|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 我国婴幼儿中存在不同基因型杯状病毒的感染显示文摘Human caliciviruses were detected from stool specimens collected from infants with diarrhea from Beijing and Anhui Province by using RT PCR PCR products with molecular weight around 330 were obtained by using the primer pair of 289/290,which is proved to be able to amplify both Norwalk like and Sapporo like human caliciviruses The PCR products amplified from specimens collected in Beijing(CR480) and Anhui(A141) were cloned into the T A cloning vector pUCm T and sequenced The cDNA fragment amplified from CR480 is 319bp in length,which is consistent with the molecular weight of the cDNA fragment amplified from Norwalk like viruses with the primer pair 289/290,whereas the cDNA fragment amplified from A141 is 331 bp in length,which is the size of the cDNA fragment from Sapporo like viruses The sequence analysis revealed that the cDNA from CR480(the stool specimen collected in Beijing) shared higher nucleotide and amino acid identities with selected Norwalk like viruses (from 60% to 97% and 62% to 99%,respectively)than with selected Sapporo like viruses(less than 58%),having the highest identity with Takl 1999 jp and ARG320,which belong to genotype Ⅱ of Norwalk like viruses The sequence of the cDNA from A141 (collected form Anhui Province) shared higher nucleotide and amino acid identities with selected Sapporo like viruses(from 68% to 92% and 75% to 96%,respectively) than with selected Norwalk like viruses(less than 52%) It suggests that both Norwalk like and Sapporo like human caliciviruses are circulating in China and cause diarrhea in infants and young | 陈冬梅 张又 钱渊 Jason Jiang | 2001 | 病毒学报2001，17，3： | 37 |
| 2 | The joint automated repository for various integrated simulations (JARVIS) for data-driven materials design显示文摘The Joint Automated Repository for Various Integrated Simulations(JARVIS)is an integrated infrastructure to accelerate materials discovery and design using density functional theory(DFT),classical force-fields(FF),and machine learning(ML)techniques.JARVIS is motivated by the Materials Genome Initiative(MGI)principles of developing open-access databases and tools to reduce the cost and development time of materials discovery,optimization,and deployment. | Kamal Choudhary Kevin F.Garrity Andrew C.E.Reid Brian DeCost Adam J.Biacchi Angela R.Hight Walker Zachary Trautt Jason Hattrick-Simpers A.Gilad Kusne Andrea Centrone Albert Davydov Jie Jiang Ruth Pachter Gowoon Cheon Evan Reed Ankit Agrawal Xiaofeng Qian Vinit Sharma Houlong Zhuang Sergei V.Kalinin Bobby G.Sumpter Ghanshyam Pilania Pinar Acar Subhasish Mandal Kristjan Haule David Vanderbilt Karin Rabe Francesca Tavazza | 2020 | npj Computational Materials2020，，1： | 10 |
| 3 | A novel receptor-binding domain (RBD)-based mRNA vaccine against SARS-CoV-2显示文摘Dear Editor,The pandemic of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)highlights the need to develop effective and safe vaccines.Similar to SARS-CoV,SARS-CoV-2 recognizes angiotensin-converting enzyme 2(ACE2)as receptor for host cell entry.1,2 SARS-CoV-2 spike(S)protein consists of S1,including receptor-binding domain(RBD),and S2 subunits.3,4 We previously demonstrated that RBDs of SARS-CoV and MERS-CoV serve as important targets for the development of effective vaccines. | Wanbo Tai Xiujuan Zhang Aleksandra Drelich Juan Shi Jason CHsu Larry Luchsinger Christopher D.Hillyer Chien-Te KTseng Shibo Jiang Lanying Du | 2020 | Cell Research2020，30，10： | 5 |
