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| 1 | Emissions of polycyclic aromatic hydrocarbons from coking industries in China显示文摘这研究开始估计多不的芳香的烃的特征(哼) 从 coking 工业的排放,与在四典型焦炭植物进行的领域采样。为每选择植物,栈烟道气体样品在包括的进程期间是镇定的控告煤进炉(CC ) ,推焦炭(PC ) 和焦炭炉气体(CG ) 的燃烧。十六个个人在 US EPA 优先级表上哼被煤气的层析 / 团 spectrometry (GC/MS ) 分析。结果证明总数哼在烟道气体的集中从 45.776 ~ 414.874 g/m3 ,与为 CC (359.545 g/m3 ) 的最高的排放水平。集中哼在 CP1 (收费的邮票) 从 CC 过程射出从 CP3 和 CP4 (收费的顶) 是比那低的。Low-molecular-weight 哼(即,二 -- 到三戒指哼) 到总数的占优势的贡献者哼内容,和小睡, AcPy,流感, PhA,和蚂蚁被发现是最丰富的。为 CC (2.248 g/m3 ) 的全部的 BaPeq 集中比为 PC (1.838 g/m3 ) 的那些高, CG (1.082 g/m3 ) ,和 DbA 作为在从 coking 过程的排出物的 BaP 是到 carcinogenic 风险的一个重要贡献者。微粒哼比对总数的相应贡献哼的占了超过 20% 全部的 BaPeq 集中,它显著地高集体集中(5%) 。微粒并且气体哼当时,应该被考虑潜在的毒性风险哼污染在 coking 期间,过程被估计。吝啬的总数 -- 哼排放因素分别地是为 CC 和 PC 的 346.132 和 93.173 g/kg。 | Ling Mu Lin Peng Junji Cao Qiusheng He Fan Li Jianqiang Zhang Xiaofeng Liu Huiling Bai | 2013 | Particuology2013，11，1： | 17 |
| 2 | Ultrasound features of extranodal extension in the metastatic cervical lymph nodes of papillary thyroid cancer:a case-control study显示文摘Objective:Extranodal extension in cervical lymph nodes is an important risk factor for the progression and prognosis of papillary thyroid cancer.The purpose of this study was to identify the common and characteristic preoperative ultrasonography features that are associated with the pathologic extranodal extension of metastatic papillary thyroid carcinoma.Methods:We retrospectively assessed and compared clinicopathologic and ultrasound features between 60 papillary thyroid cancer patients with extranodal extension and 120 control patients with papillary thyroid cancer without extranodal extension.Results:With respect to the pathological N stage and clinicopathologic features,N1b stage papillary thyroid carcinomas were more frequently found in patients who were extranodal extension-positive,in comparison with those who were extranodal extension-negative(78.3%vs.63.3%,P=0.043).Extranodal extension was detected most frequently in level VI cervical lymph nodes(48.7%).In our univariate analysis of patients with papillary thyroid carcinoma,cervical lymph nodes with extranodal extension showed higher incidences of node matting,microcalcification,cystic area,aspect ratio<2,and larger diameter than those without extranodal extension(all P<0.05).Our multivariate analysis demonstrated that node matting and cystic area were independent risk factors for the presence of extranodal extension[odds ratio(OR):4.751,95%confidence interval(CI):1.212~18.626,P=0.025;OR:2.707,95%CI:1.127~6.502,P=0.026].Conclusions:Common ultrasound features may indicate the presence of extranodal extension in patients with metastatic cervical lymph nodes of papillary thyroid carcinoma. | Jiali Mu Xiaofeng Liang Fangxuan Li Juntian Liu Sheng Zhang Jing Tian | 2018 | Cancer Biology & Medicine2018，15，2： | 7 |
| 3 | Vertical motions of tide gauge stations near the Bohai Sea and Yellow Sea显示文摘A modified Gauss-Markov model with weighted constraints was constructed by combining satellite altimeter and tide gauge records. Vertical motion rates of nine tide gauge stations around the Bohai Sea and Yellow Sea are estimated. This is the first time systematic estimates have been derived in this region. Downward trends were seen at the six tide gauge stations located at Tanggu, Longkou, Laohutan, Bayuquan, Xiaochangshan, and Yantai; with vertical motion rates of-1.82±0.50,-1.65±0.46,-0.88±0.42,-0.58±0.62,-0.13±0.43, and-0.01±0.43 mm/yr, respectively. Upward trends were seen at the three tide gauge stations located at Qinhuangdao, Huludao and Chengshantou; with vertical motion rates of 1.12±0.46, 0.55±0.49 