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| 1 | Research progress on reduced lodging of high-yield and-density maize显示文摘Increasing plant density is an effective way to enhance maize yield, but often increases lodging rate and severity, significantly elevating the risk and cost of maize production. Therefore, lodging is a major factor restricting future increases in maize yield through high-density planting. This paper reviewed previous research on the relationships between maize lodging rate and plant morphology, mechanical strength of stalks, anatomical and biochemical characteristics of stalks, root characteristics, damage from pests and diseases, environmental factors, and genomic characteristics. The effects of planting density on these factors and explored possible ways to improve lodging resistance were also analyzed in this paper. The results provide a basis for future research on increasing maize lodging resistance under high-density planting conditions and can be used to develop maize cultivation practices and lodging-resistant maize cultivars. | XUE Jun XIE Rui-zhi ZHANG Wang-feng WANG Ke-ru HOU Peng MING Bo GOU Ling LI Shao-kun | 2017 | Journal of Integrative Agriculture2017，16，12： | 42 |
| 2 | Tillage Effect on Organic Carbon in a Purple Paddy Soil显示文摘The distribution and storage of soil organic carbon (SOC) based on a long-term experiment with various tillage systems were studied in a paddy soil derived from purple soil in Chongqing, China. Organic carbon storage in the 0-20 and 0-40 cm soil layers under different tillage systems were in an order: ridge tillage with rice-rape rotation (RT-rr) > conventional tillage with rice only (CT-r) > ridge tillage with rice only (RT-r) > conventional tillage with rice-rape rotation (CT-rr). The RT-rr system had significantly higher levels of soil organic carbon in the 0-40 cm topsoil, while the proportion of the total remaining organic carbon in the total soil organic carbon in the 0-10 cm layer was greatest in the RT-rr system. This was the reason why the RT-rr system enhanced soil organic carbon storage. These showed that tillage system type was crucial for carbon storage. Carbon levels in soil humus and crop-yield results showed that the RT-rr system enhanced soil fertility and crop productivity. Adoption of this tillage system would be beneficial both for environmental protection and economic development. | HUANG Xue-Xia GAO Ming WEI Chao-Fu XIE De-Ti PAN Gen-Xing | 2006 | Pedosphere2006，16，5： | 38 |
| 3 | Effect of hepatocyte apoptosis induced by TNF-α on acute severe hepatitis in mouse models显示文摘AIM To study the effect of hepatocyteapoptosis and necrosis induced by TNF-α on thepathogenesis of acute severe hepatitis(ASH).METHODS The model of ASH was prepared inD-galactosamine(GAIN)sensitized BALB/c miceby injection of either endotoxin(ET)or tumornecrosis factor-α(TNF-α).Morphologicalchanges of apoptotic hepatocytes were studiedby both light and electron microscope and in siteend labeling method(ISEL).Molecular biologicalchanges of DNA ladder were observed byelectrophoresis of extract from liver tissues.Biochemical changes were measured by alanineaminotransferase(ALT),asparticaminotransferase(AST)and TNF-α.The relationbetween apoptosis and necrosis was evaluatedsimultaneously.RESULTS The sequence of hepatocyteapoptosis,necrosis,and final death from ASHwas observed both in GAIN/ET and GAIN/TNF-agroup.Apoptosis was prominent at 3.5 h and 5 hafter injection of inducer,while necrosis becamedominant at 9 h after challenge.The appearanceof apoptosis was earlier in GAIN/TNF-α groupthan that in GAIN/ ET group.Pretreatment ofmice with antiTNF IgG1 may completely preventthe liver injury induced by GalN/ET.CONCLUSION TNF-α can cause liver damageby inducing hepatic apoptosis and necrosis inmice with endotoxemia. | Guo Qing Zang Xia Qiu Zhou Hong Yu Qing Xie Guo Ming Zhao Bin Wang Qing Guo Yue Qin Xiang Dan Liao Department of Infectious Diseases,Rujin Hospital,Shanghai Second Medical University,Shanghai 200025,China | 2000 | World Journal of Gastroenterology2000，6，5： | 30 |
