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| 1 | A versatile photodetector assisted by photovoltaic and bolometric effects显示文摘The advent of low-dimensional materials with peculiar structure and superb band properties provides a new canonical form for the development of photodetectors.However,the limited exploitation of basic properties makes it difficult for devices to stand out.Here,we demonstrate a hybrid heterostructure with ultrathin vanadium dioxide film and molybdenum ditelluride nanoflake.Vanadium dioxide is a classical semiconductor with a narrow bandgap,a high temperature coefficient of resistance,and phase transformation.Molybdenum ditelluride,a typical two-dimensional material,is often used to construct optoelectronic devices.The heterostructure can realize three different functional modes:(i)the p-n junction exhibits ultrasensitive detection(450 nm-2μm)with a dark current down to 0.2 pA and a response time of 17μs,(ii)the Schottky junction works stably under extreme conditions such as a high temperature of 400 K,and(iii)the bolometer shows ultrabroad spectrum detection exceeding 10μm.The flexible switching between the three modes makes the heterostructure a potential candidate for next-generation photodetectors from visible to longwave infrared radiation(LWIR).This type of photodetector combines versatile detection modes,shedding light on the hybrid application of novel and traditional materials,and is a prototype of advanced optoelectronic devices. | Wei Jiang Tan Zheng Binmin Wu Hanxue Jiao Xudong Wang Yan Chen Xiaoyu Zhang Meng Peng Hailu Wang Tie Lin Hong Shen Jun Ge Weida Hu Xiaofeng Xu Xiangjian Meng Junhao Chu Jianlu Wang | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 2 | Heat stress-induced mucosal barrier dysfunction is potentially associated with gut microbiota dysbiosis in pigs显示文摘Heat stress(HS)can be detrimental to the gut health of swine.Many negative outcomes induced by HS are increasingly recognized as including modulation of intestinal microbiota.In turn,the intestinal microbiota is a unique ecosystem playing a critical role in mediating the host stress response.Therefore,we aimed to characterize gut microbiota of pigs’exposure to short-term HS,to explore a possible link between the intestinal microbiota and HS-related changes,including serum cytokines,oxidation status,and intestinal epithelial barrier function.Our findings showed that HS led to intestinal morphological and integrity changes(villus height,serum diamine oxidase[DAO],serum D-lactate and the relative expressions of tight junction proteins),reduction of serum cytokines(interleukin[IL]-8,IL-12,interferongamma[IFN-g]),and antioxidant activity(higher glutathione[GSH]and malondialdehyde[MDA]content,and lower superoxide dismutase[SOD]).Also,16S rRNA sequencing analysis revealed that although there was no difference in microbial a-diversity,some HS-associated composition differences were revealed in the ileum and cecum,which partly led to an imbalance in the production of short-chain fatty acids including propionate acid and valerate acid.Relevance networks revealed that HS-derived changes in bacterial genera and microbial metabolites,such as Chlamydia,Lactobacillus,Succinivibrio,Bifidobacterium,Lachnoclostridium,and propionic acid,were correlated with oxidative stress,intestinal barrier dysfunction,and inflammation in pigs.Collectively,our observations suggest that intestinal damage induced by HS is probably partly related to the gut microbiota dysbiosis,though the underlying mechanism remains to be fully elucidated. | Bing Xia Weida Wu Wei Fang Xiaobin Wen Jingjing Xie Hongfu Zhang | 2022 | Animal Nutrition2022，，1： | 3 |
| 3 | Clinical significance of SOD2 and GSTP1 gene polymorphisms in Chinese patients with gastric cancer显示文摘 | Zhi Xu Haixia Zhu John M. Luk Dongmei Wu Dongying Gu Weida Gong Yongfei Tan Jianwei Zhou Jinhai Tang Zhengdong Zhang Meilin Wang Jinfei Chen | 2012 | Cancer2012，，22： | 2 |
