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| 1 | Manganese salts function as potent adjuvants显示文摘Aluminum-containing adjuvants have been used for nearly 100 years to enhance immune responses in billions of doses of vaccines.To date,only a few adjuvants have been approved for use in humans,among which aluminum-containing adjuvants are the only ones widely used.However,the medical need for potent and safe adjuvants is currently continuously increasing,especially those triggering cellular immune responses for cytotoxic T lymphocyte activation,which are urgently needed for the development of efficient virus and cancer vaccines.Manganese is an essential micronutrient required for diverse biological activities,but its functions in immunity remain undefined.We previously reported that Mn^(2+) is important in the host defense against cytosolic dsDNA by facilitating cGAS-STING activation and that Mn^(2+)alone directly activates cGAS independent of dsDNA,leading to an unconventional catalytic synthesis of 2′3′-cGAMP.Herein,we found that Mn^(2+) strongly promoted immune responses by facilitating antigen uptake,presentation,and germinal center formation via both cGAS-STING and NLRP3 activation.Accordingly,a colloidal manganese salt(Mn jelly,MnJ)was formulated to act not only as an immune potentiator but also as a delivery system to stimulate humoral and cellular immune responses,inducing antibody production and CD4^(+)/CD8^(+)T-cell proliferation and activation by either intramuscular or intranasal immunization.When administered intranasally,MnJ also worked as a mucosal adjuvant,inducing high levels of secretory IgA.MnJ showed good adjuvant effects for all tested antigens,including T cell-dependent and T cell-independent antigens,such as bacterial capsular polysaccharides,thus indicating that it is a promising adjuvant candidate. | Rui Zhang Chenguang Wang Yukun Guan Xiaoming Wei Mengyin Sha Mengran Yi Miao Jing Mengze Lv Wen Guo Jing Xu Yi Wan Xin-Ming Jia Zhengfan Jiang | 2021 | Cellular & Molecular Immunology2021，18，5： | 7 |
| 2 | Establishment of a dmp based maternal haploid induction system for polyploid Brassica napus and Nicotiana tabacum显示文摘Doubled haploid(DH) technology is used to obtain homozygous lines in a single generation, a technique that significantly accelerates the crop breeding trajectory. Traditionally, in vitro culture is used to generate DHs, but this technique is limited by species and genotype recalcitrance. In vivo haploid induction(HI) through seed is widely and efficiently used in maize and was recently extended to several other crops. Here we show that in vivo HI can be triggered by mutation of DMP maternal haploid inducer genes in allopolyploid(allotetraploid) Brassica napus and Nicotiana tabacum. We developed a pipeline for selection of DMP orthologs for clustered regularly interspaced palindromic repeats mutagenesis and demonstrated average amphihaploid induction rates of2.4% and 1.2% in multiple B. napus and N. tabacum genotypes, respectively. These results further confirmed the HI ability of DMP gene in polyploid dicot crops. The DMP-HI system offers a novel DH technology to facilitate breeding in these crops. The success of this approach and the conservation of DMP genes in dicots suggest the broad applicability of this technique in other dicot crops. | Yu Zhong Yuwen Wang Baojian Chen Jinchu Liu Dong Wang Mengran Li Xiaolong Qi Chenxu Liu Kim Boutilier Shaojiang Chen | 2022 | Journal of Integrative Plant Biology2022，64，6： | 4 |
| 3 | Multiple Ways of BES1/BZR1 Degradation to Decode Distinct Developmental and Environmental Cues in Plants显示文摘 | Mengran Yang Xuelu Wang | 2017 | Molecular Plant2017，10，7： | 4 |