| 4 | Ozone pollution characteristics and sensitivity analysis using an observation-based model in Nanjing,Yangtze River Delta Region of China显示文摘Ground-level ozone(O3)has become a critical pollutant impeding air quality improvement in Yangtze River Delta region of China.In this study,we present O3 pollution characteristics based on one-year online measurements during 2016 at an urban site in Nanjing,Jiangsu Province.Then,the sensitivity of O3 to its precursors during 2 O3 pollution episodes in August was analyzed using a box model based on observation(OBM).The relative incremental reactivity(RIR)of hydrocarbons was larger than other precursors,suggesting that hydrocarbons played the dominant role in O3 formation.The RIR values for NOX ranged from–0.41%/%to 0.19%/%.The O3 sensitivity was also analyzed based on relationship of simulated O3 production rates with reductions of VOC and NOX derived from scenario analyses.Simulation results illustrate that O3 formation was between VOCs-limited and transition regime.Xylenes and light alkenes were found to be key species in O3 formation according to RIR values,and their sources were determined using the Positive Matrix Factorization(PMF)model.Paints and solvent use was the largest contributor to xylenes(54%),while petrochemical industry was the most important source to propene(82%).Discussions on VOCs and NOX reduction schemes suggest that the 5%O3 control goal can be achieved by reducing VOCs by 20%.To obtain 10%O3 control goal,VOCs need to be reduced by 30%with VOCs/NOX larger than 3:1. | Ming Wang Wentai Chen Lin Zhang Wei Qin Yong Zhang Xiangzhi Zhang Xin Xie | 2020 | Journal of Environmental Sciences2020，32，7： | 30 |
| 5 | Pilose antler aqueous extract promotes the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells by stimulating the BMP-2/Smad1, 5/Runx2 signaling pathway显示文摘Peptides from Pilose antler aqueous extract(PAAE) have been shown to stimulate the proliferation and differentiation of bone marrow mesenchymal stem cells(BMSCs). However, the underlying molecular mechanisms are not well understood. Here, PAAE was isolated and purified to explore the molecular mechanisms underlying PAAE’s effects on BMSCs as well as its osteoprotective effects in ovariectomized rats. Our results showed that PAAE promoted proliferation and differentiation of BMSCs to become osteoblasts by enhancing ALP activity and increasing extracellular matrix mineralization. The trabecular microarchitecture of ovariectomized rats was also found to be protected by PAAE. Quantitative reverse transcription-polymerase chain reaction(Quantitative RT-PCR) results suggest that PAAE also increased the expression of osteogenic markers including, alkaline phosphatase(ALP), runt-related transcription factor 2(Runx2), osteocalcin(OCN), bone morphogenetic protein-2(BMP-2), and collagen I(COL-I). Immunoblotting results indicated that PAAE upregulated the levels of BMP-2 and Runx2 and was associated with Smad1/5 phosphorylation. PAAE A at the concentration of 200μg·mL^-1 showed the strongest effect on proliferation and osteogenic differentiation of BMSCs after 48 h. Using matrix-assisted laser desorption/ionization time of flight mass spectrometry(MALDI-TOF MS), we identified the molecular weight of PAAE A and found that it is less than 3000 Da and showed several significant peaks. In conclusion, PAAE activates the BMP-2/Smad1, 5/Runx2 pathway to induce osteoblastic differentiation and mineralization in BMSCs and can inhibit OVX-induced bone loss. These mechanisms are likely responsible for its therapeutic effect on postmenopausal osteoporosis. | REN Cong GONG Wei LI Feng XIE Ming | 2019 | Chinese Journal of Natural Medicines2019，17，10： | 25 |
