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| 1 | FADD and TRADD expression and apoptosis in primary hepatocellular carcinoma显示文摘AIM To investigate the clinical features ofFADD and TRADD expressions in primaryhepatocellular carcinoma(HCC)and todetermine their relationship with hepaticapoptosis.METHODS FADD and TRADD expressions weredetected by immunohistochemistry and hepaticapoptosis were determined by in situ end-labeling(ISEL).RESULTS Ten(25.6%)cases of HCC weredetected to express FADD protein.The positiverate in HCC is lower than that in non-cancerousadjacent liver tissues(62.5%)(P<0.05).Inthose of grade Ⅰ-Ⅱ,8(38.1%)cases wereFADD positive,while only 2/18(11.1%)casesof grade Ⅲ-Ⅳ had detectable FADD protein(P<0.05).No relationship was found betweenFADD expression and other clinical features,such as gender,age,tumor size,differentiationor metastasis.ISEL positive cells can be seen inall cases of HCC.The hepatic apoptosis wasassociated with FADD expression as moreapoptotic cells were detected in those caseswhich had moderately to strongly positiveFADD,as compared with negative or weakpositive FADD cases(P<0.05).No relationshipwas found between FADD expression and hepaticapoptosis in non-cancerous adjacent livertissues.Fifteen of 39(38.5%)cases of HCCwere found positive for TRADD protein,andsimilar positive rate(37.5%)in non-cancerousadjacent liver tissues(P>0.05).The expressionof TRADD is correlated with HCC differentiation, as only 22.2% of moderately to highlydifferentiated HCC showed positive TRADDprotein,while as high as 52.4% of poorlydifferentiated HCC had TRADD(P<0.05),Norelationship was found between TRADDexpression and gender,age,tumor size or gradeor metastasis,although 42.9% of HCC of gradeⅠ/Ⅱ showed positive TRADD which wasslightly higher than that of grade Ⅲ/Ⅳ(33.3%,P>0.05).Hepatic apoptosis was not related toTRADD expression in HCC or non-cancerousadjacent liver tissues.CONCLUSION Loss of FADD expression playsan important role in HCC carcinogenesis,andexpression of TRADD also contributes to HCCdevelopment.The cell apoptosis in HCC isassociated with FADD expression.However,theexpression of TRADD does not correlate wellwith hepatic apoptosis in HCC. | Sun BH Zhao XP Wang BJ Yang DL Hao LJ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | 超重和正常体质量患者的心力衰竭新发率的荟萃分析显示文摘肥胖和新发心力衰竭之间的关系已经反复确立,关于超重与心力衰竭发展风险知之甚少。该系统回顾和荟萃分析旨在探讨超重、肥胖与新发心力衰竭发生率的关系。在该研究中,研究者从数据库创建开始到2017年6月,系统检索了MEDLINE,Medline InProcess and Other Non-Indexed Citations,EMBASE,Scopus和Cochrane对照试验中心登记册。 | Krittanawong C Tunhasiriwet A Wang Z Zhang H Prokop LJ Chirapongsathorn S Sun T Kitai T Tang WHW 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，4： | 4 |
| 3 | In vitro efficacy,resistance selection,and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin显示文摘 | Sidhu AB Sun Q Nkrumah LJ | | 0，，04： | 1 |
| 4 | Evaluation on t he toxicity of nano-Ag to bovine serum albumin显示文摘 | Liu Rt Sun F Zhang LJ | 2009 | Science of the Total Environment2009，407，13： | 1 |
| 5 | Induction of DNA topoisomerase Ⅱ-mediated DNA cleavage by β-lapachone and related naphtnoquinones显示文摘 | Frydman B Marton LJ Sun JS | 1997 | Cancer res1997，57，4： | 1 |
