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| 1 | microRNA-29b is a novel mediator of Sox2 function in the regulation of somatic cell reprogramming显示文摘成纤维细胞能由 Yamanaka 因素(OSKM ) 的申请是进导致的 pluripotent 干细胞(iPSCs ) 的 reprogrammed,但是位于这 reprogramming 下面的机制仍然保持糟糕理解。这里,我们报导 Sox2 直接调整内长的 microRNA-29b (miR-29b ) 表示为调停 OSKM 、调停 OSK 的 reprogramming 在 iPSC 产生和那 miR-29b 表情期间被要求。Dnmt3a 和 Dnmt3b 在 miR-29b 和那 Dnmt3a 和 Dnmt3b 表示的 vivo 目标的机械学的研究表演相反地在 reprogramming 期间与 miR-29b 表示被相关。而且, reprogramming 上的 miR-29b 的效果能被 Dnmt3a 或 Dnmt3b overexpression 堵住。进一步的实验显示发信号的 miR-29b-DNMT 显著地涉及 DNA methylation 相关的 reprogramming 事件的规定,例如 mesenchymal-to-epithelial 转变(相遇) 并且 Dlk1-Dio3 区域抄写。因此,我们的研究不仅表明 miR-29b 是 reprogramming 因素 Sox2 的一个新奇调停人而且为 Sox2 在驾驶表明调整 DNA 的轴的 miR-29b-DNMT 的 multistep 机制提供证据 methylation 相关的事件在 reprogramming 期间。 | Xudong Guo Qidong Liu Guiying Wang Songcheng Zhu Longfei Gao Wujun Hong Yafang Chen Minjuan Wu Houqi Liu Cizhong Jiang Jiuhong Kang | 2013 | Cell Research2013，23，1： | 9 |
| 2 | Novel Video Steganography Algorithm Based on Secret Sharing and Error-Correcting Code for H.264/AVC显示文摘In this paper, we analyze the video steganography technique, which is used to ensure national security and the confidentiality of the information of governmental agencies and enterprises. Videos may be used to transmit secrets and conduct covert communication. As such, we present an algorithm based on a secret sharing scheme and an Error-Correcting Code(ECC), which combines Grey Relational Analysis(GRA) with a partition mode in video compression standard H.264/AVC. First, we process secret information by secret sharing, and then use an ECC to process the obtained information. Moreover, we choose the Discrete Cosine Transform(DCT) blocks using GRA, and then use rules to hide the pretreated information in DCT coefficients of the video frames. Experimental results indicate that our algorithm has good invisibility, better robustness, good anti-steganalysis ability, and little influence on the bit rate of the video carrier. In addition, the bit error rate is low after attacks such as noise, filtering,or frame loss in the simulation environment. | Yingnan Zhang Minqing Zhang Xiaoyuan Yang Duntao Guo Longfei Liu | 2017 | Tsinghua Science and Technology2017，22，2： | 4 |
| 3 | METTL4 is an snRNA m^6Am methyltransferase that regulates RNA splicing显示文摘Dear Editor,Protein coding mRNAs and non-coding RNAs are extensively modifed by chemical modifications,'including methylation of the N^6position of adenosine(m^6A).^2While mRNA internal m^6A methylation is mediated by METTL3 and METTL14,which are members of the MT-A70 family,N^6-methylation of cap-adjacent No,2'-O-dimethyladenosine(m^6Am)is catalyzed by PCIF1.^3-6 Non-coding RNAs are also m^6Am methylated internally,7but the corresponding enzyme remains unknown.Here we provide evidence that METTL4 mediates internal m^6Am methylation of U2 small nuclear RNA(snRNA). | Hao Chen Lei Gu Esteban A.Orellana Yuanyuan Wang Jiaojiao Guo Qi Liu Longfei Wang Zhangfei Shen Hao Wu Richard I.Gregory Yi Xing Yang Shi | 2020 | Cell Research2020，30，6： | 4 |
| 4 | Temperature-dependent evolution of surface charge screening and polarization at ferroelectric surfaces显示文摘The polarization and domain behavior on the surface of a ferroelectric material are significantly affected by the screening processes [1-12].Recently,there has been a notable increase in the theoretical calculations and experiments investigating the dynamics of polarization and domain behaviors coexisting in phase transitions of ferroelectric materials. | LongFei Wang Yi Luo JieSu Wang XiuShi Huang ZhaoMeng Gao TieYing Yang XiaoLong Li Pei Li KuiJuan Jin WeiFeng Zhang HaiZhong Guo | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，8： | 3 |
| 5 | Searching for the Nano-Hertz Stochastic Gravitational Wave Background with the Chinese Pulsar Timing Array Data ReleaseⅠ显示文摘Observing and timing a group of millisecond pulsars with high rotational stability enables the direct detection of gravitational waves(GWs).The GW signals can be identified from the spatial correlations encoded in the times-of-arrival of widely spaced pulsar-pairs.The Chinese Pulsar Timing Array(CPTA)is a collaboration aiming at the direct GW detection with observations carried out using Chinese radio telescopes.This short article serves as a“table of contents”for a forthcoming series of papers related to the CPTA Data Release 1(CPTA DR1)which uses observations from the Five-hundred-meter Aperture