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| 1 | Gastric cancer: Epidemiology, risk factors and prevention strategies显示文摘Gastric cancer(GC) is a global health problem, with more than 1 million people newly diagnosed with GC worldwide each year. GC is more prevalent in less developed countries than in more developed countries. About half of all GC cases worldwide occur in East Asia, notably China. Globally, overall incidence rates of GC are declining, which is potentially attributed to a decrease in Helicobacter pylori(H. pylori) infection and the use of refrigeration to preserve foods rather than salt. GC is a multifactorial disease, and its occurrence and development were impacted by environmental and genetic factors. H. pylori infection is the primary risk factor for GC, especially for non-cardia. The prognosis of GC is poor due to stages at the first diagnosis. The 5-year survival rate is less than 10% when patients are diagnosed at an advanced stage, but the rate is as high as 85% if patients are detected at an earlier stage. Endoscopic screening can potentially prevent GC by early diagnosis and early treatment and has been widely adopted in screening programs in East Asian countries, such as Japan and Korea. This review summarizes updated epidemiological aspects, risk factors, and prevention strategies of GC in recent years to help researchers determine the most effective intervention strategies for reducing risk of GC. | Lei Yang Xiangji Ying Shuo Liu Guoqing Lyu Zekuan Xu Xi Zhang Huichao Li Qingyu Li Ning Wang Jiafu Ji | 2020 | Chinese Journal of Cancer Research2020，32，6： | 52 |
| 2 | Recent Advances in Synthesis of Waterborne Polyurethane and Their Application in Water-based Ink:A Review显示文摘Over the last few years,waterborne polyurethane(WPU) was applied to various fibers,adhesives,primers for metals,caulking materials,emulsion polymerization media,paint additives,defoamers,associate thickeners,pigment pastes,textile dyes and biomaterials,resulting in the increasing enthusiasm of researchers to design and synthesize novel WPU with unique properties.Thus,various processes and raw materials have been developed to prepare WPU.This review gives an overview on the developments of WPU mainly derived from novel polyols,analyzes the potential application in water-based inks and presents the probable future research area about water-based inks.Notably,the poly(ε-caprolactone) and poly(lactic acid) are the versatile materials used in WPU synthesis and supply the potential special performance for preparing WPU.Meanwhile,addition-fragmentation chain transfer(RAFT) polymerization and atom transfer radical polymerization(ATRP) processes provide an opportunity to control the chain sequence of WPU and obtain products with the desired performance. | Xing Zhou Yan Li Changqing Fang Shujuan Li Youliang Cheng Wanqing Lei Xiangjie Meng | 2015 | Journal of Materials Science & Technology2015，31，7： | 47 |
| 3 | The PI3K/AKT Pathway and Renal Cell Carcinoma显示文摘The phosphatidylinositol 3 kinase(PI3K)/AKT pathway is genetically targeted in more pathway components and in more tumor types than any other growth factor signaling pathway,and thus is frequently activated as a cancer driver.More importantly,the PI3K/AKT pathway is composed of multiple bifurcating and converging kinase cascades,providing many potential targets for cancer therapy.Renal cell carcinoma(RCC) is a high-risk and high-mortality cancer that is notoriously resistant to traditional chemotherapies or radiotherapies.The PI3K/AKT pathway is modestly mutated but highly activated in RCC,representing a promising drug target.Indeed,PI3 K pathway inhibitors of the rapalog family are approved for use in RCC.Recent large-scale integrated analyses of a large number of patients have provided a molecular basis for RCC,reiterating the critical role of the PI3K/AKT pathway in this cancer.In this review,we summarize the genetic alterations of the PI3K/AKT pathway in RCC as indicated in the latest large-scale genome sequencing data,as well as treatments for RCC that target the aberrant activated PI3K/AKT pathway. | Huifang Guo Peter German Shanshan Bai Sean Barnes Wei Guo Xiangjie Qi Hongxiang Lou Jiyong Liang Eric Jonasch Gordon B.Mills Zhiyong Ding | 2015 | Journal of Genetics and Genomics2015，42，7： | 39 |
