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| 1 | Single-cell triple omics sequencing reveals genetic, epigenetic, and transcriptomic heterogeneity in hepatocellular carcinomas显示文摘 | Yu Hou Huahu Guo then Cao Xianlong Li Boqiang Hu Ping Zhu Xinglong Wu Lu Wen FuchouTang Yanyi Huang Jirun Peng | 2016 | Cell Research2016，26，3： | 48 |
| 2 | Single-cell multi-omics sequencing of mouse early embryos and embryonic stem cells显示文摘定序技术的单个房间的 epigenome 最近被开发了。然而,在一个单个房间定序的 epigenome 的不同的层的联合还没被完成了。这里,我们开发了定序能分析染色质的技术(单个房间的 COOL-seq ) 的单个房间的 multi-omics 放的 state/nucleosome, DNA methylation,拷贝数字变化和 ploidy 同时从一样的单个哺乳动物的房间。我们使用了这个方法在老鼠 preimplantation 胚胎分析染色质状态和 DNA methylation 的 reprogramming。我们发现了那在以内 < 授精的 12 h,每个单个房间和母亲、父亲的染色体的快速、全球的 reprogramming 经历全球染色体 demethylation 到一个高度打开的染色质状态。这被减少的坦诚在迟了的接合子阶段以后跟随。而且,从迟了的接合子上演到 4 房间,剩余 DNA methylation 优先地在各单个的分裂球在父亲的等位基因的 intergenic 区域和母亲的等位基因的 intragenic 区域上被保存。然而,染色质可接近性在在从迟了的接合子的每个单个房间的父亲、母亲的等位基因之间是类似的到胚囊阶段。几个 pluripotency 管理者的有约束力的主题在远侧的 nucleosome 被充实弄空的区域从象 2 房间阶段一样早。这显示如此的目标基因的 cis 规章的元素从 2 房间阶段被告知到一个开的状态向前,在 pluripotency 最后在胚囊的 ICM 被建立以前,渴望。基因可以被分类进同类地开,同类地关门了并且分叉的状态基于他们在单个房间之中的倡导者区域的染色质可接近性。这能在 preimplantation 开发期间被跟踪到逐步的转变。我们的学习在早老鼠胚胎在单个底的分辨率提供染色体规模染色质状态和 DNA methylation 动力学的第一单个房间、父母的等位基因特定的分析并且提供新卓见进异构还高度在这个过程期间订了 epigenomic reprogramming 的特征。 | Fan Guo Lin Li Jingyun Li Xinglong Wu Boqiang Hu Ping Zhu Lu Wen Fuchou Tang | 2017 | Cell Research2017，27，8： | 34 |
| 3 | Progresses in Sustainable Recycling Technology of Spent Lithium-Ion Batteries显示文摘The number of lithium-ion batteries(LIBs)is steadily increasing in order to meet the ever-growing demand for sustainable energy and a high quality of life for humankind.At the same time,the resulting large number of LIB waste certainly poses safety hazards if it is not properly disposed of and will seriously harm the environment due to its inherent toxicity due to the use of toxic substances.Moreover,the consumption of many scarce precious metal resources is behind the mass production of batteries.In the light of severe environmental,resources,safety and recycling problems,recycling spent LIBs have become an essential urgently needed action to achieve sustainable social development.This review therefore critically analyses the value and the need for recycling of spent LIBs from a variety of resources and the environment.A range of existing technologies for recycling and reusing spent LIBs,such as pretreatment,pyrometallurgy,hydrometallurgy,and direct recycled methods,is subsequently summarized exclusively.In addition,the benefits and problems of the methods described above are analyzed in detail.It also introduces recycling progress of other LIB components,such as anodes,separators,and electrolytes,as well as the high-value cathode.Finally,the prospects for recycling LIBs are addressed in four ways(government,users,battery manufacturers,and recyclers).This review should contribute to the development of the recycling of used LIBs,particularly in support of industrialization and recycling processes. | Kaidi Du Edison Huixiang Ang Xinglong Wu Yichun Liu | 2022 | Energy & Environmental Materials2022，5，4： | 7 |
| 4 | A microporous surface containing Si3N4/Ta microparticles of PEKK exhibits both antibacterial and osteogenic activity for inducing cellular response and improving osseointegration显示文摘As an implantable biomaterial,polyetherketoneketone(PEKK)exhibits good mechanical strength but it is biologically inert while tantalum(Ta)possesses outstanding osteogenic bioactivity but has a high density and elastic modulus.Also,silicon nitride(SN)has osteogenic and antibacterial activity.In this study,a microporous surface containing both SN and Ta microparticles on PEKK(STP)exhibiting excellent osteogenic and antibacterial activity was created by sulfonation.Compared with sulfonated PEKK(SPK)without microparticles,the surface properties(roughness,surface energy,hydrophilicity and protein adsorption)of STP significantly increased due to the SN and Ta particles presence on the microporous surface.In addition,STP also exhibited outstanding antibacterial activity,which inhibited bacterial growth in vitro and prevented bacterial