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| 1 | 26mA cm^(-2) J_(sc) from organic solar cells with a low-bandgap nonfullerene acceptor显示文摘Nonfullerene-based organic solar cells(NFOSCs)have received great interest recently due to their higher performance and greater potential compared with fullerene-based solar cells[1].Power conversion efficiencies(PCEs)over 13% have been realized in single-junction NFOSCs[2].Compared with traditional fullerene acceptors,the greatest advantage of nonfullerene acceptors is their stronger light-harvesting capability in the visible and | Zuo Xiao Xue Jia Dan Li Shizhe Wang Xinjian Geng Feng Liu Junwu Chen Shangfeng Yang Thomas P.Russell Liming Ding | 2017 | Science Bulletin2017，62，22： | 28 |
| 2 | Rapid improvement of PM2.5 pollution and associated health benefits in China during 2013–2017显示文摘Exposure to fine particulate matter(PM2.5)is known to harm public health.In China,after implementation of aggressive emissions control measures under the Action Plan of Air Pollution Prevention and Control(2013-2017),air quality has significantly improved.In this work,we investigated changes in PM2.5 exposure and the associated health impacts in China for the period 2013-2017.We used an optimal estimator of PM2.5 combining in-situ observations,satellite measurements,and simulations from a chemical transport model to derive the spatial and temporal variations in PM2.5 exposure,and then used welldeveloped exposure-response functions to estimate the premature deaths attributable to PM2.5 exposure.We found that national population-weighed annual mean PM2.5 concentrations decreased from 67.4μgm-3 in 2013 to 45.5μgm-3 in 2017(32%reduction).This rapid decrease in PM2.5 pollution led to a 14%reduction in premature deaths due to long-term exposure.We estimated that,during 2013-2017,the premature deaths attributable to long-term PM2.5 exposure decreased from 1.2 million(95%CI:1.0,1.3;fraction of total mortality:13%)in 2013 to 1.0 million(95%CI:0.9,1.2;10%)in 2017.Despite the rapid decrease in annual mean PM2.5 concentrations,health benefits associated with reduced long-term exposure were limited,because for many cities,the PM2.5 levels remain at the portion where the exposure-response function is less steeper than that at the lowconcentration end.We also found that the deaths associated with acute exposure decreased by 61%during 2013-2017 due to rapid reduction in the number of heavily polluted days.Our results confirm that clean air policies in China have mitigated the air pollution crisis;however,continuous emissions reduction efforts are required to protect citizens from air pollution. | Tao XUE Jun LIU Qiang ZHANG Guannan GENG Yixuan ZHENG Dan TONG Zhu LIU Dabo GUAN Yu BO Tong ZHU Kebin HE Jiming HAO | 2019 | Science China Earth Sciences2019，62，12： | 17 |
| 3 | MiR-30a Positively Regulates the Inflammatory Response of Microglia in Experimental Autoimmune Encephalomyelitis显示文摘Multiple sclerosis(MS) is a classical inflammatory demyelinating disease of the central nervous system(CNS). Microglia are the main resident immune cells in the CNS and are closely associated with the pathogenesis of MS.In the present study, we found that mi R-30 a was highly expressed in jellyfish-like microglia in chronic active lesions of MS patients, as well as in the microglia of mice with experimental autoimmune encephalomyelitis(EAE) at the chronic phase. In vitro, the conditioned supernatant of mouse microglia overexpressing miR-30 a promoted the apoptosis of oligodendrocyte precursor cells(OPCs), and inhibited OPC differentiation. In vivo, overexpressing miR-30 a in transplanted microglia exacerbated the progression of EAE.Overexpression and knock-down experiments in primary cultured mouse microglia showed that mi R-30 a increased the expression of IL-1 b and i NOS, which are pro-inflammatory, while inhibiting the expression of Ym-1 and CD206.Mechanistically, mi R-30 a inhibited the expression of Ppargc1 b, which is the co-activator of peroxisome proliferator-activated receptor gamma, resulting in pro-inflammatory effects. Our work shows that mi R-30 a is an important regulator of the inflammatory response in microglia, and may be a promising therapeutic target for inflammatory diseases like MS in the CNS. | Xue Fang Dingya Sun Zhihong Wang Zhongwang Yu Weili Liu Yingyan Pu Dan Wang Aijun Huang Mingdong Liu Zhenghua Xiang Cheng He Li Cao | 2017 | Neuroscience Bulletin2017，33，6： | 16 |