| 4 | Stretching characteristics and its dynamic significance of the northern continental margin of South China Sea显示文摘To investigate the thinning of the whole crust, and the contribution of the upper versus lower crust to the stretching since Cenozoic, we calculated the stretching factor of the northern margin of South China Sea with data such as whole crustal thickness, depth of Cenozoic sedimentary basement and the horizontal displacement of faults. An isometric line drawing on whole crustal stretching factor is then obtained. Along the seismic Line 1530 in Baiyun sag, we also calculated the stretching factors of the upper and lower crust. The results suggest that the whole crustal thickness decreases seaward while the whole crustal stretching factor increases from shelf to slope. The Moho upwells highest beneath where the crust is thinned most. The value of the whole crustal stretching factor ranges from 1.5 to 6. Two areas were thinned intensely: the center of Yinggehai Basin, and the Baiyun sag in the Pearl River Mouth Basin. The calculation of the upper and lower crustal stretching factors from DSP1530 in Baiyun sag shows that the original crust of Baiyun sag should be thinned before deformation. Its pre-Cenozoic evolution as well as tectonic position during Cenozoic might be responsible for that. | ZHANG YunFan SUN Zhen ZHOU Di GUO XingWei SHI XiaoBin WU XiangJie PANG Xiong | 2008 | Science China Earth Sciences2008，51，3： | 15 |
| 5 | Distributed Model Predictive Load Frequency Control of Multi-area Power System with DFIGs显示文摘Reliable load frequency control(LFC) is crucial to the operation and design of modern electric power systems. Considering the LFC problem of a four-area interconnected power system with wind turbines, this paper presents a distributed model predictive control(DMPC) based on coordination scheme.The proposed algorithm solves a series of local optimization problems to minimize a performance objective for each control area. The generation rate constraints(GRCs), load disturbance changes, and the wind speed constraints are considered. Furthermore, the DMPC algorithm may reduce the impact of the randomness and intermittence of wind turbine effectively. A performance comparison between the proposed controller with and without the participation of the wind turbines is carried out. Analysis and simulation results show possible improvements on closed–loop performance, and computational burden with the physical constraints. | Yi Zhang Xiangjie Liu Bin Qu | 2017 | IEEE/CAA Journal of Automatica Sinica2017，4，1： | 15 |
| 6 | Clinical evaluation following the use of mineralized collagen graft for bone defects in revision total hip arthroplasty显示文摘Revision total hip arthroplasty(THA)with massive bone loss has been a real challenge for orthopaedic surgeons.Here we describe an approach using mineralized collagen(MC)graft to reconstruct acetabulum and femur with massive bone defects.We identified 89 patients suffering acetabular or femoral bone defects after primary THA,who required revision THA for this study.During the surgery,MC was applied to reconstruct both the acetabular and femoral defects.Harris hip score was used to evaluate hip function while radiographs were taken to estimate bone formation in the defect regions.The average follow-up period was 33.662.4 months.None of the components needed re-revised.Mean Harris hip scores were 42.563.5 before operation,75.264.0 at 10th month and 95.063.6 at the final follow-up.There were no instances of deep infection,severe venous thrombosis or nerve palsy.The present study demonstrated that MC graft can serve as a promising option for revision THA with massive bone deficiency.Meanwhile,extended follow-up is needed to further prove its long-term performance. | Cheng Huang Liwu Qin Wei Yan Xisheng Weng Xiangjie Huang | 2015 | Regenerative Biomaterials2015，2，4： | 12 |