infection in vivo because of the presence of SN particles.Moreover,the microporous surface of STP containing both SN and Ta particles remarkably induced response(e.g.,proliferation and differentiation)of rat bone mesenchymal stem(rBMS)cells in vitro.Furthermore,STP significantly improved new bone regeneration and osseointegration in vivo.Regarding the induction of cellular response in vitro and improvement of osseointegration in vivo,the microporous surface containing Ta was better than the surface with SN particles.In conclusion,STP with optimized surface properties activated cellular responses in vitro,enhanced osseointegration and prevented infection in vivo.Therefore,STP possessed the dual biofunctions of excellent osteogenic and antibacterial activity,showing great potential as a bone substitute. | Xinglong Hu Shiqi Mei Fan Wang Songchao Tang Dong Xie Chao Ding Wenli Du Jun Zhao Lili Yang Zhaoying Wu Jie Wei | 2021 | Bioactive Materials2021，6，10： | 6 |
| 5 | Implantable PEKK/tantalum microparticles composite with improved surface performances for regulating cell behaviors,promoting bone formation and osseointegration显示文摘Polyetherketoneketone(PEKK)exhibits admirable biocompatibility and mechanical performances but bioinert while tantalum(Ta)possesses excellent osteogenesis and osseointegration but high elastic modulus and density,and processing is too difficult and expensive.In the present study,combining of the advantages of both PEKK and Ta,implantable composites of PEKK/Ta were fabricated by blending PEKK with Ta microparticles of 20 v%(PT20)and 40 v%(PT40)content.In comparison with PT20 and PEKK,the surface hydrophilicity,surface energy,roughness and proteins adsorption as well as mechanical performances of PT40 significantly increased because of the higher Ta particles content in PEKK.Furthermore,PT40 exhibited the mechanical performances(e.g.,compressive strength and modulus of elasticity)close to the cortical bone of human.Compared with PT20 and PEKK,PT40 with higher Ta content remarkably enhanced the responses(including adhesion,proliferation and osteogenic differentiation)of MC3T3-E1 cells in vitro.Moreover,PT40 markedly improved bone formation as well as osseointegration in vivo.In short,incorporation of Ta microparticles into PEKK created implantable composites with improved surface performances,which played key roles in stimulating cell responses/bone formation as well as promoting osseointegration.PT40 might have great potential for bear-loading bone substitute. | Xinglong Hu Shiqi Mei Fan Wang Jun Qian Dong Xie Jun Zhao Lili Yang Zhaoying Wu Jie Wei | 2021 | Bioactive Materials2021，6，4： | 6 |
| 6 | Surveying brain tumor heterogeneity by single-cell RNA-sequencing of multi-sector biopsies显示文摘Brain tumors are among the most challenging human tumors for which the mechanisms driving progression and heterogeneity remain poorly understood.We combined single-cell RNA-seq with multi-sector biopsies to sample and analyze single-cell expression profiles of gliomas from 13 Chinese patients.After classifying individual cells;we generated a spatial and temporal landscape of glioma that revealed the patterns of invasion between the different sub-regions of gliomas.We also used single-cell inferred copy number variations and pseudotime trajectories to inform on the crucial branches that dominate tumor progression.The dynamic cell components of the multi-region biopsy analysis allowed us to spatially deconvolute with unprecedented accuracy the transcriptomic features of the core and those of the periphery of glioma at single-cell level.Through this rich and geographically detailed dataset,we were also able to characterize and construct the chemokine and chemokine receptor interactions that exist among different tumor and non-tumor cells.This study provides the first spatial-level analysis of the cellular states that characterize human gliomas.It also presents an initial molecular map of the cross-talks between glioma cells and the surrounding microenvironment with single-cell resolution. | Kai Yu Yuqiong Hu Fan Wu Qiufang Guo Zenghui Qian Waner Hu Jing Chen Kuanyu Wang Xiaoying Fan Xinglong Wu John EJ Rasko Xiaolong Fan Antonio lavarone Tao Jiang Fuchou Tang Xiao-Dong Su | 2020 | National Science Review2020，7，8： | 4 |
