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| 1 | Passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts and assessment of clinical outcomes显示文摘AIM To assess for passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts(TIPS) and compare outcomes with maximally dilated TIPS.METHODS Polytetrafluoroethylene covered TIPS(Viatorr) from July 2002 to December 2013 were retrospectively reviewed at two hospitals in a single institution. Two hundred and thirty patients had TIPS maximally dilated to 10 mm(m TIPS), while 43 patients who were at increased risk for hepatic encephalopathy(HE), based on clinical evaluation or low pre-TIPS portosystemic gradient(PSG), had 10 mm TIPS sub-maximally dilated to 8 mm(sm TIPS). Group characteristics(age, gender, Model for End-Stage Liver Disease score, post-TIPS PSG and clinical outcomes were compared between groups, including clinical success(ascites or varices), primary patency,primary assisted patency, and severe post-TIPS HE. A subset of fourteen patients with sm TIPS underwent follow-up computed tomography imaging after TIPS creation, and were grouped based on time of imaging(< 6 mo and > 6 mo). Change in diameter and crosssectional area were measured with 3D imaging software to evaluate for passive expansion.RESULTS Patient characteristics were similar between the sm TIPS and m TIPS groups, except for pre-TIPS portosystemic gradient, which was lower in the sm TIPS group(19.4 mm Hg ± 6.8 vs 22.4 mm Hg ± 7.1, P = 0.01). Primary patency and primary assisted patency between sm TIPS and m TIPS was not significantly different(P = 0.64 and 0.55, respectively). Four of the 55 patients(7%) with sm TIPS required TIPS reduction for severe refractory HE, while this occurred in 6 of the 218 patients(3%) with m TIPS(P = 0.12). For the 14 patients with follow-up computed tomography(CT) imaging, the median imaging follow-up was 373 d. There was an increase in median TIPS diameter, median percent diameter change, median area, and median percent area change in patients with CT follow-up greater than 6 mo after TIPS placement compared to follow-up within 6 mo(8.45 mm, 5.58%, 56.04 mm^2, and 11.48%, respectively, P = 0.01).CONCLUSION Passive expansion of sm TIPS does occur but clinical outcomes of sm TIPS and m TIPS were similar. Sub-maximal dilation can prevent complications related to overshunting in select patients. | Michael C Hsu Charles N Weber S William Stavropoulos Timothy W Clark Scott O Trerotola Richard D Shlansky Goldberg Michael C Soulen Gregory J Nadolski | 2017 | World Journal of Hepatology2017，9，12： | 11 |
| 2 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 3 | LIGHT, a New Member of the TNF Superfamily, and Lymphotoxin α Are Ligands for Herpesvirus Entry Mediator显示文摘 | Davide N Mauri Reinhard Ebner Rebecca I Montgomery Kristine D Kochel Timothy C Cheung Guo-Liang Yu Steve Ruben Marianne Murphy Roselyn J Eisenberg Gary H Cohen Patricia G Spear Carl F Ware | 1998 | Immunity1998，，： | 1 |
| 4 | Transparent conducting Nnc oxide thin films doped with aluminum and molybdenum显示文摘 | JOEL N D TIMOTHY A G DAVID M W TERESA M B MATTHEW Y BOBBY T TIMOTHY J C | 2007 | Journal V-acuum Society Technology2007，25，4： | 1 |
| 5 | Isolation and characterization of avian influenza viruses,including highly pathogenic H5N1,from poultry in live bird markets in Hanoi,Vietnam,in 2001显示文摘 | Doan C N Timothy M U Samadhan J | 2005 | Journal of Virology2005，79，7： | 1 |
