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101篇 您的检索式:作者名="Shibo Li"
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1AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells显示文摘The current coronavirus disease 2019(COVID-19)pandemic presents a global public health challenge.The viral pathogen responsible,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),binds to the host receptor ACE2 through its spike(S)glycoprotein,which mediates membrane fusion and viral entry.Although the role of ACE2 as a receptor for SARS-CoV-2 is clear,studies have shown that ACE2 expression is extremely low in various human tissues,especially in the respiratory tract.Thus,other host receptors and/or co-receptors that promote the entry of SARS-CoV-2 into cells of the respiratory system may exist.In this study,we found that the tyrosine-protein kinase receptor UFO(AXL)specifically interacts with the N-terminal domain of SARS-CoV-2 S.Using both a SARS-CoV-2 virus pseudotype and authentic SARS-CoV-2,we found that overexpression of AXL in HEK293T cells promotes SARS-CoV-2 entry as efficiently as overexpression of ACE2,while knocking out AXL significantly reduces SARS-CoV-2 infection in HI 299 pulmonary cells and in human primary lung epithelial cells.Soluble human recombinant AXL blocks SARS-CoV-2 infection in cells expressing high levels of AXL.The AXL expression level is well correlated with SARS-CoV-2 S level in bronchoalveolar lavage fluid cells from COVID-19 patients.Taken together,our findings suggest that AXL is a novel candidate receptor for SARS-CoV-2 which may play an important role in promoting viral infection of the human respiratory system and indicate that it is a potential target for future clinical intervention strategies.Shuai Wang Zongyang Qiu Yingnan Hou Xiya Deng Wei Xu Tingting Zheng Peihan Wu Shaofang Xie Weixiang Bian Chong Zhang Zewei Sun Kunpeng Liu Chao Shan Aifu Lin Shibo Jiang Youhua Xie Qiang Zhou Lu Lu Jing Huang Xu Li 2021Cell Research2021,31,2:39
2A novel strategy for rapid construction of libraries of full-length antibodies highly expressed on mammalian cell surfaces显示文摘一个万用的哺乳动物的显示器系统的开发为有高亲密关系的功能的人的抗体的选择是必要的。这里,我们为能高效地在哺乳动物的房间表面上被表示的全身的抗体图书馆的快速的建设描述了新奇策略。通用向量 pDGB-HC-TM 被插入唯一的序列为兴趣的基因的突然发生在里面和突然发生外面由限制 endonucleases BsmBI, SfiI,和 BstXI 认出了的多重克隆的地点构造。 Cytomegalovirus 倡导者,为在许多哺乳动物的房间的蛋白质的高表示的一个通常使用的倡导者,被用来从导出血小板的生长驾驶插入的抗体基因和一个 transmembrane 领域的表示因素受体在框架被熔化到重链的C终点一致区域到抗体在哺乳动物的房间表面上表示了的锚。用这策略,我们构造了一个全身的人的抗体显示图书馆。DNA 顺序分析和表示分析显示图书馆构造了有 6.58 e 的组合可表现的、可检测的差异 ???汩 l 吗??Ye Zhou Zhen-Rui Chen Chang-Zheng Li Wei He Shuwen Liu Shibo Jiang Wen-Li Ma Wanlong Tan Chen Zhou 2010Acta Biochimica et Biophysica Sinica2010,42,8:11
3Abnormal expression of bHLH3 disrupts a flavonoid homeostasis network,causing differences in pigment composition among mulberry fruits显示文摘Mulberry fruits with high concentrations of anthocyanins are favored by consumers because of their good taste,bright color,and high nutritional value.However,neither the regulatory mechanism controlling flavonoid biosynthesis in mulberry nor the molecular basis of different mulberry fruit colors is fully understood.Here,we report that a flavonoid homeostasis network comprising activation and feedback regulation mechanisms determines mulberry fruit color.In vitro and in vivo assays showed that MYBA-bHLH3-TTG1 regulates the biosynthesis of anthocyanins,while TT2L1 and TT2L2 work with bHLH3 or GL3 and form a MYB-bHLH-WD40(MBW)complex with TTG1 to regulate proanthocyanidin(PA)synthesis.Functional and expression analyses showed that bHLH3 is a key regulator of the regulatory network controlling mulberry fruit coloration and that MYB4 is activated by MBW complexes and participates in negative feedback control of the regulatory network to balance the accumulation of anthocyanins and proanthocyanidins.Our research