| 4 | Interferon-c and interleukin-4 detected in serum and saliva from patients with oral lichen planus显示文摘Our previous salivary study had demonstrated an apparent T helper 2(Th2)-predominance in saliva of oral lichen planus(OLP) patients and suggested a potential of salivary interleukin-4(IL-4) as a biomarker for monitoring disease severity. To further determine the consistency of Th1/Th2 bias of OLP, this study investigated the expression profile of interferon-c(IFN-c) and IL-4 in serum and the relationship of the serum levels of these cytokines with their saliva partners. Sixty ethnic Chinese patients with OLP(40 of the erythematous/ulcerative form and 20 of the reticular form) were recruited for this study, with 40 age–sex-matched healthy volunteers as control group. IFN-c and IL-4 levels in serum and paired saliva samples were screened by enzyme-linked immunosorbent assay. OLP patient showed a low-level IFN-c but high-level IL-4 expression profile in both serum and saliva, with a lower IFN-c/IL-4 ratio. Serum IL-4 level in the erythematous/ulcerative group was significantly higher than that in the reticular group. Serum levels of IFN-c and IL-4 were significantly and positively correlated with their saliva partners. These results provided more evidence for Th2 cytokinepredominant immune imbalance in OLP, as well as the potential of IL-4 as the biomarker for monitoring severity of OLP. | Wen-Zhao Liu Ming-Jing He Long Long Dong-Liang Mu Ming-Shu Xu Xue Xing Xin Zeng Ga Liao Hong-Xia Dan Qian-Ming Chen | 2014 | International Journal of Oral Science2014，6，1： | 10 |
| 5 | Typical atmospheric haze during crop harvest season in northeastern China:A case in the Changchun region显示文摘This study presents the mass concentrations of PM_(2.5),O_3,SO_2 and NOxat one urban,one suburban and two rural locations in the Changchun region from September 25 to October 272013. Major chemical components of PM_(2.5)at the four sites were daily sampled and analyzed. Most of daily concentrations of SO_2(7–82 μg/m^3),O_3(27–171 μg/m^3) and NOx(14–213 μg/m^3) were below the limits of the National Ambient Air Quality Standard(NAAQS)in China. However,PM_(2.5)concentrations(143–168 μg/m^3) were 2-fold higher than NAAQS.Higher PM_(2.5)concentrations(~ 150 μg/m^3) were measured during the pre-harvest and harvest at the urban site,while PM_(2.5)concentrations significantly increased from 250 to400 μg m^(-3) at suburban and rural sites with widespread biomass burning. At all sites,PM_(2.5)components were dominated by organic carbon(OC) and followed by soluble component sulfate(SO_4^(2-)),ammonium(NH_4^+) and nitrate(NO_3^-). Compared with rural sites,urban site had a higher mineral contribution and lower potassium(K^+and K) contribution to PM_(2.5).Severe atmospheric haze events that occurred from October 21 to 23 were attributed to strong source emissions(e.g.,biomass burning) and unfavorable air diffusion conditions.Furthermore,coal burning originating from winter heating supply beginning on October 18 increased the atmospheric pollutant emissions. For entire crop harvest period,the Positive Matrix Factorization(PMF) analysis indicated five important emission contributors in the Changchun region,as follows: secondary aerosol(39%),biomass burning(20%),supply heating(18%),soil/road dust(14%) and traffic(9%). | Wei Wei Chen Daniel Q.Tong Mo Dan Shi Chun Zhang Xue Lei Zhang Yue Peng Pan | 2017 | Journal of Environmental Sciences2017，29，4： | 10 |