| 6 | Comparison of Talaromyces marneffei Infection in Human Immunodeficiency Virus-positive and Human Immunodeficiency Virus-negative Patients from Fujian, China显示文摘 | Hong-Ru Li Shao-Xi Cai Yu-Sheng Chen Mei-E Yu Neng-Luan Xu Bao-Song Xie Ming Lin Xin-Lan Hu | 2016 | Chinese Medical Journal2016，，9： | 23 |
| 7 | The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in China.PD is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural instability.As the disease progresses,additional complications can arise such as non-motor and neurobehavioral symptoms.Pharmacological treatment and surgical intervention for PD have been implemented in China.Until 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different physicians.Since then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,respectively.Correspondingly,the overall level of treatment for PD in China improved.Objectives:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of PD.Summary:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the disease.The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications.Moreover,different treatment strategies should be considered at different stages of the disease.Importantly,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China. | Shengdi Chen Piu Chan Shenggang Sun Haibo Chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan Cheng Ming Shao Zhenguo Liu Zhenfu Wang Xiaochun Chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen Chen Xingyue Hu Anmu Xie Qin Xiao | 2016 | Translational Neurodegeneration2016，5，1： | 23 |
| 8 | Controlling factors on the submarine canyon system: A case study of the Central Canyon System in the Qiongdongnan Basin, northern South China Sea显示文摘Based on an integrated analysis of high-resolution 2D/3D seismic data and drilling results, this study analyzes the tectonicsedimentary evolution of the Qiongdongnan Basin(QDNB) since the late Miocene, and discusses the controlling factors on the formation and development of the Central Canyon System(CCS). The sediment failures caused by the relative sea level falling might have discharged deposits from the slope to the canyon. The two suits of the infillings, i.e., turbidites and mass transport complex(MTC), were derived from the northwestern source and northern source, respectively. The sediment supplies, which differ significantly among different areas, might have led to the variations observed in the internal architectures. Tectonic transformation around 11.6 Ma had provided the tectonic setting for the CCS and formed an axial sub-basin in the central part of the Changchang Depression, which could be called the rudiment of the CCS. The tectonic activity of the Red River Fault(RRF) at about 5.7 Ma might have strengthened the hydrodynamics of the deposits at the junction of the Yinggehai Basin(YGHB) and the QDNB to trigger a high-energy turbidity current. The MTC from the northern continental slope system might have been constrained by the Southern Uplift, functioning as a barrier for the infillings of the CCS. Thanks to a sufficient sediment supply during the Holocene period and the paleo-seafloor morphology, the relief of modern central canyon with the starving landform in the eastern Changchang Depression might have been accentuated by deposition of sediments and vertical growth along the canyon flanks, where collapse deposits were widely developed. Corresponding to the segmentation of the CCS, the forming mechanisms of the canyon between the three segments would be different. The turbidite channel in the head area had likely been triggered by the abundant sediment supply from the northwestern source together with the fault activity at about 5.7 Ma of the RRF. The formation and evolution of the canyon in the western segment were caused by combined effects of the turbidite channel from the northwestern source, the MTC from the northern continental slope, and the paleo-seafloor geomorphology. In the eastern segment, the canyon was constrained by the tectonic transformation occurring at approximately 11.6 Ma and the insufficient sediment supply from the wide-gentle slope. | SU Ming ZHANG Cheng XIE XiNong WANG ZhenFeng JIANG Tao HE YunLong ZHANG CuiMei | 2014 | Science China Earth Sciences2014，57，10： | 21 |