demonstrates that the interaction between bHLH3 and MYB4 in the homeostasis regulatory network ensures that the fruits accumulate desirable flavonoids and that this network is stable in pigmentrich mulberry fruits.However,the abnormal expression of bHLH3 disrupts the balance of the network and redirects flavonoid metabolic flux in pale-colored fruits,resulting in differences in the levels and proportions of anthocyanins,flavones,and flavonols among differently colored mulberry fruits(red,yellow,and white).The results of our study reveal the molecular basis of the diversity of mulberry fruit colors.Han Li Zhen Yang Qiwei Zeng Shibo Wang Yiwei Luo Yan Huang Youchao Xin Ningjia He 2020Horticulture Research2020,7,1:8
4Identification of HBsAg-specific antibodies from a mammalian cell displayed full-length human antibody library of healthy immunized donor显示文摘肝炎 B 免疫球蛋白(HBIG ) 在肝炎 B 的管理是重要的病毒(HBV ) 感染。试图作为 HBIG 的一种选择开发 recombinant monoclonal 抗体,我们报导 HBV 表面抗原(HBsAg ) 的成功的鉴定从在哺乳动物的房间上显示的一个全身的人的抗体图书馆的特定的抗体出现。把一个生来地使免疫的施主的外部血 mononuclear 房间的全部的 RNA 用作模板,抗体全部剧目被放大。联合四方法的结扎和 Flp 调停 recombinase 的集成(Flp 在里面) 系统,我们构造了每个房间在显示了一个种仅仅抗体分子的一个哺乳动物的基于房间的、充分人的、全身的抗体显示图书馆。由屏蔽使用激活荧光的房间排序的房间图书馆(FACS ) ,八个房间克隆显示那房间表面上的 HBsAg 特定的抗体被识别。抗体基因的 DNA 顺序分析揭示了三唯一的抗体。FACS 数据显示了那荧光灯表示(FSE ) 的力量,荧光灯绑定(FSB ) 的力量和相对有约束力的能力(RBA ) 都在他们之中是不同的。这些结果由使用我们的抗体表明了那哺乳动物的显示和屏蔽站台,我们能成功地从一个使免疫的全身的抗体图书馆识别抗原特定的抗体。因此,这个平台为治疗学的抗体的开发是很有用的。Chang-Zheng Li Zhong-Kun Liang Zhen-Rui Chen Hai-Bo Lou Ye Zhou Zhe-Huan Zhang Fei Yu Shuwen Liu Yuanping Zhou Shuguang Wu Wenling Zheng Wanlong Tan Shibo Jiang Chen Zhou 2012Cellular & Molecular Immunology2012,9,2:7
5Mg-Zn-Y-Nd coated with citric acid and dopamine by layer-by-layer self-assembly to improve surface biocompatibility显示文摘Magnesium alloy has been generally accepted as an important biodegradable material on cardiovascular stent development for a long time. However, its limited biocompatibility, especially delayed endothelialization process restricts its further application. In this contribution, we modified the Mg-Zn-Y-Nd alloy surface with citric acid and dopamine via a layer-by-layer self-assembly assay, aiming at improving the biocompatibility of the magnesium alloy. The citric acid/dopamine(CA/PDA) layer exhibited a remarkable suppression of platelet activation/aggregation and thrombosis under 15 dyn/cm2 blood flowing. Inhibition on vascular smooth muscle cells growth and macrophages attachment/activation were also observed on this layer. In particular, the CA/PDA layer presented a promoted property for the vascular endothelial cells growth and spreading compared with the bare magnesium alloy, suggesting the pro-endotelialized function. In conclusion, this research may support potential application on surface modification of magnesium alloy based cardiovascular stents for better biocompatibility.CHEN Li LI JingAn CHANG JiaWei JIN ShiBo WU Di YAN HaoHao WANG XiaoFeng GUAN ShaoKang 2018Science China(Technological Sciences)2018,61,8:7
6Four-way ligation for construction of a mammalian cell-based full-length antibody display library显示文摘唯一的四方法的结扎策略为一个全身的抗体图书馆的快速的建设被开发。哺乳动物的表示向量被构造盒子和序列由唯一的限制酶 BsmBI, BstXI,和 SfiI 认出了的那包含的双哺乳动物的表情。重链的基因的全身的轻链、可变的领域被四方法的结扎在一步插入到向量,并且全身的二原子价的抗体在哺乳动物的房间表面上被显示。用这策略,仅仅 2 个星期被要求成功地构造高质量的、全身的人的抗体图书馆。Ivan Zhou Zhe-Huan Zhang Chang-Zheng Li Zhen-Rui Chen Wei He Ye Zhou Shuwen Liu Shuguang Wu Yuanping Zhou Wanlong Tan Shibo Jiang Chen Zhou 2011Acta Biochimica et Biophysica Sinica2011,43,3:6