| 4 | Effect of the processing route on the microstructure and mechanical behavior of superlight Mg-9Li-1Zn alloy via friction stir processing显示文摘In this study, the effect of the processing route using a friction stir processing(FSP) method on the microstructure and mechanical behavior of a Mg-9Li-1Zn alloy was systematically investigated. In the FSP method, the odd-numbered(1st and 3rd) process directions and even-numbered(2nd and 4th) passes were alternated to distribute the strain throughout the whole processed zone uniformly. Consequently, the processed zone had a much more uniform microstructure and hardness distribution than the processed zone obtained using the conventional FSP method. Using this method, the grain size of a Mg-9Li-1Zn sheet alloy was refined from ~31 μm to ~0.21 μm with uniformly distributedα and β phases. The processed alloy exhibited a high strength-ductility synergy with an ultimate tensile strength(UTS) of 220.1 MPa and total elongation of 70.0% at a strain rate of 10^(-3)s^(-1), overwhelmingly higher than those of the base metal, 155.6 MPa in UTS and 36.0%in elongation. The in-situ SEM-DIC analysis and TEM observation demonstrated that such an outstanding ductility with moderate strength is caused by grain boundary sliding, the dominant deformation mechanism of the ultra-fine-grained sample after FSP. The processing route with reverse processing direction was proven to be efficient in producing the ultrafine grain size microstructure and improving the mechanical properties of superlight Mg-9Li-1Zn alloy. | Mengran Zhou Zhuoran Zeng Chun Cheng Yoshiaki Morisada Qingyu Shi Jian-Yih Wang Hidetoshi Fujii | 2022 | Journal of Magnesium and Alloys2022，10，11： | 2 |
| 5 | Oral nanoparticles containing naringenin suppress atherosclerotic progression by targeting delivery to plaque macrophages显示文摘Atherosclerosis is the main cause of ischemic stroke and myocardial infarction diseases.Nanoparticles have shown unique benefits for atherosclerosis treatment by targeting the lesional macrophages of plaques.However,most of the nanocarriers are administered intravenously,which is inconvenient and may cause complications.Herein,we developed an oral lipid-polymer based nanoparticles(FA-LNPs)decorated with folic acid,which can not only effectively overcome intestinal mucosal-epithelial barrier by increasing the transmembrane transport through intestinal epithelial and the accumulation in Peyer’s patches but also actively target to the aortic plaque sites and accumulate in lesional macrophages.Subsequently,naringenin(Nrg),one of the antiinflammation drugs,was designed to be the oral nanomedicine(FA-LNPs/Nrg)for the first time via the encapsulation of FALNPs.FA-LNPs/Nrg presented highly anti-atherosclerotic efficacy.After the atherosclerotic ApoE−/−mice were treated by FALNPs/Nrg via oral administration for three months,the aortic lesion area,plaque area,and necrotic core area of the aortic root were significantly decreased.Meanwhile,the lipid-related blood parameters recovered to normal levels.Our study provides a promising approach to atherosclerosis treatment based on the novel oral targeting delivery system. | Mengran Guo Zhongshan He Zhaohui Jin Lingjing Huang Jingmei Yuan Shugang Qin Xinchun Wang Lili Cao Xiangrong Song | 2023 | Nano Research2023，16，1： | 0 |
| 6 | Structural regulation chemistry of lithium-ion solvation in nonflammable phosphate-based electrolytes for high interfacial compatibility with graphite anode显示文摘With the booming development of lithium-ion batteries,safety has become one of the most primary focuses of current researches.Although there are various approaches to enhance the safety of lithiumion batteries,phosphate-based electrolyte holds the greatest potential for practical application due to their non-flammability.Nonetheless,its compatibility issue with the graphite anode remains a significant obstacle to its widespread use.Herein,an effective method is proposed to improve the compatibility of electrolyte with graphite(Gr)anode by rationally adjusting the proportion of lithium salt and solvent components to optimize the Li^(+)solvation structure.By slightly increasing the Li^(+)/triethyl phosphate(TEP)ratio,TEP alone cannot fully occupy the inner solvation sheath and therefore less polar ethylene carbonate(EC)has to be recruited,and the solvation structure