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| 1 | Listening to Turkish classical music decreases patients’anxiety,pain,dissatisfaction and the dose of sedative and analgesic drugs during colonoscopy:A prospective randomized controlled trial显示文摘AIM: To determine whether listening to music decreases the requirement for dosages of sedative drugs, patients’ anxiety, pain and dissatisfaction feelings during colonoscopy and makes the procedure more comfortable and acceptable. METHODS: Patients undergoing elective colonoscopy between October 2005 and February 2006 were randomized into either listening to music (Group 1, n = 30) or not listening to music (Group 2, n = 30). Anxiolytic and analgesic drugs (intravenous midazolam and meperidine) were given according to the patients’ demand. Administered medications were monitored. We determined their levels of anxiety using the State-Trait Anxiety Inventory Test form. Patients’ satisfaction, pain, and willingness to undergo a repeated procedure were self-assessed using a visual analog scale.RESULTS: The mean dose of sedative and analgesic drugs used in group 1 (midazolam: 2.1 ± 1.4, meperidine: 18.1 ± 11.7) was smaller than group 2 (midazolam: 2.4 ± 1.0, meperidine: 20.6 ± 11.5), but without a significant difference (P > 0.05). The mean anxiety level in group 1 was lower than group 2 (36.7 ± 2.2 vs 251.0 ± 1.9, P < 0.001). The mean satisfaction score was higher in group 1 compared to group 2 (87.8 ± 3.1 vs 58.1 ± 3.4, P < 0.001). The mean pain score in group 1 was lower than group 2 (74.1 ± 4.7 vs 39.0 ± 3.9, P < 0.001).CONCLUSION: Listening to music during colonoscopy helps reduce the dose of sedative medications, as well as patients’ anxiety, pain, dissatisfaction during the procedure. Therefore, we believe that listening to music can play an adjunctive role to sedation in colonoscopy. It is a simple, inexpensive way to improve patients’ comfort during the procedure. | Nimet Ovayolu Ozlem Ucan Seda Pehlivan Yavuz Pehlivan Hakan Buyukhatipoglu M Cemil Savas Murat T Gulsen | 2006 | World Journal of Gastroenterology2006，12，46： | 10 |
| 2 | Prognostic role of sensitive-to-apoptosis gene expression in rectal cancer显示文摘AIM:To investigate the association between prognosis of rectal cancer treated with chemoradiotherapy(CRT) and expression of sensitive-to-apoptosis(SAG),B-cell lymphoma-extra large(Bcl-X L) and Bcl-2 homologous antagonist/killer(Bak).METHODS:Real-time quantitative polymerase chain reaction was used to determine the expression of proteins of interest,namely SAG,Bcl-X L,Bak and β-actin,in rectal carcinoma patients who had a follow-up period of 3 years after CRT.Biopsy specimens were excised from the rectal tumor preceding CRT.RESULTS:SAG,Bcl-X L and Bak proteins showed significant correlations with each other.In multivariate analysis,patients with high vs low SAG expression showed a statistically significant difference in 2-year survival rates:56% vs 73%,respectively(P = 0.056).On the other hand,there were no significant correlations between the expression levels of all three genes