| 7 | Characteristics and risk assessment of agricultural meteorological disasters based on 30 years’disaster data from Heilongjiang Province of China显示文摘To determine the influence of agricultural meteorological disasters on agriculture in Heilongjiang Province,the disaster areas associated with different types of disasters and their variation characteristics were analyzed based on the statistical data of agricultural disasters from 1983 to 2013 in Heilongjiang Province,China.The moving average and the Mann-Kendall test were applied to identify the variation trends of drought,flooding,hailstorms and freezing(based on the disaster ratio and the disaster intensity index).Then,the Morlet wavelet analysis method was used to identify the periodicity of these four kinds of agricultural meteorological disasters.Finally,a fuzzy comprehensive evaluation method was adopted to analyze the degrees of agricultural loss induced by these disasters.The following results were obtained:1)The disaster ratio and disaster intensity index for drought exhibited increasing trends;the disaster ratio and disaster intensity index for flooding exhibited decreasing trends;for hailstorms,the disaster ratio exhibited no obvious trend of change,whereas the disaster intensity index exhibited an increasing trend;and for freezing,the disaster ratio also exhibited no obvious trend of change,whereas the disaster intensity index exhibited a decreasing trend.2)Mutation points were observed in the disaster ratio series for drought,flooding and hailstorms,whereas no mutation point was evident in the disaster ratio series for freezing.3)Multiple time-scale characteristics were observed in the disaster ratio series for all four types of agricultural meteorological disasters.Furthermore,the disaster ratio series for the different types of disasters had different main periodicities.4)From the perspective of the degree of agricultural loss induced by each type of disaster,drought was identified as the most severe type of agricultural meteorological disaster,followed by flooding,freezing,and hailstorms.The degree of agricultural loss caused by each type of disaster was different during different periods.Finally,based on the results,several strategies were identified for mitigating the effect of agricultural meteorological disasters in Heilongjiang Province. | Xing Zhenxiang Yang Zhaorui Fu Qiang Li Heng Gong Xinglong Wu Jingyan | 2017 | International Journal of Agricultural and Biological Engineering2017，10，6： | 4 |
| 8 | H3K4me3 epigenomic landscape derived from ChIP-Seq of 1000 mouse early embryonic cells显示文摘 | Jie Shen Dongqing Jiang Yusi Fu Xinglong Wu Hongshan Guo Binxiao Feng Yuhong Pang Aaron M Streets Fuchou Tang Yanyi Huang | 2015 | Cell Research2015，25，1： | 4 |
| 9 | Large-scale Ni-MOF derived Ni_(3)S_(2) nanocrystals embedded in N-doped porous carbon nanoparticles for high-rate Na+ storage显示文摘Metal organic framework(MOF) has been confirmed as the promising precursor to develop the conve rsion-typed anode mate rials of sodium-ion batteries(SIBs) because of the tunable structure design and simple functional modification.Here,we prepare the ultrasmall Ni_(3)S_(2) nanocrystals embedded into N-doped porous carbon nanoparticles using the scalable Ni-MOF as precursor(denoted as Ni_(3)S_(2)@NPC).The ultrasmall size of Ni_(3)S_(2) can work for accelerated electro n/ion transfer to facilitate the electrochemical reaction kinetics.Moreover,the robust conductivity network originated from N-doped porous carbon nanoparticles can not only improve the electron conductivity,but also enhance the electrode integrity and stability of the electrode/electrolyte interface.In addition,the N heteroatoms provide extra Na storage sites.Accordingly,the electrode delivers the obviously competitive capacities and high-power output with respect to the currently reported Ni_(3)S_(2)/C composites.This study provides a scalable and universal strategy to develop the advanced transition metal sulfides for practically feasible SIBs. | Miao Yang Qiuli Ning Chaoying Fan Xinglong Wu | 2021 | Chinese Chemical Letters2021，32，2： | 3 |
