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| 1 | Antioxidant activity and identification of bioactive compounds from leaves of Anthocephalus cadamba by ultra-performance liquid chromatography/electrospray ionization quadrupole time of flight mass spectrometry显示文摘Objective:To evaluate the antioxidant potential of different extract/fractions of Anthocephalus cadamba(A.cadamba)(Roxb.) Miq.(Rubiaceae) and study the tentative identification of their active constituents.Methods:The extract/fractions were screened for antioxidant activity using various in vitro assays viz.DPPH assay,ABTS assay,superoxide anion radical scavenging assay, reducing power assay and plasmid DNA nicking assay.Total phenolic content of extract/fractions was determined by colorimetric method.An ultra-performance LC-electrospray-quadrupoletime of flight mass spectrometry method was used to analyse the active constituents of extract/ fractions of A.cadamba.Results:The ethyl acetate fraction was found to be most active fraction in all the assays as compared to other extract/fractions.The IC50 value of ethyl acetate fraction (ETAC fraction) was 21.24μg/mL,1.12μg/mL,9.68μg/mL and S7.81μg/mL in DPPH assay, ABTS assay,reducing power assay and superoxide scavenging assay respectively.All the extract/ fractions also showed the potential to protect the plasmid DNA(pBR322) against the attack of hydroxyl radicals generated by Fenton’s reagent.The bioactive compounds were identified by UPLC-ESI-QTOF-MS,by comparing the mass andλmax with literature values.Conclusions:The potential of the extract/fractions to scavenge different free radicals in different systems indicated that they may be useful therapeutic agents for treating radical-related pathologic damage. | Madhu Chandel Upendra Sharma Neeraj Kumar Bikram Singh Satwinderjeet Kaur | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，12： | 6 |
| 2 | Who benefits from percutaneous closure of patent foramen ovale vs medical therapy for stroke prevention? In-depth and updated metaanalysis of randomized trials显示文摘BACKGROUND A few randomized clinical trials(RCT) and their meta-analyses have found patent foramen ovale closure(PFOC) to be beneficial in prevention of stroke compared to medical therapy. Whether the benefit is extended across all groups of patients remains unclear.AIM To evaluate the efficacy and safety of PFOC vs medical therapy in different groups of patients presenting with stroke, we performed this meta-analysis of RCTs.METHODS Electronic search of PubMed, EMBASE, Cochrane Central, CINAHL and ProQuest Central and manual search were performed from inception through September 2018 for RCTs. Ischemic stroke(IS), transient ischemic attack(TIA), a composite of IS, TIA and systemic embolism(SE), mortality, major bleeding,atrial fibrillation(AF) and procedural complications were the major outcomes.Random-effects model was used to perform analyses.RESULTS Meta-analysis of 6 RCTs including 3560 patients showed that the PFOC,compared to medical therapy reduced the risk of IS [odds ratio: 0.34; 95%confidence interval: 0.15-0.78; P = 0.01] and the composite of IS, TIA and SE [0.55(0.32-0.93); P = 0.02] and increased the AF risk [4.79(2.35-9.77); P < 0.0001]. No statistical difference was observed in the risk of TIA [0.86(0.54-1.38); P = 0.54],mortality [0.74(0.28-1.93); P = 0.53] and major bleeding [0.81(0.42-1.56); P = 0.53]between two strategies. Subgroup analyses showed that compared to medical therapy, PFOC reduced the risk of stroke in persons who were males, ≤ 45 years of age and had large shunt or atrial septal aneurysm.CONCLUSION In certain groups of patients presenting with stroke, PFOC is beneficial in preventing future stroke compared to medical therapy. | Khagendra Dahal Adil Yousuf Hussam Watti Brannen Liang Sharan Sharma Jharendra Rijal Pavan Katikaneni Kalgi Modi Neeraj TANDon Michael Azrin Juyong Lee | 2019 | World Journal of Cardiology2019，11，4： | 4 |