| 4 | Van der Waals two-color infrared photodetector显示文摘With the increasing demand for multispectral information acquisition,infrared multispectral imaging technology that is inexpensive and can be miniaturized and integrated into other devices has received extensive attention.However,the widespread usage of such photodetectors is still limited by the high cost of epitaxial semiconductors and complex cryogenic cooling systems.Here,we demonstrate a noncooled two-color infrared photodetector that can provide temporal-spatial coexisting spectral blackbody detection at both near-infrared and mid-infrared wavelengths.This photodetector consists of vertically stacked back-to-back diode structures.The two-color signals can be effectively separated to achieve ultralow crosstalk of~0.05%by controlling the built-in electric field depending on the intermediate layer,which acts as an electron-collecting layer and hole-blocking barrier.The impressive performance of the two-color photodetector is verified by the specific detectivity(D^(*))of 6.4×10^(9)cm Hz^(1/2)W^(−1)at 3.5μm and room temperature,as well as the promising NIR/MWIR two-color infrared imaging and absolute temperature detection. | Peisong Wu Lei Ye Lei Tong Peng Wang Yang Wang Hailu Wang Haonan Ge Zhen Wang Yue Gu Kun Zhang Yiye Yu Meng Peng Fang Wang Min Huang Peng Zhou Weida Hu | 2022 | Light(Science & Applications)2022，11，2： | 2 |
| 5 | [Corrigendum] Cidan inhibits liver cancer cell growth by reducing COX-2and VEGF expression and cell cycle arrest显示文摘 | Nan Li Donghai Zheng Jie Xue Weixing Guo Jie Shi Juxian Sun Chongde Lu Weida Zheng Mengchao Wu Shuqun Cheng | 2015 | Experimental and Therapeutic Medicine2015，，4： | 1 |
| 6 | A functional polymorphism in MIR 196 A 2 is associated with risk and prognosis of gastric cancer显示文摘 | Shizhi Wang Guoquan Tao Dongmei Wu Haixia Zhu Yan Gao Yongfei Tan Meilin Wang Weida Gong Yan Zhou Jianwei Zhou Zhengdong Zhang | 2013 | Mol Carcinog2013，，1： | 1 |
| 7 | Karyotype Analysis of Cryptococcus Neoformans with Pulse Electrophoresis显示文摘 | Xiaodong She Weida Liu Shaoxi Wu Ningru Guo | 2006 | Journal of US-China Medical Science2006，3，2： | 1 |
| 8 | A gate-free MoS2 phototransistor assisted by ferroelectrics显示文摘During the past decades,transition metal dichalcogenides(TMDs) have received special focus for their unique properties in photoelectric detection.As one important member of TMDs,MoS2 has been made into photodetector purely or combined with other materials,such as graphene,ionic liquid,and ferroelectric materials.Here,we report a gate-free MoS2 phototransistor combined with organic ferroelectric material poly(vinylidene fluoride-trifluoroethylene)(P(VDF-TrFE)).In this device,the remnant polarization field in P(VDF-TrFE) is obtained from the piezoelectric force microscope(PFM) probe with a positive or negative bias,which can turn the dipoles from disorder to be the same direction.Then,the MoS2 channel can be maintained at an accumulated state with downward polarization field modulation and a depleted state with upward polarization field modulation.Moreover,the P(VDF-TrFE) segregates MoS2 from oxygen and water molecules around surroundings,which enables a cleaner surface state.As a photodetector,an ultra-low dark current of 10^–11 A,on/off ration of more than 10^4 and a fast photoresponse time of 120 μs are achieved.This work provides a new method to make high-performance phototransistors assisted by the ferroelectric domain which can operate without a gate electrode and demonstrates great potential for ultra-low power consumption applications. | Shuaiqin Wu Guangjian Wu Xudong Wang Yan Chen Tie Lin Hong Shen Weida Hu Xiangjian Meng Jianlu Wang Junhao Chu | 2019 | Journal of Semiconductors2019，40，9： | 1 |
| 9 | Preparation of a gene-engineering mutant of bacteriorhodopsin BR-D96V and corresponding poly(vinyl alcohol)-based functional composite films显示文摘Bacteriorhodopsin(BR)exhibits,as a membrane protein in Halobacterium salinarum,unique photoresponsive behaviors,and shows promise as a functional information material.A new mutant of BR with the 96th aspartic acid replaced by valine(BR-D96V)was obtained and then a composite film of BR-D96V in a synthetic polymer matrix was prepared in this research.The mutant BR-D96V was expressed in a bacterio-opsin deficient halobacterial strain(L33)by gene engineering.Although valine is very hydrophobic,this point mutant keeps the basic biological activities,namely,photoelectric and photochromic responses.Nevertheless,the lifetime of M intermediate in the BR mutant is nearly two orders of magnitude longer than that of wild-type BR in neutral aqueous solution,which benefits its potential application as an information material.The M lifetime is further significantly prolonged after embedding BR-D96V into poly(vinyl alcohol)(PVA).It was also found that BR-D96V is very sensitive to water content in comparison with wild-type BR and another BR mutant. | ZHAO YingChun MING Ming HONG Jie MA DeWang WU Jia LI QingGuo HUANG WeiDa DING JianDong | 2010 | Chinese Science Bulletin2010，55，33： | 1 |