Spherical radio Telescope.Here,after summarizing the time span and accuracy of CPTA DR1,we report the key results of our statistical inference finding a correlated signal with amplitude logA_(c)=-14.4_(-2.8)^(+1.0)for spectral index in the range ofα∈[-1.8,1.5]assuming a GW background(GWB)induced quadrupolar correlation.The search for the Hellings–Downs(HD)correlation curve is also presented,where some evidence for the HD correlation has been found that a 4.6σstatistical significance is achieved using the discrete frequency method around the frequency of 14 n Hz.We expect that the future International Pulsar Timing Array data analysis and the next CPTA data release will be more sensitive to the n Hz GWB,which could verify the current results. | Heng Xu Siyuan Chen Yanjun Guo Jinchen Jiang Bojun Wang Jiangwei Xu Zihan Xue RNicolas Caballero Jianping Yuan Yonghua Xu Jingbo Wang Longfei Hao Jingtao Luo Kejia Lee Jinlin Han Peng Jiang Zhiqiang Shen Min Wang Na Wang Renxin Xu Xiangping Wu Richard Manchester Lei Qian Xin Guan Menglin Huang Chun Sun Yan Zhu | 2023 | Research in Astronomy and Astrophysics2023，23，7： | 3 |
| 6 | Experimental Study on Dynamic Mechanical Properties of Sprayed Concrete-Surrounding Rock Combined Body显示文摘To investigate the dynamic response problem of the double medium formed by the adherence of sprayed concrete and surrounding rock in the tunnel,a split Hopkinson pressure bar of 75 mm in diameter was adopted at the ages of 3,7 and 10 d.Experimental results showed that dynamic compressive strength and dynamic increase factors(DIF)of the combined bodies increase with the strain rate.With the growth of strain rate,the critical strain of the combined bodies first increases,then deceases.Furthermore,the combined bodies of 3 d reveal the plastic property and brittle property for 7 d and 10 d when the strain rate is over 80/s.The failure characteristic of the sprayed concrete changes from tearing strain damage to crushing damage as the growth of strain rate,and the failure characteristic of rock presents the tensile failure mode as demonstrated by the scanning electron microscope(SEM). | Dongming Guo Pengyang Yan Longfei Fan Yingshi Zhang Xiaoye Wang | 2019 | Journal of Beijing Institute of Technology2019，28，2： | 3 |
| 7 | Aluminum hydride for solid-state hydrogen storage:Structure,synthesis, thermodynamics, kinetics, and regeneration显示文摘Aluminum hydride(AlH3) is a binary metal hydride that contains more than 10.1 wt% of hydrogen and possesses a high volumetric hydrogen density of 148 kg H2 m^(-3).Pristine AlH3 can readily release hydrogen at a moderate temperature below 200℃.Such high hydrogen density and low desorption temperature make AlH3 one of most promising hydrogen storage media for mobile application.This review covers the research activity on the structures,synthesis,decomposition thermodynamics and kinetics,regeneration and application validation of AlH3 over the past decades.Finally,the future research directions of AlH3 as a hydrogen storage material will be revealed. | Haizhen Liu Longfei Zhang Hongyu Ma Chenglin Lu Hui Luo Xinhua Wang Xiantun Huang Zhiqiang Lan Jin Guo | 2021 | Journal of Energy Chemistry2021，30，1： | 2 |
| 8 | Natural astaxanthin enhanced antioxidant capacity and improved semen quality through the MAPK/Nrf2 pathway in aging layer breeder roosters显示文摘Background:Natural astaxanthin(ASTA)has strong antioxidant properties and has been widely used as a health product to improve human health.However,the effects of ASTA on the reproductive performance of aging roosters have been poorly studied.We aimed to investigate the effects of dietary ASTA on semen quality and antioxidant capacity in aging roosters and to explore the potential mechanism of semen quality change via antioxidation defense system.Methods:In the present study,9653-week-old Jinghong No.1 layer breeder roosters were fed a corn-soybean meal basal diet containing 0,25,50,or 100 mg/kg ASTA for 6 weeks.Results:Semen quality in the ASTA groups remarkably improved than that in the control group,and antioxidant activities,the abilities to scavenge hydroxyl radicals and superoxide anions,increased gradually with ASTA addition(P<0.05).In addition,the mRNA levels of antioxidant enzymes as well as the mRNA and protein levels of the mitogen-activated protein kinase(MAPK)and nuclear factor-erythroid 2-related factor 2(Nrf2)were markedly increased in the 50-100 mg/kg ASTA group(P<0.05).Conclusions:Collectively,these results demonstrate that dietary ASTA may improve semen quality by increasing antioxidant enzyme activities and the ability to scavenge hydroxyl radicals,which may be related to upregulation of the MAPK/Nrf2 pathway. | Shan Gao Nuo Heng Fang Liu Yong Guo Yu Chen Liang Wang Hemin Ni Xihui Sheng Xiangguo Wang Kai Xing Longfei Xiao Xiaolong Qi | 2022 | Journal of Animal Science and Biotechnology2022，13，2： | 2 |