| 3 | 利用卫星遥感和GIS技术测定印度切蒂斯格尔地区干旱热带森林的土地利用、生物量和碳贮量(英文)显示文摘2001-2002年间,利用卫星遥感和GIS技术研究印度切蒂斯格尔邦的赖布尔地区干旱热带森林的土地利用、生物量和碳贮量情况。主要森林类型为:柚木森林、混合林、衰退森林和婆罗双树混交林。在这些不同森林类型中,立地的坡度和坡面影响森林植被类型、生物量和碳贮量。不同森林类型中,木材积蓄积量、生物量和碳贮量的变化范围分别为:35.59~64.31 m3·hm-2、45.94~78.31Mg·hm-2和22.97~33.27Mg·hm-2。混合林中每公顷的木材蓄积量、生物量和碳贮量最大,衰退森林中的最低。混合林、柚木森林、衰退森林和婆罗双树混交林的总碳量分别为8170.72 Mg、81656.91 Mg、7833.23 Mg和7470.45 Mg。蒂斯格尔邦地区干旱热带森林处于不成熟的生长阶段,且具有很强的碳回收潜力。图6表7参49。 | Arvind Bijalwan S.L.Swamy Chandra Mohan Sharma Neeraj Kumar Sharma A.K.Tiwari | 2010 | Journal of Forestry Research2010，21，2： | 3 |
| 4 | Coexistence of pneumothorax and chilaiditi sign:A case report显示文摘We present a case of 50 year old male patient with coexistence of Pneumothorax and Chilaiditi sign.Chilaiditi sign is an incidental radiographic finding of a usually asymptomatic condition in which a part of intestine is located between the liver and diaphragm;however,the term'Chilaiditi syndrome'is used for symptomatic hepatodiaphragmatic interposition.The patient had no symptoms of abdominal pain,constipation,diarrhea,or emesis.Incidentally,Chilaiditi sign was diagnosed on chest radiography.Pneumothorax is defined as air in the pleural space.Pneumothoraces are classified as spontaneous or traumatic.Spontaneous pneumothorax is labelled as primary when no underlying lung disease is present,or secondary,when it is associated with pre-existing lung disease.Our case is the rare in the literature indicating the coexistence of Chilaiditi sign and pneumothorax. | Tangri Nitin Singhal Sameer Sharma Priyanka Mehta Dinesh Bansal Sachin Bhushan Neeraj Singla Sulbha Singh Puneet | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，1： | 2 |
| 5 | Erythropoietin therapy after out-of-hospital cardiac arrest:A systematic review and meta-analysis显示文摘AIM To assess safety and efficacy of early erythropoietin(Epo) administration in patients with out-of-hospital cardiac arrest(OHCA).METHODS A systematic literature search was performed using PubM ed,MEDLINE,EMBASE,EBSCO,CINAHL,Web of Science and Cochrane databases,of all studies published from the inception through October 10,2016.Inclusion criteria included:(1) Adult humans with OHCA and successful sustained return of spontaneous circulation;and(2) studies including mortality/brain death,acute thrombotic events as their end points.Primary efficacyoutcome was 'brain death or Cerebral Performance Category(CPC) score of 5'.Secondary outcomes were 'CPC score 1,and 2-4','overall thrombotic events' and 'acute coronary stent thrombosis'.RESULTS We analyzed a total of 606 participants(n = 276 received Epo and n = 330 with standard of care alone) who experienced OHCA enrolled in 3 clinical trials.No significant difference was observed between the Epo and no Epo group in brain death or CPC score 5(OR = 0.77;95%CI:0.42-1.39),CPC score 1(OR = 1.16,95%CI:0.82-1.64),and CPC score 2-4(OR = 0.77,95%CI:0.44-1.36).Epo group was associated with increased thrombotic complications(OR = 2.41,95%CI:1.26-4.62) and acute coronary stent thrombosis(OR = 8.16,95%CI:1.39-47.99).No publication bias was observed.CONCLUSION Our study demonstrates no improvement in neurological outcomes and increased incidence of thrombotic events and acute coronary stent thrombosis in OHCA patients who were treated with Epo in addition to standard therapy. | Rahul Chaudhary Jalaj Garg Parasuram Krishnamoorthy Kevin Bliden Neeraj Shah Nayan Agarwal Rahul Gupta Abhishek Sharma Karl B Kern Nainesh C Patel Paul Gurbel | 2017 | World Journal of Cardiology2017，9，12： | 2 |
| 6 | Li 2 MnSiO 4 cathodes modified by phosphorous substitution and the structural consequences显示文摘 | Rosalind J. Gummow Guihong Han Neeraj Sharma Yinghe He | 2014 | Solid State Ionics2014，，： | 1 |
| 7 | Challenges and countermeasures in optical noninva- sive blood glucose detection 显示文摘 | Koushik Chowdhury Anuj Srivastava Neeraj Sharma | 2013 | International Journal of Innovative Research in Science Engineering and Tech- nology2013，2，1： | 1 |
| 8 | Role of ADAM33 gene and associated single nucleotide polymorphisms in asthma显示文摘 | Neeraj sharma M Priya tripathi M shally awasthi MD | 2011 | Allergy Rhinol( Providence)2011，2，2： | 1 |