| 10 | Next-generation machine vision systems incorporating two-dimensional materials: Progress and perspectives显示文摘Machine vision systems(MVSs)are an important component of intelligent systems,such as autonomous vehicles and robots.However,with the continuous increase in data and new application scenarios,new requirements are put forward for the next generation of MVS.There is an urgent need to find new material systems to complement the existing semiconductor technology based on thin-film materials,and new architectures must be explored to improve efficiency.Because of their unique physical properties,two-dimensional(2D)materials have received extensive attention for use in MVSs,especially in biomimetic ones:the human visual system,which can process complex visual information with low power consumption,provides a model for next-generation MVSs.This review paper summarizes the progress and challenges of applying 2D material photodetectors in sense-memory-computational integration and biomimetic image sensors for machine vision. | Peisong Wu Ting He He Zhu Yang Wang Qing Li Zhen Wang Xiao Fu Fang Wang Peng Wang Chongxin Shan Zhiyong Fan Lei Liao Peng Zhou Weida Hu | 2022 | InfoMat2022，4，1： | 1 |
| 11 | Pectin modulates intestinal immunity in a pig model via regulating the gut microbiota-derived tryptophan metabolite-AhR-IL22 pathway显示文摘Background Pectin is a heteropolysaccharide that acts as an intestinal immunomodulator,promoting intestinal development and regulating intestinal flora in the gut.However,the relevant mechanisms remain obscure.In this study,pigs were fed a corn-soybean meal-based diet supplemented with either 5%microcrystalline cellulose(MCC)or 5%pectin for 3 weeks,to investigate the metabolites and anti-inflammatory properties of the jejunum.Result The results showed that dietary pectin supplementation improved intestinal integrity(Claudin-1,Occludin)and inflammatory response[interleukin(IL)-10],and the expression of proinflammatory cytokines(IL-1β,IL-6,IL-8,TNF-α)was down-regulated in the jejunum.Moreover,pectin supplementation altered the jejunal microbiome and tryptophan-related metabolites in piglets.Pectin specifically increased the abundance of Lactococcus,Enterococcus,and the microbiota-derived metabolites(skatole(ST),3-indoleacetic acid(IAA),3-indolepropionic acid(IPA),5-hydroxyindole-3-acetic acid(HIAA),and tryptamine(Tpm)),which activated the aryl hydrocarbon receptor(AhR)pathway.AhR activation modulates IL-22 and its downstream pathways.Correlation analysis revealed the potential relationship between metabolites and intestinal morphology,intestinal gene expression,and cytokine levels.Conclusion In conclusion,these results indicated that pectin inhibits the inflammatory response by enhancing the AhR-IL22-signal transducer and activator of transcription 3 signaling pathway,which is activated through tryptophan metabolites. | Guoqi Dang Xiaobin Wen Ruqing Zhong Weida Wu Shanlong Tang Chong Li Bao Yi Liang Chen Hongfu Zhang Martine Schroyen | 2023 | Journal of Animal Science and Biotechnology2023，14，4： | 1 |
| 12 | Genetic variation in C12orf51 is associated with prognosis of intestinal-type gastric cancer in a Chinese population显示文摘 | Gang Zhang Dongying Gu Qinghong Zhao Haiyan Chu Zhi Xu Meilin Wang Cuiju Tang Dongmei Wu Na Tong Weida Gong Jianwei Zhou Yong Xu Zhengdong Zhang Jinfei Chen | 2014 | Biomedicine & Pharmacotherapy2014，，： | 1 |
| 13 | Altered Expression of Transcription Factor Sp1 Critically Impacts the Angiogenic Phenotype of Human Gastric Cancer显示文摘 | 王理伟 GUAN Xiaohong GONG Weida YAO James PENG Zhihai WEI Daoyan WU Tsung - Teh HUANG Suyun XIE Keping | 2006 | 同济大学学报(医学版)2006，27，5： | 1 |