and 0.26±0.44 mm/yr, respectively. There was significant subsidence in Tanggu and Longkou, and a rising trend in Qinhuangdao. According to our results, the rate of sea level rise calculated from these tide gauge records can be improved using a more accurate measurement of the land elevation accounting for lifting or subsidence. The model derived can be used to estimate vertical motions of tide gauge stations, and can be widely applied to revise the benchmark levels of tide gauges. | LIU ShouHua CHEN ChangLin LIU KeXiu MU Lin WANG Hui WU XinRong ZHANG JianLi DUAN XiaoFeng GAO Jia | 2015 | Science China Earth Sciences2015，58，12： | 4 |
| 4 | Glucose metabolism controls humanγδ-cell-mediated tumor immunosurveillance in diabetes显示文摘Patients with type 2 diabetes mellitus(T2DM)have an increased risk of cancer.The effect of glucose metabolism onγδT cells and their impact on tumor surveillance remain unknown.Here,we showed that high glucose induced Warburg effect type of bioenergetic profle in Vy9vδ2 T cells,leading to excessive lactate accumulation,which further inhibited lytic granule secretion by impairing the traffcking of cytolytic machinery to the Vy9vδ2 T-cell-tumor synapse by suppressing AMPK activation and resulted in the loss of antitumor activity in vitro,in vivo and in patients.Strikingly,activating the AMPK pathway through glucose control or metformin treatment reversed the metabolic abnormalities and restored the antitumor activity of Vy9vδ2 T cells.These results suggest that the impaired antitumor activity of Vy9vδ2 T cells induced by dysregulated glucose metabolism may contribute to the increased cancer risk in T2DM patients and that metabolic reprogramming by targeting the AMPK pathway with metformin may improve tumor immunosurveillance. | Xiaofeng Mu Zheng Xiang Yan Xu Jing He Jianwen Lu Yuyuan Chen Xiwei Wang Chloe Ran Tu Yanme Wenyue Zhang Zhinan Yin Wing-hang Leung Yu-Lung Lau Yinping Liu Wenwei Tu | 2022 | Cellular & Molecular Immunology2022，19，8： | 2 |
| 5 | Inhibitory effect of a new gossypol derivative apogossypolone (ApoG2) on xenograft of human prostate cancer cell line PC-3显示文摘Objective: To investigate the inhibitory effect of apogossypolone (ApoG2) on prostate cancer cell line PC-3 in vivo, and explore its mechanism. Methods: The models of transplantation tumors in Balb/c nu/nu mice were established via subcutaneous injection of PC-3 cells and the tumor-transplanted mice were divided into 4 groups: control group and three ApoG2 treatment groups, with 10 mice in each group. Volumes of the tumor were estimated every 2 d and the morphology of tumor tissues was observed. Immunohistochemistry was employed to observe the expression of Bcl-2, PCNA, CD31, caspase-3 and caspase-8 in tumor tissues. Results: ApoG2 (2.5 mg/kg-10 mg/kg) given intraperitoneally once a day can obviously inhibit the growth of subcutaneous prostatic carcinoma implant. The tumor volume decreased obviously when the treatment dosage was bigger than 5.0 mg/kg (P<0.01). Meanwhile, ApoG2 decreased the expression of PCNA and CD31, and enhanced the expression of caspases-3, caspase-8 in tumor tissues. Conclusion: ApoG2 exert an inhibitory effect on prostatic carcinoma possibly by inducing apoptosis and inhibiting tumor angiogenesis. | Zhang Xianqing Huang Xiaofeng Mu Shijie Chen Rui An Qunxing Xia Aijun Wu Daocheng | 2009 | Journal of Medical Colleges of PLA(China)2009，24，5： | 2 |