| 7 | Study on seepage and deformation characteristics of coal microstructure by 3D reconstruction of CT images at high temperatures显示文摘To study the seepage and deformation characteristics of coal at high temperatures,coal samples from six different regions were selected and subjected to computed tomography(CT)scanning studies.In conjunction with ANSYS software,3 D reconstruction of CT images was used for the establishment of fluidsolid conjugate heat transfer model and coal thermal deformation model based on the microstructures of coal.In addition,the structure of coal was studied in 2 D and 3 D perspectives,followed by the analysis of seepage and deformation characteristics of coal at high temperatures.The results of this study indicated that porosity positively correlated with the fractal dimension,and the connectivity and seepage performances were roughly identical from 2 D and 3 D perspectives.As the porosity increased,the fractal dimension of coal samples became larger and the pore-fracture structures became more complex.As a result,the permeability of coal samples decreased.In the meantime,fluid was fully heated,generating high-temperature water at outlet.However,when the porosity was low,the outlet temperature was very high.The average deformation of coal skeleton with different pore-fracture structures at high temperatures showed a trend of initial increase and subsequent decrease with the increase of porosity and fractal dimension.The maximum deformation of coal skeleton positively correlated with connectivity but negatively correlated with the fractal dimension. | Gang Wang Xiangjie Qin Dongyang Han Zhiyuan Liu | 2021 | International Journal of Mining Science and Technology2021，31，2： | 11 |
| 8 | Oxaliplatin plus S-1 or capecitabine as neoadjuvant or adjuvant chemotherapy for locally advanced gastric cancer with D2lymphadenectomy: 5-year follow-up results of a phase II-III randomized trial显示文摘Objective: To compare the effect of neoadjuvant chemotherapy(NACT) with adjuvant chemotherapy(ACT)using oxaliplatin plus S-1(SOX) or capecitabine(CapeOX) on gastric cancer patients with D2 lymphadenectomy.Methods: This was a two-by-two factorial randomized phase II-III trial, and registered on ISRCTN registry(No. ISRCTN12206108). Locally advanced gastric cancer patients were randomized to neoadjuvant SOX,neoadjuvant CapeOX, adjuvant SOX, or adjuvant CapeOX arms. Primary analysis was performed on an intentionto-treat(ITT) basis using overall survival(OS) as primary endpoint.Results: This trial started in September 2011 and closed in December 2012 with 100 patients enrolled.Treatment completion rate was 56%, 52%, 38% and 30% in the four arms, respectively. NACT group had fewer dropouts due to unacceptable toxicity(P=0.042). Surgical complication rate did not differ by the four groups(P=0.986). No survival significant difference was found comparing NACT with ACT(P=0.664; 5-year-OS: 70% vs.74% respectively), nor between the SOX and CapeOX groups(P=0.252; 5-year-OS: 78% vs. 66% respectively).Subgroup analysis showed SOX significantly improved survival in patients with diffuse type(P=0.048).Conclusions: No significant survival difference was found between NACT and ACT. SOX and CapeOX had good safety and efficacy as neoadjuvant regimens. Diffuse type patients may survive longer due to SOX. | Kan Xue Xiangji Ying Zhaode Bu Aiwen Wu Zhongwu Li Lei Tang Lianhai Zhang Yan Zhang Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 10 |
