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| 1 | Enteric glial cells and their role in gastrointestinal motor abnormalities: Introducing the neuro-gliopathies显示文摘The role of enteric glial cells has somewhat changed from that of mere mechanical support elements, gluing together the various components of the enteric nervous system, to that of active participants in the complex interrelationships of the gut motor and inflammatory events. Due to their multiple functions, spanning from supporting elements in the myenteric plexuses to neurotransmitters, to neuronal homeostasis, to antigen presenting cells, this cell population has probably more intriguing abilities than previously thought. Recently, some evidence has been accumulating that shows how these cells may be involved in the pathophysiological aspects of some diseases. This review will deal with the properties of the enteric glial cells more strictly related to gastrointestinal motor function and the human pathological conditions in which these cells may play a role, suggesting the possibility of enteric neuro- gliopathies. | Gabrio Bassotti Vincenzo Villanacci Simona Fisogni Elisa Rossi Paola Baronio Carlo Clerici Christoph A Maurer Gieri Cathomas Elisabetta Antonelli | 2007 | World Journal of Gastroenterology2007，13，30： | 16 |
| 2 | Radiofrequency ablation of liver tumors: Actual limitations and potential solutions in the future显示文摘Over the past decade,radiofrequency ablation(RFA) has evolved into an important therapeutical tool for the treatment of non resectable primary and secondary liver tumors.The clinical benefit of RFA is represented in several clinical studies.They underline the safety and feasibility of this new and modern concept in treating liver tumors.RFA has proven its clinical impact not only in hepatocellular carcinoma(HCC) but also in metastatic disease such as colorectal cancer(CRC).Due to the increasing number of HCC and CRC,RFA might play an even more important role in the future.Therefore,the refinement of RFA technology is as important as the evaluation of data of prospective randomized trials that will help define guidelines for good clinical practice in RFA application in the future.The combination of hepatic resection and RFA extends the feasibility of open surgical procedures in patients with extensive tumors.Adverse effects of RFA such as biliary tract damage,liver failure and local recurrence remain an important task today but overall the long term results of RFA application in treating liver tumors are promising.Incomplete ablation of liver tumors due to insufficient technology of ablation needles,tissue cooling by the neighbouring blood vessels,large tumor masses and ablation of tumors in close vicinity to heat sensitive organs remain difficult tasks for RFA.Future solutions to overcome these limitations of RFA will include refinement of ultrasonographic guidance(accuracy of probe placement),improvements in needle technology(e.g.needles preventing charring)and intraductal cooling techniques. | Beat M Künzli Paolo Abitabile Christoph A Maurer | 2011 | World Journal of Hepatology2011，3，1： | 15 |
| 3 | Ovarian stem cells:From basic to clinical applications显示文摘The field of reproductive biology has undergone significant developments in the last decade. The notion that there is a fixed reserve pool of oocytes before birth was established by Zuckerman in 1951. However, in 2004, an article published in nature challenged this central dogma of mammalian reproductive biology. Tilly's group reported the existence of ovarian germline stem cells(GSCs) in postnatal ovaries of mice and suggested that the bone marrow could be an extragonadal source of ovarian GSCs. These findings were strongly criticized; however, several independent groups have sincesuccessfully isolated and characterized ovarian GSCs in postnatal mice. The ovarian GSCs are located in the ovarian surface epithelium