| 6 | CD137 costimulation enhances the antiviral activity of Vγ9Vδ2-T cells against influenza virus显示文摘Influenza epidemics and pandemics are constant threats to global public health.Although strategies including vaccines and antiviral drugs have achieved great advances in controlling influenza virus infection,the efficacy of these strategies is limited by the highly frequent mutations in the viral genome and the emergence of drug-resistant strains.Our previous study indicated that boosting the immunity of human Vγ9Vδ2-T cells with the phosphoantigen pamidronate could be a therapeutic strategy to treat seasonal and avian influenza virus infections.However,one notable drawback ofγδ-T cell-based immunotherapy is the rapid exhaustion of proliferation and effector responses due to repeated treatments with phosphoantigens.Here,we found that the expression of CD137 was inducible in Vγ9Vδ2-T cells following antigenic stimulation.CD137^(+)Vγ9Vδ2-T cells displayed more potent antiviral activity against influenza virus than their CD137−counterparts in vitro and in Rag2^(-/-)γc^(-/-)mice.We further demonstrated that CD137 costimulation was essential for Vγ9Vδ2-T cell activation,proliferation,survival and effector functions.In humanized mice reconstituted with human peripheral blood mononuclear cells,CD137 costimulation with a recombinant human CD137L protein boosted the therapeutic effects of pamidronate against influenza virus.Our study provides a novel strategy of targeting CD137 to improve the efficacy of Vγ9Vδ2-T cell-based immunotherapy. | Yujun Pei Kun Wen Zheng Xiang Chunyu Huang Xiwei Wang Xiaofeng Mu Liyan Wen Yinping Liu Wenwei Tu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 7 | Stereolithography 3D printing of ceramic cores for hollow aeroengine turbine blades显示文摘Hollow superalloy or single-crystal superalloy turbine blades are the most important component of advanced aeroengines for fifth-and higher-generation fighter aircrafts [1,2,3]. The thrust-toweight ratio is largely influenced by the turbine inlet temperature,which places strict requirements on the performance of the turbine blades at high operating temperatures [4]. To reduce the operating temperature of the blades, complex internal cooling structures are required. However, the fabrication of complex cooling channels inside the blades is an unquestionably challenging task [5]. | Xiaolong An Yahang Mu Jingjing Liang Jinguo Li Yizhou Zhou Xiaofeng Sun | 2022 | Journal of Materials Science & Technology2022，，32： | 1 |
| 8 | Identification and characterization of a novel protective antigen,Enolase of Streptococcus suis serotype2显示文摘 | Anding Zhang Bo Chen Xiaofeng Mu | 2009 | Vaccine2009，27，： | 1 |
| 9 | Reinforcement learning based dynamic distributed routing scheme for mega LEO satellite networks显示文摘Recently,mega Low Earth Orbit(LEO)Satellite Network(LSN)systems have gained more and more attention due to low latency,broadband communications and global coverage for ground users.One of the primary challenges for LSN systems with inter-satellite links is the routing strategy calculation and maintenance,due to LSN constellation scale and dynamic network topology feature.In order to seek an efficient routing strategy,a Q-learning-based dynamic distributed Routing scheme for LSNs(QRLSN)is proposed in this paper.To achieve low end-toend delay and low network traffic overhead load in LSNs,QRLSN adopts a multi-objective optimization method to find the optimal next hop for forwarding data packets.Experimental results demonstrate that the proposed scheme can effectively discover the initial routing strategy and provide long-term Quality of Service(QoS)optimization during the routing maintenance process.In addition,comparison results demonstrate that QRLSN is superior to the virtual-topology-based shortest path routing algorithm. | Yixin HUANG Shufan WU Zeyu KANG Zhongcheng MU Hai HUANG Xiaofeng WU Andrew Jack TANG Xuebin CHENG | 2023 | Chinese Journal of Aeronautics2023，36，2： | 1 |
