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| 1 | Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a^(-/-) mice显示文摘AIM: To investigate the ability of a Prunella vulgaris(P. vulgaris) ethanolic extract to attenuate spontaneous typhlocolitis in mdr1a-/- mice. METHODS: Vehicle(5% ethanol) or P. vulgaris ethanolic extract(2.4 mg/d) were administered daily by oral gavage to mdr1a-/- or wild type FVBWT mice from 6 wk of age up to 20 wk of age. Clinical signs of disease were noted by monitoring weight loss. Mice experiencingweight loss in excess of 15% were removed from the study. At the time mice were removed from the study, blood and colon tissue were collected for analyses that included histological evaluation of lesions, inflammatory cytokine levels, and myeloperoxidase activity. RESULTS: Administration of P. vulgaris extracts to mdr1a-/- mice delayed onset of colitis and reduced severity of mucosal inflammation when compared to vehicle-treated mdr1a-/- mice. Oral administration of the P. vulgaris extract resulted in reduced(P < 0.05) serum levels of IL-10(4.6 ± 2 vs 19.4 ± 4), CXCL9(1319.0 ± 277 vs 3901.0 ± 858), and TNFα(9.9 ± 3 vs 14.8 ± 1) as well as reduced gene expression by more than two-fold for Ccl2, Ccl20, Cxcl1, Cxcl9, IL-1 α, Mmp10, VCAM-1, ICAM, IL-2, and TNFα in the colonic mucosa of mdr1a-/- mice compared to vehicle-treated mdr1a-/-mice. Histologically, several microscopic parameters were reduced(P < 0.05) in P. vulgaris-treated mdr1a-/-mice, as was myeloperoxidase activity in the colon(2.49 ± 0.16 vs 3.36 ± 0.06, P < 0.05). The numbers of CD4+ T cells(2031.9 ± 412.1 vs 5054.5 ± 809.5) and germinal center B cells(2749.6 ± 473.7 vs 4934.0 ± 645.9) observed in the cecal tonsils of P. vulgaris-treated mdr1a-/- were significantly reduced(P < 0.05) from vehicle-treated mdr1a-/- mice. Vehicle-treated mdr1a-/- mice were found to produce serum antibodies to antigens derived from members of the intestinal microbiota, indicative of severe colitis and a loss of adaptive tolerance to the members of the microbiota. These serum antibodies were greatly reduced or absent in P. vulgaris-treated mdr1a-/- mice. CONCLUSION: The anti-inflammatory activity of P. vulgaris ethanolic extract effectively attenuated the severity of intestinal inflammation in mdr1a-/- mice. | Kelley MK Haarberg Meghan J Wymore Brand Anne-Marie C Overstreet Catherine C Hauck Patricia A Murphy Jesse M Hostetter Amanda E Ramer-Tait Michael J Wannemuehler | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 8 |
| 2 | Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2R[gamma]c-deficient mice显示文摘 | Sarry Jean-Emmanuel Murphy Kathleen Perry Robin Sanchez Patricia V Secreto Anthony Keefer Cathy Swider Cezary R Strzelecki Anne-Claire Cavelier Cindy Récher Christian Mansat-De Mas Véronique Delabesse Eric Danet-Desnoyers G Carroll Martin | 2011 | Journal of Clinical Investigation2011，，1： | 2 |
| 3 | LIGHT, a New Member of the TNF Superfamily, and Lymphotoxin α Are Ligands for Herpesvirus Entry Mediator显示文摘 | Davide N Mauri Reinhard Ebner Rebecca I Montgomery Kristine D Kochel Timothy C Cheung Guo-Liang Yu Steve Ruben Marianne Murphy Roselyn J Eisenberg Gary H Cohen Patricia G Spear Carl F Ware | 1998 | Immunity1998，，： | 1 |
| 4 | Clinical and pathologic findings of prophylactic salpingo-oophorectomies in 159 BRCA1 and BRCA2 carriers显示文摘 | Amy Finch Patricia Shaw Barry Rosen Joan Murphy Steven A. Narod Terence J. Colgan | 2005 | Gynecologic Oncology2005，，： | 1 |