and metastatic rates or tumor responses to CRT.Mean overall survival in the patients with elevated SAG expression was 27.1 mo ± 3.9 mo [95% confidence interval(CI):19.3-34.9],and in patients with reduced expression,it was 32.1 mo ± 2.5 mo(95% CI:27.3-36.9).The corresponding values for Bcl-X L were 28.0 mo ± 4.1 mo(95% CI:19.9-36.1) and 31.7 mo ± 2.9 mo(95% CI:26.0-37.5),and those for Bak were 29.8 mo ± 3.7 mo(95% CI:22.5-37.2) and 30.6 mo ± 2.4 mo(95% CI:25.5-35.0),respectively.CONCLUSION:Two-year survival rates significantly correlated with low SAG expression,and SAG may be a candidate gene for good prognosis,independent of therapeutic response of different individuals. | Sevgi A Ozden Hazan Ozyurt Zerrin Ozgen Olca Kilinc Mustafa Oncel Aylin E Gul Nimet Karadayi Nedime Serakinci Beki Kan Oya Orun | 2011 | World Journal of Gastroenterology2011，17，44： | 6 |
| 3 | 两种方法研究大学生群体优势眼与左/右利手间的关系(英文)显示文摘目的:评估大学生群体优势眼和左/右利手间的关系。方法:受试对象为179名大学生志愿者,平均年龄为19.4±1.6岁,其中女110名(61.5%),男69名(38.5%)。优势眼由Gndogˇan和McManus两种方法测得,左或右利手则由Edinburgh Handedness Inventory Oldfield和McManus法确定,t检验评估实验的可信度。结果:Gndogˇan法测得受试者中110人(61.5%)为右眼优势,69人(38.5%)为左眼优势,无性别差异。McManus法重测相同受试者,则右/左眼优势分别为128人(71.5%)和51人(28.5%)。两法测得的结果相关,一致度κ=0.256(P<0.01)。女性受试者中,Gndogˇan法测得右/左眼优势分别为62人(56.4%)和48人(43.6%),McManus法测得的结果为右/左眼优势分别为74人(67.3%)和36人(32.7%)。Fisher检验两法测得的结果相关(P<0.05),一致度κ=0.239(P<0.01)。男性受试者中,Gndogˇan法测得右/左眼优势为48人(69.6%)和21人(30.3%),Mc-Manus法检测为54人(78.3%)和15人(21.7%)。Fisher检验两法测得结果相关(P>0.05),一致度κ=0.239(P<0.01)。Oldfield和McManus法分别测得右利手比例为91.6%(n=164)和91.1%(n=163),两者间有较高的一致度κ=0.753(P<0.01)。McManus法检测出的优势眼和左或右利手间的统计学相关性具有显著性意义(Fisher检测P<0.017;一致度评分phi=0.193(P<0.05)。结论:大学生以右利手为主,McManus法检测发现右利手似乎与有眼优势更为相关。左或右利手和优势眼似乎是研究大脑功能不对称性和大脑偏侧型的最可靠的方法。 | Nimet Unay Gǔndogan | 2009 | 国际眼科杂志2009，9，12： | 5 |
| 4 | 优势眼测量法的研究(英文)显示文摘目的:为了检查一项新的性能测试,对同以受试者用两种不同的方法进行检测和再测试,并比较和讨论这些检测方法的可靠性。方法:共179个大学生(平均年龄±标准差为19.37±1.62)a自愿参加这项由110名女性(61.5%)和69名男性(38.5%)组成的调查。优势眼由两种不同的方法检测,一个为McManus方法,一个为Gndo■an方法。利用SPSS的重测信度的可靠性分析保证该项调查的可靠性。结果:McManus方法检测128名(71.5%)参加者右眼为优势眼,无性别差异。同样利用Gndogˇan方法再检测发现110名(61.5%)参加者右眼为优势眼。两种方法的检测结果由Fisher确切概率法分析发现呈显著性相关(P<0.01),一致性数值为为κ=0.256,P<0.001。利用Mc-Manus法发现女性参加者中74名(67.3%)右眼为优势眼,36名(32.7%)左眼为优势眼。利用Gndog■an法再检测发现62名女(56.4%)右眼为优势眼,48名女(43.6%)左眼为优势眼。通过Fisher确切概率法分析发现McMa-nus和Gndo■an两种方法在女性优势眼检测方面呈显著性相关(P<0.05),一致性数值为κ=0.239,P<0.01。在男性参与者中,通过McManus法检测右眼优势眼为54眼(78.3%),左眼优势眼为15眼(21.7%),利用Gndo■an法再检测右眼优势眼为48眼(69.6%),左眼优势眼为21眼(30.4%)。利用χ2检验和Fisher确切概率法分析数据。利用Kappa一致性检验分析不同方法的一致性。比例的比较由z检验完成,P值小于0.05为差异显著。结论:通过检测观察到女性和男性均以右眼优势眼为主,没有性别差异。右眼优势这种功能性偏侧化现象可能是由于大脑左半球的主导作用造成的。这对于将来在一侧面偏重方面的研究很重要,也许会成为一个重要的模式系统。 | Nimet Unay Gundogan Ayse Canan Yazici Ayten Simsek | 2008 | 国际眼科杂志2008，8，10： | 3 |
| 5 | 高度近视伴色觉缺失的家系分析(英文)显示文摘目的:评估高度近视伴色觉缺失患者的遗传学特征和临床表现方法:就同一家族4代42个成员中有8位患者给予了详细的眼科检查,Ishihara盘和FM100H试验检测患者有无红绿色觉缺失,全视野视网膜电图评价其视网膜功能。结果:患者8位均因高度近视视力下降,其中6例有红绿色觉缺失,眼底检查显示以弥漫性视网膜脉络膜萎缩为特征的近视改变。2例患者ERG检查出现视杆细胞的暗适应异常和视锥细胞的反应消失,根据家系,红绿色觉缺失属X连锁的隐性遗传。结论:在这个家族成员中,同时发生的高度近视和色觉缺失可能有共同的遗传学基础。 | Nimet nay Gündogan Ay■e Gül Koak Altinta■ Nezih Durmazlar Koray Gümüs Zerrin Yilmaz Kemal Ksemehmetoglu | 2007 | 国际眼科杂志2007，7，3： | 2 |
