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| 1 | Does Helicobacter pylori infection play a role in iron deficiency anemia? A meta-analysis显示文摘AIM:To perform a meta-analysis of observational studies and randomized controlled trials(RCTs)on the association between Helicobacter pylori(H.pylori)and iron deficiency anemia(IDA).METHODS:A defined search strategy was used to search Medline,Embase,the Cochrane Library,Clinical Trials,Cochrane Central Register of Controlled Trials,Premedline and Healthstar.Odds ratio(OR)was used to evaluate observational epidemiology studies,and weighted mean difference(WMD)was used to demonstrate the difference between control and intervention groups.RESULTS:Fifteen observational studies and 5 RCTs were identified and used for calculation.The pooled OR for observational studies was 2.22(95%CI:1.52-3.24,P<0.0001).The WMD for hemoglobin(HB) was 4.06 g/L(95%CI:-2.57-10.69,P=0.01),and the WMD for serum ferritin(SF)was 9.47μg/L(95%CI:-0.50-19.43,P<0.0001).Results were heterogeneous for all comparisons.CONCLUSION:This meta-analysis on observational studies suggests an association between H.pylori and IDA.In RCTs,eradication of H.pylori can improve HB and SF levels but not significantly. | Qu, Xin-Hua Huang, Xiao-Lu Xiong, Ping Zhu, Cui-Ying Huang, You-Liang Lu, Lun-Gen Sun, Xu Rong, Lan Zhong, Liang Sun, Da-Yu Lin, Hai Cai, Ming-Ci Chen, Zhi-Wei Hu, Bing Wu, Lian-Ming Jiang, Yi-Bin Yan, Wei-Li | 2010 | World Journal of Gastroenterology2010，16，7： | 34 |
| 2 | 电针和经皮穴位电刺激技术在生殖医学中的应用:专家共识(英文)显示文摘本文从传统针刺治疗不孕症的选穴依据与现代电针/经皮穴位电刺激技术的相关原理着手,从最优刺激参数选择、穴位辨证、疗程与治疗次数的确定及基本原理等方面阐述了电针/经皮穴位电刺激技术在多囊卵巢综合症、取卵镇痛、卵巢储备功能降低、胚胎移植以及男性少/弱精症等生殖领域中的具体应用。首次对电针/经皮穴位电刺激技术在生殖领域优势病种中的应用进行了系统的分析和总结,在最优刺激参数选择、穴位辨证、疗程与治疗次数的确定等方面提出了一系列专家共识,并为临床实践提供了指导意见和理论依据。 | Fan QU Rong LI Wei SUN Ge LIN Rong ZHANG Jing YANG Li TIAN Guo-gang XING Hui JIANG Fei GONG Xiao-yan LIANG Yan MENG Jia-yin LIU Li-ying ZHOU Shu-yu WANG Yan WU Yi-jing HE Jia-yu YE Song-ping HAN Ji-sheng HAN | 2017 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2017，18，3： | 24 |
| 3 | Tectorigenin inhibits the inflammation of LPS-induced acute lung injury in mice显示文摘AIM: In a previous study, the anti-inflammatory effects of tectorigenin were disclosed. In this study, the anti-inflammatory effects of tectorigenin on acute lung injury using a lipopolysaccharide(LPS)-induced acute lung injury(ALI) mouse model were investigated. METHOD: The cell-count in the bronchoalveolar lavage fluid(BALF) was measured. The animal lung edema degree was evaluated by the wet/dry weight(W/D) ratio. The superoxidase dismutase(SOD) activity and myeloperoxidase(MPO) activity was assayed using SOD and MPO kits, respectively. The levels of inflammatory mediators, including tumor necrosis factor-α(TNF-α), IL-1β, and IL-6 were assayed using an enzyme-linked immunosorbent assay method. Pathological changes of lung tissues were observed through HE staining. The inflammatory signal pathway related protein nuclear factor NF-κB p65 mR NA expression was measured by real-time PCR, and the protein level of NF-κB p65 was measured using Western blotting analysis. RESULTS: The data showed that treatment with the tectorigenin markedly attenuated the inflammatory cell numbers in the BALF, decreased nuclear factor NF-κB p65 mR NA level and protein level in the lungs, and improved SOD activity and inhibited MPO activity. Histological studies showed that tectorigenin substantially inhibited LPS-induced neutrophils in lung tissue compared with the model group. CONCLUSION: The results indicated that tectorigenin had a protective effect on LPS-induced ALI in mice. | MA Chun-Hua LIU Ji-Ping QU Rong MA Shi-Ping | 2014 | Chinese Journal of Natural Medicines2014，12，11： | 14 |