| 9 | Risk factors of intra-abdominal bacterial infection after liver transplantation in patients with hepatocellular carcinoma显示文摘Objective: To explore the risk factors of intra-abdominal bacterial infection(IAI) after liver transplantation(LT) in patients with hepatocellular carcinoma(HCC). Methods: A series of 82 HCC patients who received LT surgeries in our department between March 2004 and April 2010 was recruited in this study. Then we collected and analyzed the clinical data retrospectively. Statistical analysis system(SPSS) software was adopted to perform statistical analysis. Chi-square test, t-test and Wilcoxon rank sum test were used to analyze the clinical data and compute the significance of the incidences of early-stage IAI after LT for HCC patients. Binary logistic regression was performed to screen out the risk factors, and multiple logistic regression analyses were performed to compute the independent risk factors. Results: A series of 13 patients(13/82, 15.9%) had postoperative IAI. The independent risk factors of postoperative intra-abdominal bacterial infections after LT for HCC patients were preoperative anemia [Hemoglobin(HGB) <90 g/L] and postoperative abdominal hemorrhage(72 hours >400 mL), with the odds ratios at 8.121(95% CI, 1.417 to 46.550, P=0.019) and 5.911(95% CI, 1.112 to 31.432, P=0.037). Conclusions: Postoperative IAI after LT in patients with HCC was a common complication. Preoperative moderate to severe anemia, as well as postoperative intra-abdominal hemorrhage more than 400 mL within the first 72 hours might independently indicate high risk of IAI for these patients. | Kai Nie Rongzheng Ran Weifeng Tan Bin Yi Xiangji Luo Yong Yu Xiaoqing Jiang | 2014 | Chinese Journal of Cancer Research2014，26，3： | 10 |
| 10 | Rational optimization of reprogramming culture conditions for the generation of induced pluripotent stem cells with ultra-high efficiency and fast kinetics显示文摘几个抄写因素的宫外的表示能恢复胚胎的房间命运到有教养的体的房间并且产生导致的 pluripotent 干细胞(iPSCs ) ,揭示到 pluripotency 的一条以前未知的小径。然而,这种技术被低效率,慢动力学和多因素的要求当前限制。这里,我们证明 reprogramming 能被优化文化条件改进并且戏剧性地加速了。首先,我们开发了优化定义媒介, iCD1,它允许 Oct4/Sox2/Klf4 (OSK ) 完成的调停的 reprogramming 超离频效率(~10% 在白天 8 点) 。我们也发现这个优化条件使 Sox2 和 Klf4 变为非必需,尽管这二个因素的消除导致更低的效率和更慢的动力学。我们的研究定义一条弄短的线路,两个在预定和因素要求,向 pluripotency。这个新范例不仅提供一个基本原理进一步改进 iPSC 产生而且由定义因素简化 reprogramming 的概念的理解。 | Jiekai Chen Jing Liu You Chen Jiaqi Yang Jing Chen He Liu Xiangjie Zhao Kunlun Mo Hong Song Lin Guo Shilong Chu Deping Wang Ke Ding Duanqing Pei | 2011 | Cell Research2011，21，6： | 9 |
| 11 | Additive effects of alkaline-earth metals and nickel on the performance of Co/γ-Al_2O_3 in methane catalytic partial oxidation显示文摘Nano-sized γ-alumina (γ-Al2O3) was first prepared by a precipitation method. Then, active component of cobalt and a series of alkaline- earth metal promoters or nickel (Ni) with different contents were loaded on the γ-Al2O3 support. The catalysts were characterized by N2 adsorption-desorption, X-ray diffraction (XRD) and thermogravimetry analysis (TGA). The activity and selectivity of the catalysts in catalytic partial oxidation (CPO) of methane have been compared with Co/γ-Al2O3, and it is found that the catalytic activity, selectivity, and stability are enhanced by the addition of alkaline-earth metals and nickel. The optimal loadings of strontium (Sr) and Ni were 6 and 4 wt%, respectively. This finding will be helpful in designing the trimetallic Co-Ni-Sr/γ-Al2O3 catalysts with high performance in CPO of methane. | Changlin Yu Weizheng Weng Qing Shu Xiangjie Meng Bin Zhang Xirong Chen Xiaochun Zhou | 2011 | Journal of Natural Gas Chemistry2011，20，2： | 8 |
