|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Obesity leads to higher risk of sperm DNA damage in infertile patients显示文摘在在富饶上的男营养的影响的过去几年有成长兴趣。不孕被连接了到男过重或肥胖,并且常规精液参数值似乎在高身体团索引(BMI ) 的情况下被改变。在精子 DNA 正直上估计 BMI 的影响的一些研究被出版了,但是他们没导致强壮的一致。我们的目的是进一步探索在精子 DNA 正直和 BMI 之间的关系,通过 3 年的 multicentre 研究。在 subfertile 夫妇的 330 个男搭挡被包括。用标记的终端 uridine 刻痕结束(TUNEL ) 试金,我们在肥胖的人观察了精子 DNA 损坏的增加的率(机会比率(95 %信心间隔) :2.5 (1.2-5.1 )) 。 | Charlotte Dupont Celine Fauret Nathalie Sermondade Marouane Boubaya Florence Eustache Patrice Clement Pascal Briot Isabelle Berthaut Vincent Levy Isabelle Cedrin-Durnerin Brigitte Benzacken Pascale Chavatte-Palmer Rachel Levy | 2013 | Asian Journal of Andrology2013，15，5： | 27 |
| 2 | 睾丸后精子成熟,不育与高胆固醇血症显示文摘胆固醇是参与哺乳动物生理活动的重要分子,由于它是固醇类激素合成的通用前体物质,因而对生殖系统尤为重要。胆固醇不仅仅对于配子发生起到重要作用,它也是公认的精子功能的调节分子。胆固醇体内平衡的调节对睾丸后精子的成熟至关重要,胆固醇水平失衡会影响到睾丸后调控事件。代谢性脂质紊乱(血脂异常症)会影响男性的生育能力,但大多数这方面的研究是从内分泌/睾丸的角度进行探讨的,而这篇综述将关注像高胆固醇血症这样的特定血脂异常症在哺乳动物精子的睾丸后成熟过程中的有害影响。 | Marjorie Whitfield Xavier PoUet-Villard Rachel Levy Joel R Drevet Fabrice Saez | 2015 | Asian Journal of Andrology2015，17，5： | 8 |
| 3 | Body mass index is not associated with sperm-zona pellucida binding ability in subfertile males显示文摘生活方式因素,可以影响男富饶例如重量和营养的地位,包括精子授精能力。这回顾的研究的目的是评估在身体团索引(BMI ) 和根据带绑定(ZB ) 估计的精子带 pellucida 绑定能力之间的协会测试,它被描述了是为预言的一个相关诊断工具在 vitro 授精(IVF ) 能力。从与主要自发或温和的男因素不孕诊断的夫妇的 306 个男病人被包括。在根据 ZB,测试索引的 BMI 和精液参数之间的关联被估计,和越过 BMI 范畴的阳性、否定的测试的频率。在这张选择人口, BMI 不与根据精子的能力估计绑在带 pellucida 的常规精液参数或精子质量有关。在男肥胖的情况下的 IVF 过程的以前描述的差的结果能由于另外的精子缺点,例如精子 capacitation 或 acrosome 反应的改变。在男 BMI 和生物结果之间的连接例如授精率,应该进一步在 IVF 过程期间被评估。 | Nathalie Sermondade Charlotte Dupont Celine Faure Marouane Boubaya Isabelle Cedrin-Durnerin Pascale Chavatte-Palmer Christophe Sifer Rachel Levy | 2013 | Asian Journal of Andrology2013，15，5： | 4 |
| 4 | Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair显示文摘Macrophage plasticity is critical for normal tissue repair following injury.In pathologic states such as diabetes,macrophage plasticity is impaired,and macrophages remain in a persistent proinflammatory state;however,the reasons for this are unknown.Here,using single-cell RNA sequencing of human diabetic wounds,we identified increased JMJD3 in diabetic wound macrophages,resulting in increased inflammatory gene expression.Mechanistically,we report that in wound healing,JMJD3 directs early macrophage-mediated inflammation via JAK1,3/STAT3 signaling.However,in the diabetic state,we found that IL-6,a cytokine increased in diabetic wound tissue at later time points post-injury,regulates JMJD3 expression in diabetic wound macrophages via the JAK1,3/STAT3 pathway and that this late increase in JMJD3 induces NFκB-mediated inflammatory gene transcription in wound macrophages via an H3K27me3 mechanism.Interestingly,RNA sequencing of wound macrophages isolated from mice with JMJD3-deficient myeloid cells(Jmjd3f/fLyz2Cre+)identified that the STING gene(Tmem173)is regulated by JMJD3 in wound macrophages.STING limits inflammatory cytokine production by wound macrophages during healing.However,in diabetic mice,its role changes to limit wound repair and enhance inflammation.This finding is important since STING is associated with chronic inflammation,and we found STING to be elevated in human and murine diabetic wound macrophages at late time points.Finally,we demonstrate that macrophage-specific,nanoparticle inhibition of JMJD3 in diabetic wounds significantly improves diabetic wound repair by decreasing inflammatory cytokines and STING.Taken together,this work highlights the central role of JMJD3 in tissue repair and identifies cell-specific targeting as a viable therapeutic strategy for nonhealing diabetic wounds. | Christopher O.Audu William J.Melvin Amrita D.Joshi Sonya J.Wolf Jadie Y.Moon Frank M.Davis Emily C.Barrett Kevin D.Mangum Hongping Deng Xianying Xing Rachel Wasikowski Lam C.Tsoi Sriganesh B.Sharma Tyler M.Bauer James Shadiow Matthew A.Corriere Andrea TObi Steven LKunkel Benjamin Levi Bethany BMoore Johann EGudjonsson Andrew MSmith Katherine A.Gallagher | 2022 | Cellular & Molecular Immunology2022，19，11： | 2 |
