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| 1 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 2 | Recent Advances in Design Strategies and Multifunctionality of Flexible Electromagnetic Interference Shielding Materials显示文摘With rapid development of 5G communication technologies,electromagnetic interference(EMI)shielding for electronic devices has become an urgent demand in recent years,where the development of corresponding EMI shielding materials against detrimental electromagnetic radiation plays an essential role.Meanwhile,the EMI shielding materials with high flexibility and functional integrity are highly demanded for emerging shielding applications.Hitherto,a variety of flexible EMI shielding materials with lightweight and multifunctionalities have been developed.In this review,we not only introduce the recent development of flexible EMI shielding materials,but also elaborate the EMI shielding mechanisms and the index for'green EMI shielding'performance.In addition,the construction strategies for sophisticated multifunctionalities of flexible shielding materials are summarized.Finally,we propose several possible research directions for flexible EMI shielding materials in near future,which could be inspirational to the fast-growing next-generation flexible electronic devices with reliable and multipurpose protections as offered by EMI shielding materials. | Junye Cheng Chuanbing Li Yingfei Xiong Huibin Zhang Hassan Raza Sana Ullah Jinyi Wu Guangping Zheng Qi Cao Deqing Zhang Qingbin Zheng Renchao Che | 2022 | Nano-Micro Letters2022，14，5： | 5 |
| 3 | Rapid growth and properties of large-aperture 98%-deuterated DKDP crystals显示文摘In this paper,a highly deuterated potassium dihydrogen phosphate(DKDP)crystal with sizes up to 318 mm×312 mm×265 mm was grown by the rapid-growth method.The synthesis tank device was specially designed to synthesize a higher deuterium concentration and high-purity DKDP solution.The deuterium content of the as-grown crystal,which was 97.9%,was determined by two methods,including infrared(IR)spectroscopy and thermo-gravimetric analysis(TGA)measurements.The performances of the 97.9%DKDP crystal,including transmission,absorption coefficient,and laserinduced damage threshold(LIDT)were measured.The results indicate that,in the near-infrared band,the transmission of the 97.9%DKDP crystal is higher than that of KDP and 70%DKDP crystals,and the absorption coefficient is lower.The LIDT of the crystal reached 23.2 J·cm^-2(R-on-1,1064 nm,3 ns),which meets the engineering requirements for use in optical applications. | Xumin Cai Xiuqing Lin Guohui Li Junye Lu Ziyu Hu Guozong Zheng | 2019 | High Power Laser Science and Engineering2019，7，3： | 4 |
| 4 | Rapid growth of a large-scale(600 mm aperture) KDP crystal and its optical quality显示文摘Potassium dihydrogen phosphate(KDP) single crystals are the only nonlinear crystals currently used for electro-optic switches and frequency converters in inertial confinement fusion research, due to their large dimension and exclusive physical properties. Based on the traditional solution-growth process, large bulk KDP crystals, usually with sizes up to600 × 600 mm2 so as to make a frequency doubler for the facility requirement loading highly flux of power laser, can be grown in standard Holden-type crystallizers, without spontaneous nucleation and visible defects, one to two orders of magnitude faster than by conventional methods. Pure water and KDP raw material with a few ion impurities such as Fe,Cr, and Al(less than 0.1 ppm) were used. The rapid-growth method includes extreme conditions such as temperature range from 60 to 35℃ , overcooling up to 5℃ , growth rates exceeding 10 mm/day, and crystal size up to 600 mm. The optical parameters of KDP crystals were determined. The optical properties of crystals determined indicate that they are of favorable quality for application in the facility. | Guohui Li Guozong Zheng Yingkun Qi Peixiu Yin En Tang Fei Li Jing Xu Taiming Lei Xiuqin Lin Min Zhang Junye Lu Jinbo Ma Youping He Yuangen Yao | 2014 | High Power Laser Science and Engineering2014，2，1： | 3 |
| 5 | Efficacy and safety of high-dose esomeprazole–amoxicillin dual therapy for Helicobacter pylori rescue treatment:a multicenter,prospective,randomized,controlled trial显示文摘Background:High-dose dual therapy(HDDT)with proton pump inhibitors(PPIs)and amoxicillin has attracted widespread attention due to its favorable efficacy in eradicating Helicobacter pylori(H.pylori).This study aimed to compare the efficacy and safety of high-dose PPI-amoxicillin dual therapy and bismuth-containing quadruple therapy for H.pylori rescue treatment.Methods:This was a prospective,randomized,multicenter,non-inferiority trial.Patients recruited from eight centers who had failed previous treatment were randomly(1:1)allocated to two eradication groups:HDDT(esomeprazole 40 mg and amoxicillin 1000 mg three times daily;theHDDTgroup)and bismuth-containing quadruple therapy(esomeprazole 40 mg,bismuth potassium