| 14 | Recent progress and challenges on two-dimensional material photodetectors from the perspective of advanced characterization technologies显示文摘Atomically thin two-dimensional(2D)materials exhibit enormous potential in photodetectors because of novel and extraordinary properties,such as passivated surfaces,tunable bandgaps,and high mobility.High-performance photodetectors based on 2D materials have been fabricated for broadband,position,polarization-sensitive detection,and large-area array imaging.However,the current performance of 2D material photodetectors is not outstanding enough,including response speed,detectivity,and so forth.The way to further promote the development of 2D material photodetectors and their corresponding practical applications is still a tremendous challenge.In this article,these issues of 2D material photodetectors are analyzed and expected to be solved by combining micro-nano characterization technologies.The inherent physical properties of 2D materials and photodetectors can be accurately characterized by Raman spectroscopy,transmission electron microscopy(TEM),and scattering scanning near-field optical microscope(s-SNOM).In particular,the precise probe of lattice defects,doping concentration,and near-field light absorption characteristics can promote the researches of low-noise and high-responsivity photodetectors.Scanning photocurrent microscope(SPCM)can show the overall spatial distribution of photocurrent and analyze the mechanism of photocurrent.Photoluminescence(PL)spectroscopy and Kelvin probe force microscope(KPFM)can characterize the material bandgap,work function distribution and interlayer coupling characteristics,making it possible to design high-performance photodetectors through energy band engineering.These advanced characterization techniques cover the entire process from material growth,to device preparation,and to performance analysis,and systematically reveal the development status of 2D material photodetectors.Finally,the prospects and challenges are discussed to promote the application of 2D material photodetectors. | Fang Zhong Hao Wang Zhen Wang Yang Wang Ting He Peisong Wu Meng Peng Hailu Wang Tengfei Xu Fang Wang Peng Wang Jinshui Miao Weida Hu | 2021 | Nano Research2021，14，6： | 1 |
| 15 | Light-modulated vertical heterojunction phototransistors with distinct logical photocurrents显示文摘The intriguing carrier dynamics in graphene heterojunctions have stimulated great interest in modulating the optoelectronic features to realize high-performance photodetectors.However,for most phototransistors,the photoresponse characteristics are modulated with an electrical gate or a static field.In this paper,we demonstrate a graphene/C_(60)/pentacene vertical phototransistor to tune both the photoresponse time and photocurrent based on light modulation.By exploiting the power-dependent multiple states of the photocurrent,remarkable logical photocurrent switching under infrared light modulation occurs in a thick C_(60) layer(11 nm)device,which implies competition of the photogenerated carriers between graphene/C_(60) and C_(60)/pentacene.Meanwhile,we observe a complete positive-negative alternating process under continuous 405 nm irradiation.Furthermore,infrared light modulation of a thin C_(60)(5 nm)device results in a photoresponsivity improvement from 3425 A/W up to 7673 A/W,and we clearly probe the primary reason for the distinct modulation results between the 5 and 11 nm C_(60) devices.In addition,the tuneable bandwidth of the infrared response from 10 to 3×10^(3) Hz under visible light modulation is explored.Such distinct types of optical modulation phenomena and logical photocurrent inversion characteristics pave the way for future tuneable logical photocurrent switching devices and high-performance phototransistors with vertical graphene heterojunction structures. | Jiayue Han Meiyu He Ming Yang Qi Han Fang Wang Fang Zhong Mengjian Xu Qing Li He Zhu Chongxin Shan Weida Hu Xiaoqing Chen Xinran Wang Jun Gou Zhiming Wu Jun Wang | 2020 | Light(Science & Applications)2020，9，1： | 1 |