| 4 | IRF5 regulates lung macrophages M2 polarization during severe acute pancreatitis in vitro显示文摘AIM To investigate the role of interferon regulatory factor 5(IRF5) in reversing polarization of lung macrophages during severe acute pancreatitis(SAP) in vitro.METHODS A mouse SAP model was established by intraperitoneal(ip) injections of 20 μg/kg body weight caerulein. Pathological changes in the lung were observed by hematoxylin and eosin staining. Lung macrophages were isolated from bronchoalveolar lavage fluid. The quantity and purity of lung macrophages were detectedby fluorescence-activated cell sorting and evaluated by real-time polymerase chain reaction(RT-PCR). They were treated with IL-4/IRF5 specific siR NA(IRF5 siR NA) to reverse their polarization and were evaluated by detecting markers expression of M1/M2 using RTPCR.RESULTS SAP associated acute lung injury(ALI) was induced successfully by ip injections of caerulein, which was confirmed by histopathology. Lung macrophages expressed high levels of IRF5 as M1 phenotype during the early acute pancreatitis stages. Reduction of IRF5 expression by IRF5 siR NA reversed the action of macrophages from M1 to M2 phenotype in vitro. The expressions of M1 markers, including IRF5(S + IRF5 siR NA vs S + PBS, 0.013 ± 0.01 vs 0.054 ± 0.047, P < 0.01), TNF-α(S + IRF5 siR NA vs S + PBS, 0.0003 ± 0.0002 vs 0.019 ± 0.018, P < 0.001), iN OS(S + IRF5 siR NA vs S + PBS, 0.0003 ± 0.0002 vs 0.026 ± 0.018, P < 0.001) and IL-12(S + IRF5 si RNA vs S + PBS, 0.000005 ± 0.00004 vs 0.024 ± 0.016, P < 0.001), were decreased. In contrast, the expressions of M2 markers, including IL-10(S + IRF5 siR NA vs S + PBS, 0.060 ± 0.055 vs 0.0230 ± 0.018, P < 0.01) and Arg-1(S + IRF5 siR NA vs S + PBS, 0.910 ± 0.788 vs 0.0036 ± 0.0025, P < 0.001), were increased. IRF5 si RNA could reverse the lung macrophage polarization more effectively than IL-4.CONCLUSION Treatment with IRF5 siR NA can reverse the pancreatitisinduced activation of lung macrophages from M1 phenotype to M2 phenotype in SAP associated with ALI. | Kang Sun Song-Bing He Jian-Guo Qu Sheng-Chun Dang Ji-Xiang Chen Ai-Hua Gong Rong Xie Jian-Xin Zhang | 2016 | World Journal of Gastroenterology2016，22，42： | 13 |
| 5 | The correlation study on antimicrobial resistance and biofilm related genes in clinical isolates of Acinetobacter baumannii显示文摘 | DONG Rong GUAN Chun HU Dan XIN Ting-ting QU Yan | 2013 | 中华危重病急救医学2013，25，8： | 8 |
| 6 | Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2显示文摘Host cellular receptors play key roles in the determination of virus tropism and pathogenesis.However,little is known about SARS-CoV-2 host receptors with the exception of ACE2.Furthermore,ACE2 alone cannot explain the multi-organ tropism of SARS-CoV-2 nor the clinical differences between SARS-CoV-2 and SARS-CoV,suggesting the involvement of other receptor(s).Here,we performed genomic receptor profiling to screen 5054 human membrane proteins individually for interaction with the SARS-CoV-2 capsid spike(S)protein.Twelve proteins,including ACE2,ASGR1,and KREMEN1,were identified with diverse S-binding affinities and patterns.ASGR1 or KREMEN1 is sufficient for the entry of SARS-CoV-2 but not SARS-CoV in vitro and in vivo.SARS-CoV-2 utilizes distinct ACE2/ASGR1/KREMEN1(ASK)receptor combinations to enter different cell types,and the expression of ASK together displays a markedly stronger correlation with virus susceptibility than that of any individual receptor at both the cell and tissue levels.The cocktail of ASK-related neutralizing antibodies provides the most substantial blockage of SARS-CoV-2 infection in human lung organoids when compared to individual antibodies.Our study revealed an interacting host receptome of SARS-CoV-2,and identified ASGR1 and KREMEN1 as alternative functional receptors that play essential roles in ACE2-independent virus entry,providing insight into SARS-CoV-2 tropism and pathogenesis,as well as a community resource and potential therapeutic strategies for further COVID-19 investigations. | Yunqing Gu Jun Cao Xinyu Zhang Hai Gao Yuyan Wang Jia Wang Juan He Xiaoyi Jiang Jinlan Zhang Guanghui Shen Jie Yang Xichen Zheng Gaowei Hu Yuanfei Zhu Shujuan Du Yunkai Zhu Rong Zhang Jianqing Xu Fei Lan Di Qu Guoliang Xu Yun Zhao Dong Gao Youhua Xie Min Luo Zhigang Lu | 2022 | Cell Research2022，32，1： | 8 |