| 4 | Guest Editorial for Special Issue on Blockchain for Internet-of-Things and Cyber-Physical Systems显示文摘Cyber-physical systems(CPS)are increasingly commonplace,with applications in energy,health,transportation,and many other sectors.One of the major requirements in CPS is that the interaction between cyber-world and man-made physical world(exchanging and sharing of data and information with other physical objects and systems)must be safe,especially in bi-directional communications.In particular,there is a need to suitably address security and/or privacy concerns in this human-in-the-loop CPS ecosystem.However,existing centralized architecture models in CPS,and also the more general IoT systems,have a number of associated limitations,in terms of single point of failure,data privacy,security,robustness,etc.Such limitations reinforce the importance of designing reliable,secure and privacy-preserving distributed solutions and other novel approaches,such as those based on blockchain technology due to its features(e.g.,decentralization,transparency and immutability of data).This is the focus of this special issue. | Mohammad Mehedi Hassan Giancarlo Fortino Laurence T.Yang Hai Jiang Kim-Kwang Raymond Choo Jun Jason Zhang Fei-Yue Wang | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，12： | 2 |
| 5 | Nature:研究鉴定出侵袭性胰腺癌细胞及其弱点显示文摘在一项新的研究中,来自美国德州大学MD安德森癌症中心的研究人员利用患者源性肿瘤异种移植(patient—derived tumorxenograft,PDx)和模式小鼠开展一系列临床前实验,鉴定出一种门卫蛋白(gatekee Perprotein)阻止胰腺癌细胞转化为一种极具侵袭性的细胞类型,并且也发现剔除这种门卫蛋白的疗法能够阻止这些癌细胞。这些发现有助为携带这种进展迅速的治疗抵抗性的胰腺癌细胞亚群的患者开发出潜在的疗法。 | Genovese, Giannicola Carugo, Alessandro Tepper, James Robinson, Frederick Scott Li, Liren Svelto, Maria Nezi, Luigi Corti, Denise Minelli, Rosalba Pettazzoni, Piergiorgio Gutschner, Tony Wu, Chia-Chin Seth, Sahil Akdemir, Kadir Caner Leo, Elisabetta Amin, Samirkumar Dal Molin, Marco Ying, Haoqiang Kwong, Lawrence N. Colla, Simona Takahashi, Koichi Ghosh, Papia Giuliani, Virginia Muller, Florian Dey, Prasenjit Jiang, Shan Garvey, Jill Liu, Chang-Gong Zhang, Jianhua Heffernan, Timothy P. Toniatti, Carlo Fleming, Jason B. Goggins, Michael G. Wood, Laura D. Sgambato, Alessandro Agaimy, Abbas Maitra, Anirban Roberts, Charles W. M. Wang, Huamin Viale, Andrea DePinho, Ronald A. Draetta, Giulio F. Chin, Lynda | 2017 | 现代生物医学进展2017，17，14： | 2 |
| 6 | Direct demonstration of carrier distribution and recombination within step-bunched UV-LEDs显示文摘AlGaN-based solid state UV emitters have many advantages over conventional UV sources. However, UV-LEDs still suffer from numerous challenges, including low quantum efficiency compared to their blue LED counterparts. One of the inherent reasons is a lack of carrier localization effect inside fully miscible AlGaN alloys. In the pursuit of phase separation and carrier localization inside the active region of AlGaN UV-LED, utilization of highly misoriented substrates proves to be useful, yet the carrier distribution and recombination mechanism in such structures has seldom been reported. In this paper, a UV-LED with step-bunched surface morphology was designed and fabricated, and the internal mechanism of high internal quantum efficiency was studied in detail. The correlation between microscale current distribution and surface morphology was provided, directly demonstrating that current prefers to flow through the step edges of the epitaxial layers. Experimental results were further supported by numerical simulation. It was found that efficient radiative recombination centers were formed in the inclined quantum well regions. A schematic three-dimensional energy band structure of the multiple quantum wells(MQWs) across the step was proposed and helps in further understanding the luminescence behavior of LEDs grown on misoriented substrates. Finally, a general principle to achieve carrier localization was proposed, which is valid for most ternary Ⅲ-Ⅴ semiconductors exhibiting phase separation. | HOUQIANG XU JIEAN JIANG LI CHEN JASON HOO LONG YAN SHIPING GUO CAI SHEN YANPING WEI HUA SHAO ZI-HUI ZHANG WEI GUO JICHUN YE | 2021 | Photonics Research2021，9，5： | 2 |