| 6 | Comparative analysis of the complete chloroplast genome among Prunus mume,P.armeniaca,and P.salicina显示文摘Prunus mume Sieb.et Zucc.,P.armeniaca L.,and P.salicina L.are economically important fruit trees in temperate regions.These species are taxonomically perplexing because of shared interspecific morphological traits and variation,which are mainly attributed to hybridization.The chloroplast is cytoplasmically inherited and often used for evolutionary studies.We sequenced the complete chloroplast genomes of P.mume,P.armeniaca,and P.salicina using Illumina sequencing followed by de novo assembly.The three chloroplast genomes exhibit a typical quadripartite structure with conserved genome arrangement,structure,and moderate divergence.The lengths of the genomes are 157,815,157,797,and 157,916 bp,respectively.The length of the large single-copy region(LSC)region is 86,113,86,283,and 86,122 bp,and the length of the SSC region is 18,916,18,734,and 19,028 bp;the IR region is 26,393,26,390,and 26,383 bp,respectively.Each of the three chloroplast genomes encodes 133 genes,including 94 protein-coding,31 tRNA,and eight rRNA genes.Differential gene analysis for the three species revealed that trnY-ATA is a unique gene in P.armeniaca;in contrast,the gene trnI-TAT is only present in P.mume and P.salicina,though the position of the gene in these chloroplast genomes differs.Further comparative analysis of the complete chloroplast genome sequences revealed that the ORF genes and the sequences of linked regions rps16 and atpA,atpH and atpI,trnc-GCA and psbD,ycf3 and atpB,and rpL32 and ndhD are significantly different and may be used as molecular markers in taxonomic studies.Phylogenetic evolution analysis of the three species suggests that P.mume has a closer genetic relationship to P.armeniaca than to P.salicina. | Song Xue Ting Shi Wenjie Luo Xiaopeng Ni Shahid Iqbal Zhaojun Ni Xiao Huang Dan Yao Zhijun Shen Zhihong Gao | 2019 | Horticulture Research2019，6，1： | 10 |
| 7 | Investigation into the Formation, Structure, and Evolution of an EF4 Tornado in East China Using a High-Resolution Numerical Simulation显示文摘Devastating tornadoes in China have received growing attention in recent years, but little is known about their formation, structure, and evolution on the tornadic scale. Most of these tornadoes develop within the East Asian monsoon regime, in an environment quite different from tornadoes in the U.S. In this study, we used an idealized, highresolution(25-m grid spacing) numerical simulation to investigate the deadly EF4(Enhanced Fujita scale category 4)tornado that occurred on 23 June 2016 and claimed 99 lives in Yancheng, Jiangsu Province. A tornadic supercell developed in the simulation that had striking similarities to radar observations. The violent tornado in Funing County was reproduced, exceeding EF4(74 ms–1), consistent with the on-site damage survey. It was accompanied by a funnel cloud that extended to the surface, and exhibited a double-helix vorticity structure. The signal of tornado genesis was found first at the cloud base in the pressure perturbation field, and then developed both upward and downward in terms of maximum vertical velocity overlapping with the intense vertical vorticity centers. The tornado's demise was found to accompany strong downdrafts overlapping with the intense vorticity centers. One of the interesting findings of this work is that a violent surface vortex was able to be generated and maintained, even though the simulation employed a free-slip lower boundary condition. The success of this simulation, despite using an idealized numerical approach, provides a means to investigate more historical tornadoes in China. | Dan YAO Haile XUE Jinfang YIN Jisong SUN Xudong LIANG Jianping GUO | 2018 | Journal of Meteorological Research2018，32，2： | 10 |
| 8 | XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cells显示文摘Autophagy 被激活响应滋养的饥饿维持细胞的精力动态平衡。然而, autophagy 固执地没被激活,它糟糕在机械学的水平被理解。这里,我们报导 FoxO1 的那周转涉及夫酸安饥饿引起的动态 autophagic 过程。X-box-binding protein-1u (XBP-1u ) 由招募在 FoxO1 降级有一个关键角色 FoxO1 到 20S proteasome。另外,由 Ser61 和 Ser176 上的细胞外的调整蛋白质 kinases1/2 (ERK1/2 ) 的 XBP-1u 的 phosphorylation 被发现在夫酸安饥饿之上为在 XBP-1u 和 FoxO1 之间的增加的相互作用批评。而且,引起 FoxO1 的持续水平和 autophagy 的坚持的激活的 XBP-1u 击倒,在房间生存能力导致重要减少。最后,在 XBP-1u 之间的反的关联和 FoxO1 表示同意很好,表示侧面在许多人的癌症纸巾观察了。因此,我们的调查结果连接到 XBP-1u-induced FoxO1 的 autophagy 的动态过程降级。 | Ying Zhao Xue Li Mu-Yan Cai Ke Ma Jing Yang Jingyi Zhou Wan Fu Fu-Zheng Wei Lina Wang Dan Xie Wei-Guo Zhu | 2013 | Cell Research2013，23，4： | 8 |