| 9 | Gravity Flow on Slope and Abyssal Systems in the Qiongdongnan Basin,Northern South China Sea显示文摘新地震数据的学习在架并且在 Qiongdongnan 盆(QDNB ) 的深渊的设定上以内部建筑学和分发允许沉积严肃流动的鉴定。六种严肃流动类型被认出:(1 ) 有基础、一致的 truncational 的 turbidite 隧道压垂沿着架边和斜坡的关系,包括旁边地转移、使河床升高得垂直地的隧道建筑群;(2 ) 有塑造汤勺的形态学的滑坡在架裂缝上滑动步并且从变丑产生了糟糕巩固并且高水位线内容沉积;(3 ) 商业萧条在架斜坡上被限制,由一个异常斜坡坡度或由差错活动被触发;(4 ) turbidite 表建筑群(TSC ) 被归功于到盆地板扇子和斜坡扇子起源,偶尔由混浊水流喂深海洋的存款;(5 ) 沉积飘动在更低的斜坡盆地板发生,并且盖住约 400 km2 的一个区域,在越过海床流动的水流下面被产生;并且(6 ) 在深水区域的中央峡谷表示严肃流动的一种例外的类型碎片流动, turbidite 隧道,和 TSC 的一个协会创作了。它介绍平面 multisegment 和垂直多相的特征。在峡谷与好 petrophysical 性质联系的 Turbidite 能在 QDNB 被当作一个潜在的探索目标。 | SU Ming XIE Xinong LI Junliang JIANG Tao ZHANG Cheng HE Yunlong TIAN Shanshan ZHANG Cuimei | 2011 | Acta Geologica Sinica(English Edition)2011，85，1： | 19 |
| 10 | SOIL AGGREGATE AND ITS RESPONSE TO LAND MANAGEMENT PRACTICES显示文摘This paper provides a broad review of the existing study on soil aggregate and its responses to land management practices. Soil aggregate is used for structural unit, which is a group of primary soil particles that cohere to each other more strongly than other surrounding particles. The mechanism of soil particle aggregation may be expressed by a hierarchical model, which is based upon the hypothesis that macroaggregates (>250 μm) are collections of smaller microaggregates (<250 μm) held together with organic binding agents. Primary particles form microaggregates and then macroaggregates. Carbon (C)-rich young plant residues form and stabilize macroaggregates, whereas old organic C is occluded in the microaggregates. The interaction of aggregate dynamics with soil organic carbon (SOC) is complex and embraces a range of spatial and temporal processes within macroaggregates and microaggregates. The nature and properties of aggregates are determined by the quantity and quality of coarse residues and humic compounds and by the degree of their interaction with soil particles. The mechanisms resulting in the binding of primary soil particles into stable aggregates vary with soil parent material, climate, vegetation, and land management practices. Land management prac- tices, including tillage methods, residue management, amendments, and soil fertility management, enhance soil aggre- gation. However, there is still much uncertainty in the dynamics of organic matter in macroaggregation and microaggre- gation, and research is still needed to understand further the mechanisms of aggregate formation and its responses to human activities. | Chaofu Wei Ming Gao Jingan Shao Deti Xie Genxing Pan | 2006 | China Particuology2006，4，5： | 17 |
| 11 | Recurrent gain-of-function USP8 mutations in Cushing's disease显示文摘库欣的疾病,引起过量皮质醇生产的也已知的同样促肾上腺皮质的荷尔蒙(ACTH )-secreting 垂体腺瘤(舞步) ,占多达 85%corticotrophin 依赖的库欣的症候群盒子。然而,在这疾病的基因改变是不清楚的。这里,我们执行了从 12 秘密 ACTH 舞步导出并且匹配血样品的 DNA 定序的 whole-exome,它在候选人基因揭示了体的变化的三种类型, USP8 (编码 ubiquitin 特定的朊酶 8 ) ,专门在 exon 14 在 12 秘密 ACTH 舞步中的 8 个。我们进一步评估了体的 USP8 变化在另外由定序的 Sanger 的 258 舞步。进一步定序指向在 108 秘密 ACTH 舞步(62.04%) 中的 67 个识别了 USP8 变体的 17 种类型的一个总数。然而,任何一个都没在舞步的另外的类型这些变化被检测(n = 150 ) 。这些变化在 USP8 的 14-3-3 绑定主题以内聚集并且破坏在 USP8 和 14-3-3 蛋白质之间的相互作用,导致保护 EGFR 免受 lysosomal 降级的伤害的一个提高的能力。因此,有 EGFR 表示,提高的 EGFR 蛋白质丰富和 mRNA 表示的更高的发生 POMC 铺平的变异的 USP8 显示的舞步,它编码 ACTH 的先锋。有变异的 USP8 的舞步在尺寸是显著地更小的并且比野类型的舞步有更高的 ACTH 生产。在里面通过手术 resected 主要变异 USP8 的肿瘤房间, USP8 击倒或堵住的 EGFR 有效地稀释 ACTH 分泌物。一起拿,体的 gain-of-function USP8 变化是普通的并且在库欣的疾病贡献 ACTH 生产过剩。USP8 或 EGFR 的抑制为对待变异 USP8 的 corticotrophin 腺瘤是有希望的。