| 12 | “Wrapping the gastroduodenal artery stump” during pancreatoduodenectomy reduced the stump hemorrhage incidence after operation显示文摘Objective: After pancreaticoduodenectomy(PD), the postoperative gastroduodenal artery stump(GDAS) hemorrhage is one of the most serious complications. The purpose of this study is to determine whether wrapping the GDAS during PD could decrease the postoperative GDAS hemorrhage incidence.Methods: A retrospective review involving 280 patients who underwent PD from 2005 to 2012 was performed. Wrapping the GDAS during PD was defined as 'Wrapping the GDAS using the teres hepatis ligamentum during PD'. A total of 140 patients accepted the 'wrapping' procedure(wrapping group). The other 140 patients didn't apply the procedure(non-wrapping group). Age, sex, preoperative data, estimated intraoperative blood loss, postoperative complications, pathologic parameters and hospitalization time were compared between two groups.Results: There were no significant differences in patient characteristics between two groups. After wrapping, the incidence of postoperative GDAS bleeding decreased significantly(1/140 vs. 9/140, P=0.01). The rates of the other complications(such as intra-abdominal infection pancreatic fistula, billiary fistula, gastrointestinal bleeding, et al.) showed no significant differences. Conclusions: Wrapping the GDAS during PD significantly reduced the postoperative GDAS hemorrhage incidence. And the 'wrapping' had no obvious influence on other complications. | Chang Xu Xinwei Yang Xiangji Luo Feng Shen Mengchao Wu Weifeng Tan Xiaoqing Jiang | 2014 | Chinese Journal of Cancer Research2014，26，3： | 7 |
| 13 | Chemical conversion coating on AZ31B magnesium alloy and its corrosion tendency显示文摘The morphology change of the magnesium matrix after pre-treatment and the mor- phology as well as the phase composition of chemical conversion coating formed by phosphate were studied using scanning electron microscope and X-ray diffraction. The corrosion resistance of the coating was studied by salt spray and damp test, and the corrosion tendency during salt immersion test was analyzed. The results show that the phase composition before and after pre-treatment is almost change- less, and the deep microflaw appears between α and β phases during acidic pickling. The phosphate conversion coating is mainly composed of Mg, MgO, and some amor- phous phase, and it can provide a good protection for the AZ31B alloy. Results from corrosive morphology indicate that the growth and the corrosion resistance of the phosphate conversion coating are related to the forming process of the AZ31B matrix. | Hualan JIN Xiangjie YANG Ming WANG | 2009 | Acta Metallurgica Sinica(English Letters)2009，22，1： | 7 |
| 14 | Generalized Predictive Control for Superheated Steam Temperature Regulation in a Supercritical Coal-fired Power Plant显示文摘The design and implementation of a Generalized Predictive Control(GPC)strategy for the superheated steam temperature regulation in a supercritical(SC)coal-fired power plant is presented.A Controlled Auto-Regressive MovingAverage(CARMA)model of the plant is derived from using the experimental data to approximately predict the plant’s future behavior.This model is required by the GPC algorithm to calculate the future control inputs.A new GPC controller is designed and its performance is tested through extensive simulation studies.Compared with the performance of the plant using a conventional PID controller,the steam temperature controlled by the GPC controller is found to be more stable.The stable steam temperature leads to more efficient plant operation and energy saving,as demonstrated by the simulation results.Plant performance improvement is also tested while the plant experiences the load demand changes and disturbances resulting from the malfunctioning of coal mills. | Mihai Draganescu Shen Guo Jacek Wojcik Jihong Wang Xiangjie Liu Guolian Hou Yali Xue Qirui Gao | 2015 | CSEE Journal of Power and Energy Systems2015，1，1： | 7 |
