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| 1 | Overexpression of PGA37/MYB118 and MYB115 promotes vegetative-to-embryonic transition in Arabidopsis显示文摘从 non-germline 房间的体的胚胎的形成对更高的植物唯一并且能被操作在许多种类。以前的研究表明包括 WUSCHEL (WUS )/PLANT 生长 ACTIVATOR6 (PGA6 ) ,几 Arabidopsis 基因的 overexpression 纵容繁荣,叶状的 COTYLEDON1 (LEC1 ) ,和 LEC2,能引起 vegetative-to-embryonic 转变或体的胚胎的形成。这里,我们报导那在 Arabidopsis PGA37 基因的一个 gain-of-function 变化,编码 MYB118 抄写因素,导致的 vegetative-to-embryonic 转变,从根将生物的活组织移植于培养基中培养的体的胚胎的形成,和提高的 LEC1 表示水平。两倍变异的分析证明 WUS 没被 PGA37/MYB118 为体的胚胎的正式就职要求。另外, MYB115 的 overexpression, PGA37/MYB118 的一个相当或相同的事物,引起了象 pga37 一样显型。两倍异种没显示出的 myb118 myb115 明显的发展畸形。一起,这些结果建议 PGA37/MYB118 和 MYB115 支持 vegetative-to-embryonic 转变,通过 WUS 的一个发信号的小径独立人士。 | Xingchun wang Qi-Wen Niu Chong Teng Chao Li Jinye Mu Nam-Hai Chua Jianru Zuo | 2009 | Cell Research2009，19，2： | 30 |
| 2 | Gastric Lgr5+ stem cells are the cellular origin of invasive intestinal-type gastric cancer in mice显示文摘 | Xiu-Bin Li Guan Yang Liang Zhu Yu-Ling Tang Chong Zhang Zhenyu Ju Xiao Yang Yan Teng | 2016 | Cell Research2016，26，7： | 20 |
| 3 | Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis显示文摘Sphingolipids 被建议了在植物房间为一连串的细胞的发信号活动充当第二个送信人,包括压力回答并且规划了房间死亡(PCD ) 。然而,这些过程不是的机制 underpinning 很好理解。这里,我们报导那 Arabidopsis 异种, fumonisin B1 抵抗 11-1 ( fbr 11-1 )没能产生反应的氧中介( ROI ),不能当异种被 fumonisin B ( 1 )( FB ( 1 ))质问时,开始 PCD , ceramide synthase 的一个特定的禁止者。显示的分子的分析 FBR11 编码一个长链的底 1 (LCB1 ) 丝氨酸 palmitoyltransferase (SPT ) 的子单元,它催化 de novo sphingolipid 的第一限制率的步合成。sphingolipid 集中的集体度谱的分析表明而 fbr 11-1 变化没影响 sphingoid 底的基础层次,异种响应 FB (1 ) 显示出 sphingoid 底的稀释形成。由一个直接的喂实验,我们证明免费 sphingoid 底 dihydrosphingosine, phytosphingosine 和鞘氨醇高效地导致产生由房间死亡跟随了的 ROI。相反地, dihydrosphingosine 导致的 ROI 产生和房间死亡被它的 phosphorylated 形式 dihydrosphingosine-1-phosphate 明确地以一种剂量依赖者方式堵住,建议在一个免费 sphingoid 底和它的 phosphorylated 衍生物之间的动态平衡的维护对决定房间命运批评。因为 sphingolipid 水平的改变发生在 ROI 生产以前,我们建议免费 sphingoid 库在 Arabidopsis 涉及 PCD 的控制,大概在收到不同发展或环境的暗示之上通过 ROI 的规定铺平。 | Lihua Shi Jacek Bielawski Jinye Mu Haili Dong Chong Teng Jian Zhang Xiaohui Yang Nario Tomishige Kentaro Hanada Yusuf A Hannun Jianru Zuo | 2007 | Cell Research2007，17，12： | 12 |
| 4 | A Novel Hexanordammarane Glycoside from the Roots of Panax notoginseng显示文摘Notoginsenoside R10, a novel hexanordammarane glycoside was isolated from the roots of Panax nototginseng, as a minor constituent. Its structure was determined as 6-O-(?-D-glucopyranosyl)-3?,6?,12?-trihydroxy-22,23,24,25,26,27-hexanordammaran-20-one(1), by means of spectroscopic methods. | Hai Zhou LI, Rong Wei TENG, Chong Ren YANG* Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 | 2001 | Chinese Chemical Letters2001，12，1： | 12 |
| 5 | Relation Classification via Sequence Features and Bi-Directional LSTMs显示文摘Structure features need complicated pre-processing, and are probably domain-dependent. To reduce time cost of pre-processing, we propose a novel neural network architecture which is a bi-directional long-short-term-memory recurrent-neural-network(Bi-LSTM-RNN) model based on low-cost sequence features such as words and part-of-speech(POS) tags, to classify the relation of two entities. First, this model performs bi-directional recurrent computation along the tokens of sentences. Then, the sequence is divided into five parts and standard pooling functions are applied over the token representations of each part. Finally, the token representations are concatenated and fed into a softmax layer for relation classification. We evaluate our model on two standard benchmark datasets in different domains, namely Sem Eval-2010 Task 8 and Bio NLP-ST 2016 Task BB3. In Sem Eval-2010 Task 8, the performance of our model matches those of the state-of-the-art models, achieving 83.0% in F1. In Bio NLP-ST 2016 Task BB3, our model obtains F_1 51.3% which is comparable with that of the best system. Moreover, we find that the context between two target entities plays an important role in relation classification and it can be a replacement of the shortest dependency path. | REN Yuanfang TENG Chong LI Fei CHEN Bo JI Donghong | 2017 | Wuhan University Journal of Natural Sciences2017，22，6： | 6 |
