (P = 1 × 10-6, OR = 13.07; 95% CI, 2.82-85.14). CONCLUSION: HLA-DQ locus may play a different role in the development of H pylori-related chronic gastritis and diffuse-type gastric adenocarcinoma in the Mexican Mestizo population. | Roberto Herrera-Goepfert Jesús K Yamamoto-Furusho Luis F Oate-Ocaa Margarita Camorlinga-Ponce Leopoldo Muoz Jorge A Ruiz-Morales Gilberto Vargas-Alarcón Julio Granados Cellular Biology Section | 2006 | World Journal of Gastroenterology2006，12，48： | 4 |
| 2 | Acute fatty liver of pregnancy associated with severe acute pancreatitis:A case report显示文摘Acute fatty liver of pregnancy is a rare disease that affects women in the third trimester of pregnancy. Although infrequent, the disease can cause maternal mortality. The diagnosis is not always clear until the pregnancy is terminated, and significant complications, such as acute pancreatitis, can occur. Pancreatic involvement typically only occurs in severe cases after the development of hepatic and renal impairment. To date, little knowledge is available regarding how the disease causes pancreatitis. Treatment involves supportive measures and pregnancy interruption. In this report, we describe a case of a previously healthy 26-year-old woman at a gestational age of 27 wk and 6 d who was admitted with severe abdominal pain and vomiting. This case illustrates the clinical and laboratory overlap between acute fatty liver of pregnancy and pancreatitis, highlighting the difficulties in differentiating each disease. Furthermore, the hypothesis for this overlapping is presented, and the therapeutic options are discussed. | Cássio Vieira de Oliveira Alecsro Moreira Julio P Baima Leticia de C Franzoni Talles B Lima Fabio da S Yamashiro Kunie Yabuki Rabelo Coelho Ligia Y Sassaki Carlos Antonio Caramori Ferno G Romeiro Giovanni F Silva | 2014 | World Journal of Hepatology2014，6，7： | 3 |
| 3 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 4 | The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: the first 4 years显示文摘 | Mark R Nelson Christine Katlama Julio S Montaner David A Cooper Brian Gazzard Bonaventura Clotet Adriano Lazzarin Knud Schewe Joep Lange Christina Wyatt Sue Curtis Shan-Shan Chen Stephen Smith Norbert Bischofberger James F Rooney | 2007 | AIDS2007，，10： | 2 |
| 5 | Immobilization ofFe, Mn and Co tetraphenylporphyrin complexes in MCM-41 and their catalytic activity in cyclohexene oxidationreaction by hydrogen peroxide 显示文摘 | Costa A A Grace F G Julio L ei al | 2008 | J Mol Catal A:Chemical2008，282，： | 1 |
| 6 | Mechanisms of karyotype differentiation in Cassidinae sensu lato (Coleoptera, Polyphaga, Chrysomelidae) based on seven species of the Brazilian fauna and an overview of the cytogenetic data显示文摘 | JULIO M D FEMANDES F R COSTA C | 2010 | Micron2010，41，1： | 1 |
| 7 | Interface evaluations of overlay-concrete bi-layer composites by a direct shear test method 显示文摘 | Ray Indrajit Davalos Julio F Luo Shiwei | 2005 | Cement and Concrete Research2005，27，3： | 1 |
| 8 | Health professionals for a new Century:transforming education to strengthen health systems in an In- terdependent world 显示文摘 | Julio F Lincoln C Zulfi qar AB | 2010 | The Lancet2010，9756，376： | 1 |
| 9 | Effect of olfactory stimula- tion during suckling on agonistic behavior in weaned pigs显示文摘 | Maria F Julio O Maria L H | 2012 | J Swine Health Prod2012，20，1： | 1 |
| 10 | Health insurance in Mexico: Achieving universal coverage through structural reform 显示文摘 | Felicia M K Julio F | 2005 | Health Affairs2005，24，6： | 1 |
| 11 | A survey on the light-fastness properties of organic-based Alaska native artifacts 显示文摘 | DEL HOYO-MELTNDEZ Julio M MECKLENBURG Marion F | 2011 | J Cult Herit2011，，11： | 1 |
| 12 | Reducing the content of nornicotine in tobacco via targeted mutation breeding显示文摘 | Julio E Laporte F Reis S | | 0，，： | 1 |
| 13 | Optimization of cellulase-free xylanase activity produced by Bacillus coagulans BL69 in solid-state cultivation显示文摘 | Julio X H Simone H F Plinho F H | 2005 | Process Biochemistry2005，40，： | 1 |
| 14 | Optimization of transverse shear module for composite honeycomb cores 显示文摘 | QIAO Pizhong FAN Wei JULIO F | 2008 | Composite Structures2008，85，： | 1 |
| 15 | Health professionals for a new cen- tre-y: transforming education to strengthen health systems in an interde- pendent wodd显示文摘 | Julio F Lincoln C Zu]fiqar A B | 2010 | Laneet2010，9756，376： | 1 |
| 16 | In vivo transfer interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints显示文摘 | Julio F Ginette T Johanne MP | | 0，，： | 1 |
| 17 | Optimi- zation of cellulase-free xylanase activity produced by Ba- cillus coagulans BL69 in solid-state cultivation 显示文摘 | JULIO X H SIMONE H F PLINHO F H | 2005 | Process Biochemistry2005，40，1： | 1 |
| 18 | Ryanodine receptor calcium release channels显示文摘 | Michael F Julio A C | 2002 | Physiological Reviews2002，82，： | 1 |
| 19 | Influence of citric acid as chemical modifier for lead determination in dietary calcium supplement samples by graphite furnace atomic absorption spectrometry显示文摘 | Julio Cezar Paz de M Adriane M N Ayrton F M | 2005 | Spectrochimica Acta Part B2005，60，5： | 1 |
| 20 | Health professionals for a new century: Transforming education to strengthen health sys terns in an interdependent world显示文摘 | Julio F Lincoln C Zulfiqar AB | 2010 | The Lancet2010，376，： | 1 |
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