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| 1 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 2 | Multi-Method Chronometric Constraints on the Thermal Evolution of the Central Tianshan,NW China显示文摘The Tianshan orogenic belt is a major part of the southern Central Asian Orogenic Belt(CAOB),extending from west to east for over 2500 km through Uzbekistan,Tajikistan,Kyrgyzstan and Kazakhstan to Xinjiang in NW China,and contains the record of multi-phase tectonothermal evolution.Till now,various research methods have been employed to reveal the | YIN Jiyuan CHEN Wen XIAO Wenjiao ZHANG Bin CAI Keda | 2015 | Acta Geologica Sinica(English Edition)2015，89，6： | 4 |
| 3 | Theoretical study on rotary-sliding disk triboelectric nanogenerators in contact and non-contact modes显示文摘摩擦电 nanogenerator (TENG ) 作为收获技术的一个新、有效的机械精力出现了。在这个工作,为有栅栏结构的旋转滑动的磁盘 TENG 的一个理论模型被构造,包括 dielectric-to-dielectric 和 conductor-to-dielectric 盒子。有限元素方法(女性) 被利用描绘在接触和非接触模式工作的 rotarysliding 磁盘 TENG 的基本物理。磁盘 TENG 的基本性质被发现被象 tribo 表面间距,栅栏数字,和几何尺寸那样的结构的参数控制。从女性的计算,一种近似 V-Q- 关系通过插值方法被造,然后有任意的负担抵抗的 TENG 动态产量特征是数字地计算的。最后,结构的参数和旋转上的力量和匹配的抵抗评估的输出的相关性被揭示。现在的工作提供旋转滑动的磁盘 TENG 的工作原则的深入的理解并且为在特定的应用程序优化 TENG 输出性能用作重要指导。 | Tao Jiang Xiangyu Chen Keda Yang Changbao Han Wei Tang Zhong Lin Wang | 2016 | Nano Research2016，9，4： | 3 |
| 4 | The advance of adjuvant treatment for triple-negative breast cancer显示文摘Triple-negative breast cancer(TNBC)is a subtype of breast cancer characterized by its highly aggressive behavior,early recurrence,and poor outcomes,when compared with other subtypes.Due to the absence of the estrogen receptor,progesterone receptor,and human epidermal growth factor receptor 2 expression,TNBC lacks meaningful biomarkers and an effective therapeutic strategy.Chemotherapy remains the main adjuvant treatment for patients with TNBC.Anthracycline/taxane-based regimens are the standard of care in adjuvant settings.The addition of capecitabine or platinum may offer extra benefits to patients with TNBC,but at the cost of increased toxicity or adverse events.Dose-dense chemotherapy may enhance treatment efficacy in patients who are able to tolerate the treatment regimen,especially in high-risk patients.As a heterogenous disease,TNBC can be classified into several molecular subtypes according to genomic or transcriptional features,which may indicate potential targets for more precise and individualized treatment strategies.With our increased understanding of signal pathways associated with TNBC,as well as the discovery of novel biomarkers indicative of TNBC prognosis,several new therapeutic options are under investigation,and some have already reported good results.In this review,we summarized the current conventional therapeutic strategies and emerging clinical trials regarding adjuvant treatment for TNBC.Furthermore,we evaluated the prognostic value of several potential targets and the progress of targeted therapy in TNBC,both in neoadjuvant and adjuvant settings. | Jingyu Ge Wenjia Zuo Yiyu Chen Zhiming Shao Keda Yu | 2022 | Cancer Biology & Medicine2022，19，2： | 2 |
| 5 | Feasibility of sentinel lymph node biopsy omission after integration of ^(18)F-FDG dedicated lymph node PET in early breast cancer: a prospective phase II trial显示文摘Objective:Sentinel lymph node biopsy(SLNB)is currently the standard of care in clinically node negative(cN0)breast cancer.The present study aimed to evaluate the negative predictive value(NPV)of 18F-FDG dedicated lymph node positron emission tomography(LymphPET)in cN0 patients.Methods:This was a prospective phase II trial divided into 2 stages(NCT04072653).In the first stage,cN0 patients underwent axillary LymphPET followed by SLNB.In the second stage,SLNB was omitted in patients with a negative preoperative axillary assessment after integration of LymphPET.Here,we report the results of the first stage.The primary outcome was the NPV