| 15 | Preparation of SiO_2/TiO_2 Janus particles by electrostatic assembly,hydrolysis and calcination显示文摘This paper describes a novel chemical method for preparing SiO_2/TiO_2 Janus particles.First,polystyrene(PSt)/SiO_2 particles with a raspberry-like structure are prepared by electrostatic assembly.The influences of the reaction time of sulfonation and the treatment times of polyelectrolyte solutions(PDADMAC,PSS)on PSt and SiO_2 are investigated with respect to the surface charge density of the particles.SiO_2/TiO_2 Janus particles are then obtained by hydrolysis of butyl titanate on the surface of PSt/SiO_2 particles followed by a calcination process.Particle size analyzer,Zeta potential instrument,FTIR,TEM and SEM are used to characterize the particle size,the amount of charge on the surface of PSt and SiO_2 particles and the compositions and morphologies of PSt/SiO_2,SiO_2/TiO_2 and PSt/SiO_2/TiO_2.The diameters of the PSt,SiO_2,PSt/SiO_2 and SiO_2/TiO_2 particles are 2.0 μm,303 nm,2.7 μm and 330nm,respectively. | Baoliang Zhang Qiuyu Zhang Hepeng Zhang Xinlong Fan Dezhong Yin Xiangjie Li Wei Li | 2013 | Particuology2013，11，5： | 6 |
| 16 | 自由游动检测仪对大直径PCCP管的现场检测显示文摘遥控领域变压耦合检查法(RFTC),自1997年商业化推出后,已成为条件预应力钢筋混凝土管(PCCP管)行业评估的标准。虽然这种技术几乎适合所有类型的PCCP管,但是在实际中进行许多PCCP输水线路RFEC/TC巡查时,还有一个巨大的挑战,就是其中大部分PCCP管线不能暂停服务和完全脱水。2007年,自由游动检测仪被开发并成功用于小直径PCCP管(24”-48”)领域。它拥有在现场进行PCCP管道线RFTC检查的能力。可以通过小型带压钻孔分接技术将这种新型仪器投入到在用管道中,沿着水流穿越管线的同时收集RFTC数据,然后在下游另一个带压钻孔分接装置中被回收。目前,这个自由游动检测仪正在大口径(60”及以上)应用中扩大规模。本文将介绍其在大直径PCCP管现场检查时的技术要领和操作要求。现场测试结果也将呈现。 | Xiangjie Kong Xinlu Tang Dave Humphrey Brian Mergelas Roberto Mascarenhas 张峰(译) 乌效鸣(校) | 2011 | 非开挖技术2011，，2： | 5 |
| 17 | Transjugular intrahepatic portosystemic shunt for portal vein thrombosis with symptomatic portal hypertension in liver cirrhosis显示文摘 | Guohong Han Xingshun Qi Chuangye He Zhanxin Yin Jianhong Wang Jielai Xia Zhiping Yang Ming Bai Xiangjie Meng Jing Niu Kaichun Wu Daiming Fan | 2010 | Journal of Hepatology2010，，： | 5 |
| 18 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 19 | Neuro-fuzzy generalized predictive control of boiler steam temperature显示文摘Power plants are nonlinear and uncertain complex systems.Reliable control of superheated steam temper-ature is necessary to ensure high efficiency and high load-following capability in the operation of modern power plant.A nonlinear generalized predictive controller based on neuro-fuzzy network(NFGPC)is proposed in this paper.The proposed nonlinear controller is applied to control the superheated steam temperature of a 200MW power plant.From the experiments on the plant and the simulation of the plant,much better performance than the traditional controller is obtained. | Xiangjie LIU Jizhen LIU Ping GUAN | 2007 | 控制理论与应用(英文版)2007，5，1： | 5 |
| 20 | A multi-axis robot-based bioprinting system supporting natural cell function preservation and cardiac tissue fabrication显示文摘Despite the recent advances in artificial tissue and organ engineering,how to generate large size viable and functional complex organs still remains as a grand challenge for regenerative medicine.Three-dimensional bioprinting has demonstrated its advantages as one of the major methods in fabricating simple tissues,yet it still faces difficulties to generate vasculatures and preserve cell functions in complex organ production.Here,we overcome the limitations of conventional bioprinting systems by converting a six degree-of-freedom robotic arm into a bioprinter,therefore enables cell printing on 3D complex-shaped vascular scaffolds from all directions.We also developed an oil bath-based cell printing method to better preserve cell natural functions after printing.Together with a self-designed bioreactor and a repeated print-and-culture strategy,our bioprinting system is capable to generate vascularized,contractible,and long-term survived cardiac tissues.Such bioprinting strategy mimics the in vivo organ development process and presents a promising solution for in vitro fabrication of complex organs. | Zeyu Zhang Chenming Wu Chengkai Dai Qingqing Shi Guoxin Fang Dongfang Xie Xiangjie Zhao Yong-Jin Liu Charlie CLWang Xiu-Jie Wang | 2022 | Bioactive Materials2022，7，12： | 4 |
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