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| 1 | Correlation between expression of cyclooxygenase-2 and the presence of inflammatory cells in human primary hepatocellular carcinoma: Possible role in tumor promotion and angiogenesis显示文摘AIM: To investigate the association of cyclooxygenase-2(COX-2) expression with angiogenesis and the number and type of inflammatory cells (macrophages/Kupffer cells;mast cells) within primary hepatocellular carcinoma (HCC)tissues and adjacent non-tumorous (MT) tissues.METHODS: Immunohistochemistry for COX-2, CD34,CD68 and mast cell tryptase (MCT) was performed on 14 well-characterized series of liver-cirrhosis-associated HCC patients. COX-2 expression and the number of inflammatory cells in tumor lesions and surrounding liver tissues of each specimen were compared. Moreover,COX-2, CD34 staining and the number of inflammatory cells in areas with different histological degrees within each tumor sample were comparatively analyzed.RESULTS: The percentage of COX-2 positive cells was significantly higher in NT tissues than in tumors. COX-2 expression was higher in well-differentiated HCC than in poorly-differentiated tissues. Few mast cells were observed within the tumor mass, whereas a higher number was observed in the surrounding tissue, especially in peri-portal spaces of NT tissues. Abundant macrophages/Kupffer cells were observed in NT tissues, whereas the number of cells was significantly lower in the tumor mass.However, a higher cell number was observed in the well-differentiated tumor and progressively decreased in relation to the differentiation grade. Within the tumor, a positive correlation was found between COX-2 expression and the number of macrophages/Kupffer cells and mast cells. Moreover, there was a positive correlation between CD34 and COX-2 expression in tumor tissues. Comparison between well- and poorly-differentiated HCC showed that the number of CD34-positive cells decreased with dedifferentiation. However, COX-2 was the only independent variable showing a positive correlation with CD34 in a multivariate analysis.CONCLUSION: The presence of inflammatory cells and COX-2 expression in liver tumor suggests a possible relationship with tumor angiogenesis. COX-2 expressing cells and the number of macrophages/Kupffer cells and mast cells decrease with progression of the disease. | Melchiorre Cervello Daniela Foderà Ada Maria Florena Maurizio Soresi Claudio Tripodo Natale D'Alessandro Giuseppe Montalto | 2005 | World Journal of Gastroenterology2005，11，30： | 21 |
| 2 | Inulin–iron complexes: A potential treatment of iron deficiency anaemia显示文摘 | Giovanna Pitarresi Giuseppe Tripodo Gennara Cavallaro Fabio Salvatore Palumbo Gaetano Giammona | 2007 | European Journal of Pharmaceutics and Biopharmaceutics2007，，2： | 2 |
| 3 | Peripheral T-cell lymphoma classification: the matter of cellular derivation显示文摘 | Piccaluga PP Agostinelli C Tripodo C | 2011 | Expert Rev Hematol2011，4，4： | 1 |
| 4 | Antiulcer activity of Opuntia ficus indica (L) Mill (Cactaceae) : ultrastructural study 显示文摘 | E M Galati M T Monforte M M Tripodo | 2001 | Journal of Ethnopharmacology2001，76，： | 1 |
| 5 | Citrus waste recovery: a new environmentally friendly procedure to obtain animal feed显示文摘 | TRIPODO M M LANUZZA F MICALI G | 2004 | Bioresource Technology2004，91，： | 1 |
| 6 | Use of intrapleural bortezomib in myelomatous pleural effusion显示文摘 | Iannitto E Minardi V Tripodo C | 2007 | Br J Haematol2007，139，62： | 1 |
| 7 | Mesenchymal stro- mal cells loading curcumin-INVITE-micelles: a drug delivery system for neurodegenerative diseases显示文摘 | Tripodo G Chlapanidas T Perteghella S | 2015 | Colloids SurfB Bioint- egCaces2015，125，： | 1 |
| 8 | Study on the increment of the production of gastric mucus in rats treated with Opuntia ficus indica (L.) Mill. cladodes显示文摘 | E.M Galati S Pergolizzi N Miceli M.T Monforte M.M Tripodo | 2002 | Journal of Ethnopharmacology2002，，3： | 1 |
| 9 | Bone marrow biopsy in Hodgkin's lymphoma显示文摘 | Franco Tripodo C Rizzo A | 2004 | Eur J Haematol2004，73，3： | 1 |
| 10 | Primary T-cell rich B-cell lymphoma of the penis:a first case显示文摘 | Pomara G Cuttano MG Tripodo C | 2003 | BJU Int2003，91，9： | 1 |
| 11 | Flavonoids recovery and SCP production from orange peel显示文摘 | CURTO R L TRIPODO M M LEUZZI U | 1992 | Bioresouree Technology1992，42，2： | 1 |
| 12 | Peripheral T-cell lymphoma classification: the matter of cellular derivation显示文摘 | Piccaluga PP Agostinelli C Tripodo C | 2011 | Expert Rev Hematol2011，4，4： | 1 |
| 13 | The interleukin(IL)-31/IL-31R axis contributes to tumor growth in human follicular lymphoma显示文摘 | Ferretti E Tripodo C Pagnan G | 2015 | Leukemia2015，29，4： | 1 |
| 14 | Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic ceils toward ANCA induction and associated autoimmunity 显示文摘 | Sangaletti S Tripodo C Chiodoni C | 2012 | Blood2012，120，15： | 1 |
| 15 | Use of intrapleural bortecomib in myelomatous pleural effusion显示文摘 | Iannitto E Minardi V Tripodo C | 2007 | British Journal of Haematology2007，139，4： | 1 |
| 16 | The abrogation of the HOXB7/PBX2 complex induces apoptosis in melanoma through the miR‐221&222‐c‐FOS pathway显示文摘 | M. Cristina Errico Federica Felicetti Lisabianca Bottero Gianfranco Mattia Alessandra Boe Nadia Felli Marina Petrini Maria Bellenghi Hardev S. Pandha Marco Calvaruso Claudio Tripodo Mario P. Colombo Richard Morgan Alessandra Carè | 2013 | Int J Cancer2013，，4： | 1 |
| 17 | Citrus waste recovery:a new environmentally friendly procedure to obtain animal feed显示文摘 | Maria Marcella Tripodo Francesco Lanuzza Giuseppe Micali | 2004 | Bioresource Technology2004，91，2： | 1 |
| 18 | High liver RBP4 protein content is associated with histological features in patients with genotype 1 chronic hepatitis C and with nonalcoholic steatohepatitis显示文摘 | Petta S Tripodo C Grimaudo S | 2011 | Dig Liver Dis2011，43，： | 1 |
| 19 | Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity显示文摘 | Sangaletti S Tripodo C Chiodoni C | 2012 | Blood2012，120，15： | 1 |
| 20 | MERTK rs4374383 polymorphism affects the severity of fibrosis in nonalcoholic fatty liver disease显示文摘 | Salvatore Petta Luca Valenti Fabio Marra Stefania Grimaudo Claudio Tripodo Elisabetta Bugianesi Calogero Cammà Andrea Cappon Vito Di Marco Giovanni Di Maira Paola Dongiovanni Raffaela Rametta Alessandro Gulino Enrico Mozzi Emanuele Orlando Marco Maggioni | 2015 | Journal of Hepatology2015，，： | 1 |
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