| 10 | Improved evolutionary algorithm and its application in PID controller optimization显示文摘Dear editor,As a common control loop feedback mechanism,the proportional-integral-derivative(PID)controller has been widely applied in industrial control systems[1–3].The PID control method is simple,stable,and reliable;thus,it has realized considerable economic benefits in the field of industrial process control. | Dewen QIAO Nankun MU Xiaofeng LIAO Junqing LE Fan YANG | 2020 | Science China(Information Sciences)2020，63，9： | 1 |
| 11 | Emissions of polycyclic aromatic hydrocarbons from coking industries in China显示文摘 | Ling Mu Lin Peng Junji Cao Qiusheng He Fan Li Jianqiang Zhang Xiaofeng Liu Huiling Bai | 2012 | Particuology2012，，： | 1 |
| 12 | A New and Efficient Signature on Commitment Values显示文摘 | Zhang Fangguo Chen Xiaofeng Mu Yi | 2008 | International Journalof Network Security2008，7，1： | 1 |
| 13 | Docking MOF crystals on graphene support for highly selective electrocatalytic peroxide production显示文摘Tailoring the reaction kinetics is the central theme of designer electrocatalysts,which enables the selective conversion of abundant and inert atmospheric species into useful products.Here we show a supporting effect in tuning the electrocatalytic kinetics of oxygen reduction reaction(ORR)from four-electron to two-electron mechanism by docking metalloporphyrin-based metal-organic frameworks(MOFs)crystals on graphene support,leading to highly selective peroxide production with faradaic efficiency as high as 93.4%.A magic angle of 38.1°tilting for the co-facial alignment was uncovered by electron diffraction tomography,which is attributed to the maximization of n-n interaction for mitigating the lattice and symmetry mismatch between MOF and graphene.The facilitated electron migration and oxygen chemisorption could be ascribed to the supportive effect of graphene that disperses of the electron state of the active center,and ultimately regulates rate-determining step. | Xiaofeng Huang Peter Oleynikov Hailong He Alvaro Mayoral Linqin Mu Feng Lin Yue-Biao Zhang | 2022 | Nano Research2022，15，1： | 1 |
| 14 | Stromal Cell–Derived Factor-1α Confers Protection Against Myocardial Ischemia/Reperfusion Injury: Role of the Cardiac Stromal Cell–Derived Factor-1α–CXCR4 Axis显示文摘 | Xiaofeng Hu Shujing Dai Wen-Jian Wu Wei Tan Xiaoping Zhu Jingyao Mu Yiru Guo Roberto Bolli Gregg Rokosh | 2007 | Circulation2007，，6： | 1 |
| 15 | The anti-inflammatory effects of Caragana tangutica ethyl acetate extract显示文摘 | Xiaofeng Niu Yongmei Li Weifeng Li Hua Hu Huan Yao Huani Li Qingli Mu | 2013 | Journal of Ethnopharmacology2013，，： | 1 |
| 16 | Identification of a TGF-β1 homologue in the large yellow croaker(Larimichthys crocea)revealed its role in regulation of immune response显示文摘Mammalian TGF-β1 plays a crucial role in maintaining immune tolerance and inhibiting autoimmunity.Although several TGF-β1 homologues have been identified in teleosts,their immunosuppressive functions remain unclear.Herein,we identified and characterized LcTGF-β1,a TGF-β1 homologue from the large yellow croaker(Larimichthys crocea).LcTGF-β1 possesses several features characteristic of the TGF-βsuperfamily,including an RGD integrin binding site,an RSKR tetrabasic cut site,and nine conserved cysteines in the mature peptide.The LcTGFβ1 gene was constitutively expressed in all examined tissues,with the highest expression in the spleen,which is rich in immune cells.LcTGF-β1 was significantly upregulated in the head kidney and spleen after Vibrio alginolyticus