| 7 | Increased circulating of myeloid-derived suppressor cells in myelodysplastic syndrome显示文摘Myelodysplastic syndrome (MDS) is a group of clonal hematopoietic stem cell disorders,characterized by varying degrees of peripheral cytopenia caused by ineffective dysplasia of the myeloid lineages.MDS also has a high risk of progression to acute myeloid leukemia.But the role of immune abnormalities in the pathogenesis of MDS is still not clear. | JIANG Hui-juan FU Rong WANG Hua-quan LI Li-juan QU Wen LIANG Yong WANG Guo-jin WANG Xiao-ming WU Yu-hong LIU Hong SONG Jia GUAN Jing X1NG Li-min RUAN Er-bao SHAO Zong-hong | 2013 | Chinese Medical Journal2013，，13： | 7 |
| 8 | Planning and analysis of the demonstration project of the MVDC distribution network in Zhuhai显示文摘The DC distribution system is an important development direction of the distribution system,which can improve the reliability and the quality of the power supply,and support the new energy,the energy storage,the electric vehicles,and the flexible access of AC and DC loads to grid.To realize the demonstration application of the DC distribution technology,China's first demonstration project of the medium voltage DC distribution network will be built in Zhuhai,Guangdong Province to support the construction of the city energy internet.First,this paper analyzes the demand of the DC distribution network project,and puts forward the construction content and construction target.Then,it designs and analyzes the electrical connection mode,system operation mode,and startup and shutdown mode of the DC distribution network,and proposes the overall project construction plan.Finally,it conducts the specific project design and analysis,which mainly in elude the selection of equipment such as inverters,DC transformers and DC circuit breakers,the design and analysis of the DC control and protection system,the design and analysis of the overvoltage protection and the configuration scheme of the lightning arrester,and analysis of the system transient characteristics.The design and analysis of the engineering program is a combination of China's distribution network engineering practice and technical characteristics,which lays a solid foundation for the advancement of the DC power distribution technology in China,and has reference value and demonstration effect for the design and construction of other projects. | Lu QU Zhanqing YU Qiang SONG Zhichang YUAN Biao ZHAO Dawei YAO Jianfu CHEN Yao LIU Rong ZENG | 2019 | Frontiers in Energy2019，13，1： | 7 |
| 9 | Cryotherapy for cirrhosis-based hepatocellular carcinoma: a single center experience from 1595 treated cases显示文摘Cryoablation 是为 hepatocellular 癌(HCC ) 的不太流行的经皮的夺格的治疗,并且关于它的实用性的当前的证据是有限的。我们在与经皮的 cryoablation 对待 1595 个 HCC 案例关于有效性,安全和这治疗的长期的结果给全面侧面报导我们的经验。从 2003 年 1 月到 2013 年 12 月,有 2313 个 HCC 小瘤的 1595 个病人在我们的中心与 2958 个 cryoablation 会议被切除。完全的脱离与 3.4 朠湥浯捩椠獮慴楢楬祴 ? 畢 ? 的一条吝啬的直径为 1893 个小瘤在 1294 个病人被完成 ?? 潣扭湩摥眠瑩 ??? 瑡整畮瑡摥琠敨攠瑸湥 ? 景朠湥浯捩椠獮慴楢楬祴椠 ? 牰浩牡 ? 塖′畴潭 ? 楴獳敵瑡吗?? | Guanghua Rong Wenlin Bai Zheng Dong Chunping Wang Yinying Lu Zhen Zeng Jianhui Qu Min Lou Hong Wang Xudong Gao Xiujuan Chang Linjing An Yan Chen Yongping Yang | 2015 | Frontiers of Medicine2015，9，1： | 7 |