| 5 | Exploring the potential impact of nutritionally actionable genetic polymorphisms on idiopathic male infertility:a review of current evidence显示文摘Infertility affects about 15%of the world's population.In 40%-50%of infertile couples,a male factor underlies the problem,but in about 50%of these cases,the etiology of male infertility remains unexplained.Some clinical data show that lifestyle interventions may contribute to male reproductive health.Cessation of unhealthy habits is suggested for preserving male fertility;there is growing evidence that most preexisting comorbidities,such as obesity and metabolic syndrome,are highly likely to have an impact on male fertility.The analysis of genetic polymorphisms implicated in metabolic activity represents one of the most exciting areas in the study of genetic causes of male infertility.Although these polymorphisms are not directly connected with male infertility,they may have a role in specific conditions associated with it,that is,metabolic disorders and oxidative stress pathway genes that are potentially associated with an increased risk of male infertility due to DNA and cell membrane damage.Some studies have examined the impact of individual genetic differences and gene-diet interactions on male infertility,but their results have not been synthesized.We review the current research to identify genetic variants that could be tested to improve the chances of conceiving spontaneously through personalized diet and/or oral vitamin and mineral supplementation,by examining the science of genetic modifiers of dietary factors that affect nutritional status and male fertility. | Sinda Mahbouli Charlotte Dupont Yaelle Elfassy Eric Lameignere Rachel Levy | 2021 | Asian Journal of Andrology2021，23，5： | 1 |
| 6 | An analysis of science-industry collaborative patterns in a large European University 显示文摘 | Rachel Levy Pascale Roux Sandrine Wolff | 2009 | Journal of Technology Transfer2009，，34： | 1 |
| 7 | An analysis of science–industry collaborative patterns in a large European University显示文摘 | Rachel Levy Pascale Roux Sandrine Wolff | 2009 | The Journal of Technology Transfer2009，，1： | 1 |
| 8 | An analy- sis of science - industry collaborative patterns in a large European University 显示文摘 | Rachel Levy Pascale Roux Sandrine Wolff | 2009 | Journal of Technology Transfer2009，，34： | 1 |
| 9 | Vitamin E and diabetic nephropathy in mice model and humans显示文摘Diabetes mellitus(DM) is associated with increased oxidative stress due to elevated glucose levels in the plasma. Glucose promotes glycosylation of both plasma and cellular proteins with increased risk for vascular events. Diabetic patients suffer from a higher incidence of cardiovascular complications such as diabetic nephropathy. Haptoglobin(Hp) is an antioxidant plasma protein which binds free hemoglobin, thus preventing heme-iron mediated oxidation. Two alleles exist at the Hp gene locus(1 and 2) encoding three possible Hp genotypes that differ in their antioxidant ability, and may respond differently to vitamin E treatment. Several clinical studies to have shown that Hp 1-1 genotype is a superior antioxidant to the Hp 2-2 genotype and Hp 2-2 genotype is associated with a higher incidence ofcardiovascular disease. Vitamin E was found to have beneficial effect in patient and mice with Hp 2-2 genotype. In this review we have summarized the results of our studies in patients with diabetic nephropathy treated with vitamin E and in diabetic mice with different haptoglobin genotypes. | Nakhoul Farid Dahan Inbal Nakhoul Nakhoul Farber Evgeny Rachel Miller-Lotan Andrew P Levy Asleh Rabea | 2013 | World Journal of Nephrology2013，2，4： | 1 |