我们的学习在库欣的疾病加亮潜在地功能的变异的基因并且提供卓见进这疾病的治疗学。 | Zeng-Yi Ma Zhi-Jian Song Jian-Hua Chen Yong-Fei Wang Shi-Qi Li Liang-Fu Zhou Ying Mao Yi-Ming Li Rong-Gui Hu Zhao-Yun Zhang Hong-Ying Ye Ming Shen Xue-Fei Shou Zhi-Qiang Li Hong Peng Qing-Zhong Wang Dai-Zhan Zhou Xiao-Lan Qin Jue Ji Jie Zheng Hong Chen Yin Wang Dao-Ying Geng Wei-Jun Tang Chao-Wei Fu Zhi-Feng Shi Yi-Chao Zhang Zhao Ye Wen-Qiang He Qi-Lin Zhang Qi-Sheng Tang Rong Xie Jia-Wei Shen Zu-Jia Wen Juan Zhou Tao Wang Shan Huang Hui-Jia Qiu Ni-Dan Qiao Yi Zhang Li Pan Wei-Min Bao Ying-Chao Liu Chuan-Xin Huang Yong-Yong Shi Yao Zhao | 2015 | Cell Research2015，25，3： | 16 |
| 12 | Reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients显示文摘B 房间对再感染在肝炎 B 病毒(HBV ) 和保护的清理起一个重要作用。然而,与长期的 HBV 感染的结果被联系的这些房间的功能的特征仍然保持未知。我们包括地在不同阶段从 CHB 病人调查了外部 B 房间子集的频率,显型,和功能:有免疫力的忍耐(信息技术) ,有免疫力的激活(IA ) ,有免疫力的清理(IC ) ,有 HBsAg seroconversion 的应答者(解决的病人, RP ) ,并且健康控制(HC ) 。IA 病人与另外的组相比显示了外部血记忆 B 房间的更低的百分比。B 房间的全面 polyclonal 激活,由激活标记和 IgG 和 IgM 的分泌物的高水平显示了,在 IA 病人被观察。这 B 房间 hyperactivation 能被增加的 IFN-α 导致;并且在 IA 病人的可溶的 CD40 ligands。尤其是,合作激发器分子 CD80 和浆液 HBsAb 的表示和 HBsAg 特定的 B 房间的频率显著地与 HC 题目相比在信息技术, IA,和 IC 病人被减少。更重要地, B 房间 hyperactivation, co-stimulatory 分子 downregulation 和 HBsAg 特定的 B 房间缺陷在 RP 病人被颠倒。B 房间 hyperactivation 和功能的缺陷的颠倒在长期的肝炎 B 病人与 HBsAg seroconversion 被联系。 | Xiangsheng Xu Qinghua Shang Xinyue Chen Weimin Nie Zhengsheng Zou Ang Huang Ming Meng Lei Jin Ruonan Xu Ji-Yuan Zhang Junliang Fu Lifeng Wang Zirong Tang Yunbo Xie Xiaoming Yang Zheng Zhang Fu-Sheng Wang | 2015 | Cellular & Molecular Immunology2015，12，3： | 15 |
| 13 | ShHTL7 is a non-canonical receptor for strigolactones in root parasitic weeds显示文摘 | Yao, Ruifeng Wang, Fei Ming, Zhenhua Du, Xiaoxi Chen, Li Wang, Yupei Zhang, Wenhao Deng, Haiteng Xie, Daoxin | 2017 | Cell Research2017，27，6： | 15 |
| 14 | Clinical practice guidelines on liver transplantation for hepatocellular carcinoma in China(2018 edition)显示文摘Introduction Over 300000 people in China die each year of hepatocellular carcinoma(HCC),which accounts for approximately half of HCCrelated deaths worldwide.Liver transplantation(LT)is generally recognized as one of the most effective therapeutic approaches for end-stage liver diseases.Since the beginning of the second LT boom in the 1990s,LT in China has been developed rapidly with professional and large-scale trends,and it is approaching or has reached the level of developed countries in terms of quantity and quality.According to the China Liver Transplant Registry,the number of transplants for HCC accounted for 36.8%of the total number of LT cases during the past 5 years in the mainland of China.In order to develop an effective,safe and standardized protocol to guide the national LT practice,the clinical guidelines of LT for HCC was launched in 2014 by multidisciplinary experts from Chinese Society of Organ Transplantation,Chinese Medical Association and Chinese Association of Organ Transplantation,Chinese Medical Doctor Association.Recently,there have been new clinical and scientific advances in the field of LT and to keep abreast of these achievements,the original clinical practice guidelines need to be updated. | Xiao Xu Jun Chen Qiang Wei Zhi-Kun Liu a Zhe Yang Ming Zhang Guo-Ying Wang Jie Gao Zhao-Xu Yang Wen-Yuan Guo Tong-Hai Xing Zhou Shao Qin-Fen Xie Shu-Sen Zheng | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，4： | 14 |
| 15 | Long-term effects of drug-eluting stents versus bare metal stents on patients with acute ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: outcomes of 3-year clinical follow-up显示文摘 | WANG Chong-hui FANG Quan ZHANG Shu-yang SHEN Zhu-jun FAN Zhong-jie J1N Xiao-feng ZENG Yong LIU Zhen-yu XIE Hong-zhi YANG Ming | 2012 | Chinese Medical Journal2012，，16： | 14 |