gradually changes from Li^(+)–[TEP]_(4)to Li^(+)–[TEP]_(3)[EC]with the coexistence of EC and TEP.Simultaneously,EC molecules in the Li^(+)–[TEP]_(3)[EC]could be preferentially reduced on graphite compared to the TEP molecules,resulting in the formation of a uniform and durable solid-electrolyte interphase(SEI)layer.Benefiting from the optimized phosphate-based electrolyte,the Gr|Li battery exhibits a capacity retention rate of 96.8%after stable cycling at 0.5 C for 470 cycles which shows a longer cycle life than the battery with carbonate electrolyte(cycling at 0.5 C for 450 cycles).Therefore,this work provides the guidance for designing a non-flammable phosphate-based electrolyte for high-safety and long cycling-life lithium-ion batteries. | Chenyang Shi Xinjing Huang Jiahao Gu Zeyu Huang Fangyan Liu Mengran Wang Qiyu Wang Bo Hong Zhian Zhang Jie Li Yanqing Lai | 2023 | Journal of Energy Chemistry2023，，12： | 0 |
| 7 | Transient Simulation and Optimization of Regional Integrated Energy System显示文摘A modeling method of regional integrated energy system based on bus method and transient simulation is proposed,and the system optimization is based on the dynamic balance of supply and demand in the whole year energy supply cycle.A CCHP systemof gas turbine coupled with ground source heat pump and electric refrigeration unit is constructed.The energy relationship of the systemis described by bus structure,and the transient calculationmodel is built on TRNSYS platform.The weighted sum of annual total cost saving rate,primary energy saving rate and environmental pollutant shadow cost saving rate is taken as the optimized objective function,and on the basis of annual dynamic balance,the Hooke-Jeeves algorithm is used for optimization of the system configuration.A complex commercial area in Beijing is taken as an example,and different weighting coefficients are set for optimization of the system configuration.The results show that,from the perspective of economy,environmental benefit and primary energy consumption,performance of the system increases and then decreases with rise of gas turbine power;under the simulated cooling/heating load,the maximum number of optimum configuration is seen in the combination of 35 kW gas turbine+723 kW GSHP and 1178 kW electric chiller;in comparison with traditional distributed system,the annual cost saving rate,primary energy saving rate and environmental pollutant shadow cost saving rate of the system are 29.4%,49.6%and 58.2%,respectively. | Xueqin Tian Mengran Cui Tong Xu Jinfei Sun Xinlei Wang Jiangxiang Guo De-Gejirifu Na Wang | 2022 | Energy Engineering2022，119，3： | 0 |
| 8 | In-situ coating and surface partial protonation co-promoting performance of single-crystal nickel-rich cathode in all-solid-state batteries显示文摘The poor electrochemical performance of all-solid-state batteries(ASSBs),which is assemblied by Ni-rich cathode and poly(ethylene oxide)(PEO)-based electrolytes,can be attributed to unstable cathodic interface and poor crystal structure stability of Ni-rich cathode.Several coating strategies are previously employed to enhance the stability of the cathodic interface and crystal structure for Ni-rich cathode.However,these methods can hardly achieve simplicity and high efficiency simultaneously.In this work,polyacrylic acid(PAA)replaced traditional PVDF as a binder for cathode,which can achieve a uniform PAA-Li(LixPAA(0 | Maoyi Yi Jie Li Mengran Wang Xinming Fan Bo Hong Zhian Zhang Aonan Wang Yanqing Lai | 2024 | Journal of Energy Chemistry2024，89，2： | 0 |