stimulation.LcTGF-β1 was also expressed in primary head kidney lymphocytes(PKLs),monocytes/macrophages(MO/Mφs),and granulocytes(PKGs),and was significantly upregulated in the MO/Mφs after lipopolysaccharide(LPS)stimulation.Recombinant LcTGF-β1 protein(rLcTGF-β1)significantly suppressed reactive oxygen species(ROS)and nitrogen oxide(NO)production in LPS-activated head kidney MO/Mφs.Furthermore,in these MO/Mφs,rLcTGF-β1 strongly inhibited the expression of pro-inflammatory cytokine(TNFα)and inducible NO synthase(iNOS),while it induced anti-inflammatory cytokines(TGF-β1 and IL-10),arginase1,and CD206.The phagocytic activity of LPS-activated MO/Mφs was also increased by rLcTGF-β1.Finally,rLcTGF-β1 significantly inhibited the proliferation of T cells(ZAP70þcells)and downregulated T-cell activation genes(CD3ζ,TCRα,and ZAP70),T-cell marker genes(CD4 and CD8),and IL-2 in PKLs.These results thus provide strong evidence that LcTGF-β1 promotes the alternative activation of head kidney MO/Mφs and inhibits T-cell proliferation in PKLs,highlighting its role in the regulation of immune response in large yellow croaker. | Xiaofeng Li Pengfei Mu Yan Teng Xiaomeng Li Yinanzi Wu Xinhua Chen | 2022 | Water Biology and Security2022，1，1： | 0 |
| 17 | Antibody and T cell responses against wild-type and Omicron SARS-CoV-2 after third-dose BNT162b2 in adolescents显示文摘The high effectiveness of the third dose of BNT162b2 in healthy adolescents against Omicron BA.1 has been reported in some studies,but immune responses conferring this protection are not yet elucidated.In this analysis,our study(NCT04800133)aims to evaluate the humoral and cellular responses against wild-type and Omicron(BA.1,BA.2 and/or BA.5)SARS-CoV-2 before and after a third dose of BNT162b2 in healthy adolescents.At 5 months after 2 doses,S IgG,S IgG Fc receptor-binding,and neutralising antibody responses waned significantly,yet neutralising antibodies remained detectable in all tested adolescents and S IgG avidity increased from 1 month after 2 doses.The antibody responses and S-specific IFN-γ^(+)and IL-2^(+)CD8^(+)T cell responses were significantly boosted in healthy adolescents after a homologous third dose of BNT162b2.Compared to adults,humoral responses for the third dose were non-inferior or superior in adolescents.The S-specific IFN-γ^(+)and IL-2^(+)CD4^(+)and CD8^(+)T cell responses in adolescents and adults were comparable or non-inferior.Interestingly,after 3 doses,adolescents had preserved S IgG,S IgG avidity,S IgG FcγRIIIa-binding,against Omicron BA.2,as well as preserved cellular responses against BA.1 S and moderate neutralisation levels against BA.1,BA.2 and BA.5.Sera from 100 and 96%of adolescents tested at 1 and 5 months after two doses could also neutralise BA.1.Our study found high antibody and T cell responses,including potent cross-variant reactivity,after three doses of BNT162b2 vaccine in adolescents in its current formulation,suggesting that current vaccines can be protective against symptomatic Omicron disease. | Xiaofeng Mu Carolyn A.Cohen Daniel Leung Jaime S.Rosa Duque Samuel M.S.Cheng Yuet Chung Howard H.W.Wong Amos M.T.Lee Wing Yan Li Issan Y.S.Tam Jennifer H.Y.Lam Derek H.L.Lee Sau Man Chan Leo C.H.Tsang Karl C.K.Chan John K.C.Li Leo L.H.Luk Sara Chaothai Kelvin K.H.Kwan Nym Coco Chu Masashi Mori Trushar Jeevan Ahmed Kandeil Richard JWebby Wenwei Tu Sophie A.Valkenburg Malik Peiris Yu Lung Lau | 2023 | Signal Transduction and Targeted Therapy2023，8，1： | 0 |