| 6 | Relation of eye dominancy with color vision discrimination performance ability in normal subjects显示文摘AIM:To evaluate the performance of dominant eye(DE) for color vision discrimination ability among the medical students with normal color vision.METHODS:Total of 50 students studying at Baskent University Faculty of Medicine,including 31 males(62%) and 19 females(38%),with visual acuity of 20/20 and without congenital color vision deficiency(CCVD) evaluated by Ishihara pseudoisochromatic plate test(IPPT) were recruited for this prospective comparative study upon their voluntary participation.DE was determined by the Gündogan Method.The color discrimination ability was examined with the FarnsworthMunsell 100 hue(FM100) test.Test was applied by two days interval to all subjects for the three times while two eyes(TE),right eye(RE) and left eye(LE) were seeing for detecting red-green(r/g),blue-yellow(b/y) local color spectral regions error scores.The error scores were evaluated for both in DE and non-dominant(NDE).P values below 0.05 were considered to be statistically significant.RESULTS:The students aged 21.18±2.52 years(mean±SD).Without sex difference the RE and the LE dominancy were found 22(44%) and 28(56%) respectively and FM 100 test total error scores of DE in both r/g-b/y regions were found without gender difference 24.12±14.70,34.68±18.95,respectively.For the NDE in both,r/gb/y regions error scores without gender difference were 32.20±19.21,36.24±17.56,respectively.The difference of total error scores between the DE and NDE was found as 58.80±29.92,68.44±31.46.The statistical differences among the DE and the NDE in r/g local region and total error scores were found significant in both genders(P<0.05,P<0.001). CONCLUSION:The color vision discrimination performance ability was found prominent for DE.This superiority was attributed to higher sensitivity of the r/g local color spectral region.We conclude that DE has priority in r/g color spectral region,probably including inhibition of NDE. | Belkis Koctekin Nimet ünay Gündogan Ays Gül Kocak Altintas Ayse Canan Yazici | 2013 | International Journal of Ophthalmology(English edition)2013，6，5： | 2 |
| 7 | 一种新的计算机适应色觉试验(英文)显示文摘目的:提出一种新的计算机适应色觉试验(NCACVT)并且解释它在实际应用中的可靠性和重要性。方法:法-孟二式100色度试验(FM100HT)和Holmgren试验已经被改良并且适应计算机应用。经典的Ishihara假同色法试验方法(IPPT)已被假定是色盲的一个简便的筛选检查工具;因此依照Ishihara试验结果,受试者被分为色觉有缺陷组(第1组)和对照组(第2组)。第1组为色觉有缺陷者13例(男12例,女1例),年龄在19~29(平均21)岁,而第2组为对照组,13个受试者色觉无缺陷(男8例,女5例),年龄在19~28(平均22)岁。为了研究两组人的色觉敏感性,所有的受试者都要进行FM100HT和NCACVT试验。将经典的IPPT,FM100HT和NCACVT的试验结果用统计学方法进行比较。在这两组中NCACVT和FM100HT的误差计分用秩和检验来分析。结果:在误差计分中的差别分别在统计学上是有显著意义的(U=169,P<0.05;U=153P<0.05)。根据NCACVT来诊断色觉缺陷的临界点是通过使用接受机器作特征曲线(ROC)而被发现是23。根据23这个临界点的误差计分,在筛选检查色觉缺陷方面,发现NCACVT具有100%的敏感性和100%的特异性。结论:根据Harper和Reeves,这些特点使得这个试验成为一个可靠的、有创意的眼科实践筛选试验。 | Nimet ünay Gündogan Nezih Durmazlar Aysegül Kocak Altintas Koray Gümüs | 2007 | 国际眼科杂志2007，7，2： | 2 |
| 8 | Evalu-ation of the effect of cryotherapy in preventing oral mucositisassociated with chemotherapy - A randomized controlled trial显示文摘 | Nilgiln Katranci Nimet Ovayolu Ozlem Ovayolu | 2011 | European Journal of Oncology Nursing2011，，： | 1 |