| 5 | Physicochemical and Functional Properties of Soy Protein Substrates Modified by Low Levels of Protease Hydrolysis显示文摘 | Stephanie Jung Patricia A Murphy Lawrence A Johnson | 2005 | Food Science2005，，70： | 1 |
| 6 | Simplified process for soybean glycinin and β-conglycinin fractionation 显示文摘 | Shaowen Wu Patricia A Murphy Lawrence A Johnson | 2000 | Agric Food Chem2000，48，： | 1 |
| 7 | Isoflavone composition of American and Japanese soybeans in Iowa:effects of variety,crop year,and location显示文摘 | Huei-ju Wang Patricia A Murphy | 1994 | J Agric Food Chem1994，42，： | 1 |
| 8 | Pilotplant Fractionation of Soybean Glcinin显示文摘 | Wu Shawen Patricia Murphy A | 1999 | JAOCS1999，，76： | 1 |
| 9 | Fortification: new findings and implications显示文摘 | Johanna T Dwyer Catherine Woteki Regan Bailey Patricia Britten Alicia Carriquiry P Courtney Gaine Dennis Miller Alanna Moshfegh Mary M Murphy Marianne Smith Edge | 2014 | Nutr Rev2014，，2： | 1 |
| 10 | Lipid Infusion Accelerates Removal of Bupivacaine and Recovery From Bupivacaine Toxicity in the Isolated Rat Heart显示文摘 | Guy L. Weinberg Richard Ripper Patricia Murphy Lucas B. Edelman William Hoffman Gary Strichartz Douglas L. Feinstein | 2006 | Regional Anesthesia and Pain Medicine2006，，： | 1 |
| 11 | Isoflavone content in commercial soybean foods 显示文摘 | Wang H Murphy Patricia A | 1994 | J Agric Food Chem1994，42，8： | 1 |
| 12 | Isoflavone Composition of Amercican and Japanese Soybeans in Iowa: Effect of Variety,Crop Year,and Location显示文摘 | Huei-ju Wang and Patricia A Murphy | 1994 | J Agric Food Chem1994，42，： | 1 |
| 13 | Beliefs about Schooled Knowledge: Domain Specific or Domain General?显示文摘 | Michelle M. Buehl Patricia A. Alexander P.Karen Murphy | 2002 | Contemporary Educational Psychology2002，，3： | 1 |
| 14 | Soybean protein composition and tofu quality 显示文摘 | Patricia A Murphy | 1997 | Food Technology1997，51，88： | 1 |
| 15 | Non-steroidal anti-inflammatory drug use and ovarian cancer risk: findings from the NIH-AARP Diet and Health Study and systematic review显示文摘 | Megan A. Murphy Britton Trabert Hannah P. Yang Yikyung Park Louise A. Brinton Patricia Hartge Mark E. Sherman Albert Hollenbeck Nicolas Wentzensen | 2012 | Cancer Causes & Control2012，，11： | 1 |
| 16 | Bitterness of soy extracts containing isoflavones and saponins显示文摘 | ERICA ALDIN HERYLL ANN REITMEIER PATRICIA MURPHY | 2006 | Journal of Food Science2006，71，3： | 1 |
| 17 | Isoflavone Composition of Amercican and Japanese Soybeans in Iowa:Effect of Variety,Crop Year,and Location显示文摘 | Huei- ju Wang and Patricia A Murphy | 1994 | Agric Food Chem1994，42，： | 1 |
| 18 | Recovery and Functional Properties of Soy Storage Proteins from Lab- and Pilot-Plant Scale Oleosome Production显示文摘 | Virginie Kapchie Lili Towa Catherine Hauck Patricia Murphy | 2012 | Journal of the American Oil Chemists’ Society2012，，5： | 1 |
| 19 | Recycling of Aqueous Supernatants in Soybean Oleosome Isolation显示文摘 | Virginie N. Kapchie Lili T. Towa Catherine Hauck Patricia A. Murphy | 2010 | Journal of the American Oil Chemists’ Society2010，，2： | 1 |
| 20 | Evaluation of enzyme efficiency for soy oleosome isolation and ultrastructural aspects显示文摘 | Virginie N. Kapchie Lili T. Towa Catherine Hauck Patricia A. Murphy | 2009 | Food Research International2009，，1： | 1 |
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