and express markers of undifferentiated GSCs. When transplanted into mouse ovaries, mouse ovarian GSCs could differentiate and produce embryos and offspring. Similarly, in a recent study, ovarian GSCs were found to be present in the ovaries of women of reproductive age. Conversely, there is increasing evidence that stem cells responsible for maintaining a healthy state in normal tissue may be a source of some cancers, including ovarian cancer. Cancer stem cells(CSCs) have been found in many tissues, including ovaries. Some researchers have suggested that ovarian cancer may be a result of the transformation and dysfunction of ovarian GSCs with self-renewal properties. Drug resistant and metastasisgenerating CSCs are responsible for many important problems affecting ovarian cancer patients. Therefore, the identification of CSCs will provide opportunities for the development of new therapeutic strategies for treatments for infertility and ovarian cancer. In this article, we summarize the current understanding of ovarian GSCs in adult mammals, and we also discuss whether there is a relationship between GSCs and CSCs. | Ozlem Bingol Ozakpinar Anne-Marie Maurer Derya Ozsavci | 2015 | World Journal of Stem Cells2015，7，4： | 8 |
| 4 | Liver resections can be performed safely without Pringle maneuver: A prospective study显示文摘AIM To evaluate liver resections without Pringle maneuver, i.e., clamping of the portal triad. METHODS Between 9/2002 and 7/2013, 175 consecutive liver resections(n = 101 major anatomical and n = 74 large atypical > 5 cm) without Pringle maneuver were performed in 127 patients(143 surgeries). Accompanying, 37 wedge resections(specimens < 5 cm) and 43 radiofrequency ablations were performed. Preoperative volumetric calculation of the liver remnant preceeded all anatomical resections. The liver parenchyma was dissected by waterjet. The median central venous pressure was 4 mmH g(range: 5-14). Data was collected prospectively. RESULTS The median age of patients was 60 years(range: 16-85). Preoperative chemotherapy was used in 70 cases(49.0%). Liver cirrhosis was present in 6.3%, and liver steatosis of ≥ 10% in 28.0%. Blood loss was median 400 mL(range 50-5000 mL). Perioperative blood transfusions were given in 22/143 procedures(15%). The median weight of anatomically resected liver specimens was 525 g(range: 51-1850 g). One patient died postoperatively. Biliary leakages(n = 5) were treated conservatively. Temporary liver failure occurred in two patients.CONCLUSION Major liver resections without Pringle maneuver are feasible and safe. The avoidance of liver inflow clamping might reduce liver damage and failure, and shorten the hospital stay. | Christoph A Maurer Mikolaj Walensi Samuel A Kaser Beat M Künzli Rene Lotscher Anne Zuse | 2016 | World Journal of Hepatology2016，8，24： | 6 |
| 5 | 急性冠状动脉综合征发生1个月后的生长分化因子15水平与主要出血风险增加相关显示文摘用双重抗血小板治疗的急性冠状动脉综合征(acutecoronarysyndromes,ACS)患者在初次就诊测量的生长分化因子15(growthdifferentiationfactor-15,GDF-15)与大出血相关。 | Lindholm D Hagstrm E James SK Becker RC Cannon CP Himmelmann A Katus HA Maurer G López-Sendón JL Steg PG Storey RF Siegbahn A Wallentin L 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，5： | 5 |
| 6 | Regular nicotine intake increased tooth movement velocity,osteoclastogenesis and orthodontically induced dental root resorptions in a rat model显示文摘Orthodontic forces have been reported to significantly increase nicotine-induced periodontal bone loss. At present, however, it is unknown, which further(side) effects can be expected during orthodontic treatment at a nicotine exposure corresponding to that of an average European smoker. 