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| 1 | The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in China.PD is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural instability.As the disease progresses,additional complications can arise such as non-motor and neurobehavioral symptoms.Pharmacological treatment and surgical intervention for PD have been implemented in China.Until 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different physicians.Since then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,respectively.Correspondingly,the overall level of treatment for PD in China improved.Objectives:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of PD.Summary:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the disease.The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications.Moreover,different treatment strategies should be considered at different stages of the disease.Importantly,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China. | Shengdi Chen Piu Chan Shenggang Sun Haibo Chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan Cheng Ming Shao Zhenguo Liu Zhenfu Wang Xiaochun Chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen Chen Xingyue Hu Anmu Xie Qin Xiao | 2016 | Translational Neurodegeneration2016，5，1： | 23 |
| 2 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
| 3 | Pressure Regulation for Earth Pressure Balance Control on Shield Tunneling Machine by Using Adaptive Robust Control显示文摘Most current studies about shield tunneling machine focus on the construction safety and tunnel structure stability during the excavation. Behaviors of the machine itself are also studied, like some tracking control of the machine. Yet, few works concern about the hydraulic components, especially the pressure and flow rate regulation components. This research focuses on pressure control strategies by using proportional pressure relief valve, which is widely applied on typical shield tunneling machines. Modeling of a commercial pressure relief valve is done. The modeling centers on the main valve, because the dynamic performance is determined by the main valve. To validate such modeling, a frequency-experiment result of the pressure relief valve, whose bandwidth is about 3 Hz, is presented as comparison. The modeling and the frequency experimental result show that it is reasonable to regard the pressure relief valve as a second-order system with two low corner frequencies. PID control, dead band compensation control and adaptive robust control(ARC) are proposed and simulation results are presented. For the ARC, implements by using first order approximation and second order approximation are presented. The simulation results show that the second order approximation implement with ARC can track 4 Hz sine signal very well, and the two ARC simulation errors are within 0.2 MPa. Finally, experiment results of dead band compensation control and adaptive robust control are given. The results show that dead band compensation had about 30° phase lag and about 20% off of the amplitude attenuation. ARC is tracking with little phase lag and almost no amplitude attenuation. In this research, ARC has been tested on a pressure relief valve. It is able to improve the valve's dynamic performances greatly, and it is capable of the pressure control of shield machine excavation. | XIE Haibo LIU Zhibin YANG Huayong | 2016 | Chinese Journal of Mechanical Engineering2016，29，3： | 7 |
| 4 | Efficacy and safety of the Chinese herbal medicine shuganjieyu with and without adjunctive repetitive transcranial magnetic stimulation (rTMS) for geriatric depression: a randomized controlled trial显示文摘 | Minmin XIE Wenhai JIANG Haibo YANG | 2015 | 上海精神医学2015，27，2： | 6 |
| 5 | Effects of high-frequency oscillatory ventilation and conventional mechanical ventilation on oxygen metabolism and tissue perfusion in sheep models of acute respiratory distress syndrome显示文摘 | Liu Songqiao Huang Yingzi Wang Maohua Chen Qiuhua Liu Ling Xie Jianfeng Tan Li Guo Fengmei Yang Congshan Pan Chun Yang Yi Qiu Haibo | 2014 | Chinese Medical Journal2014，，18： | 6 |