| 10 | New Isoforms of VEGF Are Translated from Alternative Initiation CUG Codons Located in Its 5′UTR显示文摘 | Moran Meiron Rachel Anunu Eyal J. Scheinman Sharon Hashmueli Ben-Zion Levi | 2001 | Biochemical and Biophysical Research Communications2001，，4： | 1 |
| 11 | Dcveloping a New Teaching Approach for the Chemical Bonding Concept Aligned With Current Scientific and Pedagogical Knowledge显示文摘 | Tami Levy Nahum Rachel Joseph Krajcik | | 0，，： | 1 |
| 12 | Multiple-Type Human Papillomavirus (HPV) Infections: A Cross-Sectional Analysis of the Prevalence of Specific Types in 309,000 Women Referred for HPV Testing at the Time of Cervical Cytology显示文摘 | Elizabeth Louise Dickson Rachel Isaksson Vogel Robin L. Bliss Levi S. Downs | 2013 | International Journal of Gynecological Cancer2013，，7： | 1 |
| 13 | Haptoglobin Genotype– and Diabetes-Dependent Differences in Iron-Mediated Oxidative Stress In Vitro and In Vivo显示文摘 | Rabea Asleh Julia Guetta Shiri Kalet-Litman Rachel Miller-Lotan Andrew P. Levy | 2005 | Circulation Research2005，，4： | 1 |
| 14 | Expression of adipokines in seminal fluid of men of normal weight显示文摘Dear Editor,Infertility affects about 48.5 million couples worldwide,and a male disorder is estimated to be a causative or contributing factor in 20%-50%of cases.^1 Notably,increasing data support the view that obese men are at higher risk of fertility disorders.^2 As is known,obesity is defined by an excess of white adipose tissue,currently recognized as being able to secrete many endocrinologically active molecules called adipokines. | Alice Bongrani Yaelle Elfassy Jean Sebastien Brun Christelle Rame Namya Mellouk Soraya Fellahi Jean Philippe Bastard Rachel Levy Claudine Vasseur Pascal Froment Joelle Dupont | 2019 | Asian Journal of Andrology2019，21，5： | 1 |
| 15 | Combined measurement of procalcitonin and soluble TREM-1 in the diagnosis of nosocomial sepsis显示文摘 | Sebastien Gibot Aurelie Cravoisy Rachel Dupays Damien Barraud Lionel Nace Bruno Levy Pierre-Edouard Bollaert | 2007 | 2007 (6-7)2007，，6： | 1 |
| 16 | Poor lysosomal membrane integrity in proximal tubule cells of haptoglobin 2-2 genotype mice with diabetes mellitus显示文摘 | Rabea Asleh Farid M. Nakhoul Rachel Miller-Lotan Hoda Awad Dan Farbstein Nina S. Levy Nakhoul Nakhoul Theodore C. Iancu Irena Manov Michael Laue Maret G. Traber Katie M. Lebold Andrew P. Levy | 2012 | Free Radical Biology and Medicine2012，，4： | 1 |
| 17 | Correction of HDL Dysfunction in Individuals With Diabetes and the Haptoglobin 2-2 Genotype显示文摘 | Asleh Rabea Blum Shany Kalet-Litman Shiri Alshiek Jonia Miller-Lotan Rachel Asaf Roy Rock Wasseem Aviram Michael Milman Uzi Shapira Chen Abassi Zaid Levy Andrew P | 2008 | Diabetes2008，，10： | 1 |
| 18 | Screening Colonoscopy for Colorectal Cancer in Asymptomatic People:A Meta-Analysis显示文摘 | Yaron Niv Rachel Hazazi Zohar Levi | 2008 | Dig Dis Sci2008，53，： | 1 |
| 19 | Moleculat variability among Exserohilum turcicum isolates using RAPD显示文摘 | RAFAEL P T LEVY Y | 1996 | Canadian journal of plant pathology1996，18，： | 1 |
| 20 | 经皮电刺激系统对标准剂量质子泵抑制剂无应答患者食管酸暴露的治疗效果:概念验证性研究显示文摘背景:胃食管反流病(GERD)是一种常见病。有接近35%的GERD患者无法通过标准剂量质子泵抑制剂(PPI)治疗控制症状。考虑到PPI治疗的高失败率和低满意度,GERD患者需要一种新的治疗方法。本研究旨在评估经皮电刺激系统(TESS)能否减轻标准剂量PPI治疗失败的GERD患者的食管酸暴露。方法:我们前瞻性入组了10例标准剂量PPI治疗失败、具有烧心和反流症状且食管酸暴露异常的GERD患者。在放置了食管pH胶囊后,所有患者予以TESS治疗。主要研究终点是24小时内pH<4时长占比下降和/或DeMeester评分减少50%。结果:最终7例GERD患者完成研究,其中男性2例,女性5例,年龄(49.3˘10.1)岁。治疗前24小时内pH<4时长占比为(12.0˘4.9)%;TESS治疗后14天,该占比分别为(5.5˘3.4)%、(4.5˘2.6)%、(3.7˘2.9)%和(4.4˘2.5)%。治疗前平均DeMeester评分为39.0˘18.5;TESS治疗14天,该评分分别降至15.8˘9.2、13.2˘6.8、11.2˘9.4和12.0˘6.8。结论:对于标准剂量PPI治疗失败的GERD患者,TESS是一种安全且潜在有效的治疗方法,可以减轻食管酸暴露。需要大样本前瞻性对照研究来验证上述初步结果。 | Ram Dickman Sigal Levy Tsachi Tsadok Perets Maor Hazani-Pauker Doron Boltin Hemda Schmilovitz-Weiss Issa Nidal Matan Siterman Dan Carter Ronnie Fass Rachel Gingold-Belfer | 2021 | Gastroenterology Report2021，9，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员