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| 1 | Hepatitis B and D Viruses Exploit Sodium Taurocholate Co-transporting Polypeptide for Species-specific Entry into Hepatocytes显示文摘 | Yi Ni Florian A. Lempp Stefan Mehrle Shirin Nkongolo Christina Kaufman Maria F?lth Jan Stindt Christian K?niger Michael Nassal Ralf Kubitz Holger Sültmann Stephan Urban | 2013 | Gastroenterology2013，，： | 5 |
| 2 | Bisphenol A exposure alters release of immune and developmental modulators and expression of estrogen receptors in human fetal lung fibroblasts显示文摘Bisphenol A(BPA) has been shown to exert biological effects through estrogen receptor(ER)-dependent and ER-independent mechanisms. Recent studies suggest that prenatal exposure to BPA may increase the risk of childhood asthma. To investigate the underlying mechanisms in the actions of BPA, human fetal lung fibroblasts(h FLFs) were exposed to varying doses of BPA in culture for 24 hr. Effects of BPA on localization and uptake of BPA,cell viability, release of immune and developmental modulators, cellular localization and expression of ERα, ERβ and G-protein coupled estrogen receptor 30(GPR30), and effects of ERs antagonists on BPA-induced changes in endothelin-1(ET-1) release were examined.BPA at 0.01–100 μmol/L caused no changes in cell viability after 24 hr of exposure. h FLFs expresses all three ERs. BPA had no effects on either cellular distribution or protein expression of ERα, however, at 100 μmol/L(or 23 μmol/L intracellular BPA) increased ERβprotein levels in the cytoplasmic fractions and GPR 30 protein levels in the nuclear fractions.These paralleled with increased release of growth differentiation factor-15, decreased phosphorylation of nuclear factor kappa B p65 at serine 536, and decreased release of ET-1,interleukin-6, and interferon gamma-induced protein 10. ERs antagonists had no effects on BPA-induced decrease in ET-1 release. These data suggest that BPA at 100 μmol/L altered the release of immune and developmental modulators in h FLFs, which may negatively influence fetal lung development, maturation, and susceptibility to environmental stressors, although the role of BPA in childhood asthma remains to be confirmed in in vivo studies. | Laziyan Mahemuti Qixuan Chen Melanie C. Coughlan Min Zhang Maria Florian Ryan J Mailloux Xu-Liang Cao Kylie A. Scoggan William G. Willmore Xiaolei Jin | 2016 | Journal of Environmental Sciences2016，28，10： | 3 |
| 3 | Is Preoperative Chemotherapy Followed by Surgery the Appropriate Treatment for Signet Ring Cell Containing Adenocarcinomas of the Esophagogastric Junction and Stomach?显示文摘 | Ulrike Heger Susanne Blank Christiane Wiecha Rupert Langer Wilko Weichert Florian Lordick Thomas Bruckner Martin Dobritz Maria Burian Christoph Springfeld Lars Grenacher J?rg-Rüdiger Siewert Markus Büchler Katja Ott | 2014 | Annals of Surgical Oncology2014，，5： | 2 |
| 4 | Nature:研究鉴定出侵袭性胰腺癌细胞及其弱点显示文摘在一项新的研究中,来自美国德州大学MD安德森癌症中心的研究人员利用患者源性肿瘤异种移植(patient—derived tumorxenograft,PDx)和模式小鼠开展一系列临床前实验,鉴定出一种门卫蛋白(gatekee Perprotein)阻止胰腺癌细胞转化为一种极具侵袭性的细胞类型,并且也发现剔除这种门卫蛋白的疗法能够阻止这些癌细胞。这些发现有助为携带这种进展迅速的治疗抵抗性的胰腺癌细胞亚群的患者开发出潜在的疗法。 | Genovese, Giannicola Carugo, Alessandro Tepper, James Robinson, Frederick Scott Li, Liren Svelto, Maria Nezi, Luigi Corti, Denise Minelli, Rosalba Pettazzoni, Piergiorgio Gutschner, Tony Wu, Chia-Chin Seth, Sahil Akdemir, Kadir Caner Leo, Elisabetta Amin, Samirkumar Dal Molin, Marco Ying, Haoqiang Kwong, Lawrence N. Colla, Simona Takahashi, Koichi Ghosh, Papia Giuliani, Virginia Muller, Florian Dey, Prasenjit Jiang, Shan Garvey, Jill Liu, Chang-Gong Zhang, Jianhua Heffernan, Timothy P. Toniatti, Carlo Fleming, Jason B. Goggins, Michael G. Wood, Laura D. Sgambato, Alessandro Agaimy, Abbas Maitra, Anirban Roberts, Charles W. M. Wang, Huamin Viale, Andrea DePinho, Ronald A. Draetta, Giulio F. Chin, Lynda | 2017 | 现代生物医学进展2017，17，14： | 2 |
| 5 | Thymine DNA Glycosylase Is Essential for Active DNA Demethylation by Linked Deamination-Base Excision Repair显示文摘 | Salvatore Cortellino Jinfei Xu Mara Sannai Robert Moore Elena Caretti Antonio Cigliano Madeleine Le Coz Karthik Devarajan Andy Wessels Dianne Soprano Lara K. Abramowitz Marisa S. Bartolomei Florian Rambow Maria Rosaria Bassi Tiziana Bruno Maurizio Fanciul | 2011 | Cell2011，，1： | 1 |