| 16 | The Predictive Value of Baseline HBs Ag Level and Early Response for HBs Ag Loss in Patients with HBe Ag-positive Chronic Hepatitis B during Pegylated Interferon Alpha-2a Treatment显示文摘Objective To explore the predictive value of baseline HBsAg level and early response for HBsAg loss in patients with HBeAg-positive chronic hepatitis B during pegylated interferon alpha-2a treatment. Methods A total of 121 patients with HBeAg-positive chronic hepatitis B who achieved HBsAg loss were enrolled; all patients were treated with PEG-IFNα-2a 180 μg/week. Serum HBV DNA and serological indicators(HBsAg, anti-HBs, HBeAg, and anti-HBe) were determined before and every 3 months during treatment. Results The median treatment time for HBsAg loss was 84 weeks(7-273 weeks), and 74.38%(90 cases) of the patients needed extended treatment(> 48 weeks). The correlation between baseline HBsAg levels and the treatment time of HBsAg loss was significant(B = 14.465, t = 2.342, P = 0.021). Baseline HBsAg levels together with the decline range of HBsAg at 24 weeks significantly correlated with the treatment time of HBsAg loss(B = 29.862, t = 4.890, P = 0.000 and B = 27.993, t = 27.993, P = 0.005). Conclusion Baseline HBsAg levels and extended therapy are critical steps toward HBsAg loss. Baseline HBsAg levels together with early response determined the treatment time of HBsAg loss in patients with HBeAg-positive chronic hepatitis B during pegylated interferon alpha-2a treatment. | LI Ming Hui ZHANG Lu QU Xiao Jing LU Yao SHEN Ge LI Zhen Zhen WU Shu Ling LIU Ru Yu CHANG Min HU Lei Ping HUA Wen Hao SONG Shu Jing WAN Gang XIE Yao | 2017 | Biomedical and Environmental Sciences2017，30，3： | 14 |
| 17 | Differentiation of intrahepatic cholangiocarcinoma from hepatocellular carcinoma in high-risk patients: a predictive model using contrast-enhanced ultrasound显示文摘AIM To develop a contrast-enhanced ultrasound(CEUS)predictive model for distinguishing intrahepatic cholangiocarcinoma(ICC) from hepatocellular carcinoma(HCC) in high-risk patients.METHODS This retrospective study consisted of 88 consecutive high-risk patients with ICC and 88 high-risk patients with HCC selected by propensity score matching between May 2004 and July 2016. Patients were assigned to two groups, namely, a training set and validation set, at a 1:1 ratio. A CEUS score for diagnosing ICC was generated based on significant CEUS features. Then, a nomogram based on the CEUS score was developed, integrating the clinical data. The performance of the nomogram was then validated and compared with that of the LR-M of the CEUS Liver Imaging Reporting and Data System(LI-RADS).RESULTS The most useful CEUS features for ICC were as follows: rim enhancement(64.5%), early washout(91.9%), intratumoral vein(58.1%), obscure boundary of intratumoral non-enhanced area(64.5%), and marked washout(61.3%, all P < 0.05). In the validation set, the area under the curve(AUC) of the CEUS score(AUC = 0.953) for differentiation between ICC and HCC was improved compared to the LI-RADS(AUC = 0.742)(P < 0.001). When clinical data were added, the CEUS score nomogram was superior to the LI-RADS nomogram(AUC: 0.973 vs 0.916, P = 0.036, Net Reclassification Improvement: 0.077, Integrated Discrimination Index: 0.152). Subgroup analysis demonstrated that the CEUS score model was notably improved compared to the LIRADS in tumors smaller than 5.0 cm(P < 0.05) but not improved in tumors smaller than 3.0 cm(P > 0.05).CONCLUSION The CEUS predictive model for differentiation between ICC and HCC in high-risk patients had improved discrimination and clinical usefulness compared to the CEUS LIRADS. | Li-Da Chen Si-Min Ruan Jin-Yu Liang Zheng Yang Shun-Li Shen Yang Huang Wei Li Zhu Wang Xiao-Yan Xie Ming-De Lu Ming Kuang Wei Wang | 2018 | World Journal of Gastroenterology2018，24，33： | 14 |