of LymphPET to detect macrometastasis of lymph nodes(LN-macro).Results:A total of 189 patients with invasive breast cancer underwent LymphPET followed by surgery with definitive pathological reports.Forty patients had LN-macro,and 16 patients had only lymph node micrometastasis.Of the 131 patients with a negative LymphPET result,16 patients had LN-macro,and the NPV was 87.8%.After combined axillary imaging evaluation with ultrasound and LymphPET,100 patients were found to be both LymphPET and ultrasound negative,9 patients had LN-macro,and the NPV was 91%.Conclusions:LymphPET can be used to screen patients to potentially avoid SLNB,with an NPV>90%.The second stage of the SOAPET trial is ongoing to confirm the safety of omission of SLNB according to preoperational axillary evaluation integrating LymphPET. | Junjie Li Jingyi Cheng Guangyu Liu Yifeng Hou Genghong Di Benglong Yang Yizhou Jiang Liang Huang Feilin Qu Sheng Chen Yan Wang Keda Yu Zhimin Shao | 2022 | Cancer Biology & Medicine2022，19，7： | 1 |
| 6 | Structural,Kinematic and Geochronological Study of the Main Tianshan Shear Zone in the Borohoro Ranges,NW China显示文摘The western segment of the Main Tianshan shear zone(MTSZ)branches into three major dextral strike-slip shear zones in the Borohoro Ranges,northwestern China.Mylonitic rocks within these zones exhibit vertical foliations,subhorizontal lineations,and dextral kinematics.The microstructures and CPO patterns of calcite and quartz in the tectonites suggest shearing at temperatures of 200℃ to 500℃ or above.The amount of dextral displacement along the zones is less than 100 km.LA-ICP-MS U-Pb dating of zircons from some pre-kinematic granites gave ages of 364-325 Ma and 316 Ma,and zircons from a syn-kinematic leucogranite gave an age of 291 Ma.We propose that dextral shearing along the MTSZ started in the earliest Permian.Our data indicate that collision between the Yili and Junggar plates might have finished before 325 Ma or 316 Ma,with a tectonic transformation from 325 Ma to 300 Ma,resulting in intracontinental transpression from 300 Ma or 291 Ma.We suggest that the formation of the Kazakhstan orocline(KO)took place in two stages,with the early stage of bending driven by convergence related to oblique subduction,and the late stage possibly associated with lateral disarticulation as a result of the dextral strike-slip shear zones. | LIU Tianlun CHEN Siyu ZHANG Bo CAI Keda HAN Baofu QU Junfeng GUO Lei WANG Meng | 2021 | Acta Geologica Sinica(English Edition)2021，95，5： | 1 |
| 7 | CACA Guidelines for Holistic Integrative Management of Breast Cancer显示文摘Purpose:Breast cancer is now the most common malignant tumor worldwide.About one-fourth of female cancer patients all over the world sufer from breast cancer.And about one in six female cancer deaths worldwide is caused by breast cancer.In terms of absolute numbers of cases and deaths,China ranks frst in the world.The CACA Guidelines for Holistic Integrative Management of Breast Cancer were edited to help improve the diagnosis and comprehensive treatment in China.Methods:The Grading of Recommendations Assessment,Development and Evaluation(GRADE)was used to classify evidence and consensus.Results:The CACA Guidelines for Holistic Integrative Management of Breast Cancer include the epidemiology of breast cancer,breast cancer screening,breast cancer diagnosis,early breast cancer treatment,advanced breast cancer treatment,follow-up,rehabilitation,and traditional Chinese medicine treatment of breast cancer patients.Conclusion:We to standardize the diagnosis and treatment of breast cancer in China through the formulation of the CACA Guidelines. | Jiong Wu Daiming Fan Zhimin Shao Binghe Xu Guosheng Ren Zefei Jiang Yongsheng Wang Feng Jin Jin Zhang Qingyuan Zhang Fei Ma Jinli Ma Zhonghua Wang Shusen Wang Xiaojia Wang Shu Wang Haibo Wang Tao Wang Xiang Wang Jing Wang Jia Wang Biyun