7Roles of the hemagglutinin of influenza A virus in viral entry and development of antiviral therapeutics and vaccines显示文摘Seasonal influenza epidemics and influenza pandemics caused by influenza A virus(IAV)has resulted in millions of deaths in the world.The development of anti-IAV vaccines and therapeutics is urgently needed for prevention and treatment of IAV infection and for controlling future influenza pandemics.Hemagglutinin(HA)of IAV plays a critical role in viral binding,fusion and entry,and contains the major neutralizing epitopes.Therefore,HA is an attractive target for developing anti-IAV drugs and vaccines.Here we have reviewed the recent progress in study of conformational changes of HA during viral fusion process and development of HA-based antiviral therapeutics and vaccines.Shibo Jiang Runming Li Lanying Du Shuwen Liu 2010Protein & Cell2010,1,4:5
8Salvianolic acid C potently inhibits SARS-CoV-2 infection by blocking the formation of six-helix bundle core of spike protein显示文摘Dear Editor,The pandemic of COVID-19 caused by SARS-CoV-2 infection has posed a serious threat to global public health and the economy.Up to now,although several potentially effective antiviral drugs are under evaluating in clinical trials around the world,1 there are still no specific antiviral countermeasures beyond supportive therapies have been established.We herein report that the hydrophilic compound Salvianolic acid C(Sal-C)from Danshen,a traditional Chinese medicine(TCM),potently inhibit SARS-CoV-2 infection by blocking the formation of six-helix bundle(6-HB)core of spike(S)protein.Chan Yang Xiaoyan Pan Xinfeng Xu Chen Cheng Yuan Huang Lin Li Shibo Jiang Wei Xu Gengfu Xiao Shuwen Liu 2020Signal Transduction and Targeted Therapy2020,5,1:5
9Engineered trimeric ACE2 binds viral spike protein and locks it in'Thfee-up'conformation to potently inhibit SARS-CoV-2 infection显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has resulted in a severe global pandemic Following SARS-CoV,SARS-CoV-2 is yet another emerge nt beta-coronavirus threate ning human health.1 However,seventeen years after the SARS pandemic,no targeted vaccines or therapeutics have been approved for SARS,while some of them might have held promise for treating COVID-19.Many neutralizing antibodies against SARS-CoV-2 are currently being developed.However,RNA viruses are known to have high mutation rates.Liang Guo Wenwen Bi Xinling Wang Wei Xu Renhong Yan Yuanyuan Zhang Kai Zhao Yaning Li Mingfeng Zhang Xia Cai Shibo Jiang Youhua Xie Qiang Zhou Lu Lu Bobo Dang 2021Cell Research2021,31,1:5
10Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc显示文摘Proper control of B cell growth and metabolism is crucial for B-cell-mediated immunity,but the underlying molecular mechanisms remain incompletely understood.In this study,Sin1,a key component of mTOR complex 2(mTORC2),specifically regulates B cell growth and metabolism.Genetic ablation of Sin1 in B cells reduces the cell size at either the transitional stage or upon antigen stimulation and severely impairs metabolism.Sin1 deficiency also severely impairs B-cell proliferation,antibody responses,and anti-viral immunity.At the molecular level,Sin1 controls the expression and stability of the c-Myc protein and maintains the activity of mTORC1 through the Akt-dependent inactivation of GSK3 and TSC1/2,respectively.Therefore,our study reveals a novel and specific role for Sin1 in coordinating the activation of mTORC2 and mTORC1 to control B cell growth and metabolism.Man Li Adam S.Lazorchak Xinxing Ouyang Huihui Zhang Hongzhi Liu Omotooke A.Arojo Lichong Yan Jingsi Jin Yuheng Han Guojun Qu Yuhong Fu Xiaocao Xu Xiaobo Liu Wenqian Zhang Zhengfeng Yang Chuan Ruan Qijun Wang Dou Liu Chuanxin Huang Lu Lu Shibo Jiang Fubin Li Bing Su 2019Cellular & Molecular Immunology2019,16,9:4
