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| 1 | Guidance for the clinical evaluation of traditional Chinese medicine-induced liver injury Issued by China Food and Drug Administration显示文摘1. Introduction Drug-induced liver injury (DILI), defined as liver injury caused by a drug and/or its metabolites, is a common clinical adverse drug reaction1–4. This type of injury can cause acute liver failure and even death in severe cases5. | Xiaohe Xiao Jianyuan Tang Yimin Mao Xiuhui Li Jiabo Wang Chenghai Liu Kewei Sun Yong’an Ye Zhengsheng Zou Cheng Peng Ling Yang Yuming Guo Zhaofang Bai Tingting He Jing Jing Fengyi Li Na An | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 22 |
| 2 | Effect of quercetin on the expression of Bcl-2/Bax apoptotic proteins in endometrial cells of lipopolysaccharide-induced-abortion mice显示文摘OBJECTIVE: To explore the effect of quercetin on the expressions of Bcl-2/Bax apoptotic proteins in endometrial cells in mice with abortion induced by lipopolysaccharide.METHODS: For in vivo experiment, twenty five Kunming mice were randomly divided into five groups at day 4 of pregnancy, with 5 mice per group. The mice were treated with lipopolysaccharide(LPS)through tail vein intravenous injection at day 4 of pregnancy, followed by different concentrations of quercetin by oral gavage consecutively at days 5 to6 of pregnancy. On day 7 of gestation, the mice were sacrificed and the histopathological changes of the uterus tissues were observed. Immunohistochemical staining was applied to the detection of Bcl-2/Bax apoptotic proteins in the endometrial cells. For in vitro experiment, the primary endometrial cells werecultured using a uterus tissue mass culturing method sampled at day 4.5 of pregnancy. The cells were treated with LPS with or without different dosages of quercetin, respectively, for 12 h after 80% confluence. The expression of Bcl-2/Bax apoptotic proteins were detected by western blotting.RESULTS: Both the in vivo and in vitro experiments showed decreased expression of Bcl-2 and enhanced expression of Bax after LPS treatment, leading to a decreased Bcl-2/Bax ratio. The expression of Bcl-2 significantly increased while the expression of Bax was significantly elevated, in the LPS plus quercetin group compared to the LPS only group.CONCLUSION: These results suggest that quercetin has protective effect by partially regulating the expression of Bcl-2/Bax proteins, which in turn inhibits endometrial cell apoptosis and benefits the embryo implantation. | Wang Xiaodan Yan Yongping Yang Liu Li Mu Zhong Xiuhui | 2016 | Journal of Traditional Chinese Medicine2016，36，6： | 7 |
| 3 | Enhancing the dynamic electron transfer of Au species on wormhole-like TS-1 for boosting propene epoxidation performance with H_(2) and O_(2)显示文摘Engineering unique electronic structure of catalyst to boost catalytic performance is of prime scientific and industrial importance.Herein,the identification of intrinsic electronic sensitivity for direct propene epoxidation was first achieved over highly stable Au/wormhole-like TS-1 catalyst.Results show that the electron transfer of Au species can be regulated by manipulating the dynamic evolutions and contents of Au valence states,thus resulting in different catalytic performance in 100 h time-on-stream.By DFT calculations,kinetic analysis and multicharacterizations,it is found that the Au^(0) species with higher electronic population can easily transfer more electrons to activate surface O_(2) compared with Au^(1+) and Au^(3+) species.Moreover,there is a positive correlation between Au^(0) content and activity.Based on this correlation,a facile strategy is further proposed to boost Au^(0) percentage,resulting in the reported highest PO formation rate without adding promoters.This work harbors tremendous guiding significance to the design of highly efficient Au/Ti-containing catalyst for propene epoxidation with H_(2) and O_(2). | Dong Lin Xiuhui Zheng Xiang Feng Nan Sheng Zhaoning Song Yibin Liu Xiaobo Chen Zhenping Cai De Chen Chaohe Yang | 2020 | Green Energy & Environment2020，5，4： | 1 |
| 4 | Study of the adsorption kinetics of thiol-derivatized porphyrinon the surface of gold electrode显示文摘 | Guofang Zuo Xiuhui Liu Jiandong Yang | 2007 | Journal of Electroanalytical Chemistry2007，，605： | 1 |
| 5 | Silver nanocubes monolayers as a SERS substrate for quantitative analysis显示文摘Surface-enhanced Raman scattering(SERS)is a powerful spectroscopic tool in quantitative analysis of molecules,where the substrate plays a critical role in determining the detection performance.Herein,a silver nanocubes/polyelectrolyte/gold film sandwich structure was prepared as a reproducible,highperformance SERS substrate by the wate r/oil inte rfacial assembly method.In addition to the hot spots on the nanocubes surface,the edge-to-edge interspace of the Ag nanocubes led to marked enhancement of the SERS intensity,with a limit of detection of 10~(11)mol/L and limit of quantitation of 10~(10)mol/L for crystal violet.When rhodamine 6 G and crystal violet were co-adsorbed on the Ag nanocube surfaces,the characteristic SERS peaks of the two molecules remained well resolved and separated,and the peak intensities varied with the respective concentration,which could be exploited for concurrent detection of dual molecules.Results from this work indicate that organized ensembles of Ag nanocubes can serve as effective SERS substrate can for sensitive analysis for complex molecular systems. | Ziang Zhou Xiuhui Bai Peishen Li Changzheng Wang Ming Guo Yang Zhang Peiren Ding Shaowei Chen Yunyun Wu Qiang Wang | 2021 | Chinese Chemical Letters2021，32，4： | 1 |