| 7 | Effects of interactivity on website involvement and purchase intention显示文摘 | JIANG ZHENHUI CHAN JASON TAN BERNARD C Y | 2010 | Journal of Association for Information Systems2010，11，1： | 1 |
| 8 | Novel Cinobufagin Oxime Ether Derivatives as Potential Na+/K+-ATPase Inhibitors: Synthesis, Biological Screening and Molecular Docking显示文摘 | LIANG Guangping CHUNG Tseyu GUO Jinhua ZHANG Rongrong XU Wei TZEN Jason T.C JIANG Renwang | 2017 | Chemical Research in Chinese Universities2017，33，3： | 1 |
| 9 | Multiplexed Profiling of Extracellular Vesicles for Biomarker Development显示文摘Extracellular vesicles(EVs)are cell-derived membranous particles that play a crucial role in molecular trafficking,intercellular transport and the egress of unwanted proteins.They have been implicated in many diseases including cancer and neurodegeneration.EVs are detected in all bodily fluids,and their protein and nucleic acid content offers a means of assessing the status of the cells from which they originated.As such,they provide opportunities in biomarker discovery for diagnosis,prognosis or the stratification of diseases as well as an objective monitoring of therapies.The simultaneous assaying of multiple EV-derived markers will be required for an impactful practical application,and multiplexing platforms have evolved with the potential to achieve this.Herein,we provide a comprehensive overview of the currently available multiplexing platforms for EV analysis,with a primary focus on miniaturized and integrated devices that offer potential step changes in analytical power,throughput and consistency. | Cheng Jiang Ying Fu Guozhen Liu Bowen Shu Jason Davis George K.Tofaris | 2022 | Nano-Micro Letters2022，14，1： | 1 |
| 10 | Stresses and strains in the medial meniscus of an ACL deficient knee under anterior loading: A Finite element analysis with image-based experimental validation 显示文摘 | Jiang Y Jason S Michael M | 2006 | Journal of Biomechanical Engineering2006，128，： | 1 |
| 11 | Sensitivities of Medial Meniscal Motion and Deformation to Material Properties of Articular Cartilage, Meniscus and Meniscal Attachments Using Design of Experiments Methods 显示文摘 | Jiang Yao Paul DF Jason S | 2006 | Journal of Biomechanical Engineering Transactions of the ASME (S0148-0731)2006，128，3： | 1 |
| 12 | Identification of Caleosin and Two Oleosin Isoforms in Oil Bodies of Pine Megagametophytes显示文摘 | Buntora Pasaribu Tse-yu Chung Chii-Shiarng Chen Song-liang Wang Pei-Luen Jiang Jason T.C. Tzen | 2014 | Plant Physiology and Biochemistry2014，，： | 1 |
| 13 | A unique caleosin serving as the major integral protein in oil bodies isolated from Chlorella sp. cells cultured with limited nitrogen显示文摘 | I-Ping Lin Pei-Luen Jiang Chii-Shiarng Chen Jason T.C. Tzen | 2012 | Plant Physiology and Biochemistry2012，，： | 1 |
| 14 | The same oleosin isoforms are present in oil bodies of rice embryo and aleurone layer while caleosin exists only in those of the embryo显示文摘 | Da-Huang Chen Chia-Lin Chyan Pei-Luen Jiang Chii-Shiarng Chen Jason T.C. Tzen | 2012 | Plant Physiology and Biochemistry2012，，： | 1 |
| 15 | Stable oil bodies sheltered by a unique caleosin in cycad megagametophytes显示文摘 | Pei-Luen Jiang Jeff C.F. Chen Shau-Ting Chiu Jason T.C. Tzen | 2009 | Plant Physiology and Biochemistry2009，，11： | 1 |
| 16 | Passive suspensions incorporating inerters for railway vehicles 显示文摘 | JASON ZHENG JIANG ALEJANDRA Z MATAMOROS R M G | 2012 | Vehicle System Dynamics2012，50，： | 1 |
| 17 | RB1 and p53 at the crossroad of EMT and triple-negative breast cancer显示文摘 | Zhe Jiang Robert Jones Jeff C. Liu Tao Deng Tyler Robinson Philip E.D. Chung Sharon Wang Jason I. Herschkowitz Sean E. Egan Charles M. Perou Eldad Zacksenhaus | 2011 | Cell Cycle2011，，10： | 1 |