| 9 | Directly Reprogrammed Fibroblasts Show Global Epigenetic Remodeling and Widespread Tissue Contribution显示文摘 | Nimet Maherali Rupa Sridharan Wei Xie Jochen Utikal Sarah Eminli Katrin Arnold Matthias Stadtfeld Robin Yachechko Jason Tchieu Rudolf Jaenisch Kathrin Plath Konrad Hochedlinger | 2007 | Cell Stem Cell2007，，1： | 1 |
| 10 | Quality of life and job satisfaction of nurses 显示文摘 | Guler C Nimet SG | 2003 | Nuts Care Qual2003，18，2： | 1 |
| 11 | Electrospun matrices made of poly(α-hydroxy acids) for medical use显示文摘 | Erhan Piskin Nimet Bö lgen Sinan Egri Ismail Alper Isoglu | 2007 | Nanomedicine2007，，4： | 1 |
| 12 | A High-Efficiency System for the Generation and Study of Human Induced Pluripotent Stem Cells显示文摘 | Nimet Maherali Tim Ahfeldt Alessandra Rigamonti Jochen Utikal Chad Cowan Konrad Hochedlinger | 2008 | Cell Stem Cell2008，，3： | 1 |
| 13 | 计算机控制的Ishihara色觉测试法(英文)显示文摘目的:研究经计算机控制的Ishihara测试法诊断色盲的可靠性及其与经典Ishihara测试法的一致性,计算机控制的Ishihara测试法的敏感性与特异性;并探讨该测试方法在检测先天性色盲或色弱中的潜在价值。方法:用两种方法测试104名大学生的色觉,年龄20~23岁(中位数21岁)。分别采用经计算机控制的Ishihara色板和经典的Ishihara打印色板显露法对个体色觉进行检查。通过上述两种不同的方法评价每个学生对颜色的感知能力,借此探讨计算机控制的Ishihara测试法的特异性,准确性以及与经典法的一致性。结果:本实验共检测到6位男性色盲患者和1位女性色盲患者。调查该女性学生的家族史,发现其母亲为色盲基因携带者,而其父亲为色盲患者。本实验中男性色盲患病率为13.6%(6/44),女性为1.7%(1/60);整个人群总的患病率为6.7%(7/104)。进行本试验前,这些学生并未意识到自己存在色觉功能缺陷。为探讨这两种方法的一致性,分别对色觉正常和患色盲的学生的测试结果进行比较。结果表明:两种实验方法的特异性及敏感性均为100%,一致性达到100%。结论:计算机控制的Ishihara测试法是数字调控性的,但有关色觉测试的基本概念没有改变。该法总的测试时间和误差计分都已标准化,与手动测试法相比有明显的优势;而且该法与被认为是'金标准'的经典测试法的一致性达到100%。这些特征表明,计算机控制的Ishihara测试法是一种新颖和可靠的方法。 | Nimet nay Gündogan Nezih Durmazlar Koray Gümüs Pinar Geyik zdemir | 2007 | 国际眼科杂志2007，7，5： | 1 |
| 14 | Quality of life and job satisfaction of Nurses显示文摘 | Culer C Nimet SG Gulbahar K | 2003 | Journal of Nursing Care Quality2003，18，2： | 1 |
| 15 | Quality of life and job satisfaction of nurses显示文摘 | Guler C Nimet SG Gulbahar K | 2003 | J Nurs Care Qjuality2003，18，2： | 1 |
| 16 | Sedation during noninvasive mechanical ventilation with dexmedetomidine or midazolam:a randomized,double-blind,prospective study显示文摘 | Nimet S Hafize O Zafer D | 2010 | Current Therapeutic Research2010，71，： | 1 |
| 17 | Evalu-ation of the effect of cryotherapy in preventing oral mucositisassociated with chemotherapy - A randomized controlled trial显示文摘 | Nilgiln Katranci Nimet Ovayolu Ozlem Ovayolu | 2011 | European Journal of Oncology Nursing2011，，： | 1 |
| 18 | Defining Molecular Cornerstones during Fibroblast to iPS Cell Reprogramming in Mouse显示文摘 | Matthias Stadtfeld Nimet Maherali David T. Breault Konrad Hochedlinger | 2008 | Cell Stem Cell2008，，3： | 1 |
| 19 | Effect of carnitine on stress-induced lipid peroxidation in rat gastric mucosa显示文摘 | V. Nimet ?zgüt-Uysal Arzu Aˇa? Narin Deri | 2001 | Journal of Gastroenterology2001，，4： | 1 |
| 20 | Defining Molecular Cornerstones during Fibroblast to iPS Cell Reprogramming in Mouse显示文摘 | Matthias Stadtfeld Nimet Maherali David T. Breault Konrad Hochedlinger | 2008 | Cell Stem Cell2008，，： | 1 |
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