| 6 | Two New Dammarane Glycosides from the Acid Hydrolysis Product of Panax Notoginseng显示文摘Two new dammarane glycosides named notoginsenoside T1 and T2 were isolated from the mild acid hydrolysis products of the root saponins of Panax notoginseng. On the basis of spectroscopic evidences, their structures were elucidated to be 6-O-?-D-glucopyranosyl-24(25)-epoxy-3?,6?,12?,23ξ-tetrahydroxydammar-20(22)(E)-ene 1 and 6-O-?-D-glucopyranosyl-24(25)-epoxy-23ξ-methoxyl-3?,6?,12?-trihydroxydamm-ar-20(22)(E)-ene 2, respectively. | Rong Wei TENG, Hai Zhou LI, Xue Mei ZHANG, Xi Kui LIU, De Zu WANG, Chong Ren YANG* Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 | 2001 | Chinese Chemical Letters2001，12，3： | 4 |
| 7 | MULTIVARIATE ANALYSIS OF RELATIONSHIPS BETWEEN IODINE BIOLOGICAL EXPOSURE AND SUBCLINICAL THYROID DYSFUNCTIONS显示文摘Objective To assess the relationships between iodine biological exposure and subclinical thyroid dysfunctions. Methods The cross-sectional survey was performed to obtain the epidemiologic data of population in three communities with different iodine biological exposure: mild iodine deficiency [median urinary iodine concentration (MUI) of 50-99 μg/L], more than adequate iodine intake (MUI of 200-299 μg/L), and excessive iodine intake (MUI over 300 μg/L). Univariate and multivariate analysis (logistic regression analysis) were used to analyze the risk factors of subclinical hypothyroidism and subclinical hyperthyroidism. Results Logistic regression analysis with sex and age controlled suggested that more than adequate iodine intake (OR = 3.172, P = 0.0004) and excessive iodine intake (OR = 6.391, P = 0.0001) increased the risk of subclinical hypothyroidism, while excessive iodine intake decreased the risk of subclinical hyperthyroidism (OR = 0.218, P = 0.0001). Logistic regression analysis including interaction of iodine intake and antibodies [tryroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb)] suggested that excessive iodine intake was an independent risk factor of subclinical hypothyroidism (OR = 6.360, P = 0.0001), but independent protect factor of subclinical hyperthyroidism (OR = 0.193, P = 0.0001). More than adequate iodine intake and it’s interaction with TgAb increased the risk of subclinical hypothyroidism independently, in addition, it decreased the risk of subclinical hyperthyroidism at the present of TPOAb. Conclusion Both excessive iodine intake and more than adequate iodine intake could increase risk of subclinical hypo- thyroidism, supplement of iodine should be controlled to ensure MUI within the safe range. | Wei Chong Zhong-yan Shan Wei Sun Wei-ping Teng | 2005 | Chinese Medical Sciences Journal2005，20，3： | 3 |
| 8 | Monepaloside K, a New Triterpenoid Saponin from Morina nepalensis var. alba Hand. - Mazz.显示文摘One new triterpenoid saponin, monepaloside K (1) was isolated from the water-soluble part of the whole plant of a famous Tibetan medicinal herb, morina nepalensis var. alba Hand.-Mazz.. Its structure was determined to be 3-O-a-L-arabinopyranosyl-(13)-b-D- xylopyranosyl siaresinolic acid on the basis of spectroscopic evidences, especially 2D NMR techniques. | Rong Wei TENG, De Zu WANG, Chong Ren YANG* Kunming Institute of Botany, CAS, Kunming 650204 | 2002 | Chinese Chemical Letters2002，13，3： | 3 |