63 male Fischer344 rats were randomized in three consecutive experiments of 21 animals each(A/B/C) to 3 experimental groups(7 rats, 1/2/3):(A) cone-beam-computed tomography(CBCT);(B) histology/serology;(C) reversetranscription quantitative real-time polymerase chain reaction(RT-q PCR)/cotinine serology—(1) control;(2) orthodontic tooth movement(OTM) of the first and second upper left molar(Ni Ti closed coil spring, 0.25 N);(3) OTM with 1.89 mg·kg^(-1) per day s.c. of L(-)-nicotine. After 14 days of OTM, serum cotinine and IL-6 concentration as well as orthodontically induced inflammatory root resorption(OIIRR), osteoclast activity(histology), orthodontic tooth movement velocity(CBCT, within 14 and 28 days of OTM)and relative gene expression of known inflammatory and osteoclast markers were quantified in the dental-periodontal tissue(RT–q PCR). Animals exposed to nicotine showed significantly heightened serum cotinine and IL-6 levels corresponding to those of regular European smokers. Both the extent of root resorption, osteoclast activity, orthodontic tooth movement and gene expression of inflammatory and osteoclast markers were significantly increased compared to controls with and without OTM under the influence of nicotine. We conclude that apart from increased periodontal bone loss, a progression of dental root resorption and accelerated orthodontic tooth movement are to be anticipated during orthodontic therapy, if nicotine consumption is present. Thus patients should be informed about these risks and the necessity of nicotine abstinence during treatment. | christian kirschneck michael maurer michael wolf claudia reicheneder peter proff | 2017 | International Journal of Oral Science2017，9，3： | 4 |
| 7 | Inflammatory myofibroblastic tumor of the liver:A case report and review of literature显示文摘BACKGROUND Inflammatory myofibroblastic tumors of the liver(IMTL)are extremely rare neoplasms and very little is known about their clinical presentation,pathogenesis,and biological behavior.Due to their absolute rarity,it is almost impossible to obtain a definite diagnosis without histological examination.Because of their intermediate biological behavior with the risk for local recurrence and metastases,surgical resection is recommend whenever IMTL is suspect.CASE SUMMARY We herein present a case of an otherwise healthy 32-year-old woman who presented with intermittent fever,unclear anemia,malaise and right flank pain 4 mo postpartum.The liver mass in segment IVa/b was highly FDG avid in the positron emission tomography-computed tomography.Hepatic resection was performed achieving a negative resection margin and an immediate resolution of all clinical symptoms.Histological analysis diagnosed the rare finding of an inflammatory myofibroblastic tumor of the liver and revealed cytoplasmic anaplastic lymphoma kinase expression by immunohistochemistry.Twelve months follow-up magnetic resonance imaging showed no recurrence and no metastases in the fully recovered patient.CONCLUSION IMTLs are extremely rare and difficult to diagnose.Due to their intermediate biological behavior,surgical resection should be perform whenever feasible and patients should be followed-up in order to detect recurrence and metastasis as early as possible. | Alexandra Filips Martin H Maurer Matteo Montani Guido Beldi Anja Lachenmayer | 2020 | World Journal of Hepatology2020，12，4： | 4 |
| 8 | 水平钻井技术的新进展显示文摘介绍水平钻井中的多底井技术、地质导向技术、高级钻头和钻具、新颖的短半径钻具以及小井眼钻井系统方面的新技术。多底水平井可降低钻井成本的20%~30%,使海上平台的大小及数量减小50%。地质导向钻具利用随钻测井仪,能精确地引导井眼的走向,避开水和天然气等地下障碍,显著地提高水平井的产油率。改进后的PDC钻头、TSP钻头及大功率新型动力钻具,可使水平钻井钻速提高2~3倍。新颖的短半径(12~30m)动力钻井系统可较快地钻出水平段为305~457m的水平井。新的小井眼钻井系统可在144mm的套管上侧钻出92mm的水平井和多底水平井。以上新技术将明显扩大水平钻井的应用范围。 | 谭云 William Maurer | 1997 | 国外石油机械1997，8，1： | 4 |