11From structural ceramics to 2D materials with multi-applications:A review on the development from MAX phases to MXenes显示文摘MAX phases(Ti_(3)SiC_(2),Ti_(3)AIC_(2),V_(2)AlC,TiqAlN_(3),etc.)are layered ternary carbides/nitrides,which are generally processed and researched as structure ceramics.Selectively removing A layer from MAX phases,MXenes(Ti_(3)C_(2),V_(2)C,Mo_(2)C,etc.)with two-dimensional(2D)structure can be prepared.The MXenes are electrically conductive and hydrophilic,which are promising as functional materials in many areas.This article reviews the milestones and the latest progress in the research of MAX phases and MXenes,from the perspective of ceramic science.Especially,this article focuses on the conversion from MAX phases to MXenes.First,we summarize the microstructure,preparation,properties,and applications of MAX phases.Among the various properties,the crack healing properties of MAX phase are highlighted.Thereafter,the critical issues on MXene research,including the preparation process,microstructure,MXene composites,and application of MXenes,are reviewed.Among the various applications,this review focuses on two selected applications:energy storage and electromagnetic interference shielding.Moreover,new research directions and future trends on MAX phases and MXenes are also discussed.Aiguo ZHOU Yi LIU Shibo LI Xiaohui WANG Guobing YING Qixun XIA Peigen ZHANG 2021Journal of Advanced Ceramics2021,10,6:4
12Catalytic Effect Analysis of Metallic Catalyst During Diamond Single Crystal Synthesis显示文摘By transition metals(Fe,Ni,Mn,Co) and their alloys as catalysts during the diamond synthesis,some transition phases will be formed,such as Fe_3C type carbides and y solid solutions.Based on the empirical electron theory of the solid and molecules,the valence electron structures of different kinds of carbides and y solid solutions and the relative electron density differences of various diamond/carbide and y solid solution/carbide interfaces were calculated and analyzed in this paper.The electron structure conditions of the ideal catalyst were presented by analyzing the different catalytic effects of the catalysts,which provide a new theoretical path to the optimal design of the catalyst composition.Li Li Shibo Xing 2014Acta Metallurgica Sinica(English Letters)2014,27,1:4
13Engineering self-healing adhesive hydrogels with antioxidant properties for intrauterine adhesion prevention显示文摘Intrauterine adhesion (IUA) is the fibrosis within the uterine cavity. It is the second most common cause of female infertility, significantly affecting women’s physical and mental health. Current treatment strategies fail to provide a satisfactory therapeutic outcome for IUA patients, leaving an enormous challenge for reproductive science. A self-healing adhesive hydrogel with antioxidant properties will be highly helpful in IUA prevention. In this work, we prepare a series of self-healing hydrogels (P10G15, P10G20, and P10G25) with antioxidant and adhesive properties. Those hydrogels exhibit good self-healing properties and can adapt themselves to different structures. They possess good injectability and fit the shape of the human uterus. Moreover, the hydrogels exhibit good tissue adhesiveness, which is desirable for stable retention and therapeutic efficacy. The in vitro experiments using P10G20 show that the adhesive effectively scavenges ABTS+, DPPH, and hydroxyl radicals, rescuing cells from oxidative stress. In addition, P10G20 offers good hemocompatibility and in vitro and in vivo biocompatibility. Furthermore, P10G20 lowers down the in vivo oxidative stress and prevents IUA with less fibrotic tissue and better endometrial regeneration in the animal model. It can effectively downregulate fibrosis-related transforming growth factor beta 1 (TGF-β1) and vascular endothelial growth factor (VEGF). Altogether, these adhesives may be a good alternative for the clinical treatment of intrauterine adhesion.Luyao Feng Liqun Wang Yao Ma Wanglin Duan Sergio Martin-Saldana Ye Zhu Xianpeng Zhang Bin Zhu Chaowei Li Shibo Hu Mingjie Bao Ting Wang Yuan Zhu Fei Yang Yazhong Bu 2023Bioactive Materials2023,,9:3