| 18 | Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Treatment of severe Coronavirus Disease 2019(COVID-19)is challenging.We performed a phase 2 trial to assess the efficacy andsafety of human umbilical cord-mesenchymal stem cells(UC-MScs)to treat severe coViD-19 patients with lung damage,based onour phase 1 data.In this randomized,double-blind,and placebo-controlled trial,we recruited 101 severe coVID-19 patients withlung damage.They were randomly assigned at a 2:1 ratio to receive either UC-MSCs(4×10^(7)cells per infusion)or placebo on day 0,3,and 6.The primary endpoint was an altered proportion of whole lung lesion volumes from baseline to day 28.Other imagingoutcomes,6-minute walk test(6-MWT),maximum vital capacity,diffusing capacity,and adverse events were recorded and analyzed.In all,100 COVID-19 patients were finally received either UC-MSCs in=65)or placebo(n=35).UC-MSCs administrationexerted numerical improvement in whole lung lesion volume from baseline to day 28 compared with the placebo(the mediandifference was-13.31%,95%Cl-29.14%,2.13%,P=0.08).UC-MSCs significanty reduced the proportions of solid componentlesion volume compared with the placebo(median difference:-15.45%;95%CI-30.82%,-0.39%;P=0.043).The 6-MWT showedan increased distance in patients treated with UC-MSCs(difference:27.00 m;95%CI 0.00,57.00;P=0.057).The incidence of adverseevents was similar in the two groups.These results suggest that UC-MSCs treatment is a safe and potentially effective therapeuticapproach for COVID-19 patients with lung damage.A phase 3 trial is required to evaluate effects on reducing mortality andpreventing long-term pulmonary disability. | Lei Shi Hai Huang Xuechun Lu Xiaoyan Yan Xiaojing Jiang Ruonan Xu Siyu Wang Chao Zhang Xin Yuan Zhe Xu Lei Huang Jun-Liang Fu Yuanyuan Li Yu Zhang Wei-Qi Yao Tianyi Liu Jinwen Song Liangliang Sun Fan Yang Xin Zhang Bo Zhang Ming Shi Fanping Meng Yanning Song Yongpei Yu Jiqiu Wen Qi Li Qing Mao Markus Maeurer Alimuddin Zumla Chen Yao Wei-Fen Xie Fu-Sheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 13 |
| 19 | Key indicators affecting maize stalk lodging resistance of different growth periods under different sowing dates显示文摘The accurate evaluation of maize stalk lodging resistance in different growth periods enables timely management of lodging risks and ensures stable and high maize yields.Here,we established five diferent sowing dates to create diferent conditions for maize growth.We evaluated the effects of the different growth conditions on lodging resistance by determining stalk morphology,moisture content,mechanical strength and dry matter,and the relationship between stalk breaking force and these indicators during the silking stage(R1),milk stage(R3),physiological maturity stage(R6),and 20 days after R6.Plant height at R1 positively affected stalk breaking force.At R3,the cofficient of ear height and the dry weight per unit length of basal internodes were key indicators of stalk lodging resistance.At R6,the key indicators were the coefficient of the center of gravity height and plant fresh weight.After R6,the key indicator was the coefficient of the center of gravity height.The crushing strength of the fourth internode correlated significanty and positively with the stalk breaking force from R1 to R6,which indicates that crushing strength is a reliable indicator of stalk mechanical strength.These results suggest that high stalk strength and low ear height beneft lodging resistance prior to R6.During and after R6,the cofficient of the center of gravity height and the mechanical strength of basal internodes can be used to evaluate plant lodging resistance and the appropriate time for harvesting in fields with a high lodging risk. | WANG Qun XUE Jun CHEN Jiang-lu FAN Ying-hu ZHANG Guo-qiang XIE Rui-zhi MING Bo HOU Peng WANG Ke-ru LI Shao-kun | 2020 | Journal of Integrative Agriculture2020，19，10： | 13 |
| 20 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
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