| 9 | Dynamic Simulation and Performance Analysis on Multi-Energy Coupled CCHP System显示文摘Although the Combined Cooing,Heating and Power System(hereinafter referred to as“CCHP”)improves the capacity utilization rate and energy utilization efficiency,single use of CCHP system cannot realize dynamic matching between supply and demand loads due to the unbalance features of the user’s cooling and heating loads.On the basis of user convenience and wide applicability of clean air energy,this paper tries to put forward a coupled CCHP system with combustion gas turbine and ASHP ordered power by heat,analyze trends of such parameters as gas consumption and power consumption of heat pump in line with adjustment of heating load proportion of combustion gas turbine,and optimize the system ratio in the method of annual costs and energy environmental benefit assessment.Based on the analysis of the hourly simulation and matching characteristics of the cold and hot load of the 100 thousand square meter building,it is found that the annual cost of the air source heat pump is low,but the energy and environmental benefits are poor.It will lead to 6.35%shortage of cooling load in summer.Combined with the evaluation method of primary energy consumption and zero carbon dioxide emission,the coupling system of CHHP and air source heat pump with 41%gas turbine load ratio is the best configuration.This system structure and optimization method can provide some reference for the development of CCHP coupling system. | Xueqin Tian Jinfei Sun Tong Xu Mengran Cui Xinlei Wang Jianxiang Guo De-gejirifu Na Wang | 2022 | Energy Engineering2022，119，2： | 0 |
| 10 | Annotating TSSs in Multiple Cell Types Based on DNA Sequence and RNA-seq Data via DeeReCT-TSS显示文摘The accurate annotation of transcription start sites(TSSs)and their usage are critical for the mechanistic understanding of gene regulation in different biological contexts.To fulfill this,specific high-throughput experimental technologies have been developed to capture TSSs in a genome-wide manner,and various computational tools have also been developed for in silico prediction of TSSs solely based on genomic sequences.Most of these computational tools cast the problem as a binary classification task on a balanced dataset,thus resulting in drastic false positive predictions when applied on the genome scale.Here,we present Dee Re CT-TSS,a deep learningbased method that is capable of identifying TSSs across the whole genome based on both DNA sequence and conventional RNA sequencing data.We show that by effectively incorporating these two sources of information,Dee Re CT-TSS significantly outperforms other solely sequence-based methods on the precise annotation of TSSs used in different cell types.Furthermore,we develop a meta-learning-based extension for simultaneous TSS annotations on 10 cell types,which enables the identification of cell type-specific TSSs.Finally,we demonstrate the high precision of DeeReCT-TSS on two independent datasets by correlating our predicted TSSs with experimentally defined TSS chromatin states.The source code for Dee Re CT-TSS is available at http://gffzzec4b27d8b73d463asuxcoovowocp66wp9.ffgz.tsg.suse.edu.cn/Joshua Chou2018/Dee Re CT-TSS_release and http://gffzz77e3413bc06540edsuxcoovowocp66wp9.ffgz.tsg.suse.edu.cn/biocode/tools/BT007316. | Juexiao Zhou Bin Zhang Haoyang Li Longxi Zhou Zhongxiao Li Yongkang Long Wenkai Han Mengran Wang Huanhuan Cui Jingjing Li Wei Chen Xin Gao | 2022 | Genomics, Proteomics & Bioinformatics2022，20，5： | 0 |
| 11 | Design and implementation of a jellyfish otolith-inspired MEMS vector hydrophone for low-frequency detection显示文摘Detecting low-frequency underwater acoustic signals can be a challenge for marine applications.Inspired by the notably strong response of the auditory organs of pectis jellyfish to ultralow frequencies,a kind of otolith-inspired vector hydrophone(OVH)is developed,enabled by hollow buoyant spheres atop cilia.Full parametric analysis is performed to optimize the cilium structure in order to balance the resonance frequency and sensitivity.After the structural parameters of the OVH are determined,the stress distributions of various vector hydrophones are simulated and analyzed.The shock resistance of the OVH is also investigated.Finally,the OVH is fabricated and calibrated.The receiving sensitivity of the OVH is measured to be as high as−202.1 dB@100 Hz(0 dB@1 V/μPa),and the average equivalent pressure sensitivity over the frequency range of interest of the OVH reaches−173.8 dB when the frequency ranges from 20 to 200 Hz.The 3 dB polar width of the directivity pattern for the OVH is measured as 87°.Moreover,the OVH is demonstrated to operate under 10 MPa hydrostatic pressure.These results show that the OVH is promising in low-frequency underwater acoustic detection. | Renxin Wang Wei Shen Wenjun Zhang Jinlong Song Nansong Li Mengran Liu Guojun Zhang Chenyang Xue Wendong Zhang | 2021 | Microsystems & Nanoengineering2021，7，1： | 0 |