| 9 | Simultaneous Determination of Amoxicillin and Ampicillin in Eggs by Reversed-Phase High-Performance Liquid Chromatography with Fluorescence Detection using Pre-Column Derivatization显示文摘 | Kaizhou Xie Longfei Jia Dong Xu Huisheng Guo Xing Xie Yuping Huang Xuesen Chen Wenbin Bao Guojun Dai Jinyu Wang | 2012 | Journal of Chromatographic Science2012，，7： | 1 |
| 10 | Study on the Changes of the Major Nutrient Elements During Simple Composting Process of Dry Chicken Manure显示文摘[Objectives]This study was conducted to provide a theoretical basis for production and application of chicken manure compost.[Methods]With dry manure as a material,the variations of the major nutrients during simple composting process of dry chicken manure were studied,in order to get the best fermentation method.[Results]Chicken manure should not be preserved wet,but should be preserved after air-drying and fermented before use.Necessary moisture,simple sealing treatment and a certain amount of N element were conducive to simple fermentation of chicken manure.The treatments in which the chicken manure was wrapped around and compacted,added with an appropriate amount of water(50%-60%)and naturally fermented,or was wrapped around and compacted and added with an appropriate amount of water(50%-60%)and 0.2%of urea,were more appropriate for the production directly.[Conclusions]This study provides a theoretical basis for the actual production and application of chicken manure compost. | Jintao XU Longfei LI Lijuan GAO Yong GUO Hai'e ZHANG Minghui JI Baofeng HAO | 2020 | Agricultural Biotechnology2020，9，6： | 1 |
| 11 | AgPdCo hollow nanospheres electrocatalyst with high activity and stability toward the formate electrooxidation显示文摘The widespread commercial application of direct formate fuel cell(DFFC)is limited by the lack of efficient electrocatalysts for the formate oxidation reaction(FOR).AgPdCo hollow nanospheres(H-NSs)with jagged surfaces are successfully synthesized via a facile method involving the wet-chemical synthesis of AgPdCo nanospheres(NSs)and galvanic replacement reaction between Pd salt and AgPdCo NSs.Surpassing Ag_(30)Pd_(69)Co_(1) NSs and most of previously reported electrocatalysts,Ag_(9)Pd_(90)Co_(1) H-NSs exhibit extremely high FOR activity with a peak current density of 3.08 A·mg_(Pd)^(−1).Apart from the competitive activity,Ag_(9)Pd_(90)Co_(1) H-NSs show greatly improved chronoamperometric and cycling stability,whereby the current density retains about 0.24 A·mg_(Pd)^(−1) after 3,600 s electrocatalysis and the mass activity maintains 54.06%of the initial value after 500 cycles.The unique hollow nanosphere and synergistic effect are responsible for the enhanced activity and stability.This study will provide new clues for the development of outstanding electrocatalysts. | Qiao Wang Fuyi Chen Quan Tang Longfei Guo Tao Jin Bowei Pan Junpeng Wang Zhen Li Bo Kou Weiqi Bian | 2021 | Nano Research2021，14，7： | 1 |
| 12 | Negative exponential behavior of image mutual information for pseudo-thermal light ghost imaging: observation, modeling, and verification显示文摘When using the image mutual information to assess the quality of reconstructed image in pseudothermal light ghost imaging, a negative exponential behavior with respect to the measurement number is observed. Based on information theory and a few simple and verifiable assumptions, semi-quantitative model of image mutual information under varying measurement numbers is established. It is the Gaussian characteristics of the bucket detector output probability distribution that leads to this negative exponential behavior. Designed experiments verify the model. | Junhui Li Bin Luo Dongyue Yang Longfei Yin Guohua Wu Hong Guo | 2017 | Science Bulletin2017，62，10： | 1 |