| 6 | Hydroxytyrosol protects against oxidative damage by simultaneous activation of mitochondrial biogenesis and phase II detoxifying enzyme systems in retinal pigment epithelial cells 显示文摘 | Zhu L Shen WL Sun LJ | 2010 | J Nutr Biochem2010，21，： | 1 |
| 7 | Influential factors of progno- sis in lamivudine treatment for patients with acute-on-chronic hepatitis B liver failure显示文摘 | Sun LJ Yu JW Zhao YH | 2010 | Journal of Gastroenterology and Hepatology2010，25，3： | 1 |
| 8 | Prediction value of model for end-stage liver disease scoring system on prognosis in patients with acute-on-chronic hepatitis B liver failure after plasma exchange and lamivudine treatment显示文摘 | Yu JW Sun LJ Zhao YH | 2008 | J Gastroenterol Hepatol2008，23，81： | 1 |
| 9 | Factors associated with a failed closed reduction for supracondylar fractures in children显示文摘 | Sun LJ Wu ZP Yang J | 2014 | Orthop Traumatol Surg Res2014，100，6： | 1 |
| 10 | Inhibitory effect of osthole on alcohol-induced fatty liver in mice 显示文摘 | Sun F Xie ML Zhu LJ | 2009 | Digest Liver Dis2009，41，2： | 1 |
| 11 | Predictive value of rapidvirological response and early virological response on sus-tained virological response in HCV patients treated with pegy-lated interferon alpha -2a and ribavirin显示文摘 | YU JW WANG GQ SUN LJ | 2007 | J GastroenterolHepatol2007，22，6： | 1 |
| 12 | Solid tumor-targeted infil- trating eytotoxie T lymphoeytes retained by a superantigen fusion protein 显示文摘 | Sun JL Zhao LN Teng LJ et ol | 2011 | PLoS One2011，6，16： | 1 |
| 13 | Novel high-throughput screens of Anopheles gambiae odorant receptors reveal candidate behaviour-modifying chemicals for mosquitoes显示文摘 | Rinker DC Jones PL Pitts RJ Rützler M Camp G Sun LJ Xu PX Dorset DC Weaver D Zwiebel LJ | | 0，，01： | 1 |
| 14 | Effects of spring drought on carbon sequestration, evapotranspiration and water use efficiency in the Songnen meadow steppe in northeast China 显示文摘 | Dong G Guo J Chen J Sun G Gao S Hu LJ Wang YL | 2011 | Ecohydrology2011，4，2： | 1 |
| 15 | Involvement of Gas7 in nerve growth factor-independent and dependent cell processes in PC12 cells显示文摘 | Chao CC Su LJ Sun NK | 2003 | J Neurosci Res2003，74，2： | 1 |
| 16 | The effects of avermectin on a- mino acid neurotransmitters and their receptors in the pigeon brain显示文摘 | Chen LJ Sun BH Cao Y | 2014 | Pestic Bioehem Physiol2014，110，： | 1 |
| 17 | Structural characterization and hydroxyl radicals scavenging capacity ofa polysaccharide from the fruiting bodies of Auricularia polytrichua显示文摘 | SUN Y X LJ T B LIU J C | 2010 | Carbohydrate Polymers2010，80，： | 1 |
| 18 | Isolation and characterization of a co- producer of fengycins and surfactins, endophytic Bacillus amyloliquefaciens ES- 2, from Scutellaria baicalensis Georgi 显示文摘 | Sun LJ Lu ZX Bie XM | 2006 | World Journal of Microbiology and Biotechnology2006，12，： | 1 |
| 19 | Inhibitory effect of osthole on alcohol-induced fatty liver in mice 显示文摘 | Sun F Xie ML Zhu LJ | 2009 | Digest Liver Dis2009，41，2： | 1 |
| 20 | Modelling three-dimensional transient heat transfer of roasted meat during air blast cooling by the finite element method显示文摘 | Wang LJ Sun DW | 2002 | Journal of Food Engineering2002，51，4： | 1 |
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