| 9 | Monocyte chemoattractant protein 1 and fractalkine play opposite roles in angiogenesis via recruitment of different macrophage subtypes显示文摘AIM: To explore the interaction between macrophages and chemokines [monocyte chemoattractant protein 1(MCP-1/CCL2) and fractalkine/CX3CL1] and the effects of their interaction on neovascularization.METHODS: Human peripheral blood mononuclear cells, donated by healthy volunteers, were separated and cultured in RPMI-1640 medium containing 10% fetal bovine serum, then induced into macrophages by stimulation with 30 μg/L granulocyte macrophage-colony stimulating factor(GM-CSF). The expression of CCR2 and/or CX3CR1 in the macrophages was examined using flow cytometry. Macrophages were then stimulated with recombinant human CCL2(rh-CCL2) or recombinant human CX3CL1(rh-CX3CL1). The expression of angiogenesis-related genes, including VEGF-A, THBS-1 and ADAMTS-1 were examined using real-time quantitative polymerase chain reaction(PCR). Supernatants from stimulated macrophages were used in an assay of human retinal endothelial cell(HREC) proliferation. Finally, stimulated macrophages were cocultured with HREC in a migration assay.RESULTS: The expression rate of CCR2 in macrophages stimulated by GM-CSF was 42%±1.9%. The expression rate of CX3CR1 was 71%±3.3%. Compared with vehicle-treated groups, gene expression of VEGF-A in the macrophages was greater in 150 mg/L CCL2-treated groups(P<0.05), while expression of THBS-1 and ADAMTS-1 was significantly lower(P<0.05). By contrast, compared with vehicle-treated groups, expression of VEGF-A in 150 mg/L CX3CL1-treated groups was significantly lower(P<0.05), while expression of THBS-1 and ADAMTS-1 was greater(P<0.05). Supernatants from CCL2 treated macrophages promoted proliferation of HREC(P<0.05), while supernatants from CX3CL1-treated macrophages inhibited the proliferation of HREC(P<0.05). HREC migration increased when co-cultured with CCL2-treated macrophages, but decreased with CX3CL1-treated macrophages(P<0.05).CONCLUSION: CCL2 and CX3CL1 exert different effects in regulation of macrophage in expression of angiogenesisrelated factors, including VEGF-A, THBS-1 and ADAMTS-1. Our findings suggest that CCL2 and CX3CL1 may be candidate proteins for further exploration of novel targets for treatment of ocular neovascularization. | Lei Chen Gao-Qin Liu Hong-Ya Wu Ji Jin Xue Yin Dan Li Pei-Rong Lu | 2018 | International Journal of Ophthalmology(English edition)2018，11，2： | 8 |
| 10 | N-acetylcysteine alleviates angiotensin II-mediated renal fibrosis in mouse obstructed kidneys显示文摘瞄准:为了在血管收缩素 II (Ang II ) 上调查 ROS scavenger N-acetylcysteine (NAC ) 的效果,调停了在 vivo 并且在 vitro.Methods 的肾的纤维变性:老鼠受到单方的 ureteral 阻塞(UUO ) ,然后与车辆或 NAC 对待(250 mg/kg, ip ) 为 7 天。妨碍的肾的组织学的变化与 Massons 被观察三色的染色。ROS 层次被检测, DHE 染色。在妨碍的肾的相关蛋白质的表示用西方的弄污的试金被估计。肾的成纤维细胞 NRK-49F 房间在 vitro experiments.Results 被用于的有教养的老鼠:在妨碍的肾, Ang II 层次显著地被提高,并且骨胶原我在空隙的空格被积累。而且, ROS 生产和 p47 (NADPH oxidase 建筑群的一个关键子单元) 的表示以一种时间依赖者方式被增加;fibronectin 的表示, α -SMA 和 TGF-β是 upregulated。NAC 的管理显著地在妨碍的肾减轻了 fibrotic 回答。在有教养的 NRK-49F 房间,有 Ang II 的处理(0.001-10 μ mol/L ) 增加了 fibronectin 的表示,骨胶原我, α -SMA 和 TGF-β在剂量依赖者和时间依赖者礼貌。Ang II 也增加了 ROS 生产和 Smad3 的 phosphorylation。有 NAC 的预告的处理(5 μ mol/L ) 在 cells.Conclusion 的堵住的 Ang 导致 II 的氧化压力和 ECM 生产:在老鼠妨碍了肾,从 Ang II upregulation 的 fibrotic 回答结果能被 ROS scavenger N-acetylcysteine 减轻。 | Yang SHEN Nai-jun MIAO Jin-lan XU Xin-xin GAN Dan XU Li ZHOU Hong XUE Wei ZHANG Li-min LU | 2016 | Acta Pharmacologica Sinica2016，37，5： | 7 |
