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| 1 | Bromodeoxyuridine promotes full-chemical induction of mouse pluripotent stem cells显示文摘 | YuanLong, MinWang, HaifengGu and XinXie | 2015 | Cell Research2015，25，10： | 13 |
| 2 | Expression pattern of epithelial cell adhesion molecule on normal and malignant colon tissues显示文摘AIM: To investigate the expression pattern of epithelial cell adhesion molecule (Ep-CAM) on normal and malignant colon tissues to evaluate its diagnostic and therapeutic significance.METHODS: cDNA encoding Ep-CAv extracellular domain was cloned by reverse transcription-polymerase chain reaction (RT-PCR) from excised malignant colon tissues and inserted into a glutathione S-transferase (GST)-tagged vector. EpCAM-GST fusion protein was induced by isopropyl-β-D-thiogalactopyranoside (IPTG) and purified with glutathionesepharose. The Ep-CAM-GST fusion protein was mixed with Freund's adjuvant and Balb/c mice were immunized with it. Sp2/0 myeloma cells were fused with the spleen cells of the immunized mice. After having selected by indirect ELISA, the anti-Ep-CAM monoclonal antibodies (NAbs) were generated and the corresponding ascites were obtained.Finally, the human colon carcinoma tissue array prepared from seventy individual patients was stained with the antiEp-CAM NAbs.RESULTS: The isolated Ep-CAM cDNA sequence was identical to the data in GenBank. The expressed fusion protein was almost soluble and had a molecular weight (NW) of 53 ku.Four NAbs against Ep-CAM were obtained and designated as FMU-Ep1, FMU-Ep2, FMU-Ep3 and FMU-Ep4 respectively.Among them, FMU-Ep4 could recognize the natural EpCAM on Colo205 and SW480 cells, and all of them could be used for immunohistochemical staining of tissue sections.It was found that Ep-CAM was distributed differently in normal and various malignant colon tissues, including squamous cell carcinoma, signet-ring cell carcinoma and adenocarcinoma.In normal colon gland epithelia, Ep-CAM antigen was mainly distributed on the basolateral membrane and in the region between the basolateral membrane and the cytoplastic part near the nuclei, whereas the expression pattern of colon malignancies was mainly on the whole surface of epithelia and the expression was much higher than the normal colon tissues. The staining pattern of tissue array showed in adenocarcinoma and papillary adenocarcinoma, and the expression of Ep-CAM was increased from grade Ⅰ to grade Ⅲ.CONCLUSION: NAbs against Ep-CAM might be useful for research on the structure and function of Ep-CAM and may have diagnostic and therapeutic value to various colon carcinomas. | XinXie Chun-YanWang Yun-XinCao WeiWang RanZhuang Li-HuaChen Na-NaDang LiangFang Bo-QuanJin | 2005 | World Journal of Gastroenterology2005，11，3： | 7 |
| 3 | A Novel Hybrid FA-Based LSSVR Learning Paradigm for Hydropower Consumption Forecasting显示文摘Due to the nonlinearity and nonstationary of hydropower market data, a novel hybrid learning paradigm is proposed to predict hydropower consumption, by incorporating firefly algorithm(FA) into least square support vector regression(LSSVR), i.e., FA-based LSSVR model. In the novel model, the powerful and effective artificial intelligence(AI) technique, i.e., LSSVR, is employed to forecast hydropower consumption. Furthermore, a promising AI optimization tool, i.e., FA, is especially introduced to address the crucial but difficult task of parameters determination in LSSVR(e.g.,hyper and kernel function parameters). With the Chinese hydropower consumption as sample data,the empirical study has statistically confirmed the superiority of the novel FA-based LSSVR model to other benchmark models(including existing popular traditional econometric models, AI models and similar hybrid LSSVRs with other popular parameter searching tools), in terms of level and directional accuracy. The empirical results also imply that the hybrid FA-based LSSVR learning paradigm with powerful forecasting tool and parameters optimization method can be employed as an effective forecasting tool for not only hydropower consumption but also other complex data. | TANG Ling WANG Zishu LI Xinxie YU Lean ZHANG Guoxing | 2015 | Journal of Systems Engineering and Electronics2015，26，5： | 3 |
