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| 1 | Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system显示文摘允许的技术内长的基因的特定的规定为基因功能的学习是珍贵的并且在治疗学有大潜力。我们创造了在 CRISPR 上系统,由核酸酶死者 Cas9 (dCas9 ) 蛋白质组成的二部件的 transcriptional 使活跃之物与互补顺序与 transcriptional 激活域和单个指南 RNA (sgRNAs ) 熔化了到基因倡导者。我们证明在 CRISPR 上能高效地以一种悦耳的方式在人和老鼠房间激活外长的记者基因。另外,我们证明在 vivo 的柔韧的记者基因激活能被把系统部件注入老鼠接合子完成。而且,我们证明在 CRISPR 上能激活内长的 IL1RN, SOX2,和 OCT4 基因。最有效的基因激活被对近似倡导者有约束力的 3-4 sgRNAs 的簇完成,建议他们在基因正式就职的 synergistic 行动。显著地,当指向多重基因的 sgRNAs 同时被介绍进房间时,柔韧的多路的内长的基因激活被完成。染色体宽的表示介绍表明了系统的高特性。 | Albert W Cheng Haoyi Wang Hui Yang Linyu Shi Yarden Katz Thorold W Theunissen Sudharshan Rangarajan Chikdu S Shivalila Daniel B Dadon Rudolf Jaenisch | 2013 | Cell Research2013，23，10： | 65 |
| 2 | From blood to breath: New horizons for esophageal cancer biomarkers显示文摘Esophageal cancer is a lethal cancer encompassing adenocarcinoma and squamous cell carcinoma subtypes. The global incidence of esophageal cancer is increasing world-wide, associated with the increased prevalence of associated risk factors. The asymptomatic nature of disease often leads to late diagnosis and five-year survival rates of less than 15%. Current diagnostic tools are restricted to invasive and costly endoscopy and biopsy for histopathology. Minimally and non-invasive biomarkers of esophageal cancer are needed to facilitate earlier detection and better clinical management of patients. This paper summarises recent insights into the development and clinical validation of esophageal cancer biomarkers, focussing on circulating markers in the blood, and the emerging area of breath and odorant biomarkers. | Roger Yazbeck Simone E Jaenisch David I Watson | 2016 | World Journal of Gastroenterology2016，22，46： | 6 |
| 3 | One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering显示文摘 | Haoyi Wang Hui Yang Chikdu S. Shivalila Meelad M. Dawlaty Albert W. Cheng Feng Zhang Rudolf Jaenisch | 2013 | Cell2013，，4： | 5 |
| 4 | Parkinson’s Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors显示文摘 | Frank Soldner Dirk Hockemeyer Caroline Beard Qing Gao George W. Bell Elizabeth G. Cook Gunnar Hargus Alexandra Blak Oliver Cooper Maisam Mitalipova Ole Isacson Rudolf Jaenisch | 2009 | Cell2009，，5： | 2 |
| 5 | Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17~92 Family of miRNA Clusters显示文摘 | Andrea Ventura Amanda G. Young Monte M. Winslow Laura Lintault Alex Meissner Stefan J. Erkeland Jamie Newman Roderick T. Bronson Denise Crowley James R. Stone Rudolf Jaenisch Phillip A. Sharp Tyler Jacks | 2008 | Cell2008，，5： | 2 |
| 6 | Effects of mutations at the W locus (c-kit) on inner ear pigmentation and function in the mouse显示文摘 | Huszar D Jaenisch R | 1994 | Pigment Cell Res1994，7，1： | 1 |
| 7 | Infection of developing mouse embryos with murine leukemia virus:tissue specificity and genetic transmission of the virus显示文摘 | Jaenisch R Dausman J Cox V | 1976 | Hanlatol Bluttransfus1976，19，： | 1 |
| 8 | The role of DNA methylation in cancer genetic and epigenetics显示文摘 | Laird PW Jaenisch R | 1996 | Annu Rev Genet1996，30，： | 1 |
| 9 | Mammalian X chromosome inactivation 显示文摘 | Jaenisch R Beard C Lee J | 1998 | Novartis Found Symp1998，214，： | 1 |
| 10 | Targeted mutation of the DNA methyltransferase gene results in embryonic lethality显示文摘 | LI E BESTOR T H JAENISCH R | 1992 | Cell1992，69，： | 1 |
| 11 | Antisense transcription through the Xist locus mediates Tsix function in embryonic stem cells 显示文摘 | Luikenhuis S Wutz A Jaenisch R | 2001 | Mol Cell Biol2001，21，24： | 1 |
| 12 | Stem cells,the molecular circuitry ofpluripotency and nuclear reprogramming显示文摘 | Jaenisch R Young R | 2008 | Cell2008，132，： | 1 |
| 13 | Nuclear cloning and epigenetic reprogramming of the genome显示文摘 | Rideout WM Eggan K Jaenisch R | 2001 | Science2001，293，5532： | 1 |
| 14 | Monoclonal mice generated by nuclear transfer frommature B and T donor cells显示文摘 | Hochedlinger K Jaenisch R | 2002 | Nature2002，415，6875： | 1 |
| 15 | Epigenetic regulation of gene expression:how the genome integrates intrinsic and environmental signals显示文摘 | Jaenisch R Bird A | 2003 | Nat Genet2003，，： | 1 |
| 16 | Epigenetic regulation of geneexpression : how the genome integrates intrinsic andenvironmental signals显示文摘 | JAENISCH R BIRD A | 2003 | Nature Genetics2003，33，： | 1 |
| 17 | One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering显示文摘 | Hui Yang Haoyi Wang Chikdu S. Shivalila Albert W. Cheng Linyu Shi Rudolf Jaenisch | 2013 | Cell2013，，6： | 1 |
| 18 | Infection of developing mouse embroyos with murine leukemia virus:tissue specificity and genetic transmission of the virus显示文摘 | Jaenisch R Dausman J Cox V | 1976 | Hamatol Bluttransfus1976，19，： | 1 |
| 19 | Germ line integration and Mendelian transmission of the exogenous Moloney leukemia virus显示文摘 | | 1976 | Proc Natl Acad Sci U S A1976，73，4： | 1 |
| 20 | Directly Reprogrammed Fibroblasts Show Global Epigenetic Remodeling and Widespread Tissue Contribution显示文摘 | Nimet Maherali Rupa Sridharan Wei Xie Jochen Utikal Sarah Eminli Katrin Arnold Matthias Stadtfeld Robin Yachechko Jason Tchieu Rudolf Jaenisch Kathrin Plath Konrad Hochedlinger | 2007 | Cell Stem Cell2007，，1： | 1 |
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