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| 1 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 2 | Fluid flow and pumping efficiency in an ejector-venturi scrubber 显示文摘 | XAVIER G SARRA M JAVIER LAFUENTE F | 2004 | Chemical and Engineering Processing2004，43，2： | 1 |
| 3 | Affinity for inor- ganic carbon of Gracilaria tenuistipitata cultured at low and high irradiance 显示文摘 | Mercado J M Carmona R Xavier Niell F | 2000 | Planta2000，210，： | 1 |
| 4 | Lipase catalyzed modification of milk fat 显示文摘 | Balcao Victor M Xavier Malcata F | 1998 | Biotechnology Advances1998，16，2： | 1 |
| 5 | Adances and perspectives in using microalgae to produce biodiesel显示文摘 | AMANO M HELENA GUEDES CATAEINA MALCATA XAVIER F | 2011 | Applied Energy2011，88，： | 1 |
| 6 | Clear cell odonto- genic carcinoma: case report with immunohistochemical finding sadding support to the challenging diagnosis 显示文摘 | Xavier F C Rodini C O Ramalho L M | 2008 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2008，106，3： | 1 |
| 7 | Voriconazole therapeutic drug monitoring; focus on safety显示文摘 | Pasqualotto A C Xavier M O Andreolla H F etal | 2010 | Expert Opin Drug Saf2010，9，1： | 1 |
| 8 | Autohydrolysis of Almond Shells for the Production of Xylo-oligosaccharides :Product Characteristics and Reaction Kinetics 显示文摘 | Debora N Xavier F Daniel M | 2005 | Ind Eng Chem Res2005，44，20： | 1 |
| 9 | Too Much Love in the Neighborhood Can Hurt: How An Excess of Intensity and Trust in Relationship May Produce Negative Effects on Firms显示文摘 | Xavier F Molina M Teresa M | 2009 | Strategic Management Journal2009，30，9： | 1 |
| 10 | Lipase-catalyzed Modification of Butterfat via Acidolysis with Oleic Acid 显示文摘 | VICTOR M B XAVIER M F | 1997 | Journal of Molecular Catalysis B: Enzymatic1997，3，14： | 1 |
| 11 | Efficacy of a prophylactic adjuvanted bivalent L1 virus-like-particle vaccine against infection with human papillomavirus types 16 and 18 in young women: an interim analysis of a phase III double-blind, randomised controlled trial显示文摘 | Jorma Paavonen David Jenkins F Xavier Bosch Paulo Naud Jorge Salmerón Cosette M Wheeler Song-Nan Chow Dan L Apter Henry C Kitchener Xavier Castellsague Newton S de Carvalho S Rachel Skinner Diane M Harper James A Hedrick Unnop Jaisamrarn Genara AM Limson | 2007 | The Lancet2007，，9580： | 1 |
| 12 | Assessment of photo - Fenton and bi- ological treatment coupling for Diuron and Linuron removal from wa- ter 显示文摘 | Jose F M Xavier D Peral J | 2006 | Water Research2006，40，： | 1 |
| 13 | Epidemiologic Classification of Human Papillomavirus Types Associated with Cervical Cancer 显示文摘 | NUBIA D F XAVIER M D SILVIA M D | 2003 | N ENGL J MED2003，348，6： | 1 |
| 14 | Energy efficient virtual network embedding显示文摘 | JUAN F B XAVIER H DUELLI M | 2012 | IEEE Communications Letters2012，16，5： | 1 |
| 15 | Clinical potential of intra-arterial thrombolytic therapy in patients with acute ischaemic stroke显示文摘 | Xavier A R Siddiqui A M Kirmani J F | 2003 | CNS Drugs2003，17，4： | 1 |
| 16 | Contribution of biological nitrogen fixation to cowpea:a strategy for improving grain yield in the semi-arid region of Brazil 显示文摘 | Martins L M V Xavier G R Rangel F W | 2003 | Biol Fertil Soils2003，38，： | 1 |
| 17 | Interactions of the human pathogenic Brucella species with their hosts显示文摘 | Atluri V L Xavier M N de Jong M F et M | 2011 | Annu Rev Microbiol2011，65，： | 1 |
| 18 | Cu-Sn coatings obtained from pyrophosphate-based electrolytes 显示文摘 | ADRIANA N C XAVIER F M PEDRO DE L | 2007 | Surface and Coatings Technology2007，201，1617： | 1 |
| 19 | Evolution of free fatty acid profile during ripening in cheeses manufactured from bovine, ovine and caprine milks with extracts of Cynara cardunculus as coagulant 显示文摘 | M Jose SousA Victor M BalcaAo F Xavier Malcata | 1997 | Z Lebensm Unters Forsch A1997，205，： | 1 |
| 20 | Lipase catalysed modification of milk fat 显示文摘 | Balcao Victor M Xavier Malcata F | 1998 | Biotechnology Advances1998，16，2： | 1 |
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