| 4 | YTHDF2 is essential for spermatogenesis and fertility by mediating a wave of transcriptional transition in spermatogenic cells显示文摘The dynamic and reversible regulation roles of m^(6)A modification and the characterization of m^(6)A readers have provided new insights into spermatogenesis at the post-transcriptional level.YTHDF2,as an m^(6)A reader,has been reported to mediate the m^(6)A-containing transcript decay during the mouse oocyte maturation,embryonic stem cell differentiation,neural development,and zebrafish maternal-to-zygotic transition.However,the roles of YTHDF2 in mammalian spermatogenesis are uncertain.Here,we generated germ cell-specific Ythdf2 mutants(Ythdf2-vKO)at a C57BL/6J background and demonstrated that YTHDF2 is essential for mouse spermatogenesis and fertility.Ythdf2-vKO provides oligoasthenoteratozoospermia phenotype with increased apoptosis in germ cells.High-throughput RNA-seq analysis showed that a group of mRNAs is upregulated in Ythdf2-vKO mouse testis;further analysis and MeRIP-qPCR data showed that most of the upregulated genes in Ythdf2-vKO mouse testis are modified with m^(6)A and are YTHDF2 candidate binding genes.Interestingly,RNA-seq analysis combined with our previous single-cell transcriptomics data of mouse spermatogenesis pointed out the failure of a wave of transcript transition during the spermatogenesis of Ythdf2-vKO mice,which was confirmed by gene expression analysis using qPCR of diplotene spermatocytes and round spermatids obtained through fluorescence-activated cell sorting.Our study demonstrates the fundamental role of YTHDF2 during mouse spermatogenesis and provides a potential candidate for the diagnosis of male infertility with the oligoasthenoteratozoospermia syndrome. | Xinxi Zhao Zhen Lin Yong Fan Wenzhi Li Yujie Zhang Fei Li Tong Hong Hua Feng Minghan Tong Ningling Wang Yanping Kuang Qifeng Lyu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，12： | 2 |
| 5 | Preparation and Characterization of Super-paramagnetic Nano-beads for DNA Isolation显示文摘Unique coupling reagent, bis-(2-hydroxyethyl methacrylate) phosphate was used to prepare coated and functionalized superparamagnetic nanobeads, leading to a simple, effective method for coating the nanobeads. With this method, the thickness of the coating layer and the functional group contents on the nano-beads could be controlled by changing the quantity of the coated monomers. The nanobeads were characterized by means of transmission electron microscopy (TEM) and Fourier transformation infrared spectroscopy (FTIR). The carboxyl-modified magnetic nano-beads were employed to streamline the protocol of isolation of genomic DNA from the human whole blood. | XinXIE XuZHANG BingBinYU WeiYangFEI | 2004 | Chinese Chemical Letters2004，15，5： | 2 |
| 6 | Effect of chemical conditioning on the triboelectrification of coal and mineral particles显示文摘Chemical conditioning was used to modify the triboelectrification of coal and mineral particles.The chemicals tested included starch,lignin,kerosene,ethanol,acetic acid,salicylic acid,sodium oleate,Sodium Hexametaphosphate(SH),sodium silicate, Sodium Dodecylbenzenesulfonate(SDBS),Sodium Bicarbonate(SB) and ammonia.A high-speed,dry mixing method was employed.The charge-to-mass ratio of the coal and mineral samples,both untreated and treated,was tested using a Faraday cup. Dielectric constants were determined by measuring capacitance.It is found that the selectivity of the additives toward coal or minerals is not consistent.Salicylic acid is the optimal additive to enhance the triboelectrification performance of coal samples.Starch, lignin and sodium oleate are suitable for removal of pyrite.SH,sodium silicate,SDBS,SB and ammonia are suitable additives for the removal of ash-forming minerals. | WANG Haifeng CHEN Qingru ZHANG Xinxi TAN Zhihai WANG Shuai ZHOU Nianxin | 2010 | Mining Science and Technology2010，20，3： | 2 |
| 7 | Design and simulation of time-of-flight neutron reflectometer显示文摘In this paper,a time of flight neutron reflectometer model is proposed.According to the original objective inputting physical parameters and expectations,computer simulation was done by McStas package.With the open slit, neutron flux at sample position was about 1×10~5 n·cm^(-2)·S^(-1),and the optimal resolution could reach 0.5%.The results show that the model has a good performance.The design of this model can be an instruction for neutron reflectometer construction or project analysis in the future. | LI Xinxi WANG Yan HUANG Chaoqiang CHEN Bo | 2010 | Nuclear Science and Techniques2010，21，3： | 2 |