| 6 | Arterial Embolization of Unresectable Hepatocellular Carcinoma with Use of Microspheres, Lipiodol, and Cyanoacrylate显示文摘 | Thomas Rand Christian Loewe Maria Schoder Maria Theresa Schmook Markus Peck-Radosavljevic Joachim Kettenbach Florian Wolf Barbara Schneider Johannes Lammer | 2005 | CardioVascular and Interventional Radiology2005，，3： | 1 |
| 7 | Histone Deacetylases Activate Hepatocyte Growth Factor Signaling by Repressing MicroRNA-449 in Hepatocellular Carcinoma Cells显示文摘 | Reena Buurman Engin Gürlevik Vera Sch?ffer Marlies Eilers Maria Sandbothe Hans Kreipe Ludwig Wilkens Brigitte Schlegelberger Florian Kühnel Britta Skawran | 2012 | Gastroenterology2012，，3： | 1 |
| 8 | Regulation of Gene Expression through a Transcriptional Repressor that Senses Acyl-Chain Length in Membrane Phospholipids显示文摘 | Harald F. Hofbauer Florian H. Schopf Hannes Schleifer Oskar L. Knittelfelder Bartholom?us Pieber Gerald N. Rechberger Heimo Wolinski Maria L. Gaspar C. Oliver Kappe Johannes Stadlmann Karl Mechtler Alexandra Zenz Karl Lohner Oksana Tehlivets Susan A. Henr | 2014 | Developmental Cell2014，，6： | 1 |
| 9 | Antiviral effect of entecavir in chronic hepatitis B: Influence of prior exposure to nucleos(t)ide analogues显示文摘 | Jurri?n G.P. Reijnders Katja Deterding J?rg Petersen Fabien Zoulim Teresa Santantonio Maria Buti Florian van B?mmel Bettina E. Hansen Heiner Wedemeyer Harry L.A. Janssen | 2010 | Journal of Hepatology2010，，4： | 1 |
| 10 | Atropine maintenance dosage in patients with severe organophosphate pesticide poisoning显示文摘 | Horst Thiermann Dirk Steinritz Franz Worek Maria Radtke Peter Eyer Florian Eyer Norbert Felgenhauer Thomas Zilker | 2011 | Toxicology Letters2011，，1： | 1 |
| 11 | Multidetector computed tomography for preoperative assessment of hepatic vasculature and prediction of splenic artery steal syndrome in patients with liver cirrhosis before transplantation显示文摘 | Christian Grieser Timm Denecke Ingo G. Steffen Maria Avgenaki Vera Fr?hling Martina Mogl Dirk Schnapauff Lukas Lehmkuhl Lars Stelter Florian Streitparth Jan Langrehr Jan-Holger Rothe Bernd Hamm Enrique Lopez H?nninen | 2010 | European Radiology2010，，1： | 1 |
| 12 | 25 years of recombinant proteins from reactor- grown ceils- Where do we go from here? 显示文摘 | David L Maria D Florian M | 2011 | Biotechnology Advances2011，27，6： | 1 |
| 13 | Fully automatic CAD design of the occlusal morphology of partial crowns compared to dental technicians’ design显示文摘 | Andreas P. Litzenburger Reinhard Hickel Maria J. Richter Albert C. Mehl Florian A. Probst | 2013 | Clinical Oral Investigations2013，，2： | 1 |
| 14 | Peripheral blood lymphocytes analysis detects CD100/SEMA4D alteration in systemic sclerosis patients显示文摘 | Alina Besliu Leontina Banica Denisa Predeteanu Violeta Vlad Ruxandra Ionescu Gina Pistol Daniela Opris Florian Berghea Maria Stefanescu Cristiana Matache | 2011 | Autoimmunity2011，，： | 1 |
| 15 | Detection of Mycoplasma pneumoniae in serum specimens from patients with mycoplasma pneumonia by PCR显示文摘 | Florian Daxboeck Gelas Khanakah Claudia Bauer Maria Stadler Hanns Hofmann Gerold Stanek | 2005 | International Journal of Medical Microbiology2005，，4： | 1 |
| 16 | Antiviral effect of entecavir in chronic hepatitis B: Influence of prior exposure to nucleos(t)ide analogues显示文摘 | Jurri?n G.P. Reijnders Katja Deterding J?rg Petersen Fabien Zoulim Teresa Santantonio Maria Buti Florian van B?mmel Bettina E. Hansen Heiner Wedemeyer Harry L.A. Janssen | 2010 | Journal of Hepatology2010，，4： | 1 |
| 17 | Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure显示文摘 | John M. Russo Peter Florian Le Shen W. Vallen Graham Maria S. Tretiakova Alfred H. Gitter Randall J. Mrsny Jerrold R. Turner | 2005 | Gastroenterology2005，，4： | 1 |