| 13 | A method to determine the bonded-particle model parameters for simulation of ores显示文摘The bonded-particle model(BPM)is commonly used in the numerical analysis of ore samples.To improve the accuracy of simulating the mechanical process of ore process of ore crushing in a crusher,the parameters of the BPM for the ore must be calibrated.In this study,a calibration method was proposed for the scientific determination of the parameters of the BPM for ore undergoing uniaxial compression.First,physical tests and simulations were conducted to determine the mechanical response(uniaxial compressive strength and macroscopic stiffness)of ore during uniaxial compression.Then,the sensitivity of the mechanical response to the values of microscopic parameters was tested using a Plackett-Burman design.Next,the microscopic parameters with the greatest impact on the response were identified,and the range of parameters that met the target response was determined using a steepest ascent design;Second,a second-order model of the mechanical response was established using the sensitive parameters by combining a Box-Behnken design with response surface methodology to obtain the optimal BPM parameters.Simulation tests showed that the normal stiffness per unit area,critical shear stress,and bonded disk radius had significant effects on the uniaxial compressive strength(UCS)and macroscopic stiffness(MS).To verify the validity of the proposed calibration method,laboratory tests were conducted.The consistency of the simulation results with experimental results indicated that response surface methodology with the Plackett-Burman design,steepest ascent design,and Box-Behnken design can be an effective method for calibrating the BPM of ores. | Shuwei Wu Guoqiang Wang Longfei Fan Wei Guan Jianbo Guo Zhengbin Liu Yukuan Wang | 2024 | Particuology2024，86，3： | 0 |
| 14 | Study on Microblog Dissemination Law in View of Forwarding显示文摘Forwarding is a major means of information dissemination on the Microblog platform.The article,combining static analysis and dynamic analysis,takes Microblog forwarding as the object of study,and studies the network topology of grass-roots Microblog forwarding users.It also studies the correlation between characteristic quantity and forwarding times of Microblog network topology.Furthermore,it conducts modification on virus transmission model,builds and verifies the Microblog forwarding dynamical model.The study finds out that Microblog postings present qute strong dissemination capacity on the initial stage,and some Microblog postings with many forwarding times and long duration of forwarding process due to the dynamic growth of the forwarding user network and the joining of strong nodes make network infection density decrease in some phases. | CHEN Xia JIA Yuan GUO Longfei | 2014 | China Communications2014，11，2： | 0 |
| 15 | Exosomal miR-218 regulates the development of endometritis in dairy cows by targeting TGIF2/TGF-βpathway显示文摘Endometritis affects the reproductive capacity of dairy cows and leads to serious economic losses in dairy farming.Clarification of the pathogenesis of endometritis is necessary to improve the reproductive efficiency of dairy cows.Exosomes and their miRNAs have been proven to play an important role in inflammatory regulation.Exosomal miR-218 is a differentially expressed miRNA found in endometrial epithelial cells(EECs)under endometrial inflammation.Therefore,we investigated the expression of miR-218 in the uterine tissue of dairy cows,lipopolysaccharide(LPS)treated EECs,exosomal vesicles,and regulation of exosomal miR-218 by targeting TGIF-2 inducible factor homology frame 2(TGIF2)/transforming growth factor-beta(TGF-β).The expression of miR-218 was suppressed in inflammatory uterine tissues and LPS treated EECs.The expression of TGIF2 and TGF-βin inflammatory uterine tissues and LPS treated EECs was significantly higher than those in healthy uterine tissues and EECs(p<0.01).Interestingly,miR-218 derived from donor cells was found to regulate the expression of the target gene TGIF2 in recipient cells through the fusion of exosomes.Concurrently,the expression of its target gene TGIF2 was also suppressed by miR-218 in donor cells resulting in fewer TGIF2 being transported into recipient cells with exosomal fusion.This may be a novel mechanism of miRNAs-mediated regulation and provides a new reference for analyzing the pathogenesis of endometritis in dairy cows. | CHANG CHEN LIMIN QIAO KAIJUN GUO YINGQIU WANG MENGYI YUAN BOFAN FU XIAOBO GAO HEMIN NI LONGFEI XIAO XIANGGUO WANG | 2022 | BIOCELL2022，46，11： | 0 |