| 8 | Progress in plant phenology modeling under global climate change显示文摘Plant phenology is the study of the timing of recurrent biological events and the causes of their timing with regard to biotic and abiotic forces.Plant phenology affects the structure and function of terrestrial ecosystems and determines vegetation feedback to the climate system by altering the carbon,water and energy fluxes between the vegetation and near-surface atmosphere.Therefore,an accurate simulation of plant phenology is essential to improve our understanding of the response of ecosystems to climate change and the carbon,water and energy balance of terrestrial ecosystems.Phenological studies have developed rapidly under global change conditions,while the research of phenology modeling is largely lagged.Inaccurate phenology modeling has become the primary limiting factor for the accurate simulation of terrestrial carbon and water cycles.Understanding the mechanism of phenological response to climate change and building process-based plant phenology models are thus important frontier issues.In this review,we first summarized the drivers of plant phenology and overviewed the development of plant phenology models.Finally,we addressed the challenges in the development of plant phenology models and highlighted that coupling machine learning and Bayesian calibration into process-based models could be a potential approach to improve the accuracy of phenology simulation and prediction under future global change conditions. | Yongshuo FU Xinxi LI Xuancheng ZHOU Xiaojun GENG Yahui GUO Yaru ZHANG | 2020 | Science China Earth Sciences2020，63，9： | 1 |
| 9 | Study on engineering characteristics of highly weathered weak rock显示文摘 | CHEN Xiangyang YAN Hengzhen LIU Xinxi | 2011 | AdvMater Res2011，，： | 1 |
| 10 | Analysis of PAHs in air-borne particulates in Hong Kong City by heuristic evolving latent projections显示文摘 | Hailin Shen Yizeng Liang Ruqin Yu Xianchun Li Xinxi Sun | 1998 | Science in China Series B: Chemistry1998，，1： | 1 |
| 11 | Social credit:a comprehensive literature review显示文摘To avoid credit fraud,social credit within an economic system has become an increasingly important criterion for the evaluation of economic agent activity and guaranteeing the development of a market economy with minimal supervision costs.This paper provides a comprehensive review of the social credit literature from the perspectives of theoretical foundation,scoring methods,and regulatory mechanisms.The study considers the credit of various economic agents within the social credit system such as countries(or governments),corporations,and individuals and their credit variations in online markets(i.e.,network credit).A historical review of the theoretical(or model)development of economic agents is presented together with significant works and future research directions.Some interesting conclusions are summarized from the literature review.(1)Credit theory studies can be categorized into traditional and emerging schools both focusing on the economic explanation of social credit in conjunction with creation and evolution mechanisms.(2)The most popular credit scoring methods include expert systems,econometric models,artificial intelligence(AI)techniques,and their hybrid forms.Evaluation indexes should vary across different target agents.(3)The most pressing task for regulatory mechanisms that supervise social credit to avoid credit fraud is the establishment of shared credit databases with consistent data standards. | Lean Yu Xinxie Li Ling Tang Zongyi Zhang Gang Kou | 2015 | Financial Innovation2015，1，1： | 1 |
| 12 | Measurments of nitrous oxide emission from vegetable production in China显示文摘 | Zheng Qinxiong Ying Xinxie Guang Xixing | 2006 | Atmospheric Environment2006，40，12： | 1 |