| 12 | M2 macrophage-targeted iron oxide nanoparticles for magnetic resonance image-guided magnetic hyperthermia therapy显示文摘Tumor-associated macrophages(TAMs)play an important role in tumor development and progression.In particular,M2 TAMs can promote tumor growth by facilitating tumor progression and malignant behaviors.Selectively targeted elimination of M2 TAMs to inhibit tumor progression is of great significance for cancer treatment.Iron oxide nanoparticles based magnetic hyperthermia therapy(MHT)is a classical approach to destroy tumor tissue with deep penetration depth.In this study,we developed a typical M2 macrophage-targeted peptide(M2pep)functionalized superparamagnetic iron oxide nanoparticle(SPIO)for magnetic resonance imaging(MRI)-guided MHT in an orthotopic breast cancer mouse model.The obtained multifunctional SPIO-M2pep with a hydrodynamic diameter of 20 nm showed efficient targeting capability,high transverse relaxivity(149 mM^(-1) s^(-1))and satisfactory magnetic hyperthermia performance in vitro.In vivo studies demonstrated that the SPIO-M2pep based MRI can monitor the distribution of nanoparticles in tumor and indicate the suitable timing for MHT.The M2 macrophage-targeted MHT significantly reduced the tumor volume and the population of pro-tumoral M2 TAMs in tumor.In addition,the SPIO-M2pep based MHT can remodel the tumor immune microenvironment(TIME).The multifunctional SPIO-M2pep with M2 macrophage-targeting ability,high magnetic hyperthermia efficiency,MR imaging capability and effective role in remodeling the TIME hold great potential to improve clinical cancer therapy outcomes. | Wenshen Wang Fenfen Li Shibo Li Yi Hu Mengran Xu Yuanyuan Zhang Muhammad Imran Khan Shaozhen Wang Min Wu Weiping Ding Bensheng Qiu | 2021 | Journal of Materials Science & Technology2021，，22： | 0 |
| 13 | Preparation, optimization and in vitro–in vivo investigation for capsules of the choline salt of febuxostat显示文摘The objective of the present study was to exhibit the enhanced water-solubility and in vivo oral absorption when febuxostat(FXT) became the salt formation of choline. The formation of the choline salt of febuxostat was confirmed by X-ray powder diffraction, infrared spectroscopy analysis and differential scanning calorimetry. The direct filling method was used to develop a capsule formulation. Cellactose 80 was used as the filler due to its good fluidity, while cross-linked polyvinylpyrrolidone(PVPP) and magnesium stearate(MS) were used as the disintegrant and lubricant, respectively. Then the in vitro release of the formulation was carried out in five different dissolution media including HCl solution(pH 1.2),acetate buffer(pH 4.5), phosphate buffer(pH 6.8 and pH 7.2) and water. Evident improvement of release for choline febuxostat(CXT) was presented in water while the dissolution degree was decreased for CXT in the medium of phosphate buffer(pH 6.8) in comparison with FXT. Furthermore, the pharmacokinetics of CXT was studied in rats using UPLC-MS/MS compared with FXT. The data acquired illustrated that AUC0-24 h of CXT and FXT were22,245.96 ± 7342.92 μg·h/l and 12,249.70 ± 2024.04 μg·h/l, respectively. The relative bioavailability of CXT to FXT was about 181.6% and the P value of AUC0-24 h was less than 0.05. It showed significant difference between the two drugs after oral administration. In conclusion, the water-solubility and oral bioavailability were both improved remarkably for the choline salt of febuxostat and choline salinization was proved an effective way to increase the in vivo absorption for FXT. | Xuemei Han Wanpeng Qi Wenxiang Dong Mengran Guo Panqin Ma Jing Wang | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，6： | 0 |
