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| 1 | Emergence of novel strains of avian infectious bronchitis virus in Sweden显示文摘 | Shahid Hussain Abro Lena H.M. Renstr?m Karin Ullman Mats Isaksson Siamak Zohari Désirée S. Jansson Sándor Belák Claudia Baule | 2011 | Veterinary Microbiology (-)2011，，2： | 2 |
| 2 | Antidiabetic and antioxidant effects of Annona muricata (Annonaceae), aqueous extract on streptozotocin-induced diabetic rats显示文摘 | Ngueguim Tsofack Florence Massa Zibi Benoit Kouamouo Jonas Tchuidjang Alexandra Dzeufiet Djomeni Paul Désiré Kamtchouing Pierre Dimo Théophile | 2014 | Journal of Ethnopharmacology2014，，2： | 2 |
| 3 | Excluding infection through procalcitonin testing improves outcomes of congestive heart failure patients presenting with acute respiratory symptoms: Results from the randomized ProHOSP trial显示文摘 | Philipp Schuetz Alexander Kutz Eva Grolimund Sebastian Haubitz Désirée Demann Alaadin V?geli Fabienne Hitz Mirjam Christ-Crain Robert Thomann Claudine Falconnier Claus Hoess Christoph Henzen Robert J. Marlowe Werner Zimmerli Beat Mueller | 2014 | International Journal of Cardiology2014，，3： | 2 |
| 4 | Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue显示文摘AIM To evaluate brain involvement in quiescent Crohn's disease (CD) patients with fatigue using quantitative magnetic resonance imaging(MRI).METHODS Multiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue(defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study groups.RESULTS Reduced glutamate + glutamine (Glx = Glu + Gln) concentrations (P = 0.02) and ratios to total creatine(P = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow(P = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms (P < 0.001). Cognitive functioning scores related to memory (P = 0.007) and executive functioning (P = 0.02) were lower in CD patients and both scores showed correlation with depression and anxiety. No correlation was found subcortical volumes between CD patients and controls in the T1-weighted analysis. In addition, no correlation was found between mental status and MRI findings.CONCLUSION This work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls. | Sanne van Erp Ece Ercan Perla Breedveld Lianne Brakenhoff Eidrees Ghariq Sophie Schmid Matthias van Osch Mark van Buchem Bart Emmer Jeroen van der Grond Ron Wolterbeek Daniel Hommes Herma Fidder Nic van der Wee Tom Huizinga Désirée van der Heijde Huub Middelkoop Itamar Ronen Andrea van der Meulen-de Jong | 2017 | World Journal of Gastroenterology2017，23，6： | 2 |
| 5 | Rap1-Rac1 Circuits Potentiate Platelet Activation显示文摘 | Lucia Stefanini Yacine Boulaftali Timothy D. Ouellette Michael Holinstat Laurent Désiré Bertrand Leblond Patrick Andre Pamela B. Conley Wolfgang Bergmeier | 2012 | Arteriosclerosis, Thrombosis, and Vascular Biology2012，，： | 1 |
| 6 | Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis显示文摘 | Maarten Boers Arco C Verhoeven Harry M Markusse Mart AFJ van de Laar Rene Westhovens J Christiaan van Denderen Derkjen van Zeben Ben AC Dijkmans Andre J Peeters Piet Jacobs Hans R van den Brink Hubert JA Schouten Désirée MFM van der Heijde Annelies Boonen | 1997 | The Lancet1997，，9074： | 1 |
| 7 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 8 | Autophagy by hepatitis B virus and for hepatitis B virus显示文摘 | Sir D Ann D K Ou J H | 2010 | Autophagy2010，6，4： | 1 |
| 9 | The early autopahagic pathway is activated by hepatitis B virus and required for viral DNA replication显示文摘 | Sir D Tian Y Chen WL | 2010 | Proc Natl Acad Sci USA2010，107，9： | 1 |
| 10 | Microfibrillated cellulose and new nanocomposite materials:A review显示文摘 | Siró I Plackett D | | 0，，03： | 1 |
| 11 | Microsomal prostaglandin E synthase-1 is a major terminal synthase that is selectively up-regula- ted during cyclooxygenase-2-dependent prostaglandin E2 production in the rat adjuvant induced arthritis model显示文摘 | Claveau D Sir inyanM Guay J | 2003 | J Immunol2003，170，： | 1 |
| 12 | hutophagy in viral replication and pathogenesis 显示文摘 | Sir D Ou JH | 2010 | MolCells2010，29，1： | 1 |
| 13 | Autophagy in viral replication and pathogenesis显示文摘 | Sir D Ou JH | 2010 | Mol Cells2010，29，1： | 1 |
| 14 | The joint–gut axis in inflammatory bowel diseases显示文摘 | Lianne K.P.M. Brakenhoff Désirée M. van der Heijde Daniel W. Hommes Tom W.J. Huizinga Herma H. Fidder | 2009 | Journal of Crohn’s and Colitis2009，，3： | 1 |
| 15 | The early autophagic pathway is activated by hepatitis B virus and required for viral DNAreplication 显示文摘 | Sir D Tian Y Chen WL | 2010 | Proc Nat1 Acad Sci USA2010，107，9： | 1 |
| 16 | Impact of living with bipolar patients: Making sense of caregivers' burden显示文摘The aim of the present review was to examine objective and subjective burdens in primary caregivers(usually family members) of patients with bipolar disorder(BD) and to list which symptoms of the patients are considered more burdensome by the caregivers. In order to provide a critical review about caregiver's burden in patients with bipolar disorder, we performed a detailed Pub Med, Bio Med Central, ISI Web of Science, Psyc INFO, Elsevier Science Direct and Cochrane Library search to identify all papers and book chapters in English published during the period between 1963 and November 2011. The highest levels of distress were caused by the patient's behavior and the patient's role dysfunction(work, education and social relationships). Furthermore, the caregiving role compromises other social roles occupied by the caregiver, becoming part of the heavy social cost of bipolar affective disorder. There is a need to better understand caregivers' views and personal perceptions of the stresses and demands arising from caring for someone with BD in order to develop practical appropriate interventions and to improve the training of caregivers. | Maurizio Pompili Désirée Harnic Xenia Gonda Alberto Forte Giovanni Dominici Marco Innamorati Konstantinos N Fountoulakis Gianluca Serafini Leo Sher Luigi Janiri Zoltan Rihmer Mario Amore Paolo Girardi | 2014 | World Journal of Psychiatry2014，4，1： | 1 |
| 17 | The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication显示文摘 | Sir D Tian YJ Chen WT eta] | | 0，，： | 1 |
| 18 | European and Mexican vs US diagnostic extracts of Bermuda grass and cat in skin testing显示文摘 | Désirée Larenas-Linnemann Alfredo Arias Cruz Isabel Rojo Gutierrez | 2011 | Annals of Allergy Asthma&Immunology2011，5，5： | 1 |
| 19 | Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response显示文摘 | Jacquelin Béatrice Mayau Véronique Targat Brice Liovat Anne-Sophie Kunkel Désirée Petitjean Ga?l Dillies Marie-Agnès Roques Pierre Butor Cécile Silvestri Guido Giavedoni Luis D Lebon Pierre Barré-Sinoussi Fran?oise Benecke Arndt Müller-Trutw | 2009 | Journal of Clinical Investigation2009，，： | 1 |
| 20 | Aerobic and anaerobic bioprocessing of activated sludge: Floc disintegration by enzymes 显示文摘 | Ayol A Filibeli A Sir D | 2008 | Journal of Environmental Science and Health2008，43，13： | 1 |
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