| 13 | A new panel containing specific spermatogenesis markers to identify spermatogenic cells in nonobstructive azoospermia patients显示文摘Infertility is a severe problem that affects 10%-15% of couples worldwide, among which male infertility is a factor in ~50% of the cases [1]. Azoospermia, which is defined as the absence of sperm in at least two ejaculates, can be divided into two types: obstructive azoospermia (OA) and non-OA (NOA)[1]. OA patients have normal spermatogenesis and mature sperm in testes and can father a biological child through testicular sperm retrieval and intracytoplasmic sperm injection (ICSI)[2]. By contrast, NOA patients usually have various degrees of spermatogenesis impairment and can be faced with complicated assisted reproductive technology (ART) strategies to father a biological child [2]. The precise diagnosis of spermatogenesis in NOA patients is crucial for clinical decision making regarding ART. | Xinxi Zhao Yiqin Wang Meng Ma Wei Zhang Jiqiang Si Wei Wang Zhen Lin Gang Han Charlie Degui Chen Minghan Tong Yanping Kuang Qifeng Lyu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，6： | 1 |
| 14 | Analysis and design for thermal environment inside mobile operating compartment显示文摘 | Xu Xinxi Liu Yanjun Wang Taiyong l | 2007 | Inter- national Journal of Man-Machine- Environment System Engineer- ing2007，1，1： | 1 |
| 15 | Simulation and experiment of six-bed PSA process for air separation with rotating distribution valve显示文摘In this work,a six-bed pressure swing adsorption(PSA)process was investigated to produce medical oxygen from air,which uses the combination of six-way rotating distribution valve and PSA and has the main advantage of effectively saving space compared to the traditional two-bed or four-bed PSA process and can obtain greater productivity.The mathematical model of adsorption beds was developed based on the separation mechanism and the interaction among different equipment.Moreover,a pilot-scale device has been constructed to verify the accuracy of mathematical model by experiment.The oxygen product conformed to the medical standard(>93%(vol))with a recovery of over 57%.Some related parameters were also discussed in detail,such as step time,ratio of length to the diameter,flow rate of product. | Tao Tian Yayan Wang Bing Liu Zhaoyang Ding Xinxi Xu Meisheng Shi Jun Ma Yanjun Zhang Donghui Zhang | 2022 | Chinese Journal of Chemical Engineering2022，35，2： | 1 |
| 16 | Observation of the Hydrogen-Dislocation Interactions in a High-Manganese Steel after Hydrogen Adsorption and Desorption显示文摘Hydrogen embrittlement(HE)poses a significant challenge for the development of high-strength metallic materials.However,explanations for the observed HE phenomena are still under debate.To shed light on this issue,here we investigated the hydrogen-defect interaction by comparing the dislocation structure evolution after hydrogen adsorption and desorption in a Fe-28Mn-0.3C(wt%)twinning-induced plasticity steel with an austenitic structure using in situ electron channeling contrast imaging.The results indicate that hydrogen can strongly affect dislocation activities.In detail,hydrogen can promote the formation of stacking faults with a long dissociation distance.Besides,dislocation movements are frequently observed during hydrogen desorption.The required resolved shear stress is considered to be the residual stresses rendered by hydrogen segregation.Furthermore,the microstructural heterogeneity could lead to the discrepancy of dislocation activities even within the same materials. | Dayong An Yuhao Zhou Yao Xiao Xinxi Liu Xifeng Li Jun Chen | 2023 | Acta Metallurgica Sinica(English Letters)2023，36，7： | 0 |
| 17 | Effect and Risk Assessment of Animal Manure Pollution on Huaihe River Basin, China显示文摘Currently the deteriorated water quality for Huaihe River Basin(HRB) in China was still serious because of the negative influence multiple pollution sources including animal manure. However, little attention was paid to the potential risk of animal manure for farmland and water quality of HRB. This study was quantified and forecasted animal manure risk and its spatiotemporal variations in HRB from 2008 to 2018, through pollution discharge coefficient method and pollution load calculation, combined with kriging interpolation method of ArcGIS technology, based on statistics principle. All the data were originated from livestock and poultry breeding in HRB from 2008 to 2018. The future risk of farmland and water environment in HRB was further forecasted. The results indicated that the livestock and poultry manure has become a key pollution source causing a negative influence on farmland and water quality owing to a large amount of animal manure production without efficient recycle utilization. The chemical oxygen demand(COD) and total nitrogen(TN) discharge of animal manure in HRB almost accounted for 17.00% and 39.00% of the whole COD and TN discharge