| 6 | Direct laser writing of volumetric gradient index lenses and waveguides显示文摘Direct laser writing(DLW)has been shown to render 3D polymeric optical components,including lenses,beam expanders,and mirrors,with submicrometer precision.However,these printed structures are limited to the refractive index and dispersive properties of the photopolymer.Here,we present the subsurface controllable refractive index via beam exposure(SCRIBE)method,a lithographic approach that enables the tuning of the refractive index over a range of greater than 0.3 by performing DLW inside photoresist-filled nanoporous silicon and silica scaffolds.Adjusting the laser exposure during printing enables 3D submicron control of the polymer infilling and thus the refractive index and chromatic dispersion.Combining SCRIBE’s unprecedented index range and 3D writing accuracy has realized the world’s smallest(15μm diameter)spherical Luneburg lens operating at visible wavelengths.SCRIBE’s ability to tune the chromatic dispersion alongside the refractive index was leveraged to render achromatic doublets in a single printing step,eliminating the need for multiple photoresins and writing sequences.SCRIBE also has the potential to form multicomponent optics by cascading optical elements within a scaffold.As a demonstration,stacked focusing structures that generate photonic nanojets were fabricated inside porous silicon.Finally,an all-pass ring resonator was coupled to a subsurface 3D waveguide.The measured quality factor of 4600 at 1550 nm suggests the possibility of compact photonic systems with optical interconnects that traverse multiple planes.SCRIBE is uniquely suited for constructing such photonic integrated circuits due to its ability to integrate multiple optical components,including lenses and waveguides,without additional printed supports. | Christian R.Ocier Corey A.Richards Daniel A.Bacon-Brown Qing Ding Raman Kumar Tanner J.Garcia Jorik van de Groep Jung-Hwan Song Austin J.Cyphersmith Andrew Rhode Andrea N.Perry Alexander J.Littlefield Jinlong Zhu Dajie Xie Haibo Gao Jonah F.Messinger Mark L.Brongersma Kimani C.Toussaint Jr Lynford L.Goddard Paul V.Braun | 2020 | Light(Science & Applications)2020，9，1： | 6 |
| 7 | Simple β-lactones are potent irreversible antagonists for strigolactone receptors显示文摘 | Haibo Xian Ruifeng Yao Tianfei Quan Fei Wang Li Chen Xiaoxi DU Wenhao Zhang Haiteng Deng Daoxin Xie Tuoping Luo | 2017 | Cell Research2017，27，12： | 5 |
| 8 | Adaptive coherence estimator based on the Krylov subspace technique for airborne radar显示文摘A novel adaptive detector for airborne radar space-time adaptive detection(STAD) in partially homogeneous environments is proposed. The novel detector combines the numerically stable Krylov subspace technique and diagonal loading technique, and it uses the framework of the adaptive coherence estimator(ACE). It can effectively detect a target with low sample support. Compared with its natural competitors, the novel detector has higher probability of detection(PD), especially when the number of the training data is low. Moreover, it is shown to be practically constant false alarm rate(CFAR). | Weijian Liu Wenchong Xie Haibo Tong Honglin Wang Cui Zhou Yongliang Wang | 2015 | Journal of Systems Engineering and Electronics2015，26，4： | 3 |
| 9 | Low-temperature sintered(Na_(1/2)Bi_(1/2))TiO_(3)-based incipient piezoceramics for co-fired multilayer actuator application显示文摘Low-temperature sintered(Na_(1/2)Bi_(1/2))_(0.935)Ba_(0.065)Ti_(0.975)(Fe_(1/2)Nb_(1/2))_(0.025)O_(3)(NBT-BT-0.025FN)lead-free incipient piezoceramics were investigated using high-purity Li_(2)CO_(3) as sintering aids.With the ≤0.5 wt%Li_(2)CO_(3) addition,the introduced Li^(+) cations precede to enter the A-sites of the perovskite lattice to compensate for the A-site deficiencies.Once the addition exceeds 0.5 wt%,the excess Lit cations will occupy B-sites and give rise to the generation of oxygen vacancies,which accelerate the mass transport and thus lower the sintering temperature effectively from 1100℃ down to 925℃.It was also found that a small amount of Lit addition has little effect