| 10 | PRICE AND SERVICE COMPETITION WITH MAINTENANCE SERVICE BUNDLING显示文摘In many equipment manufacturing industries,firms compete with each other not only on products price,but also on maintenance service.More and more traditional products oriented firms are offering their customers products bundled with maintenance service(P&S bundles).In this study,we examine firms' incentive to offer customers products bundling with long-term maintenance or repair support service in a duopoly competitive environment.When providing P&S bundles,a firm need to determine the service level(in terms of average response time guarantee for the service in this paper) to offer and needs to build a service facility to handle the maintenance service requirements.Based on the analysis of three sub-game models,we characterize the market conditions in which only one firm,both firms or neither firm will offer P&S bundles.Finally,we analyze the affects of serval market factors on firms' strategy choices. | Yi Wang Linyan Sun Rong Qu Gang Li | 2015 | Journal of Systems Science and Systems Engineering2015，24，2： | 6 |
| 11 | Pathological and molecular examinations of postmortem testis biopsies reveal SARS-CoV-2 infection in the testis and spermatogenesis damage in COVID-19 patients显示文摘In late December 2019,the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which causes coronavirus disease 2019(COVID-19),was identified in Wuhan,China,and the ensuing pandemic has led to more than 50 million infected individuals and more than one million deaths by November 10,2020(http://gffzze7c39cdc9e894ca6sknufkuxuwkx565u5.ffgz.tsg.suse.edu.cn/).Pathologic investigations of autopsy tissue have focused primarily on the lung,heart,and kidney,whereas morphologic data on testis injury and the effects of SARS-CoV-2 infection on spermatogenesis are limited.Although two groups did not detect SARS-CoV-2 in the semen or testes of recovered COVID-19 patients,1,2 another group confirmed SARS-CoV-2 in the semen of patients.3 Therefore,it is currently unknown whether SARS-CoV-2 infection impacts spermatogenesis and male fertility.In the present study,we evaluated the effects of SARS-CoV-2 infection on spermatogenesis by examining the pathophysiology and molecular features of testes obtained from five male COVID-19 patients at autopsy. | Xixiang Ma Chuhuai Guan Rong Chen Yunyun Wang Shenglei Feng Rongshuai Wang Guoqiang Qu Sijia Zhao Fengli Wang Xiaoli Wang Dingyu Zhang Liang Liu Aihua Liao Shuiqiao Yuan | 2021 | Cellular & Molecular Immunology2021，18，2： | 6 |
| 12 | Development and prospect of direct‐current circuit breaker in China显示文摘The direct‐current circuit breaker(DCCB)is the most ideal choice for DC fault isolation in DC grids.Despite a late start,China's research and development on the DCCB have made outstanding achievements.This article provides a brief glance of current China's DCCB development status.It begins by sorting out the technical route according to the topology of DCCB.Then it systematically summarises both mechanical and hybrid DCCBs with focussing on the aspects of topology structure and principle,key technology and characteristics,prototype development and application.It is apparent that Chinese scientists and engineers confronted the worldwide problem of large capacity DC breaking,and put forward a comprehensive solution which consists of an innovative topology structure based on coupled negative voltage circuit,breaking throughs on the key technologies such as highly controllable and reliable fault current commutation,millisecond‐level ultra‐fast and efficient electromagnetic repulsion mechanism,high tolerance and high stability power electronic switch,low residual voltage and fast response energy consumption device,etc.The article states that the world's first set of hybrid high‐voltage(HV)DCCB,and the first set of mechanical HV DCCB have been developed.These DCCBs will soon be deployed to the DC grids which have the highest voltage levels therefore require the strongest breaking capacity.These achievements are leading the world in the development and application of DCCB.The article also discusses the overall development trends of DCCB in the areas of new topologies,key techno-logical breakthroughs and application scenarios,etc.These discussions serve as references for DCCB's future technological advancement and its ever‐expanding applications. | Weijiang Chen Rong Zeng Junjia He Yi Wu Xiaoguang Wei Taixun Fang Zhanqing Yu Zhao Yuan Yifei Wu Wandi Zhou Bing Yang Lu Qu | 2021 | High Voltage2021，6，1： | 6 |