| 16 | Genetic variants in the Hedgehog signaling pathway genes are associated with gastric cancer risk in a Chinese Han population显示文摘The Hedgehog signaling pathway participates in the occurrence and progression of cancers including gastric cancer.We conducted this study to evaluate whether genetic variants in the Hedgehog signaling pathway genes would affect gastric cancer risk.Multi-marker Analysis of GenoMic Annotation(MAGMA)was used to investigate the aggregated genetic effects of single nucleotide polymorphisms(SNPs)assigned to candidate genes.The relationship between SNPs and gastric cancer risk was estimated by multivariate logistic regression analyses.Gene expression was calculated using databases obtained from The Cancer Genome Atlas(TCGA)and The Gene Expression Omnibus(GEO).Kaplan‐Meier plotter was used to evaluate the association between gene expression with gastric cancer survival.Tumor Immune Estimation Resource 2.0(TIMER 2.0)was applied to determine the correlation between selected gene expression and the immune cell infiltration degree.We identified that the G allele of rs2990912 in KIF27 was associated with higher gastric cancer risk,especially in the young and male subgroups.The expression of KIF27 in gastric cancer tissues was higher than that in normal tissues,leading to poor survival in gastric cancer patients.Besides,KIF27 expression was related to immune cell infiltration and positively correlated with PD-L1 expression.Our findings highlight the key role of genetic variation in the Hedgehog signaling pathway genes in gastric cancer susceptibility,which may provide important insights into the diagnosis,prognosis,and treatment of gastric cancer. | Yujuan Zhang Kai Lu Xu Wu Hanting Liu Junyi Xin Xiaowei Wang Weida Gong Qinghong Zhao Meilin Wang Haiyan Chu Mulong Du Guoquan Tao Zhengdong Zhang | 2022 | The Journal of Biomedical Research2022，36，1： | 1 |
| 17 | Macroscopic assembled graphene nanofilms based room temperature ultrafast mid-infrared photodetectors显示文摘Graphene with linear energy dispersion and weak electron-phonon interaction is highly anticipated to harvest hot electrons in a broad wavelength range.However,the limited absorption and serious backscattering of hot-electrons result in inadequate quantum yields,especially in the mid-infrared range.Here,we report a macroscopic assembled graphene(nMAG)nanofilm/silicon heterojunction for ultrafast mid-infrared photodetection.The assembled Schottky diode works in 1.5-4.0μm at room temperature with fast response(20-30 ns,rising time,4 mm2 window)and high detectivity(1.61011 to 1.9109 Jones from 1.5 to 4.0μm)under the pulsed laser,outperforming single-layer-graphene/silicon photodetectors by 2-8 orders.These performances are attributed to the greatly enhanced photo-thermionic effect of electrons in nMAG due to its high light absorption(~40%),long carrier relaxation time(~20 ps),low work function(4.52 eV),and suppressed carrier number fluctuation.The nMAG provides a long-range platform to understand the hot-carrier dynamics in bulk 2D materials,leading to broadband and ultrafast MIR active imaging devices at room temperature. | Li Peng Lixiang Liu Sichao Du Srikrishna Chanakya Bodepudi Lingfei Li Wei Liu Runchen Lai Xiaoxue Cao Wenzhang Fang Yingjun Liu Xinyu Liu Jianhang Lv Muhammad Abid Junxue Liu Shengye Jin Kaifeng Wu Miao-Ling Lin Xin Cong Ping-Heng Tan Haiming Zhu Qihua Xiong Xiaomu Wang Weida Hu Xiangfeng Duan Bin Yu Zhen Xu Yang Xu Chao Gao | 2022 | InfoMat2022，4，6： | 1 |
| 18 | Topology Optimization of Metamaterial Microstructures for Negative Poisson’s Ratio under Large Deformation Using a Gradient-Free Method显示文摘Negative Poisson’s ratio(NPR)metamaterials are attractive for their unique mechanical behaviors and potential applications in deformation control and energy absorption.However,when subjected to significant stretching,NPR metamaterials designed under small strain assumption may experience a rapid degradation in NPR performance.To address this issue,this study aims to design metamaterials maintaining a targeted NPR under large deformation by taking advantage of the geometry nonlinearity mechanism.A representative periodic unit cell is modeled considering geometry nonlinearity,and its topology is designed using a gradient-free method.The unit cell microstructural topologies are described with the material-field series-expansion(MFSE)method.The MFSE method assumes spatial correlation of the material distribution,which greatly reduces the number of required design variables.To conveniently design metamaterials with desired NPR under large deformation,we propose a two-stage gradient-free metamaterial topology optimization method,which