on the phase structure and electromechanical properties of the system,but overweight seriously disturbs these characteristics because of the large lattice distortion.The sintered NBT-BT-0.025FN incipient piezoceramics with 1.25 wt%Li_(2)CO_(3) addition at 925℃ provides a large strain of 0.33% and a corresponding large signal piezoelectric coefficient d_(33)^(*) of 550 pm/V at 60 kV/cm,indicating this system is a very promising candidate for lead-free co-fired multilayer actuator application. | Pengyuan Fan Yangyang Zhang Shan-Tao Zhang Bing Xie Yiwei Zhu Mohsin Ali Marwat Weigang Ma Kai Liu Liang Shu Haibo Zhang | 2019 | Journal of Materiomics2019，5，3： | 3 |
| 10 | In vivo transfection of enhanced green fluorescent protein in rat retinal ganglion cells mediated by ultrasound-induced microbubbles显示文摘BACKGROUND:Studies have demonstrated that ultrasound-mediated microbubble destruction significantly improves transfection efficiency of enhanced green fluorescent protein(EGFP) in in vitro cultured retinal ganglial cells(RGCs). OBJECTIVE:To investigate the feasibility of ultrasound-mediated microbubble destruction for EGFP transfection in rat RGCs,and to compare efficiency and cell damage with traditional transfection methods. DESIGN,TIME AND SETTING:In vivo,gene engineering experiment.The study was performed at the Central Laboratory,Institute of Ultrasonic Imaging,Chongqing Medical University from March to July 2008. MATERIALS:Eukaryotic expression vector plasmid EGFP and microbubbles were prepared by the Institute of Ultrasonic Imaging,Chongqing Medical University.The microbubbles were produced at a concentration of 8.7×10^(11)/L,with a 2-4μm diameter,and 10-hour half-life in vitro. METHODS:A total of 50 Sprague Dawley rats were randomly assigned to four groups.Normal controls(n=5) were infused with 5μL normal saline to the vitreous cavity;the naked plasmid group (n=15) was infused with 5μL EGFP plasmid to the vitreous cavity;in the plasmid with ultrasound group(n=15),the eyes were irradiated with low-energy ultrasound wave(0.5 W/cm^2) for a total of 60 seconds(irradiated for 5 seconds,at 10-second intervals) immediately following infusion of EGFP plasmids to the vitreous cavities.In the microbubble-ultrasound group(n=15),the eyes were irradiated with the same power of ultrasonic wave immediately following infusion of microbubbles containing EGFP plasmids to the vitreous cavities. MAIN OUTCOME MEASURES:After 7 days,retinal preparations and EGFP expression in RGCs were observed by fluorescence microscopy.RGC quantification in the retinal ganglion cell layer was performed.In addition,EGFP mRNA expression was semi-quantitatively determined by RT-PCR. RESULTS:The transfection efficiency of EGFP to RGCs by microbubbles with ultrasound was significantly greater than the other groups,and no obvious damage was detected in the RGCs. CONCLUSION:Under irradiation of low-frequency ultrasound waves,ultrasound-mediated microbubble destruction was effective and resulted in safe transfection of the EGFP gene to the RGCs. | Hong Su Su Liu Zhigang Wang Wenyue Xie Bing Jiang Haibo Xiong | 2009 | Neural Regeneration Research2009，4，6： | 3 |
| 11 | Mechanical ventilation in acute respiratory distress syndrome: past, present and future显示文摘Acute respiratory distress syndrome (ARDS) is a life threatening respiratory failure due to lung injury from a variety of precipitants.Mechanical ventilation (MV) is the foundation in the supportive management of patients with ARDS.1 However,it is associated with several complications,such as increased risk of pneumonia and development of lung injury.The improved understanding of ARDS and complications from MV has been considered important in designing lung-protective ventilatory strategies aimed at attenuating or preventing organ dysfunction and improving outcomes. | Xie Jianfeng Qiu Haibo | 2014 | Chinese Medical Journal2014，，10： | 2 |