| 13 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 14 | Genetic association of COL1A1 polymorphisms with high myopia in Asian population: a Meta-analysis显示文摘AIM: To comprehensively evaluate the potential association of COL1A1 polymorphisms with high myopia by a systematic review and Meta-analysis.METHODS: All association studies on COL1A1 and high myopia reported up to June 10, 2014 in Pub Med,Embase, Web of Science, and the Chinese Biomedical Database were retrieved. Odds ratios(ORs) and 95%confidence intervals(95% CIs) were analyzed for singlenucleotide polymorphisms(SNPs) using fixed- and random- effects models according to between-study heterogeneity. Publication bias analyses were conducted by Egger's test.RESULTS: A total of four studies from reported papers were included in this analysis. The Meta-analyses for COL1A1 rs2075555, composed of 2304 high myopia patients and 2272 controls, failed to detect any significant association with high myopia. A total of 971 cases and 649 controls were tested for COL1A1 rs2269336. The association of COL1A1 rs2269336 with high myopia was observed in recessive model(CC vs CG+GG, P =0.03) and in heterozygous model(CG vs GG,P =0.04), but not in other models.CONCLUSION: This Meta-analysis shows that COL1A1 rs2269336(CC vs CG +GG) affects individual susceptibility to high myopia, whereas there is no association detected between SNPs rs2075555 and high myopia. Given the limited sample size, further investigations including more ethnic groups are required to validate the association. | Bo Gong Chao Qu Xiao-Fang Huang Zi-Meng Ye Ding-Ding Zhang Yi Shi Rong Chen Yu-Ping Liu Ping Shuai | 2016 | International Journal of Ophthalmology(English edition)2016，9，8： | 5 |
| 15 | Phototransformation of nitrobenzene in the Songhua River:Kinetics and photoproduct analysis显示文摘Nitrobenzene (NB) pollution of the Songhua River caused by an explosion at a petrochemical plant in Jilin City,Jilin Province, China,attracted public concern over the fate of NB in the river.As one of the efforts to predict the fate of residual NB in the river,the kinetics and mechanism of phototransformation of NB in natural water from four sections of the Songhua River were investigated.It was found that photodegradation of NB in water proceeded via pseudo-first-order reaction kinetics under simulated ... | WANG, Aimin HU, Chun QU, Jiuhui YANG, Min LIU, Huijuan RU, Jia QI, Rong SUN, Jingfang | 2008 | Journal of Environmental Sciences2008，20，7： | 4 |
| 16 | Purification function of the natural wetland in the Liaohe Delta显示文摘1IntroductionStructure,functionandchangearethreeimportantaspectsoflandscapeecology(Forman,1986).Landscapefunctionmeanstheinte... | Li Xiu Zhen, Qu Xiang rong, Wang Lian ping, Zhang Hai rong, Xiao Du ning Institute of Applied Ecology, Chinese Academy of Sciences, B.O. Box 417, Shengyang 110015, China | 1999 | Journal of Environmental Sciences1999，11，2： | 4 |