citrate 220 mg,and furazolidone 100 mg twice daily,combined with tetracycline 500 mg three times daily;the tetracycline,furazolidone,esomeprazole,and bismuth[TFEB]group)for 14 days.The primary endpoint was the H.pylori eradication rate.The secondary endpoints were adverse effects,symptom improvement rates,and patient compliance.Results:A total of 658 patients who met the criteria were enrolled in this study.The HDDT group achieved eradication rates of 75.4%(248/329),81.0%(248/306),and 81.3%(248/305)asdetermined by the intention-to-treat(ITT),modified intention-totreat(MITT),and per-protocol(PP)analyses,respectively.The eradication rates were similar to those in the TFEB group:78.1%(257/329),84.2%(257/305),and 85.1%(257/302).The lower 95%confidence interval boundary(9.19%in the ITT analysis,9.21%in the MITT analysis,and9.73%in the PP analysis)was greater than the predefined non-inferiority margin of10%,establishing a non-inferiority of the HDDT group vs.the TFEB group.The incidence of adverse events in the HDDT group was significantly lower than that in the TFEB group(11.1%vs.26.8%,P<0.001).Symptom improvement rates and patients’compliance were similar between the two groups.Conclusions:Fourteen-day HDDT is non-inferior to bismuth-containing quadruple therapy,with fewer adverse effects and good treatment compliance,suggesting HDDT as an alternative for H.pylori rescue treatment in the local region.Trial registration:Clinicaltrials.gov,NCT04678492. | Hanxin Bi Xingxing Chen Yuxin Chen Xin Zhao Shasha Wang Jiehong Wang Ting Lyu Shuang Han Tao Lin Mingquan Li Donghong Yuan Junye Liu Yongquan Shi | 2022 | Chinese Medical Journal2022，，14： | 3 |
| 6 | Application of Multi-agent Particle Swarm Algorithm in Distribution Network Reconfiguration显示文摘An improved algorithm based on Multiagent particle swarm(MAS) is proposed to solve the distribution network reconfiguration problem in this paper.The approach is a combination of the learning, competition and cooperation mechanism of multi-agent technology and the strategies of Particle swarm optimization(PSO) algorithm. Using the Von Neumann topology structure in PSO algorithm, each particle represents an agent; each agent not only competes and cooperates with its neighborhood,but also absorbs the evolutionary mechanism of PSO algorithm, so as to share the information with the agent of global optimal. The rules of particle renovating reduce unfeasible solution in the process of particle renovating,and it is able to converge to global optimal accurately and quickly. Test on the IEEE 16-node, 32-node and 69-node system shows both a rapid convergence and a good robustness of this proposed approach. | SHU Dasong HUANG Zhixiong LI Junye ZOU Xiaoyang | 2016 | Chinese Journal of Electronics2016，25，6： | 3 |
| 7 | Experimental Research of Non-linear Tube Runner of Abrasive Flow Machining Process显示文摘 | Junye Li Lifeng Yang Weina Liu | 2014 | Advances in Mechanical Engineering2014，，： | 1 |
| 8 | Study of abrasive flow machining parameter optimization based on taguchi method显示文摘 | Li Junye Liu Weina Yang Lifeng | 2013 | Journal of Computational and Theoretical Nanoscience2013，10，12： | 1 |
| 9 | Efficient learning via simulation: A marginalized resample-move approach显示文摘 | Andras Fulop Junye Li | 2013 | Journal of Econometrics2013，，2： | 1 |
| 10 | Sequential Bayesian Analysis of Time-Changed Infinite Activity Derivatives Pricing Models显示文摘 | Junye Li | 2011 | Journal of Business & Economic Statistics2011，，4： | 1 |
| 11 | Volatility Components, Leverage Effects, and the Re- turn-volatility Relations显示文摘 | Junye Li | 2011 | Journal of Banking & Finance2011，，35： | 1 |
| 12 | Effector cells derived from naive T cells used in tumor immunotherapy of mice bearing B16 melanoma显示文摘 | Wen Ming Xu Weili Ren Lili Gao Fei Cui Naipeng Wen Junye Li Xinjiang Lin Lin Ma Zhenfeng Chen Baoping Cai Jianhui | 2014 | Chinese Medical Journal2014，，7： | 1 |
| 13 | Modelling nitrous oxide emissions from grazed grassland systems显示文摘 | Junye Wang Laura M. Cardenas Tom H. Misselbrook Steve Cuttle Rachel E. Thorman Changsheng Li | 2011 | Environmental Pollution2011，，： | 1 |
| 14 | Alzheimer's Disease and Methanol Toxicity (Part 2): Lessons from Four Rhesus Macaques (Macaca mulatta) Chronically Fed Methanol显示文摘 | Meifeng Yang Junye Miao Joshua Rizak Rongwei Zhai Zhengbo Wang Tanzeel Huma Ting Li Na Zheng Shihao Wu Yingwei Zheng Xiaona Fan Jianzhen Yang Jianhong Wang Shangchuan Yang Yuanye Ma Longbao Lü Rongqiao He Xintian Hu | 2014 | Journal of Alzheimer's Disease2014，，4： | 1 |
| 15 | Study of abrasive flow machining parameter optimi- zation based on Taguchi Method 显示文摘 | Junye Li Weina Liu Lifeng Yang Fengyu Sun | 2013 | Journal of Computational and Theoretical Nanoscience2013，10，12： | 1 |