| 16 | A Training System of Pear Trees for Simplified High-density Cultivation显示文摘In view of the deficiencies of training technologies during constructing pear orchards by modern simplified dense-planting cultivation with ordinary pear seedlings widely used in production,a simple and easy-to-operate training method was proposed,mainly including constructing fence nets,determining low main trunks,leaving buds at the northwest position,multiple bud removal,winding and notching,simplified branch supporting,and simplified branch pulling. | Jintao XU Longfei LI Lijuan GAO Minghui JI Yong GUO Shujun ZHAO Hai'e ZHANG Baofeng HAO | 2022 | Agricultural Biotechnology2022，11，1： | 0 |
| 17 | Effects of acupotomy on the activity of osteoclasts and osteoblasts in the subchondral bone of rabbits with early and mid-stage knee osteoarthritis models显示文摘Objective:To investigate whether acupotomy could inhibit subchondral bone remodeling in knee osteoarthritis(KOA)rabbits by regulating the activity of osteoblasts and osteoclasts.Methods:KOA rabbits were prepared by immobilization for 6 and 9 weeks by Videman method.Nine groups of rabbits(control,6 weeks and 9 weeks model,6 weeks and 9 weeks acupotomy,6 weeks and 9 weeks electroacupuncture,and 6 weeks and 9 weeks drug groups)received acupotomy,electroacupuncture and risedronate sodium intervention,respectively,for 3 weeks.Results:Acupotomy can inhibit the activity of osteoclasts and osteoblasts in subchondral bone by reducing the proteins expression of cathepsin K(CK)and tartrate-resistant acid phosphatase(TRAP)and decreasing the proteins expression of osteocalcin(OCN)and alkaline phosphatase(ALP),to intercept the abnormal bone resorption and bone formation of subchondral bone in 6-week and 9-week immobilization-induced KOA rabbits.Conclusion:These findings indicated that acupotomy may be more advantageous than risedronate sodium intervention in modulating subchondral bone remodeling in KOA rabbits,especially in 9-week immobilization-induced KOA rabbits. | Mira Lee Yan Guo Xilin Chen Longfei Xing Wei Zhang Lia Chang Changqing Guo | 2023 | Journal of Traditional Chinese Medical Sciences2023，10，3： | 0 |
| 18 | CRMP2 promotesthe trafficking of phosphorylated AMPA receptor GluA2 subunit显示文摘CRMP2 is one of the well-studied members of the CRMPs family,which has been demonstrated not only play the roles in neurite extension,dendrites and dendritic spine development,but also in the AMPA receptor trafficking.However,the role of CRMP2 on the trafficking of AMPA receptor GluA2 subunit especially phosphorylated GluA2 is unknown.GST-Pull down and C-IP assays,immunofluorescence staining and whole cell patch clamp recording technique were performed in this study.The results showed that CRMP2 interacted with wild-type GluA2 and promoted the surface expression of wild-type GluA2.No matter GluA2 S880 was exogenously phosphorylated by phorbol myristate acetate(TPA)or endogenously phosphorylated by PKC5,CRMP2 can promote the surface expression of phosphorylated GluA2 and enhance its amplitude and frequency of mEPSCs,increasing the slope of the I-V curve. | Wu Jiaming Cheng Longfei Li Jiong Zhang Jifeng Guo Guoqing Chen Keen | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 19 | Preparation and enhanced properties of ZrMOF@CdTe nanoparticles with high-density quantum dots显示文摘ZrMOF@CdTe nanoparticles(NPs)with high fluorescence were synthe-sized by hydrothermal method.The morphology,particle size distribution,compositions,fluorescence properties and stability of the synthesized ZrMOF@CdTe were analyzed via the characterization by TEM,ICP-AES and fluorescence spectrophotometry,and the effects of the reaction time and pH value on the fluorescent property of ZrMOF@CdTe NPs were discussed.The results show that ZrMOFs could maintain its morphology and structure well during the process of loading CdTe quantum dots.With the increase of the loading reaction time,the red-shifted emission peaks of ZrMOF@CdTe NPs appear,and their fluorescence gradually changes from green to red color.With the increase of the pH value and temperature of the hydrothermal reaction,the fluorescence of ZrMOF@CdTe NPs was also consistent with the red-shifted change.The fluorescent property of ZrMOF@CdTe NPs could be remained for more than 3 months.Therefore,ZrMOF@CdTe NPs synthesized by the hydrothermal method have the characteristics of simple operation,adjustable fluorescent color and high stability,and the potential application in the fields of biological detection and sensing is expected. | Xin LIU Xiangling REN Longfei TAN Wenna GUO Zhongbing HUANG Xianwei MENG | 2020 | Frontiers of Materials Science2020，14，2： | 0 |
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