| 9 | Aryl hy- drocarbon receptor nuclear translocator (ARNT) gene as a posi- tional and functional candidate for type 2 diabetes and prediabetic intermediate traits: Mutation detection, case-control studies, and gene expression analysis 显示文摘 | Swapan K Das Neeraj K Sharma Winston S Chu | 2008 | BMC Medical Genetics2008，9，16： | 1 |
| 10 | Adult and child malaria mortality in India: a nationally representative mortality survey显示文摘 | Neeraj Dhingra Prabhat Jha Vinod P Sharma Alan A Cohen Raju M Jotkar Peter S Rodriguez Diego G Bassani Wilson Suraweera Ramanan Laxminarayan Richard Peto | 2010 | 2010 (9754)2010，，9754： | 1 |
| 11 | Immunomodulatory active compounds from Tinospora cordifolia显示文摘 | Upendra Sharma Manju Bala Neeraj Kumar Bikram Singh Renuka K. Munshi Supriya Bhalerao | 2012 | Journal of Ethnopharmacology2012，，3： | 1 |
| 12 | Security considerations in ad hoc sensor networks 显示文摘 | Fei Hu Neeraj K Sharma | 2005 | Ad Hoc Networks2005，，3： | 1 |
| 13 | Automated medical image segmentation techniques显示文摘 | Aggarwal Lalit Sharma Neeraj | 2010 | Journal of Medical Physics2010，35，1： | 1 |
| 14 | Security considerations in ad hoc sensor networks显示文摘 | Fei Hu Neeraj K. Sharma | 2003 | Ad Hoc Networks2003，，1： | 1 |
| 15 | Physical and biochemical changes in ultra-rapid air chilled broiler muscle and quality of marinated chicken breast filets显示文摘The effect of ultra-rapid chilling in air at-20℃ over water-immersion chilling on broiler carcasses was investigated for physical and biochemical attributes.Forty-eight eviscerated carcasses were divided into two groups,one group were subjected to air chilling and other to water-immersion chilling,and samples were drawn at time periods of 1,3 and 24 h post-chill to analyze for pH,ratios of adenine:inosine nucleotide(R-values),expressible moisture,cook yield,tenderness and color.Ultra-rapid air chilled carcasses showed significant differences(P<0.05)in pH,expressible moisture and cook yield at chosen post-chill time intervals over the carcasses chilled using water-immersion technique.It was concluded that air chilled carcasses had higher pH and expressible moisture,but the R-values,and shear values did not show significant differences,and only slight difference in color of carcasses processed by the two chilling methods.In a separate experiment with 108 commercially processed carcasses,quality attributes of pre-rigor marinated breast filets were studied after subjecting the carcasses to air chilling and water-immersion chilling.Twelve filets from air and water chilled carcass aged for 1,3,and 24 h were tumble marinated for 25 min in a Sodium Tri Polyphosphate(STPP)and NaCl solution with different pick up levels of 10,15 and 20%.After measuring marinade absorption,filets were aged at 2℃ for 24 h.No differences were observed between the air and water chilling treatments in terms of marinade retention at different marinade target levels(10,15 and 20%)and time intervals(24,27 and 47 h)but cook yield of air chilled marinated fillet was higher.In conclusion,processors using further-processing operations that debone meat may find that AC to be more suitable alternative for cooling poultry carcasses because fillet color,marination yield,and tenderness were not affected,but cook yield was improved. | Rakesh K.Singh Neeraj Sharma | 2022 | Food Bioscience2022，46，2： | 1 |
| 16 | A new species of Gigaspora from desert soils of Rajasthan, India显示文摘 | Neeraj Mukerji K G Sharma B C et d | 1993 | World Journal of Microbiology and Biotechnology1993，9，： | 1 |
| 17 | Improved insulin sensitivity after treatment with PPARγ and PPARα ligands is mediated by genetically modulated transcripts显示文摘 | Neda Rasouli Philip A. Kern Steven C. Elbein Neeraj K. Sharma Swapan K. Das | 2012 | Pharmacogenetics and Genomics2012，，7： | 1 |