| 10 | Optical emission spectroscopy diagnosis of energetic Ar ions in synthesis of SiC polytypes by DC arc discharge plasma显示文摘硅碳化物是有合适的 bandgaps (2.4-3.3 eV ) 和唯一的光性质的尺侧皮的陶艺。有不同形态学,尺寸,和水晶类型的 SiC@C monocrystal nanocapsules 经由快、灵巧的直接水流(DC ) 被综合弧分泌物血浆方法。nanocrystal 的形成上的 Ar 空气的影响原文如此, polytypes 被光排放光谱学(OES ) 调查在弧分泌物血浆上诊断。Boltzmanns 阴谋被用来估计作为 10,582 K 包含不同 Ar 集中的血浆的温度(在 2 ??唓 吗?? | Jian Gao Lei Zhou Jingshuang Liang Ziming wang Yue Wu Javid Muhammad Xinglong Dong Shouzhe Li Hongtao yu Xie Quan | 2018 | Nano Research2018，11，3： | 3 |
| 11 | The origins of the broadband photoluminescence from carbon nitrides and applications to white light emitting显示文摘碳氮化物在 700 点由三聚氰胺的热 polycondensation | Zhixing Gan Yun Shan Jiarui Chen Qingfeng Gui Qizhen Zhang Shouping Nie Xinglong Wu | 2016 | Nano Research2016，9，6： | 2 |
| 12 | Ultrahigh quantum efficiency photodetector and ultrafast reversible surface wettability transition of square In2O3 nanowires显示文摘由于大 surface-to-volume 比率, lowdimensional 半导体的 optoelectronic 表演基于 nanostructure 的光电探测器在暴露的表面原则上取决于 chemisorption/photodesorption,但是显示出如此的效果的实际例子仍然是无法获得的。一些理论计算预言了 { 001 } 方面在 2 O 3 能有效地在照耀下面积累 photogenerated 洞,提供模型材料检验 nanowires (NW ) 切的方面是否能增加他们的 optoelectronic 表演。此处,我们在场使用的一个新奇基于 nanowire 的光电探测器的设计和构造在 2 有四的 O 3 NW 暴露了 { 001 } 水晶方面。光电探测器与优秀重覆性交付优秀 optoelectronic 性能,快反应速度,高光谱 responsivity (R ), 和高外部量效率(EQE ) 。R 和 EQE 价值象 4.8 | Ming Meng Xinglong Wu Xiaoli Ji Zhixing Gan Lizhe Liu Jiancang Shen Paul K. Chu | 2017 | Nano Research2017，10，8： | 2 |
| 13 | Anisotrop- le polyurethane magnetorheologieal elastomer prepared through in situ polycondensation under a magnetic field显示文摘 | Wu Jinkui Gong Xinglong Fan Yancheng | 2010 | Smart Materials & Structures2010，19，10： | 1 |
| 14 | Improving the magnetorheological properties of polyurethane magneto- rheological elastomer through plasticization 显示文摘 | Wu Jinkui Gong Xinglong Fan Yancheng | 2012 | Journal of Applied Polymer Science2012，123，4： | 1 |
| 15 | Physically crosslinked poly( vinyl alcohol) hydrogels with magnetic field controlled modulus显示文摘 | Wu Jinkui Gong Xinglong Fan Yancheng | 2011 | Soft Matter2011，7，13： | 1 |
| 16 | SbPS_(4):A novel anode for high-performance sodium-ion batteries显示文摘With the in-depth research of sodium-ion batteries(SIBs),the development of novel sodium-ion anode material has become a top priority.In this work,tube cluster-shaped SbPS_(4)was synthesized by a high-temperature solid phase reaction.Then the typical short tubular ternary thiophosphate SbPS_(4)compounded with graphene oxide(SbPS_(4)/GO)was successfully synthesized after ultrasonication and freeze-drying.SbPS_(4)shows a high theoretical specific capacity(1335 mAh/g)according to the conversion-alloying dual mechanisms.The unique short tube inserted in the spongy graphene structure of SbPS_(4)/GO results in boosting the Na ions transport and alleviating the huge volume change in the charging and discharging processes,improving the sodium storage performance.Consequently,the tubular SbPS_(4)compounded with 10%GO provides an outstanding capacity of 359.58 mAh/g at 500 mA/g.The result indicates that SbPS_(4)/GO anode has a promising application potential for SIBs. | Miao Yang Zhonghui Sun Ping Nie Haiyue Yu Chende Zhao Mengxuan Yu Zhongzhen Luo Hongbo Geng Xinglong Wu | 2022 | Chinese Chemical Letters2022，33，1： | 1 |
| 17 | Directional terahertz holography with thermally active Janus metasurface显示文摘Dynamic manipulation of electromagnetic(EM)waves with multiple degrees of freedom plays an essential role in enhancing information processing.Currently,an enormous challenge is to realize directional terahertz(THz)holography.Recently,it was demonstrated that Janus metasurfaces could produce distinct responses to EM waves from two opposite incident directions,making multiplexed dynamic manipulation of THz waves possible.Herein,we show that thermally activated THz Janus metasurfaces integrating with phase change materials on the meta-atoms can produce asymmetric transmission with the designed phase delays.Such reconfigurable Janus metasurfaces can achieve asymmetric focusing