| 18 | Antidiabetic profiling of veramycins,polyketides accessible by biosynthesis,chemical synthesis and precursor-directed modification显示文摘Seven new polyketides,termed veramycins,were isolated from a Streptomyces sp.from the Sanofi microbial strain collection along with their known congeners NFAT-133 and TM-123.Veramycin A,anα-pyrone congener of TM-123 and NFAT-133 showed an increased baseline deoxy-glucose uptake in the absence of insulin in a modified L6 rat skeletal muscle cell line(L6 GLUT4 AS160-like cells).In addition,both compounds slightly increased the sensitivity to insulin in this cell line.Total syntheses of NFAT-133,TM-123 and veramycin A were accomplished starting from a central building block,which bears the three contiguous stereogenic centers of this polyketide family.Our approach enables an efficient,selective and flexible access to all possible isomers of the stereotriad for further exploration of this series as a potential anti-diabetic lead structure as exemplified by the synthesis of an NFAT-133 epimer.Finally,the corresponding biosynthetic gene cluster(BGC)was identified by genome sequencing and gene inactivation.Based on feeding experiments,a biosynthetic pathway was proposed,which enabled access to new veramycin A analogs by precursor-directed biosynthesis. | Denis Dardić Nils Böhringer Alberto Plaza Florian Zubeil Juliane Pohl Svenja Sommer Leo Padva Jonathan Becker Maria A.Patras Mona-Katharina Bill Michael Kurz Luigi Toti Sven W.Görgens Sören M.M.Schuler AndréBillion Oliver Schwengers Paulus Wohlfart Alexander Goesmann Norbert Tennagels Andreas Vilcinskas Peter E.Hammann Till F.Schäberle Armin Bauer | 2022 | Organic Chemistry Frontiers2022，9，6： | 1 |
| 19 | Simulation of urban microclimate with uhiSolver:software validation using simplifed material data显示文摘Background:Increasing urbanization as well as global warming requires an investigation of the infuence of diferent construction methods and ground surfaces on the urban heat island efect(UHI efect).The extent of the infuence of the urban structure,the building materials used and their surfaces on the UHI efect can be signifcantly reduced already in the planning phase using a designated OpenFOAM-based solver“uhiSolver”.Results:In the frst part of this research work,it is shown that inner building details and components can be neglected while still obtaining sufciently accurate results.For this purpose,the building model was divided into two layers:a surface layer without mass,where the interaction with radiation takes place,and a component layer,which contains all relevant components and cavities of the building represented with mass-averaged material properties.It has become apparent that the three parameters—albedo,heat capacity and thermal resistance—which have a decisive infuence on the interaction,have diferent efects on the component temperatures and the surface temperatures.In the second part of this research work,dynamic 3D computational fuid dynamics(CFD)simulations are performed with uhiSolver for a residential block in Vienna.Comparing the simulation results with measurement data collected on site,it is shown that the simplifed assumption of homogeneous material data for building bodies provides very good results for the validation case investigated.However,the infuence of the greening measures in the courtyard of the residential block on the air temperature is found to be negligible.Furthermore,it was observed that due to locally higher radiation density,lower air velocities and higher air humidity,the apparent temperature in the courtyard is sometimes perceived to be higher than in the adjacent streets,despite the lower air temperature.Conclusions:Simplifying the modeling process of the uhiSolver software by reducing the model complexity helps to reduce manual work for setting up appropriate boundary conditions of buildings.Compared to market competitors,good results are obtained for the validation case Kandlgasse presented in this research work,despite the simplifcations proposed.Thus,uhiSolver can be used as a robust analytical tool for urban planning. | Florian Teichmann Christina Maria Baumgartner Andras Horvath Markus Luisser Azra Korjenic | 2021 | Ecological Processes2021，10，1： | 0 |
| 20 | 轻松实现按比例放大:摇摆式一次性生物反应器具有很好的按比例放大性能显示文摘在过去的一年中,一次性摇摆式生物反应器在生物制药领域具有越来越重要的意义。与传统的酶化发酵设备相比较,其最大特点在于具有很高的使用灵活性、平行使用性和经济性。 | Tibor Anderlei Christoph Cesana Markus Kuhner Cedric Burki Maria de Jesus Florian Wurm | 2010 | 流程工业2010，，13： | 0 |
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