| 12 | Self-adaptive phosphor coating technology for white LED packaging显示文摘变换黄磷的轻射出的二极管(pclead ) 它与黄黄磷采用蓝 LEDs 产生白色点亮照明,是点亮来源的广泛地使用的 solidstate。以便在带的薄片上与高质量进行黄磷层涂层,一种自我适应的涂层技术在这份报纸被介绍。与自我暴露方法相结合的一种泥浆涂层技术被使用并且发展了表明自我适应的涂层层的好处。为自我暴露,泥浆涂层暴露于除到以外的带的本身的蓝排放紫外(紫外) 做光致抗蚀剂 crosslinking 的轻外面。测量的结果显示有自我适应的涂层的白 LEDs 与常规涂层和另外的保角的涂层比那些显示出自我适应性到蓝轻、执行的更高空间的颜色一致性的紧张的尖分发。 | Haibo RAO Kun DING Jirong SONG Likun XIE Wei WANG Xianlong WAN Linsong ZHOU Junyuan LIAO | 2012 | Frontiers of Optoelectronics2012，5，2： | 2 |
| 13 | Analysis of Protein Moiety of Polysaccharide Conjugates Water-extracted from Low Grade Green Tea显示文摘 | CHEN Xiaoqiang SHAO Shengrong XIE Jianchun YUAN Hao LI Qian WU Long WU Zhengqi YUAN Haibo JIANG Yongwen | 2018 | Chemical Research in Chinese Universities2018，34，4： | 2 |
| 14 | Nitric oxide emissions from conventional vegetable fields in southeastern China显示文摘 | Baoling Mei Xunhua Zheng Baohua Xie Haibo Dong Zaixing Zhou Rui Wang Jia Deng Feng Cui Huajun Tong Jianguo Zhu | 2009 | Atmospheric Environment2009，，17： | 2 |
| 15 | Nitric oxide emissions from conventional vegetable fields in southeastern China显示文摘 | Baoling Mei Xunhua Zheng Baohua Xie Haibo Dong Zaixing Zhou Rui Wang Jia Deng Feng Cui Huajun Tong Jianguo Zhu | 2009 | Atmospheric Environment2009，，17： | 1 |
| 16 | Dysregulated adaptive immune response contributes to severe COVID-19显示文摘Dear Editor,The outbreak of the new coronavirus 5ARS-CoV-2 has resulted in a global pandemic.Due to the lack of a specific drug against this virus,the current clinical management of this disease mainly depends on supportive care to reduce inflammatory responses and to keep the lung functioning1. | Kuai Yu Jingjing He Yongjian Wu Baosong Xie Xuefei Liu Bo Wei Haibo Zhou Bingliang Lin Zhixiang Zuo Wen Wen Wenxiong Xu Bin Zou Lai Wei Xi Huang Penghui Zhou | 2020 | Cell Research2020，30，9： | 1 |
| 17 | Chitin and chitosan dissolvedin ionic liquids as reversible sorbents of CO2显示文摘 | Xie Haibo Zhang Suobo Li Shenghai | 2006 | Green Chemistry2006，，8： | 1 |
| 18 | Flow-restricted Etching Method on Isotropic Substrates and Its Mechanism显示文摘With the development of analytical instrumentation to minimization,integration and automation,the microfluidic chips,which are more integrated,complex and diversified,have been applied widely on the manufacturing of analytical instrumentation.However,the present photolithography-based microfabrication technology,which is only able to pattern microchannels with simple inside structures,can not follow the rapid development of requirements.For solving the problem,a fabrication method based on the restricting effect of laminar flow is proposed for the micro etching on isotropic substrates.Experiments were conducted inside glass-based microchannels,in which certain etchant was used to form complicated microstructures.The flow parameters' effects on the aspect ratio,side wall profile and etching rate were revealed by the experiments.The experimental results reveal that the topography of micro structures patterned with the restricted flow etching method is mainly determined by the flowrates of separator and etchant.The computational fluid dynamics(CFD) model on the interface between multiple streams was established for the etching process,and analysis on the causes of various micro topographies was conducted based on the CFD simulation results.The experimental data consisted with the simulation results very well.The investigation depicted in this paper indicate that the flow restricted etching method provides sufficient references for the research and understanding on the mass transport at the liquid-liquid surface in the microchannel and can be used to pattern complex micro structures with high aspect ratios,meantime,it greatly enriches the microfabrication technology for microfluidic chips. | XIE Haibo ZHENG Yi FAN Yurun FU Xin YANG Huayong | 2010 | Chinese Journal of Mechanical Engineering2010，23，5： | 1 |
| 19 | Chitin and chitosan dissolved in ionic liquids as reversible sorbents of CO2 显示文摘 | Xie Haibo Zhang Suobo Li Shenghai | 2006 | Green Chemistry2006，8，： | 1 |
| 20 | Modeling of AMESim based hydraulic parallel mechanism and simulation of its coupling characteristics显示文摘 | Wang Wei Fu Xin Xie Haibo | 2007 | Journal of Zhejiang University2007，4，11： | 1 |
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