| 11 | Deformation features and failure mechanism of steep rock slope under the mining activities and rainfall显示文摘Underground mining activities and rainfall have potential important influence on the initiation and reactivation of the slope deformations,especially on the steep rock slope. In this paper,using the discrete element method(UDEC),numerical simulation was carried out to investigate deformation features and the failure mechanism of the steep rock slope under mining activities and rainfall. A steep rock slope numerical model was created based on a case study at the Wulong area in Chongqing city,China. Mechanical parameters of the rock mass have been determined by situ measurements and laboratory measurements. A preliminary site monitoring system has been realized,aiming at getting structure movements and stresses of unstablerock masses at the most significant discontinuities. According to the numerical model calibrated based on the monitoring data,four types of operation conditions are designed to reveal the effect of mining excavation and extreme rainfall on the deformation of the steep rock slope. | LI Zhi-qiang XUE Yi-guo LI Shu-cai ZHANG Le-wen WANG Dan LI Bin ZHANG Wen NING Kai ZHU Jian-ye | 2017 | Journal of Mountain Science2017，14，1： | 7 |
| 12 | Surgical high ligation of the ovarian vein and preservation of ovarian function for twisted ovarian tumors显示文摘 | LI Ju YU Yue-xin SUN Chun-yan XUE Dan QU Dong-ying | 2012 | Chinese Medical Journal2012，，20： | 6 |
| 13 | Central Obesity and Metabolic Risk Factors in Middle-aged Chinese显示文摘Objective Central obesity is considered to be a central component of metabolic syndrome. Waist circumference(WC) has been widely used as a simple indicator of central obesity. This study is aimed to evaluate the sensitivity of WC cut-off values for predicting metabolic risk factors in middle-aged Chinese. Methods The study involved 923 subjects aged 40-65 years. The metabolic risk factors were defined according to the Chinese Joint Committee for Developing Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Adults. WC cut-off 85-90 cm and ≥90 cm were used as cut-off values of central pre-obesity and central obesity in males, respectively, while WC 80-85 cm and ≥85 cm were used as cut-off values of central pre-obesity and central obesity in females. Results First, WC values corresponding to body mass index(BMI) 24 kg/m2 and visceral fat area(VFA) 80 cm2 were 88.55 cm and 88.51 cm in males, and 81.46 cm and 82.51 cm in females respectively. Second, receiver operating characteristic curves showed that the optimal WC cut-off of value was 88.75 cm in males, higher than that in females(81.75 cm). Third, the subjects with higher WC values were more likely to have accumulating metabolic risk factors. The prevalence of metabolic risk factors increased linearly and significantly in relation to WC levels. Conclusion WC cut-off values of central pre-/central obesity are optimal to predict multiple metabolic risk factors. | YIN Xue Yao ZHENG Fen Ping ZHOU Jia Qiang DU Ying PAN Qian Qian ZHANG Sai Fei YU Dan LI Hong | 2014 | Biomedical and Environmental Sciences2014，27，5： | 6 |
| 14 | An efficient synthesis of ampicillin on magnetically separable immobilized penicillin G acylase显示文摘Penicillin G acylase(PGA) was immobilized on the magnetic hydrophilic polymer microspheres with average pore size of 17.1 nm,specific surface area of 128.2 m^2/g and saturate magnetization of 6.4 emu/g.The 96.7%ampicillin yield with 1.60 of the synthesis/hydrolysis(S/H) ratio from 6-aminopenicillanic acid(6-APA) and D-(-)-alpha-phenylglycine methyl ester(D-PGME) can be achieved using the resultant magnetic biocatalyst in ethylene glycol,where only 82.1%yield with 1.40 of the S/H ratio was obtained using the free PGA under the identical reaction conditions.The immobilized PGA can be separated magnetically and recycled for five times without obvious loss of its catalytic activity. | Ping Xue Xiao Dan Song Xue Rong Cao | 2010 | Chinese Chemical Letters2010，21，7： | 6 |