| 17 | Tumour seeding after percutaneous cryoablation for hepatocellular carcinoma显示文摘AIM:To assess the rate and risk factors for tumour seeding in a large cohort of patients.METHODS:Over an 8-year period,1436 hepatocellular carcinoma(HCC) patients with 2423 tumour nodules underwent 3015 image-guided percutaneous cryoablation sessions [1215 guided by ultrasonography and 221 by spiral computed tomography(CT)].Follow-up CT or magnetic resonance imaging was performed every 3 mo.The detailed clinical data were recorded to analyse the risk factors for seeding.RESULTS:The median follow-up time was 18(range 1-90) mo.Seeding was detected in 11 patients(0.76%) at 1-24(median 6.0) mo after cryoablation.Seeding occurred along the needle tract in 10 patients and at a distant location in 1 patient.Seeded tumours usually showed similar imaging and histopathological features to the primary HCCs.Univariate analyses identified subcapsular tumour location and direct subcapsular needle insertion as risk factors for seeding.Multivariate analysis showed that only direct subcapsular needle insertion was an independent risk factor for seeding(P = 0.017;odds ratio 2.57;95%CI:1.47-3.65).Seeding after cryoablation occurred earlier in patients with poorly differentiated HCC than those with well or moderately differentiated HCC [1.33 ± 0.577 mo vs 11.12 ± 6.896 mo;P = 0.042;95%CI:(-19.115)-(-0.468)].CONCLUSION:The risk of seeding after cryoablation for HCC is small.Direct puncture of subcapsular tumours should be avoided to minimise seeding. | Chun-Ping Wang Hong Wang Jian-Hui Qu Yin-Ying Lu Wen-Lin Bai Zheng Dong Xu-Dong Gao Guang-Hua Rong Zhen Zeng Yong-Ping Yang | 2012 | World Journal of Gastroenterology2012，18，45： | 4 |
| 18 | A novel synthesis of pyrazolo[3,4-b]pyridine derivatives through multi-component reaction in ionic liquid显示文摘An efficient and novel procedure for the preparation of pyrazolo[3,4-b]pyridine derivatives through multi-component reaction of aldehyde, 5-amino-3-methyl-1-phenylpyrazole and malononitrile or cyanoacetate in [bmim][BF4] is described in this paper. Advantages of the method presented here include mild conditions, high yields together with a green nature and ease of recovery and reuse of the reaction medium. | Xin Ying Zhang Xiao Yan Li Xue Sen Fan Xia Wang Jian Ji Wang Gui Rong Qu | 2008 | Chinese Chemical Letters2008，19，2： | 3 |
| 19 | Microwave-assisted Green and Efficient Synthesis of N^6-(2-Hydroxyethyl)adenosine and its Analogues显示文摘An efficient protocol for the synthesis of N6-(2-Hydroxyethyl)adenosine and its analogues through nucleophilic substitution was developed. All the reactions were completed in 10 min under microwave irradiation. Using water as solvent makes our method eco-friendly and easy to handle with. | Gui Rong QU Ming Wei GENG Su Hui HAN Zhi Guang ZHANG Feng XUE | 2006 | Chinese Chemical Letters2006，17，9： | 3 |
| 20 | PARTICLE-COLLISION AND POROGEN-LEACHING TECHNIQUE TO FABRICATE POLYMERIC POROUS SCAFFOLDS WITH MICROSCALE ROUGHNESS OF INTERIOR SURFACES显示文摘A facile technique is herein reported to fabricate three-dimensional(3D) polymeric porous scaffolds with interior surfaces of a topographic microstructure favorable for cell adhesion.As demonstration,a well-known biodegradable polymer poly(lactide-co-glycolide)(PLGA) was employed as matrix.Under the porogen-leaching strategy,the large and soft porogens of paraffin were modified by colliding with small and hard salt particles,which generated micropits on the surfaces of paraffin spheres.The eventual PLGA scaffolds after leaching the modified porogens had thus interior surfaces of microscale roughness imprinted by those micropits.The microrough scaffolds were confirmed to benefit adhesion of bone marrow stromal cells(BMSCs) of rats and meanwhile not to hamper the proliferation and osteogenic differentiation of the cells.The insight and technique might be helpful for biomaterial designing in tissue engineering and regenerative medicine. | Zhen Pan Ze-hua Qu Zheng Zhang Rong Peng Ce Yan 丁建东 | 2013 | Chinese Journal of Polymer Science2013，31，5： | 3 |
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