14Recent advances in developing small-molecule inhibitors against SARS-CoV-2显示文摘The COVID-19 pandemic caused by the novel SARS-CoV-2 virus has caused havoc across the entire world.Even though several COVID-19 vaccines are currently in distribution worldwide,with others in the pipeline,treatment modalities lag behind.Accordingly,researchers have been working hard to understand the nature of the virus,its mutant strains,and the pathogenesis of the disease in order to uncover possible drug targets and effective therapeutic agents.As the research continues,we now know the genome structure,epidemiological and clinical features,and pathogenic mechanism of SARS-CoV-2.Here,we summarized the potential therapeutic targets involved in the life cycle of the virus.On the basis of these targets,small-molecule prophylactic and therapeutic agents have been or are being developed for prevention and treatment of SARS-CoV-2 infection.Rong Xiang Zhengsen Yu Yang Wang Lili Wang Shanshan Huo Yanbai Li Ruiying Liang Qinghong Hao Tianlei Ying Yaning Gao Fei Yu Shibo Jiang 2022Acta Pharmaceutica Sinica B2022,12,4:3
15Integrating remotely sensed water stress factor with a crop growth model for winter wheat yield estimation in the North China Plain during 2008–2018显示文摘Accurate estimation of regional-scale crop yield under drought conditions allows farmers and agricultural agencies to make well-informed decisions and guide agronomic management. However, few studies have focused on using the crop model data assimilation(CMDA) method for regional-scale winter wheat yield estimation under drought stress and partial-irrigation conditions. In this study, we developed a CMDA framework to integrate remotely sensed water stress factor(MOD16 ET PET) with the WOFOST model using an ensemble Kalman filter(En KF) for winter wheat yield estimation at the regional scale in the North China Plain(NCP) during 2008–2018. According to our results, integration of MOD16 ET PETwith the WOFOST model produced more accurate estimates of regional winter wheat yield than open-loop simulation. The correlation coefficient of simulated yield with statistical yield increased for each year and error decreased in most years, with r ranging from 0.28 to 0.65 and RMSE ranging from 700.08 to1966.12 kg ha. Yield estimation using the CMDA method was more suitable in drought years(r = 0.47, RMSE = 919.04 kg ha) than in normal years(r = 0.30, RMSE = 1215.51 kg ha). Our approach performed better in yield estimation under drought conditions than the conventional empirical correlation method using vegetation condition index(VCI). This research highlighted the potential of assimilating remotely sensed water stress factor, which can account for irrigation benefit, into crop model for improving the accuracy of winter wheat yield estimation at the regional scale especially under drought conditions, and this approach can be easily adapted to other regions and crops.Wen Zhuo Shibo Fang Dong Wu Lei Wang Mengqian Li Jiansu Zhang Xinran Gao 2022The Crop Journal2022,10,5:3
16Immunogenicity and tumor-inhibiting effects of HSP-antigen peptide complex in melanoma B16 cells in mice显示文摘目的 :黑色素瘤 B1 6细胞热休克蛋白 -抗原肽复合物 (HACs)及其粗提物 (HAC- CEs)的制备 ,以及它们的免疫原性和抑瘤效应的研究。方法 :应用 Sephacryl S- 2 0 0凝胶过滤制备HAC- CEs,应用亲和层析纯化 HACs,并测其免疫功能和抑瘤效应。结果 :应用凝胶过滤制备的HAC- CE3、HAC- CE4、HAC- CE5和应用亲和层析纯化的 HAC60 ,HAC75和 HAC97均不同程度地降低肿瘤发生率、延迟肿瘤发生时间和减少移植黑色素瘤 C57BL/6J小鼠死亡率 ;同时 ,伴有小鼠脾细胞 IFN-γ和 IL- 2分泌活性及 CTL杀伤率的增加。结论 :分子量为 60 0 0 0~ 970 0 0的 HACs具有免疫原性和抑瘤效应 ,本研究为制备肿瘤疫苗提供重要的实验依据。Gong Shouliang Yang Ying Fu Shibo Li Xiujuan Sun Zuyue Li Xiuyi 2000白求恩医科大学学报2000,26,5:3