Wang Li Fu Hongyuan Li Yehui Shi Lu Gan Yunjiang Liu Jian Liu Zhenzhen Liu Qiang Liu Qiang Sun Wenwu Cheng Keda Yu Zhongsheng Tong Xinhong Wu Chuangui Song Jianguo Zhang Jian Zhang Junjie Li Bin Li Man Li Huiping Li Wentao Yang Hongjian Yang Benlong Yang Hong Bu Juping Shen Zhenzhou Shen Yiding Chen Ceshi Chen Da Pang Zhimin Fan Ying Zheng Xiaoli Yu Guangyu Liu Xichun Hu Yiqun Ling Jinhai Tang Yongmei Yin Cuizhi Geng Peng Yuan Yajia Gu Cai Chang Xuchen Cao Yuan Sheng Yuanxi Huang Jian Huang Weijun Peng Xiaohua Zeng Yuntao Xie Ning Liao Committee of Breast Cancer Society,Chinese Anti-Cancer Association | 2022 | Holistic Integrative Oncology2022，1，1： | 0 |
| 8 | Recombinant human interferon-α1b inhibits SARS-CoV-2 better than interferon-α2b in vitro显示文摘Dear Editor,The coronavirus disease 2019(COVID-19)outbreak,has spread across the world(Wu et al.,2020).The causative agent of COVID-19,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is highly pathogenic and infectious,which become a major public health hazard that has had a devastating social and economic impact worldwide(Li Q.Q.et al.,2020).Variants of the virus have emerged that behave differently(CDC2021;Gobeil et al.,2020;Leung et al.,2021).Some of them show increased infectivity(Li Q.et al.,2020;Zhang et al.,2020)and may escape from neutralizing antibodies(Weisblum et al.,2020). | Danrong Shi Keda Chen Xiangyun Lu Linfang Cheng Tianhao Weng Fumin Liu Nanping Wu Lanjuan Li Hangping Yao | 2022 | Virologica Sinica2022，37，2： | 0 |
| 9 | The protective effects of a D-tetra-peptide hydrogel adjuvant vaccine against H7N9 influenza virus in mice显示文摘Repeated waves of influenza virus H7N9 epidemics after 2013 have caused severe influenza in humans,with mortality reaching approximately 40%–50%.To prevent possible pandemics,the development of highly effective vaccines against influenza virus H7N9 is highly desired.In the present study,by taking advantage of the D-tetra-peptide adjuvant(G^(D)F^(D)F^(D)Y),we reported a simple method to prepare H7N9 vaccines.Naproxen(Npx),with good anti inflammatory and broad anti-viral effects,was employed as an N-terminal capping group to construct a hydrogel precursor,Npx-G^(D)F^(D)F^(D)Y.The hydrogel adjuvant was prepared using a routine heating cooling protocol and the final vaccine was ready after mixing with the split A/Zhejiang/DTID-ZJU01/2013(H7N9)antigen by vortexing.Compared with the traditional Al(OH)_(3) adjuvant vaccine and the split vaccine,our hydrogel adjuvant vaccine showed the best preventive effects against H7N9 infection.A mechanistic study illustrated that higher antibody responses and variations in cytokine expression might account for its increased protective effects.Our strategy demonstrated the advantages of a peptide hydrogel adjuvant in the application of vaccines against H7N9 and demonstrated its potential application in vaccines against emerging threats from other viruses. | Keda Chen Xiaoxin Wu Qingjing Wang Ying Wang Haiyan Zhang Shuai Zhao Chaonan Li Zhiwen Hu Zhimou Yang Lanjuan Li | 2023 | Chinese Chemical Letters2023，34，1： | 0 |
| 10 | Delta(B.1.617.2)inactivated vaccine candidate elicited neutralizing antibodies to SARS-CoV-2 and circulating variants in rhesus macaques显示文摘Dear Editor,The coronavirus disease 2019(COVID-19)pandemic has resulted in 763 million cases and over 6 million deaths as of April 2023.Given the high prevalence and widespread distribution of coronaviruses,the genetic diversity and frequent recombination of their genomes,as well as the increased activity at the human-animal interface,are critical for global public health and socioeconomic impact(Zhu et al.,2020). | Yanjun Zhang Haiyan Mao Ju Li Jianhua Li Chen Huang Jiaxuan Li Minglei Chu Fengbo Xue Linhui Wang Zhongbiao Fang Zhen Wang Jinan Wu Keda Chen | 2023 | Virologica Sinica2023，38，4： | 0 |
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