| 18 | Development of a high-power blue diode laser for precision vaporization of prostate tissue for the surgical management of benign prostatic hyperplasia显示文摘This paper explores the advancement and application of high-power blue diode lasers in treating benign prostatic hyperplasia(BPH).Addressing the challenges posed by existing techniques,the study focuses on optimizing tissue removal methods.Energy platform for BPH should balance a range of factors,such as operative time,patient conditions,urinary functions,complications,durability,accessibility,and cost,all while prioritizing patient care.Blueray Medical's innovation of high-power blue diode laser systems for BPH surgery is explored,with emphasis on achieving a balance among these considerations.By illustrating the biomedical effects of lasers and their interaction with soft tissues,particularly emphasizing the role of photon absorption by biomolecules and proteins in tissue behavior,this study outlines the advantages of the highpower blue diode laser system.The initial laboratory experiments and clinical results consistently align with our theoretical predictions,especially in terms of tissue vaporization efficiency,tissue coagulation,and bleeding control.In conclusion,blue diode lasers hold potential to enhance surgical outcomes for BPH.Their unique properties offer benefits like improved tissue removal rate and reduced thermal damages.Integrating blue laser technology into BPH protocols could lead to shorter hospital stays,cost savings,and expanded patient eligibility,although rigorous clinical studies are needed to fully understand their benefits and limitations. | Liyue Mu Xiang Zhu Bing Yang Lin Yang Xiaofeng Xu Yongwei Zhao Dalin He | 2023 | UroPrecision2023，1，3： | 0 |
| 19 | Apogossypolone对人前列腺癌LNCaP移植瘤的生长抑制作用(英文)显示文摘Objective:The aim of this study was to investigate the inhibitory effect of apogossypolone (ApoG2) on subcutaneous implants of human LNCaP prostatic carcinoma cells, and explore its mechanism. Methods:To establish human LNCaP prostatic carcinoma cell line subcutaneous xenograft models and observe the inhibitory effect of ApoG2 on the tumor model. Immunohistochemistry was employed to observe the expression of Bcl-2, PCNA, CD31, caspase-3 and-8 in tumor tissues. The microvessel density was calculated. Results:ApoG2 could obviously inhibit the growth of subcutaneous prostatic carcinoma implant. ApoG2 decreased the expression of PCNA and CD31, and increased the expression of caspases-3,-8 in tumor tissues. Conclusion:ApoG2 has an inhibitory effect on prostatic carcinoma implants. | Yaozhen Chen Haishan Chen Chen Chen Xiaofeng Huang Shijie Mu Mengyao Zhang Xingbin Hu Qunxing An Xianqing Zhang | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，1： | 0 |
| 20 | Comparison of pathological findings between patients with relapsed and non-relapsed immunoglobin G4-related disease显示文摘Immunoglobin(Ig)G4-related disease(IgG4-RD)is an immune-mediated fibroinflammatory condition characterized by elevated serum IgG4 levels and multi-organ involvement.The characteristic histological findings of IgG4-RD are dense lymphoplasmacytic infiltration,fibrosis,and massive IgG4 positive plasma cells infiltrating the affected tissues.[1]Previous studies have demonstrated various relapse predictors corresponding to demographic,clinical characteristics,laboratory test results,and treatment agents.However,no study has revealed the risk factors of flares in pathology.This study aimed to ascertain whether the pathological characteristics are related to therapeutic outcomes. | Hui Lu Shan Wang Mu Wang Xiaowei Liu Linyi Peng Jiaxin Zhou Jieqiong Li Zheng Liu Xuan Luo Yu Peng Yunyun Fei Yan Zhao Xiaofeng Zeng Ruie Feng Wen Zhang | 2022 | Chinese Medical Journal2022，，4： | 0 |
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