17Mechanical properties and frictional resistance of Al composites reinforced with Ti3C2Tx MXene显示文摘Two-dimensional(2D)Ti3C2Tx MXene is an attractive additive not only used in base oil due to its low friction coefficient,but also used in composites due to its high aspect ratio and rich surface functional groups.So far there has been intense research into polymer matrix composites reinforced with Ti3C2Tx,Here we report on the use of 2D Ti3C2Tx to enhance the mechanical and frictional properties of Al matrix composites.Ti3C2Tx/Al composites were designed and prepared by pre s sureless sintering followed by hot extrusion technique.The prepared composites exhibit a homogeneous distribution of Ti3C2Tx.The Vickers hardness and the tensile strength continuously increase with increasing Ti3C2Tx content.A hardness of 0.52 GPa and a tensile strength of 148 MPa were achieved in the 3 wt%Ti3C2Tx/Al composite.The frictional properties of pure Al and the Ti3C2Tx/Al composite were comparably studied under dry sliding.A low friction coefficient of 0.2,twice lower than that of pure Al,was achieved in the 3 wt%Ti3C2Tx/Al composite.Ti3C2Tx acting as a solid lubricant reduces the abrasive wear in the composite,improving the frictional properties of Al matrix composites.Jie Hu Shibo Li Jing Zhang Qiuying Chang Wenbo Yu Yang Zhou 2020Chinese Chemical Letters2020,31,4:3
18Receptor-binding domain-specific human neutralizing monoclonal antibodies against SARS-CoV and SARS-CoV-2显示文摘The outbreaks of severe acute respiratory syndrome(SARS)and Coronavirus Disease 2019(COVID-19)caused by SARS-CoV and SARS-CoV-2,respectively,have posed severe threats to global public health and the economy.Treatment and prevention of these viral diseases call for the research and development of human neutralizing monoclonal antibodies(NMAbs).Scientists have screened neutralizing antibodies using the virus receptor-binding domain(RBD)as an antigen,indicating that RBD contains multiple conformational neutralizing epitopes,which are the main structural domains for inducing neutralizing antibodies and T-cell immune responses.This review summarizes the structure and function of RBD and RBD-specific NMAbs against SARS-CoV and SARS-CoV-2 currently under development.Fei Yu Rong Xiang Xiaoqian Deng Lili Wang Zhengsen Yu Shijun Tian Ruiying Liang Yanbai Li Tianlei Ying Shibo Jiang 2020Signal Transduction and Targeted Therapy2020,5,1:3
19Reliability tests and improvements for Sc-contacted n-type carbon nanotube transistors显示文摘钪(Sc ) 联系了 n 类型碳 nanotube (CNT ) 有背和最高门的结构的完成地的晶体管(联邦货物税) 被制作了,并且他们在空中的稳定性被调查。氧和水分子可以影响 nanotube 隧道和 Sc/nanotube 接触,这被显示出,导致败坏的接触质量和设备性能。与 n 类型碳 nanotube 联邦货物税的不稳定性联系的这些否定效果能通过使钝化被消除由 atomic-layer-deposition 的薄层的 CNT 设备成年 Al2O3 绝缘体。在钝化以后, n 类型碳 nanotube 联邦货物税被显示甚至在被测试并且暴露了通风超过 146 天,然后光滑得多的输出以后展出优秀空气稳定性特征和减少的门电压从 1 ~ 0.1 V 的磁滞现象被表明什么时候与没有钝化的设备相比。持续电源开著测试也为至少 10 h 在大门应力和在空中当前的高排水管下面在使钝化的 CNT 联邦货物税上被执行,揭示空设备降级有时平的改进性能。这些结果答应那 CNT 设备在空中是可靠的并且可以在实际应用被使用使钝化。Shibo Liang Zhiyong Zhang Tian Pei Ruoming Li Yan Li Lianmao Peng 2013Nano Research2013,6,7:3
20Silicon-based micro direct methanol fuel cell with an N-inputs-N-outputs anode flow pattern显示文摘A micro direct methanol fuel cell(μDMFC) is suitable for use in notebook computers,mobile phones,and other digital products.To resolve the poor mass-transport efficiency problem in the anode flow channel,this paper presents an N-inputs-N-outputs parallel flow pattern with rectangular convexes to reinforce methanol mass transport and reduce concentration polarization.The simulation results show that the N-inputs-N-outputs parallel flow channels with the rectangle convexes improve the performance.μDMFCs,which have four anode flow patterns,are fabricated using MEMS(microelectromechanical systems) technology.The experimental results show that the μDMFC with the rectangle convexes has a performance better than previously reported systems,and has a peak power density of 19.96 mW/cm2.The simulation and experimental results are in good agreement.ZHANG YuFeng WANG LuWen YUAN ZhenYu WANG ShiBo LI JianMin LIU XiaoWei 2011Chinese Science Bulletin2011,56,8:2
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