| 9 | Two New Steroidal Glycosides from Fermented Leaves of Agave americana显示文摘Two new spirostanol glycosides named agamenoside A and B, were isolated from the fermented leaves of Agave americana. Their structures were elucidated as (23S, 25R)-5a -spirostan-3b, 6a, 23-triol 3-O-a-L-rhamnopyranosyl-(13)- b-D-glucopyranosyl-(12)-[b-D- xylopyranosyl-(13)]-b-D-glucopyranosyl-(14)-b-D-galactopyranoside (1) and (25R)-5a-spiro- stan-3b, 6a-diol 3-O-b-D-glucopyranosyl-(12)-[ b-D-xylopyranosyl-(13)]- b-D-glucopyra- nosyl-(14)- b-D-galactopyranoside (2) by a combination of chemical and spectral methods. | Jian Ming JIN, Xi Kui LIU, Rong Wei TENG, Chong Ren YANG* Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 | 2002 | Chinese Chemical Letters2002，13，7： | 2 |
| 10 | Smart drug delivery systems for precise cancer therapy显示文摘Nano-drug delivery strategies have been highlighted in cancer treatment, and much effort has been made in the optimization of bioavailability, biocompatibility, pharmacokinetics profiles, and in vivo distributions of anticancer nano-drug delivery systems. However, problems still exist in the delicate balance between improved anticancer efficacy and reduced toxicity to normal tissues, and opportunities arise along with the development of smart stimuli-responsive delivery strategies. By on-demand responsiveness towards exogenous or endogenous stimulus, these smart delivery systems hold promise for advanced tumor-specificity as well as controllable release behavior in a spatial-temporal manner. Meanwhile, the blossom of nanotechnology, material sciences, and biomedical sciences has shed light on the diverse modern drug delivery systems with smart characteristics, versatile functions, and modification possibilities. This review summarizes the current progress in various strategies for smart drug delivery systems against malignancies and introduces the representative endogenous and exogenous stimuli-responsive smart delivery systems. It may provide references for researchers in the fields of drug delivery, biomaterials, and nanotechnology. | Xiaoyou Wang Chong Li Yiguang Wang Huabing Chen Xinxin Zhang Cong Luo Wenhu Zhou Lili Li Lesheng Teng Haijun Yu Jiancheng Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 2 |
| 11 | Laser Surface Remelting of Fe-based Alloy Coating Deposited by APS显示文摘The Fe-based amorphous alloy coatings with different porosities were deposited on Q235 steel substrates by means of atmospheric plasma spraying(APS).The as-sprayed coatings were remelted by the facility of a Nd:YAG laser to further enhance their compactness and bonding strength via orthogonal experiment design.The effects of laser remelting on the microstructure,phase compositions and mechanical properties of the as-sprayed coatings were investigated by optical microscopy,scanning electron microscope,X-ray diffraction and Vickers microhardness tester.The corrosion performance of the coatings was evaluated by both potential dynamic measurements(PDM)and electrochemical impedance spectroscopy(EIS)in a 10%NaOH solution.The results indicate that laser power of 700 W,scanning velocity of 4 mm/s,beam size of 3 mm and porosity of 1.19%are the optimized remelting process parameters.The laser-remelted coatings exhibite more homogenous structure as strong metallurgical bonding to substrates.The amorphous phases in the as-sprayed coatings crystallize toα-Fe,Fe2Si,Fe3.5B,and Fe2W phases for the high temperature and rapid solidification in the remelting process.The microhardness values of as-sprayed are in the range of 700-800 HV0.1,while the microhardness values of the remelted coatings are enhanced slightly to 750-850 HV0.1.Both PDM and EIS analysis results show that the remelted coatings exhibite relatively excellent corrosion resistance compared with the stainless steel 1Cr18Ni9Ti,however the corrosion resistance of the remelted coatings is inferior to the as-sprayed amorphous coatings. | Fu Teng Ye Fuxing Wei Haihong Cui Chong | 2012 | 稀有金属材料与工程2012，41，S1： | 2 |