| 16 | Two‑Dimensional Black Phosphorus Nanomaterials:Emerging Advances in Electrochemical Energy Storage Science显示文摘Two-dimensional black phosphorus(2D BP),well known as phosphorene,has triggered tremendous attention since the first discovery in 2014.The unique puckered monolayer structure endows 2D BP intriguing properties,which facilitate its potential applications in various fields,such as catalyst,energy storage,sensor,etc.Owing to the large surface area,good electric conductivity,and high theoretical specific capacity,2D BP has been widely studied as electrode materials and significantly enhanced the performance of energy storage devices.With the rapid development of energy storage devices based on 2D BP,a timely review on this topic is in demand to further extend the application of 2D BP in energy storage.In this review,recent advances in experimental and theoretical development of 2D BP are presented along with its structures,properties,and synthetic methods.Particularly,their emerging applications in electrochemical energy storage,including Li−/K−/Mg−/Na-ion,Li–S batteries,and supercapacitors,are systematically summarized with milestones as well as the challenges.Benefited from the fast-growing dynamic investigation of 2D BP,some possible improvements and constructive perspectives are provided to guide the design of 2D BP-based energy storage devices with high performance. | Junye Cheng Lingfeng Gao Tian Li Shan Mei Cong Wang Bo Wen Weichun Huang Chao Li Guangping Zheng Hao Wang Han Zhang | 2020 | Nano-Micro Letters2020，12，12： | 1 |
| 17 | From the Himalayan region or the Malay Archipelago:Molecular dating to trace the origin of a fern genus Phymatopteris(Polypodiaceae)显示文摘Phymatopteris Pic.Serm.,a derived polypodiaceous fern,is one of the many fern genera that still suffer from nomenclatural confusion.Its generic circumscription and phylogenetic relationships with other selligueoid ferns have been controversial,and its geographic origin,whether in the Himalayan region of continental Asia or in Malay Archipelago,is still unknown.A phylogeny of all selligueoid ferns based on 4 cpDNA(rbcL,trnL-F,rps4 and rps4-trnS) regions indicates that Phymatopteris is not monophyletic.Phymatopteris species are distributed in 5 well-supported clades that can be distinguished with frond-shape and frond-margin characters.All early-divergent species are from the Malaysian Archipelago,while the remaining species are all from the Himalayan region and form a recently diverged group that is largely unresolved,most likely having resulted from an explosive radiation.Divergence-time estimation suggests that the first diversification of selligueoid ferns occurred at ca.27 Ma in the Malaysian Archipelago,followed by migration into the Himalayan region around 20 Ma.The radiation of the Himalayan species occurred mostly within the last 20 million years,within the period of recent major uplifts of the Qinghai-Tibetan Plateau(between the early Miocene and the Pleistocene) and late-Cenozoic global cooling.Our evidence leads us to propose that the Malaysian Archipelago is the ancestral area for Phymatopteris. | LI ChunXiang LU ShuGang MA JunYe SUN XiaoYan GAI YongHua BARRINGTON David S YANG Qun | 2012 | Chinese Science Bulletin2012，57，35： | 1 |
| 18 | The Development of Nozzle Micro-hole Abrasive Flow Machining Equipment显示文摘 | Junye Li Weina Liu Lifeng Yang | 2011 | Applied Mechanics and Materials2011，，4447： | 1 |
| 19 | Robust hydrogel sensors for unsupervised learning enabled sign-to-verbal translation显示文摘Highly stretchable and robust strain sensors are rapidly emerging as promising candidates for a diverse of wearable electronics.The main challenge for the practical application of wearable electronics is the energy consumption and device aging.Energy consumption mainly depends on the conductivity of the sensor,and it is a key factor in determining device aging.Here,we design a liq-uid metal(LM)-embedded hydrogel as a sensing material to overcome the bar-rier of energy consumption and device aging of wearable electronics.The sensing material simultaneously exhibits high conductivity(up to 22 S m�1),low elastic modulus(23 kPa),and ultrahigh stretchability(1500%)with excel-lent robustness(consistent performance against 12000 mechanical cycling).A motion monitoring system is composed of intrinsically soft LM-embedded hydrogel as sensing material,a microcontroller,signal-processing circuits,Bluetooth transceiver,and self-organizing map developed software for the visu-alization of multi-dimensional data.This system integrating multiple functions including signal conditioning,processing,and wireless transmission achieves monitor hand gesture as well as sign-to-verbal translation.This approach provides an ideal strategy for deaf-mute communicating with normal people and broadens the application of wearable electronics. | Hude Ma Haiyang Qin Xiao Xiao Na Liu Shaolei Wang Junye Li Sophia Shen Shuqi Dai Mengmeng Sun Peiyi Li Xiaofang Pan Mingjun Huang Baoyang Lu Jun Chen Lidong Wu | 2023 | InfoMat2023，5，7： | 1 |
| 20 | Tile physical and functional interaction of NDRG2 with MSP58 in cells 显示文摘 | Zhang Jing Liu Junye Li Xia | 2007 | Biochem Biophys Res Commun2007，352，1： | 1 |
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