fully takes advantage of the dimension reduction benefits of the MFSE method and the Kriging surrogate model technique.Initially,we use homogenization to find a preliminary NPR design under a small deformation assumption.In the second stage,we begin with this preliminary design and minimize deviations in NPR from a targeted value under large deformation.Using this strategy and solution technique,we successfully obtain a group of NPR metamaterials that can sustain different desired NPRs in the range of[−0.8,−0.1]under uniaxial stretching up to 20% strain.Furthermore,typical microstructure designs are fabricated and tested through experiments.The experimental results show good consistency with our numerical results,demonstrating the effectiveness of the present gradientfree NPR metamaterial design strategy. | Weida Wu Yiqiang Wang Zhonghao Gao Pai Liu | 2024 | Computer Modeling in Engineering & Sciences2024，139，5： | 0 |
| 19 | Direct observation and manipulation of hot electrons at room temperature显示文摘In modern electronics and optoelectronics,hot electron behaviors are highly concerned,as they determine the performance limit of a device or system,like the associated thermal or power constraint of chips and the Shockley-Queisser limit for solar cell efficiency.To date,however,the manipulation of hot electrons has been mostly based on conceptual interpretations rather than a direct observation.The problem arises from a fundamental fact that energy-differential electrons are mixed up in real-space,making it hard to distinguish them from each other by standard measurements.Here we demonstrate a distinct approach to artificially(spatially)separate hot electrons from cold ones in semiconductor nanowire transistors,which thus offers a unique opportunity to observe and modulate electron occupied state,energy,mobility and even path.Such a process is accomplished through the scanning-photocurrent-microscopy measurements by activating the intervalley-scattering events and 1D charge-neutrality rule.Findings here may provide a new degree of freedom in manipulating non-equilibrium electrons for both electronic and optoelectronic applications. | Hailu Wang Fang Wang Hui Xia Peng Wang Tianxin Li Juzhu Li Zhen Wang Jiamin Sun Peisong Wu Jiafu Ye Qiandong Zhuang Zaixing Yang Lan Fu Weida Hu Xiaoshuang Chen Wei Lu | 2021 | National Science Review2021，8，9： | 0 |
| 20 | Integrating 2D layered materials with 3D bulk materials as van der Waals heterostructures for photodetections:Current status and perspectives显示文摘In the last decade,two-dimensional layered materials(2DLMs)have been drawing extensive attentions due to their unique properties,such as absence of surface dangling bonds,thickness-dependent bandgap,high absorption coeffi-cient,large specific surface area,and so on.But the high-quality growth and transfer of wafer-scale 2DLMs films is still a great challenge for the commerciali-zation of pure 2DLMs-based photodetectors.Conversely,the material growth and device fabrication technologies of three-dimensional(3D)semiconductors photodetectors tend to be gradually matured.However,the further improvement of the photodetection performance is limited by the difficult heterogeneous inte-gration or the inferior crystal quality via heteroepitaxy.Fortunately,2D/3D van der Waals heterostructures(vdWH)combine the advantages of the two types of materials simultaneously,which may provide a new platform for developing high-performance optoelectronic devices.Here,we first discuss the unique advantages of 2D/3D vdWH for the future development of photodetection field and simply introduce the structure categories,working mechanisms,and the typical fabrication methods of 2D/3D vdWH photodetector.Then,we outline the recent progress on 2D/3D vdWH-based photodetection devices integrating 2DLMs with the traditional 3D semiconductor materials,including Si,Ge,GaAs,AlGaN,SiC,and so on.Finally,we highlight the current challenges and pros-pects of heterointegrating 2DLMs with traditional 3D semiconductors toward photodetection applications. | Weijie Liu Yiye Yu Meng Peng Zhihua Zheng Pengcheng Jian Yang Wang Yuanchen Zou Yongming Zhao Fang Wang Feng Wu Changqing Chen Jiangnan Dai Peng Wang Weida Hu | 2023 | InfoMat2023，5，10： | 0 |
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