of THz wave and directional THz holography with free-space image projections,and particularly the information can be manipulated via temperature and incident THz wave direction.This work not only offers a common strategy for realizing the reconfigurability of Janus metasurfaces,but also shows possible applications in THz optical information encryption,data storage,and smart windows. | Benwen Chen Shengxin Yang Jian Chen Jingbo Wu Ke Chen Weili Li Yihui Tan Zhaosong Wang Hongsong Qiu Kebin Fan Caihong Zhang Huabing Wang Yijun Feng Yunbin He Biaobing Jin Xinglong Wu Jian Chen Peiheng Wu | 2023 | Light(Science & Applications)2023，12，6： | 1 |
| 18 | Carbon coatedFeaO4 nanospindles as a superior anode material for lithiumqon batteries 显示文摘 | Zhang Weiming Wu Xinglong Hu Jinsong | 2008 | Adv Funct Mater2008，18，： | 1 |
| 19 | Sodium-based dual-ion batteries via coupling high-capacity selenium/graphene anode with high-voltage graphite cathode显示文摘Dual ion batteries(DIBs) exhibit broad application prospects in the field of electrical energy storage(EES)devices with excellent properties,such as high voltage,high energy density,and low cost.In the graphitebased DIBs,high voltage is needed to store enough anions with the formation of anion intercalation compound XCn(X=AlCl4-,PF6-,TFSI-,etc.).Hence,it is difficult for graphite-based DIBs to match proper anodes and electrolytes.Here,an Se/graphene composite is prepared via a convenient method,and assembled into a dual-ion full battery(DIFB) as anode with graphite cathode and 1 mol/L NaPF6 in EC:EMC(1:1,v:v).This DIFB has achieved a high discharge capacity of 75.9 mAh/g and high medium output voltage of 3.5 V at 0.1 A/g.Actually,the suitable anode materials,such as the present Se/graphene composite,are extremely important for the development and application of graphite-based DIBs.This study is enlightening for the design of future low-cost EES devices including graphite-based DIBs. | Xiankun Hou Wenhao Li Yingying Wang Shaofang Li Yunfeng Meng Haiyue Yu Baokuan Chen Xinglong Wu | 2020 | Chinese Chemical Letters2020，31，9： | 1 |
| 20 | Flexible and breathable 3D porous SSE/MXene foam towards impact/electromagnetic interference/bacteria multiple protection performance for intelligent wearable devices显示文摘As intelligent wearable devices,they will inevitably be subjected to various damages and disturbances from the external environment during daily use.Therefore,it is urgent to develop safeguarding materials with multiple protective properties.Herein,this work developed a flexible and breathable three-dimensional(3D)porous shear stiffening elastomer(SSE)/MXene(M-SSE)foam with impact/electromagnetic interference(EMI)/bacteria multiple protection performance for intelligent wearable devices.The continuous conductive MXene network in the 3D SSE porous structure made M-SSE foam exhibit excellent electromagnetic interference shielding property with a high shielding effectiveness of 34 dB.Attributed to the shear stiffening effect of porous SSE matrix,M-SSE foam possessed unique anti-impact and protection properties.The energy dissipation rate reached up to more than 85%,illustrating M-SSE foam could effectively attenuate the external impact force and absorb the impact energy.Inherited from the excellent photothermal performance of MXene,M-SSE foam achieved a considerable saturated temperature of 98℃ under 0.57 W/cm^(2) laser power.Therefore,M-SSE foam showed extraordinary antimicrobial property for Staphylococcus aureus according to the principle of photothermal sterilization.Finally,for the development of intelligent wearable devices,conductive MSSE foam could be used as an intelligent sensor to monitor various human movements owing to the highly sensitive property.This work greatly expanded the application prospect of multifunctional protective materials in various complex environments and promoted the development of multifunctional smart wearable devices in protection field. | Min Sang Shuai Liu Jianpeng Wu Xinyi Wang Junshuo Zhang Yunqi Xu Yu Wang Jun Li Ji Li Shouhu Xuan Xinglong Gong | 2023 | Nano Research2023，16，7： | 1 |
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