| 12 | Possible key role of immune system in Schmorl’s nodes显示文摘 | Ning Zhang Fang-Cai Li Yi-Jiang Huang Chong Teng Wei-Shan Chen | 2009 | Medical Hypotheses2009，，3： | 1 |
| 13 | Conversion-coating treatment for magnesium alloys by a permanganate-phosphate solution 显示文摘 | Kwo Zong Chong Teng Shih Shih | 2003 | Materials Chemistry and Physics2003，80，1： | 1 |
| 14 | GA-based fuzzy rein- forcement learning for control of a magnetic bearing system 显示文摘 | CHIN Teng Lin CHONG Ping Jou | 2000 | IEEE Transactions on Systems Man and Cybernet- ics Part B2000，30，2： | 1 |
| 15 | Conversion coating treatment for magnesium alloys by a permanganate phosphate solution显示文摘 | Kwo Zong Chong Teng Shih | 2003 | Mater Chem Phys2003，，1： | 1 |
| 16 | Conversion-coating treatment for magnesium alloy by a penmanganate-phosphate solution显示文摘 | Chong Teng Shih | | 0，，： | 1 |
| 17 | A new type-γ'/γ''coprecipitation behavior and its evolution mechanism in wrought Ni-based ATI 718Plus superalloy显示文摘In the precipitation-hardened Ni-based superalloy,typified by ATI 718 Plus,the nano-scaleγandγphase in duplet or triple coprecipitate morphology can provide superior high-temperature strength.Thus,it is of great sense to study the evolution ofγ’/γ’’coprecipitate during long term service at elevated temperature.In this study,the new-typeγ’/γ’’coprecipitates with a sandwich or compact configuration were found firstly in wrought ATI 718 Plus superalloy during long term thermal exposure at 705℃.These co-structure of theγ’/γ’’precipitates evidently inhibit the coarsening ofγ’phase.The increase of thermal exposure time evidently leads to the increase of the volume fraction ofγ’/γ’’coprecipitate and transformation of sandwich-typeγ’/γ’’coprecipitate to compact-typeγ’/γ’’coprecipitate,which is characterized asγphase precipitate at several faces of theγphase.The main evolution mechanism ofγ’/γ’’coprecipitates is element segregation,especially the composition variations of Al+Ti and Nb and their ratio of Al+Ti/Nb.In addition,the interfacial energy betweenγ’’phase andγmatrix also plays a key role on theγ’/γ’’coprecipitates evolution.The calculated results show that the longer thermal exposure time leads to the higher interfacial energy,which is beneficial for nucleation and precipitation ofγ’’phase on the faces ofγ’phase. | Qianying Guo Zongqing Ma Zhixia Qiao Chong Li Teng Zhang Jun Li Chenxi Liu Yongchang Liu | 2022 | Journal of Materials Science & Technology2022，，24： | 1 |
| 18 | Conversion-coating treatment for magnesium alloy by a permanganate- phosphate solution显示文摘 | Kwo Zong Chong Teng Shin Shin | 2003 | Materials Chemistry and Phys- ics2003，80，1： | 1 |
| 19 | Down-regulation of Cbl-b by bufalin results in up-regulation of DR4/DR5 and sensitization of TRAIL-induced apoptosis in breast cancer cells显示文摘 | Shunchao Yan Xiujuan Qu Chong’an Xu Zhitu Zhu Lingyun Zhang Ling Xu Na Song Yuee Teng Yunpeng Liu | 2012 | Journal of Cancer Research and Clinical Oncology2012，，8： | 1 |
| 20 | Conversion-coat-ing treatment for magnesium alloys by apermanga-nate-phosphate solution显示文摘 | Kwo Zong Chong Teng Shih Shih | 2003 | Materials Chemistry and Physics2003，80，： | 1 |
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