| 18 | Bicyclic imidazolium ionic liquids as potential electrolytes for rechargeable lithium ion batteries显示文摘 | Xiao-Guang Sun Chen Liao Nan Shao Jason R. Bell Bingkun Guo Huimin Luo De-en Jiang Sheng Dai | 2013 | Journal of Power Sources2013，，： | 1 |
| 19 | Glycolytic potential enhanced by blockade of pyruvate influx into mitochondria sensitizes prostate cancer to detection and radiotherapy显示文摘Objective:This study aimed to evaluate the effects of mitochondrial pyruvate carrier(MPC)blockade on the sensitivity of detection and radiotherapy of prostate cancer(PCa).Methods:We investigated glycolysis reprogramming and MPC changes in patients with PCa by using metabolic profiling,RNASeq,and tissue microarrays.Transient blockade of pyruvate influx into mitochondria was observed in cellular studies to detect its different effects on prostate carcinoma cells and benign prostate cells.Xenograft mouse models were injected with an MPC inhibitor to evaluate the sensitivity of 18F-fluorodeoxyglucose positron emission tomography with computed tomography and radiotherapy of PCa.Furthermore,the molecular mechanism of this different effect of transient blockage towards benign prostate cells and prostate cancer cells was studied in vitro.Results:MPC was elevated in PCa tissue compared with benign prostate tissue,but decreased during cancer progression.The transient blockade increased PCa cell proliferation while decreasing benign prostate cell proliferation,thus increasing the sensitivity of PCa cells to 18F-PET/CT(SUVavg,P=0.016;SUVmax,P=0.03)and radiotherapy(P<0.01).This differential effect of MPC on PCa and benign prostate cells was dependent on regulation by a VDAC1-MPC-mitochondrial homeostasis-glycolysis pathway.Conclusions:Blockade of pyruvate influx into mitochondria increased glycolysis levels in PCa but not in non-carcinoma prostate tissue.This transient blockage sensitized PCa to both detection and radiotherapy,thus indicating that glycolytic potential is a novel mechanism underlying PCa progression.The change in the mitochondrial pyruvate influx caused by transient MPC blockade provides a critical target for PCa diagnosis and treatment. | Huan Xu Junyi Chen Zhi Cao Xi Chen Caihong Huang Jin Ji Yalong Xu Junfeng Jiang Yue Wang Guowang Xu Lina Zhou Jingyi He Xuedong Wei Jason Boyang Wu Zhong Wang Shancheng Ren Fubo Wang | 2022 | Cancer Biology & Medicine2022，19，9： | 1 |
| 20 | Microbial Electrosynthesis for Producing Medium Chain Fatty Acids显示文摘Microbial electrosynthesis(MES)employs microbial catalysts and electrochemistry to enhance CO_(2)bioconversion to organics with concurrent waste biorefining capability.The aim of this review is to comprehensively discuss the current state of the art and prospects of medium chain fatty acids(MCFAs)production in MES from CO_(2)and organic wastes.Fundamental mechanisms and development of MCFAs production via conventional fermentation are introduced as well.Studies on MCFAs production in MES are summarized,highlighting the strategy of multiple-electron donors(EDs).Challenges for MCFAs production in MES from CO_(2)are presented,and the primary discussions included methanogenesis inhibition,adenosine triphosphate(ATP)limitations of acetogens,and production of limited EDs via solventogenesis.Possible applications of electrochemical approaches to promote the bioconversion of actual waste materials with MCFAs production are analyzed.Finally,future directions are explored,including multi-stage reactions,substrate supply,product extraction,and microbial pathways. | Na Chu Wen Hao Qinglian Wu Qinjun Liang Yong Jiang Peng Liang Zhiyong Jason Ren Raymond Jianxiong Zeng | 2022 | Engineering2022，，9： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员