| 18 | Kikuchi-Fujimoto disease:A comprehensive review显示文摘Kikuchi-Fujimoto disease,a rare form of necrotizing lymphadenitis,is an uncommon,benign,self-limiting disorder of obscure etiology.It affects mostly young adults of both genders.Clinically,it presents with fever and lymphadenopathy of a firm to rubbery consistency frequently involving cervical lymph nodes while weight loss,splenomegaly,leucopenia,and elevated erythrocyte sedimentation rate feature in severely affected patients.Cutaneous involvement occurs in about 30%-40%of cases as facial erythema and nonspecific erythematous papules,plaques,acneiform or morbilliform lesions of great histologic heterogeneity.Both Kikuchi-Fujimoto disease and systemic lupus erythematosus share an obscure and complex relationship as systemic lupus erythematosus may occasionally precede,develop subsequently,or sometimes be associated concurrently with Kikuchi-Fujimoto disease.It is often mistaken for non-Hodgkin lymphoma while lupus lymphadenitis,cat-scratch disease,Sweet’s syndrome,Still’s disease,drug eruptions,infectious mononucleosis,and viral or tubercular lymphadenitis are other common differentials.Fine needle aspiration cytology mostly has features of nonspecific reactive lymphadenitis and immunohistochemistry studies usually show variable features of uncertain diagnostic value.Since its diagnosis is exclusively from histopathology,it needs to be evaluated more carefully;an early lymph node biopsy will obviate the need for unnecessary investigations and therapeutic trials.Its treatment with systemic corticosteroids,hydroxychloroquine,or antimicrobial agents mostly remains empirical.The article reviews clinicoepidemiological,diagnostic,and management aspects of KFD from the perspective of practicing clinicians. | Vikram K Mahajan Vikas Sharma Neeraj Sharma Ritu Rani | 2023 | World Journal of Clinical Cases2023，11，16： | 1 |
| 19 | An Integrative Genomics Approach Identifies Activation of Thioredoxin/Thioredoxin Reductase-1-Mediated Oxidative Stress Defense Pathway and Inhibition of Angiogenesis in Obese Nondiabetic Human Subjects显示文摘 | Swapan K. Das Neeraj K. Sharma Sandra J. Hasstedt Ashis K. Mondal Lijun Ma Kurt A. Langberg Steven C. Elbein | 2011 | The Journal of Clinical Endocrinology & Metabolism2011，，8： | 1 |
| 20 | Effect of plumbagin free alcohol extract of Plumbago zeylanica Linn,root on reproductive system of female Wistar rats显示文摘Objective:To assess the effect of plumbagin-free alcohol extract(PFAE) of Plumbago zeylanica Linn.(Plumbaginaceae)(P.zeylanica) root,on female reproductive system and ferlility of adult Female wislar rats.Methods:After the oral acute toxicity study,the PFAE was administered at two dose levels to perform the estrous cycle study,anti-implantation and ahortifacient activity and hormonal analysis.However,the estrogenic/antiestrogenic activity was evaluated at only one most effective dose.Results:LD50 cut-off was 5 000 mg/kg body weight.The extract exhibited significant anti-implantation and ahortifacient activity at the tested dose levels(300 and 500 mg/ kg.p.o.)(P<0.01).The extract dose-dependency decreased the levels of serum progesterone, follicle stimulating hormone and luteinizing hormone,while a dose-dependent increase was observed in the concentration of serum prolactin.The extract did not show any significant changes in structure and function of Uterus when given alone,hut when given along with ethinyl estradiol,it exhibited significant antiestrogenic activity in immature overieclonzed female rats(P<0.001) Biochemical parameters in the serun/blood and haematological parameters did not show appreciable changes throughout and after the course of investigation.However,all the altered parameters returned to normalcy within 30 days following withdrawal of treatment. Conclusions:All findings suggest that the anlifcrtility activity of extract could possibly he through the changes in the implantation site,altered hormonal levels,prolonged estrous cycle and anti-estrogenic activity.Hence,the extract possesses reversible antifcrtility activity without adverse toxicity in female rats. | Gupta Sandeep Ahirwar Dheeraj Sharma Neeraj Kumar Jhade Deenanath Ahirwar Bharti | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，12： | 1 |
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