in China. The diffusion concentration of TN and TP in those regions of Shangqiu, Zhoukou, Heze, Zhumadian, Luohe, Jining, Xuchang,Kaifeng, Taian and Zhengzhou of HRB has exceeded the threshold value 10.00 mg/L of TN and 0.08 mg/L of TP, causing water eutrophication and cancer villages. The assessment of farmland and water quality risk revealed that Zhumadian, Zhoukou, Shangqiu, Taian, Jining, Heze, Linyi and Rizhao belonged to high risk areas in HRB, which were still obtained high farmland and water quality risk index in 2030. The results provided insight into an important significance of sustainable balance of livestock and poultry development and ecosystem in HRB. | WANG Youbao PAN Fanghui CHANG Jiayue WU Rongkang TIBAMBA Matthew LU Xuecheng ZHANG Xinxi | 2021 | Chinese Geographical Science2021，31，4： | 0 |
| 18 | Cooperative Communication Based on Spectrum Aggregation in LTE Further Evolution显示文摘The implementation of wide band radio transmission may occur in two parallel ways:designing a new system with larger bandwidth,or constructing a cooperative system based on existing systems.The former is a spectrum aggregation scheme based on multi-carrier transmission within one system,while the latter fulfills spectrum aggregation based on multi-carrier transmission among systems.On the one hand,the advantage of the multi-carrier transmission scheme within a system and among systems is that the existing Radio Frequency (RF) techniques and elements can be sufficiently utilized,so system costs can be decreased.On the other hand,spectrum aggregation among systems,especially among heterogeneous air-interfaces,can not only expand the basic bandwidth functions,but also fulfill efficient spectrum usage for Frequency Division Duplex (FDD) system under the unbalanced Uplink/Downlink (UL/DL) service scenario.It can also efficiently guard band usage between FDD and Time Division Duplex (TDD) systems.Commercially,this has significant implications for operators. | Diao Xinxi Xu Ling Ma Zhifeng | 2010 | ZTE Communications2010，8，1： | 0 |
| 19 | AN ADAPTIVE FILTERING ALGORITHM OF VELOCITY ESTIMATION显示文摘In this paper, a novel adaptive filtering algorithm using real-time deviation of velocity estimation is presented for maneuvering target tracking. This new algorithm will be called adaptive filtering algorithm of velocity estimation. A number of simulation results indicate that the algorithm not only has good performance on tracking maneuvering target, but also greatly improves the capacity for tracking non-maneuvering target. So it is worthy to be applied widely in practice. | Tao Weigang Feng Xinxi(Dept. of the Computer and Command Automation, Telecom. Eng. Iust., Air Force Eng. University, Post Box No.111, Xi’an 710077) | 2000 | Journal of Electronics(China)2000，17，3： | 0 |
| 20 | Multi-network Cooperation and Opportunities for TD-SCDMA Industrialization显示文摘The multi-network cooperation is the basic feature and vital part of 4G. It lays emphasis on the diversity of network evolution and is different from multi-network convergence. The objective of multi-network cooperation is to create the 'emergence' effect described in the system theory, that is, to generate the capabilities that a single network fails to provide. Multi-network cooperation takes multiple forms and involves numerous core technologies. The Time Division Synchronization Code Division Multiple Access (TD-SCDMA) is one of the three 3G solutions accepted by International Telecommunication Union (ITU). If following the WCDMA or CDMA2000 evolution path, the TD-SCDMA will gradually lose its own system features and becomes disadvantageous in performance. Therefore, it is necessary to make a cooperative design for the TD-SCDMA, Digital Television-handheld (DTV-H), and cable TV systems to construct a TD-SCDMA_Co system, or multi-network cooperative TD-SCDMA system compatible with the existing systems. Supported by the industry chain, the TD-SCDMA_Co system uses relatively mature technologies to cost-effectively deliver services. Moreover, as it provide easy and good indoor and outdoor coverage, it can enter multiple markets involving mobile communications, terrestrial TV broadcast, home IPTV, and mobile IPTV. | Diao Xinxi, Song Rongfang, Ning Luyou(ZTE Corporation, Shenzhen 518004, China) | 2006 | ZTE Communications2006，4，4： | 0 |
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