| 15 | Influence of Danshen Injection on airway inflammation and CD4^+ CD25^+ regulatory T cells of asthmatic rats显示文摘Objective: To investigate the influence of Danshen Injection on airway inflammation and CD4+CD25+ regulatory T cells(CD4+CD25+ Tr) of asthmatic rats, and elucidate the possible mechanism of Danshen Injection in treatment of asthma. Methods: 30 Wister rats were randomly divided into control group, asthma group and Danshen Injection treated group. Bronchoalveolar lavage fluids(BALF) were collected, and cytology studies were conducted. Lung tissues were obtained and pathologic analyses were done with hematoxylin and eosin stain(HE). Flow cytometry was used to detect the CD4+CD25+ Tr ratio in peripheral blood mononuclear cells(PBMCs). Results: Total cell, the percentage of lymphocytes, neutrophils and eosinophils(Eos) in BALF of Danshen Injection-treated group were lower than that in asthma group(P ﹤ 0.05, P ﹤ 0.01). Compared with asthma group, less infiltration of inflammatory cells in lung tissues was observed in Danshen Injection-treated group. CD4+CD25+ Tr of asthma group was lower than that of control and Danshen Injection treated group (P ﹤ 0.05). Conclusion: Danshen Injection can suppress airway inflammation of asthmatic rats, probably by increasing the number of CD4+CD25+ Tr. | Keying Xue Yongming Zhou Shengdao Xiong Weining Xiong Dan Li | 2006 | Journal of Nanjing Medical University2006，20，5： | 6 |
| 16 | Mathematical prototypes for collocating geostationary satellites显示文摘Collocating geostationary satellites sharing the same position is much demanded for satellite operation recently,the separation strategies are adopted to safeguard the satellites collocated of leaving the relative distance beyond collision with different sets of orbit parameters.This paper presents the mathematical prototypes which establish the allowable relative distance with uncertainty of orbital determination(OD),as well as the orbital element offset for each pair of collocated satellites,and puts forward algorithms to build such relationship to face the challenge of putting three satellites sharing the same position,the algorithms to allocate the longitude,eccentricity and inclination for each satellite are also given to ascertain that the mathematical prototypes are the guide specification to design collocation strategy for geostationary satellites. | LI HengNian GAO ZhaoZhao LI JiSheng LI QuanJun XUE Dan LI DongLin | 2013 | Science China(Technological Sciences)2013，56，5： | 6 |
| 17 | Caspase-11 promotes renal fibrosis by stimulating IL-1β maturation via activating caspase-1显示文摘Caspase-11 is a key upstream modulator for activation of inflammatory response under pathological conditions. In this study, we investigated the roles of caspase-11 in the maturation of interleukin-1β (IL-1β) and development of renal interstitial fibrosis in vivo and in vitro. Mice were subjected to unilateral ureteral obstruction (UUO). The mice were treated with either caspase-11 inhibitor wedelolactone (Wed, 30 mg/kg/day, ig) for 7 days or caspase-11 siRNA (10 nmol/20 g body weight per day, iv) for 14 days. The mice were euthanized on day 14, their renal tissue and blood sample were collected. We found that the obstructed kidney had significantly higher caspase-11 levels and obvious tubular injury and interstitial fibrosis. Treatment with Wed or caspase-11 siRNA significantly mitigated renal fibrosis in UUO mice, evidenced by the improved histological changes. Furthermore, caspase-11 inhibition significantly blunted caspase-1 activation, IL-ip maturation, transforming growth factor-p (TGF-P), fibronectin, and collagen I expressions in the obstructed kidney. Renal tubular epithelial NRK-52E cells were treated in vitro with angiotensin (Ang, 1 pmol/L), which stimulated caspase-11 activation and IL-ip maturation. Treatment with IL-1β (20ng/ml) significantly increased the expression of TGF-β, fibronectin, and collagen I in the cells. Ang ll-induced expression of TGF-β, fibronectin, and collagen I were suppressed by caspase-11 siRNA or Wed. Finally, we revealed using co-immunoprecipitation that caspase-11 was able to interact with caspase-1 in NRK-52E cells. These results suggest that caspase-11 is involved in UUO-induced renal fibrosis. Elevation of caspase-11 in the obstructed kidney promotes renal fibrosis by stimulating caspase-1 activation and IL-1β maturation. | Nai-jun Miao Hong-yan Xie Dan Xu Jian-yong Yin Yan-zhe Wang Bao Wang Fan Yin Zhuan-li Zhou Qian Cheng Pan-pan Chen Li Zhou Hong Xue Wei Zhang Xiao-xia Wang Jun Liu Li-min Lu | 2019 | Acta Pharmacologica Sinica2019，40，6： | 5 |