| 9 | Composite tissue allotransplantation: opportunities and challenges显示文摘Vascularized composite allotransplants(VCAs)have unique properties because of diverse tissue components transplanted en mass as a single unit.In addition to surgery,this type of transplant also faces enormous immunological challenges that demand a detailed analysis of all aspects of alloimmune responses,organ preservation,and injury,as well as the immunogenicity of various tissues within the VCA grafts to further improve graft and patient outcomes.Moreover,the side effects of long-term immunosuppression for VCA patients need to be carefully balanced with the potential benefit of a non-life-saving procedure.In this review article,we provide a comprehensive update on limb and face transplantation,with a specific emphasis on the alloimmune responses to VCA,established and novel immunosuppressive treatments,and patient outcomes. | Jasper Iske Yeqi Nian Ryoichi Maenosono Max Maurer Igor M.Sauer Stefan G.Tullius | 2019 | Cellular & Molecular Immunology2019，16，4： | 4 |
| 10 | Early Systemic Inflammatory Response Syndrome Is Associated With Severe Acute Pancreatitis显示文摘 | Vikesh K. Singh Bechien U. Wu Thomas L. Bollen Kathryn Repas Rie Maurer Koenraad J. Mortele Peter A. Banks | 2009 | Clinical Gastroenterology and Hepatology2009，，11： | 3 |
| 11 | The Swelling Equilibria of N-isopropylacrylamide Based Hydrogel in Aqueous Solution of Ethanol显示文摘N-isopropylacrylamide (NIPAAm) was used to synthesize NIPAAm homopolymer (nonionized) and NIPAAm-sodium methacrylate copolymer (ionized). The swelling equilibria for both gels were obtained in aqueous solution of ethanol with concentration ranging from 0 to 100%(by mass) at 25℃. The swollen gel in water shrank first with the addition of a small amount of ethanol and then reswelled with further addition of ethanol showing not only a discontinuous volume phase transition but also a typical reentrant phenomenon. A thermodynamic model based on the UNIQUAC with the 'free-volume' contribution was applied to correlate and predict the swelling behavior of the poly(NIPAAM)-gels in ethanol-water mixture. | 许小平 HüTHER Andreas MAURER Gerd | 2003 | Chinese Journal of Chemical Engineering2003，11，3： | 3 |
| 12 | Effects of age on outcome of tilt-table testing显示文摘 | Daniel Bloomfield Mathew Maurer J.Thomas Bigger | 1999 | The American Journal of Cardiology1999，，7： | 2 |
| 13 | Prevalence and ethnic differences in gallbladder disease in the United States显示文摘 | James E. Everhart Meena Khare Michael Hill Kurt R. Maurer | 1999 | Gastroenterology1999，，3： | 2 |
| 14 | Solubility of carbon dioxide in acetone and propionic acid at temperatures between 298 K and 333 K显示文摘 | Adrian T Maurer G | 1997 | J Chen Eng Data1997，42，： | 2 |
| 15 | Elevations in T‐helper‐2‐initiating cytokines (interleukin‐33, interleukin‐25 and thymic stromal lymphopoietin) in lesional skin from chronic spontaneous (‘idiopathic’) urticaria显示文摘 | A.B. Kay P. Clark M. Maurer S. Ying | 2015 | Br J Dermatol2015，，5： | 2 |
| 16 | Glycosaminoglycans enhance human leukemic cell growth in vitro显示文摘 | Maurer A M Han Z C Dhermy D | 1994 | Leuk Res1994，18，11： | 2 |
| 17 | Primary care physicians as gatekeepers in managed care显示文摘 | Gerbert B Maurer T Berger T | 1996 | Arch Dermatol1996，132，： | 2 |
| 18 | Inflammation and Carotid Artery—Risk for Atherosclerosis Study (ICARAS)显示文摘 | Martin Schillinger Markus Exner Wolfgang Mlekusch Schila Sabeti Jasmin Amighi Robert Nikowitsch Ewald Timmel Bernhard Kickinger Christoph Minar Matthias Pones Wolfgang Lalouschek Helmut Rumpold Gerald Maurer Oswald Wagner Erich Minar | 2005 | Circulation2005，，17： | 2 |
| 19 | Stent Thrombosis With Ticagrelor Versus Clopidogrel in Patients With Acute Coronary Syndromes: An Analysis From the Prospective, Randomized PLATO Trial显示文摘 | P. Gabriel Steg Robert A. Harrington H?kan Emanuelsson Hugo A. Katus Kenneth W. Mahaffey Bernhard Meier Robert F. Storey Daniel M. Wojdyla Basil S. Lewis Gerald Maurer Lars Wallentin Stefan K. James | 2013 | Circulation2013，，10： | 2 |
| 20 | 中国婴儿接种肺炎球菌疫苗的成本效益分析显示文摘尽管中国儿童肺炎球菌疾病负担重,但尚未实施公费资助的肺炎球菌结合疫苗(PCV)接种。作者评估了针对中国婴儿公费资助的PCV-7,PCV-10和PCV-13疫苗接种计划的成本效益。使用Markov模型,模拟了1 600万名中国婴儿队列,从社会角度去评估PCV-7、PCV-10和PCV-13疫苗接种计划的影响。推测健康状态以期估计在一生75年的过程中该计划的影响。 | 郑伟峰 Maurer KA | 2017 | 微生物学免疫学进展2017，45，4： | 2 |
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