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| 1 | Esophageal motility abnormalities in gastroesophageal reflux disease显示文摘Esophageal motility abnormalities are among the main factors implicated in the pathogenesis of gastroesophageal reflux disease. The recent introduction in clinical and research practice of novel esophageal testing has markedly improved our understanding of the mechanisms contributing to the development of gastroesophageal reflux disease, allowing a better management of patients with this disorder. In this context, the present article intends to provide an overview of the current literature about esophageal motility dysfunctions in patients with gastroesophageal reflux disease. Esophageal manometry, by recording intraluminal pressure, represents the gold standard to diagnose esophagealmotility abnormalities. In particular, using novel techniques, such as high resolution manometry with or without concurrent intraluminal impedance monitoring, transient lower esophageal sphincter (LES) relaxations, hypotensive LES, ineffective esophageal peristalsis and bolus transit abnormalities have been better defined and strongly implicated in gastroesophageal reflux disease development. Overall, recent findings suggest that esophageal motility abnormalities are increasingly prevalent with increasing severity of reflux disease, from nonerosive reflux disease to erosive reflux disease and Barrett's esophagus. Characterizing esophageal dysmotility among different subgroups of patients with reflux disease may represent a fundamental approach to properly diagnose these patients and, thus, to set up the best therapeutic management. Currently, surgery represents the only reliable way to restore the esophagogastric junction integrity and to reduce transient LES relaxations that are considered to be the predominant mechanism by which gastric contents can enter the esophagus. On that ground, more in depth future studies assessing the pathogenetic role of dysmotility in patients with reflux disease are warranted. | Irene Martinucci Nicola de Bortoli Maria Giacchino Giorgia Bodini Elisa Marabotto Santino Marchi Vincenzo Savarino Edoardo Savarino | 2014 | World Journal of Gastrointestinal Pharmacology and Therapeutics2014，5，2： | 24 |
| 2 | Gastro-oesophageal reflux and gastric aspiration in idiopathic pulmonary fibrosis patients显示文摘 | Savarino E Carbone R Marabotto E | 2013 | Eur Respir J2013，42，5： | 1 |
| 3 | Central nervous system tuberculosis in non-HIV-positive children: a single-center, 6 year experience显示文摘 | L. Nogueira Delfino G. Fariello L. Lancella C. Marabotto L. Menchini R. Devito Y. Errante C. C. Quattrocchi D. Longo | 2012 | La radiologia medica2012，，： | 1 |
| 4 | The added value of im- III criteria in distinguishing func- reflux disease显示文摘 | Savarino E Marabotto E Zentilin pedance - pH monitoring to Rome tional heartburn from non-erosive P | 2011 | Digestive and Liver Disease2011，43，7： | 1 |
| 5 | The added value ofimpedance-pH monitoring to Rome III criteria in distinguishingfunctional heartburn from non-erosive reflux disease 显示文摘 | Savarino E Marabotto E Zentilin P | 2011 | Dig LiverDis2011，43，7： | 1 |
| 6 | Hepatocellular Carcinoma in Patients With Cryptogenic Cirrhosis显示文摘 | Edoardo Giovanni Giannini Elisa Marabotto Vincenzo Savarino Franco Trevisani Maria Anna di Nolfo Paolo Del Poggio Luisa Benvegnù Fabio Farinati Marco Zoli Franco Borzio Eugenio Caturelli Maria Chiaramonte | 2009 | Clinical Gastroenterology and Hepatology2009，，5： | 1 |
| 7 | Positive Glucose Breath Testing is More Prevalent in Patients With IBS-like Symptoms Compared With Controls of Similar Age and Gender Distribution显示文摘 | Andrea Parodi Pietro Dulbecco Edoardo Savarino Edoardo Giovanni Giannini Giorgia Bodini Marina Corbo Luca Isola Stefano De Conca Elisa Marabotto Vincenzo Savarino | 2009 | Journal of Clinical Gastroenterology2009，，10： | 1 |
| 8 | Role of gastroesophageal reflux in children with unexplained chronic cough显示文摘 | Borrelli O Marabotto C Mancini V | 2011 | J Pediatr Gastroenterol Nutr2011，53，3： | 1 |
| 9 | Gastro-oesophageal reflux and gastric aspiration in idiopathic pulmonary fibrosis patients显示文摘 | Savarino E Carbone R Marabotto E | 2013 | Eur Respir J2013，42，5： | 1 |
| 10 | Microscopic esophagitis distinguishes patients with non-erosive reflux disease from those with functional heartburn显示文摘 | Edoardo Savarino Patrizia Zentilin Luca Mastracci Pietro Dulbecco Elisa Marabotto Lorenzo Gemignani Luca Bruzzone Nicola Bortoli Anna Chiara Frigo Roberto Fiocca Vincenzo Savarino | 2013 | Journal of Gastroenterology2013，，4： | 1 |
| 11 | The added value of impedance-pH monitoring to Rome III criteria in distinguishing functional heartburn from non-erosive reflux disease显示文摘 | Edoardo Savarino Elisa Marabotto Patrizia Zentilin Marzio Frazzoni Giorgio Sammito Daria Bonfanti Luca Sconfienza Lorenzo Assandri Lorenzo Gemignani Alberto Malesci Vincenzo Savarino | 2011 | Digestive and Liver Disease2011，，7： | 1 |
| 12 | Role of gastroesophageal reflux in children with unexplained chronic cough显示文摘 | Borrelli O Marabotto C Mancini V | 2011 | J PediatrGastroenterol Nutr2011，53，3： | 1 |
| 13 | Overweight is a risk factor for both erosive and non - erosive reflux disease 显示文摘 | Savarino E Zentilin P Marabotto E | 2011 | Dig Liver Dis2011，43，12： | 1 |
| 14 | Role of gastroesophageal reflux in children with unexplained chronic cough显示文摘 | Borrelli O Marabotto C Mancini V | 2011 | Journal of pediatric gastroenterology and nutrition2011，53，3： | 1 |
| 15 | Albumin-bilirubin score in non-malignant liver diseases should be properly validated显示文摘The albumin-bilirubin(ALBI)score to assess the risk of decompensation in patients with initially compensated cirrhosis may improve their prognostic evaluation.This letter critically evaluates the research,which utilizes the ALBI score to forecast decompensation in cirrhosis patients over a three-year period.This score was initially developed to assess liver function in hepatocellular carcinoma,its prognostic utility for non-malignant liver diseases has now been explored,recognizing decompensation as a pivotal event that significantly affects patient’s survival.Some concerns regarding the methodology of this research may be raised,particularly the exclusive use of radiological diagnosis,potentially including patients without definite cirrhosis and thus skewing the decompensation risk assessment.The reported predominance of variceal bleeding as a decompensating event conflicts with established literature,that often reports ascites as the initial decompensation manifestation.The letter highlights the absence of details on esophageal varices and their management,which could introduce bias in evaluating the ALBI score's predictive power.Furthermore,the letter points out the small sample size of patients with high-risk ALBI grades,potentially compromising the score's validity in this context.We suggest prospective future research to investigate the dynamic changes in the ALBI score over time to reinforce the validity of the ALBI score as a predictor of decompensation in non-malignant liver disease. | Andrea Pasta Francesco Calabrese Maria Corina Plaz Torres Giorgia Bodini Manuele Furnari EdoardoVincenzo Savarino Vincenzo Savarino Edoardo Giovanni Giannini Elisa Marabotto | 2023 | World Journal of Gastroenterology2023，29，46： | 0 |
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