| 6 | The surgical treat ment of metastatic disease of the spine显示文摘 | Hatrick N C Lucas J D Timothy A R | 2000 | Radiother Oncol2000，56，3： | 1 |
| 7 | Dynamic stability ofa microgrid with an active load 显示文摘 | Bottrell N Prodanovic M Timothy C G | 2013 | IEEE Transactions onPower Electronics2013，28，11： | 1 |
| 8 | Effects of aerobic and resistance training on hemoglobin Alc levels in patients with type 2 diabetes:a randomized vontrolled trial显示文摘 | Timothy S Steven N Sharnon C | | 0，，20： | 1 |
| 9 | Early psychological adjustment in breast cancer patients-A prospective study显示文摘 | Chiara N Jonathan V R Timothy C | 2002 | J Psycho Res2002，53，6： | 1 |
| 10 | A flow-through chamber for toxicity testing of 80-200μm organisms显示文摘 | Andrea M D Timothy M C LaBreche N S | 2002 | Water Research2002，36，： | 1 |
| 11 | Vibration control of linear robots using a piezoelectric actuator显示文摘 | Timothy N C Roger K Reggie J C | 2003 | IEEE Transactions on Mechatronics2003，8，4： | 1 |
| 12 | The Coevolution of New Organizational Forms 显示文摘 | LEWIN A Y LONG C P TIMOTHY N | 1999 | Organization Science1999，10，5： | 1 |
| 13 | Comparing the Visual Analogue Scale and the Pediatric Quality of Life Inventory for Measuring Health-Related Quality of Life in Children with Oral Clefts显示文摘 | Wehby George L Naderi Hodad Robbins James M Ansley Timothy N Damiano Peter C | 2014 | International Journal of Environmental Research and Public Health2014，，4： | 1 |
| 14 | What Influences IT Ethical Behavior Intentions-Planned Behavior, Reasoned Action, Perceived Importance, or Individual Characteristics?显示文摘 | Leonard L N K Timothy P C Kreiec J | 2004 | Information and Management2004，，1： | 1 |
| 15 | Stability of various metalloporphyrin catalysts during hydrogen peroxide epoxidation of alkene显示文摘 | IAN D C TIMOTHY N D | 2002 | Journal of Molecular Catalysis A:Chemical2002，185，： | 1 |
| 16 | Governance of Red Tourism in China:Per spec t ive s on Power a nd Gu a n x i显示文摘 | S h e n g n a n(Na n c y) Z h a o D a l l e n J Timothy | 2015 | Tou r i smManagement2015，，2： | 1 |
| 17 | Southern Ocean iron enrichment experiment: Carbon cycling in high-and low-Si waters 显示文摘 | Coale K H Johnson K S Chavez F P Buesseler K O Barber R T Brzezinski M A Cochlan W P Millero F J Falkowski P G Bauer J E Wanninkhof R H Kudela R M Altabet M A Hales B E Takahashi T Landry M R Bidigare R R Wang Xiujun Chase Z Strutton P G Friederich G E Gorbunov M Y Lance V P Hilting A K Hiscock M R Demarest M Hiscock W T Sullivan K F Tanner S J Gordon R M Hunter C N Elrod V A Fitzwater S E Jones J L Tozzi S Koblizek M Roberts A E Herndon J Brewster J Ladizinsky N Smith G Cooper D Timothy D Brown S L Selph K E Sheridan C C Twining B S Johnson Z I | 2004 | Science2004，304，5669： | 1 |
| 18 | Early psychological adjustment in breast cancer patients-A prospective study 显示文摘 | Chiara N Jonathan VR Timothy C | 2002 | J Psycho Res2002，53，6： | 1 |
| 19 | Viscoelastic properties of human cortical bone tissue depend on gender and elastic modulus显示文摘 | Ziheng Wu Timothy C O Glen L N | 2012 | Journal of Orthopaedic Research2012，5，： | 1 |
| 20 | Direct comparison of nanoindentation and macroscopic measurements of bone viscoelasticity显示文摘 | Tara N S Jingzhou Zhang Timothy C O | 2011 | Journal of the Mechanical Behavior of Biomedical Material2011，4，： | 1 |
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