| 18 | Environmental and Psycho-social Factors Related to Prostate Cancer Risk in the Chinese Population:a Case-control Study显示文摘Objective To study the risk environmental and psycho-social factors associated to prostate cancer(PCa) in Chinese population. Methods 250 PCa patients and 500 controls were enrolled in this case-control study. Information was collected and logistic regression analysis was used to estimate the odds ratios(OR) and 95% confidence intervals(95% CI) for relationship between lifestyle, eating habits and psycho-social factors with PCa risk. Results Green vegetables and green tea were associated with a decreased risk of PCa(OR=0.39, 95% CI: 0.28-0.53; OR=0.59, 95% CI: 0.40-0.87, respectively). Family history of PCa(OR=7.16, 95% CI: 2.01-25.49), history of prostate diseases(OR=2.28, 95% CI: 1.53-3.41), alcohol consumption(OR=1.97, 95% CI: 1.33-2.90), red meat consumption(OR=1.74, 95% CI: 1.20-2.52), barbecued(OR=2.29, 95% CI: 1.11-4.73) or fried(OR=2.35, 95% CI: 1.24-4.43) foods were related with increased PCa risk. Negative psycho-social factors including occupational setbacks(OR=1.61, 95% CI: 1.00-2.59), marital separation(OR=1.94, 95% CI: 1.29-2.91), self-contained suffering(OR=2.37, 95% CI: 1.58-3.55), and high sensitivity to the personal comments(OR=1.73, 95% CI: 1.18-2.54) were related to PCa. Conclusion Regular consumption of green vegetables and green tea may suggest protective effects on PCa. Alcohol consumption, red meat consumption and barbecued or fried foods were associated with PCa. Negative psycho-social factors may also play a role in the incidence of PCa in Chinese population. | LI Mei Ling LIN Ji HOU Jian Guo XU Lei CUI Xin Gang XU Xing Xing YU Yong Wei HAN Xue WANG Guo Min GUO Jian Ming XU Dan Feng THOMPSON Timothy C CAO Guang Wen ZHANG Hong Wei | 2014 | Biomedical and Environmental Sciences2014，27，9： | 5 |
| 19 | Self-propagating high-temperature synthesis of ZrO_2 incorporated Gd_2Ti_2O_7 pyrochlore显示文摘In this research, Zr-doped Gd_2Ti_2O_7 pyrochlores, with the composition of Gd_2(Ti_(1-x)Zr_x)_2O_7, were firstly synthesized by self-propagating high-temperature synthesis plus quick pressing(SHS/QP) using CuO as the oxidant and Ti as the reductant. To improve the radiation resistance of titanate–pyrochlore, up to 35 at% Zr was incorporated to substitute the Ti site of Gd_2Ti_2O_7 pyrochlore(Gd_2(Ti_(0.75)Zr_(0.35))_2O_7). XRD and SEM microstructural characterizations showed the formation of a composite ceramic with the major pyrochlore phase and the minor Cu phase. The generated temperature of samples decreased from 1702to 1011 ℃ with increasing Zr content. The effects of sintering temperature and pressure time on phase composition and microstructure were systematically studied. Besides, the influence of thermal transmission on the whole combustion process was also explored. The pyrochlore-based waste form possessed high bulk density of 6.25 g/cm^3 and Vickers hardness of 10.81 GPa. The MCC-1 leaching test showed the normalized elemental leaching rates(42d) of Cu, Gd, and Zr are 1.27×10^(-2), 1.33×10^(-3), and 8.44×10^(-7)g·m^(-2)·d^(-1), respectively. | Le PENG Kuibao ZHANG Zongsheng HE Dan YIN Jiali XUE Chen XU Haibin ZHANG | 2018 | Journal of Advanced Ceramics2018，7，1： | 5 |
| 20 | Photocatalytic Dye Methyl Orange Decomposition on Ternary Sulfide (CdIn2S4) under Visible-light显示文摘A novel and efficient photocatalyst, CdIn2S4, was simply prepared by a programmed temperature hydrothermal method. The product had a nanometer size (10-15 nm) and strong absorption in the range of 200 to 580 nm, and it exhibited visible-light photocatalytic activity to decompose dye methyl orange in aqueous system. | Xiao Dan YU Xue Song QU Yi Hang GUO Chang Wen HU | 2005 | Chinese Chemical Letters2005，16，9： | 5 |
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