| 14 | Multiple Trajectories of Cereal Consumption and Their Associations with Type 2 Diabetes in Chinese Adults-China,1997-2018显示文摘Summary What is already known about this topic?Consuming refined grains,specifically white rice,elevates the risk of developing type 2 diabetes(T2D).Conversely,incorporating whole grains into the diet is linked to a reduced risk.What is added by this report?This study employed a novel multi-trajectory modeling technique to account for the intercorrelations among various cereal consumption patterns. | Mengran Liu Zhiru Wang Feifei Huang Weiyi Li Zhihong Wang Huijun Wang Gangqiang Ding | 2023 | China CDC weekly2023，5，41： | 0 |
| 15 | A novel oral prodrug-targeting transporter MCT 1: 5-fluorouracil-dicarboxylate monoester conjugates显示文摘Monocarboxylate transporter 1(MCT1)is responsible for oral absorption of short-chain monocarboxylic acids from small intestine,hence,it’s likely to serve as an ideal design target for the development of oral prodrugs.However,potential application of MCT1 to facilitate the oral delivery is still unclear.Irregular oral absorption,poor permeability and bioavailability greatly limit the oral delivery efficiency of 5-fluorouracil(5-FU).Herein,we design three 5-FU-fatty acid conjugates targeting intestinal MCT1 with different lipophilic linkages.Interestingly,due to high MCT1 affinity and good gastrointestinal stability,5-FUoctanedioic acid monoester prodrug exhibited significant improvement in membrane permeability(13.1-fold)and oral bioavailability(4.1-fold)compared to 5-FU.More surprisingly,stability experiment in intestinal homogenates showed that 5-FU prodrugs could be properly activated to release 5-FU within intestinal cells,which provides an ideal foundation for the improvement of oral bioavailability.In summary,good gastrointestinal stability,high membrane permeability and appropriate intestinal cell bioactivation are the important factors for high-efficiency 5-FU oral prodrugs,and such work provides a good platform for the development of novel oral prodrugs targeting intestinal transporters. | Yixin Sun Dongyang Zhao Gang Wang Qikun Jiang Mengran Guo Qiming Kan Zhonggui He Jin Sun | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，6： | 0 |
| 16 | Core-shell lipid-polymeric nanoparticles for enhanced oral bioavailability and antihypertensive efficacy of KY5 peptide显示文摘Hypertension is the leading risk factor for death and disability, and hypertensive patients always need long-term oral antihypertensive drugs. Some bioactive peptides that extracted from animals or plants have shown excellent advantages on antihypertension. However, the oral delivery of these peptides is always failure on account of instability and poor absorption in the gastrointestinal tract. Herein, we developed a core-shell lipid-polymeric nanoparticle for oral delivery of a highly efficient antihypertensive peptide KY5(KY5-CSs). KY5-CSs had a particle size of 216.7 ± 2.5 nm, with a narrow PDI of 0.07 ± 0.01.The zeta potential was-4.1 ± 0.1 m V. It exhibited good stability in 4 ℃ and possessed a controlled release behavior in gastrointestinal tract. The cellular uptake study proved that the lipid shell imparted unique capability of permeation across the mucus layer and internalization by Caco-2/HT-29 cells. In addition, KY5-CSs enhanced in situ intestinal absorption in SD rats. The pharmacokinetic studies and antihypertensive efficacy showed a superior oral absorption and antihypertensive effect of KY5-CSs than KY5-NPs. In conclusion, the core-shell lipid-polymeric nanoparticles will provide attractive potential for oral delivery of antihypertensive peptides. | Jingmei Yuan Mengran Guo Shengnan Zhao Jinhua Li Xinchun Wang Jian Yang Zhaohui Jin Xiangrong Song | 2023 | Chinese Chemical Letters2023，34，4： | 0 |
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