| 6 | Synthesis and Characterization of Porous Magnesium Aluminate Spinel by Hydrothermal Process显示文摘Magnesium aluminate spinel has a great prospect in catalyst supports due to the porous structure, good catalytic activity, high thermal stability and the presence of two active centers as acid and alkaline. The magnesium aluminate spinel powders were synthesized by a hydrothermal process. The samples were characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction and N2 adsorption-desorption isotherms, respectively. The particle surface with the laminated structure increases with the increase of hydrothermal temperature and hydrothermal time. The spinel has a worm-like porous structure, and the pores become smaller and well-distributed under hexadecyl trimethyl ammonium bromide condition. The phase of the spinel appears at 450°C and the perfect crystalline structure emerges at 600°C. The percentage of Mg Al2O4 spinel increases with the increase of heat treatment temperature. The spinel has a great specific surface area(i.e., 245.68–58.65 m2/g) when the calcinating temperature increases from 500 to 1200°C. Moreover, the specific surface area is 195.11 m2/g 1 at.% hexadecyl trimethyl ammonium bromide. | WANG Xiuhui DUAN Jinxia LU Shengbo YIN Jianlong SU Zhenguo GAO Hong YANG Jinlong | 2015 | Journal of the Chinese Ceramic Society2015，，1： | 1 |
| 7 | Kinetic determination of ascorbic acid by the B-Z oscillating chemical system显示文摘 | Jinzhang Gao Hua Yang Xiuhui Liu | 2001 | Talanta2001，55，： | 1 |
| 8 | Determination of glutamic acid by an oscillating chemical reaction using the analyte pulse perturbation technique显示文摘 | Gao Jinzhang Yang Hua Liu Xiuhui | 2002 | Talanta2002，57，1： | 1 |
| 9 | POSITIVITY-PRESERVING LOCAL DISCONTINUOUS GALERKIN METHOD FOR PATTERN FORMATION DYNAMICAL MODEL IN POLYMERIZING ACTIN FLOCKS显示文摘In this paper,we apply local discontinuous Galerkin(LDG)methods for pattern formation dynamical model in polymerizing actin focks.There are two main dificulties in designing effective numerical solvers.First of all,the density function is non-negative,and zero is an unstable equilibrium solution.Therefore,negative density values may yield blow-up solutions.To obtain positive numerical approximations,we apply the positivitypreserving(PP)techniques.Secondly,the model may contain stif source.The most commonly used time integration for the PP technique is the strong-stability-preserving Runge-Kutta method.However,for problems with stiff source,such time discretizations may require strictly limited time step sizes,leading to large computational cost.Moreover,the stiff source any trigger spurious filament polarization,leading to wrong numerical approximations on coarse meshes.In this paper,we combine the PP LDG methods with the semi-implicit Runge-Kutta methods.Numerical experiments demonstrate that the proposed method can yield accurate numerical approximations with relatively large time steps. | Xiuhui Guo Lulu Tian Yang Yang Hui Guo | 2023 | Journal of Computational Mathematics2023，41，4： | 0 |
| 10 | Analysis of the distribution characteristics of enterovirus types based on environmental surveillance from 2013 to 2021 in Fujian Province, China显示文摘Environmental surveillance (ES) is a useful approach for monitoring circulating viruses, including polioviruses (PVs) and non-polio enteroviruses (NPEVs). In this study, the results of nine years of ES from 2013 to 2021 at six sampling sites in three cities in Fujian Province, China, were summarized. It showed that the sewage samples contained abundant viruses, but the positive rate was affected by different sampling sites. From the 520 samples, 431 PVs, 1,713 NPEVs, and 281 human adenoviruses (HAdVs) were isolated. PV isolates had been markedly affected following the adjustment of the immunization strategy. All but one PV isolate were Sabin-like strains without wild PVs. One isolate was vaccine-derived PV type 3 with 10 variation points in theVP1 region. After May 2016, PV type 2 was no longer detected, and PV type 3 became a superior serotype. Of 1,713 NPEVs, 24 serotypes were identified, including echovirus11 (E11), E6, coxsackievirus B3 (CVB3), CVB5, E7, and E3 were the predominant serotypes (37.65%, 20.96%, 11.50%, 8.87%, 8.23%, and 7.06%, respectively). The temporal dynamic of the six common serotypes was inconsistent. E3 was frequently isolated, but the number of isolates was low, with no obvious peaks. E6, E7, and CVB3 exhibited periodic changes with a high peak every three to four years, and E11 only had one high peak lasting four years. Summer-fall peaks of the echoviruses and spring-winter peaks of CVB were observed in the monthly distribution of virus isolation. The infectious isolates of various serotypes of different species identified from the sewage samples showed that ES is an essential part of pathogen surveillance. | Xiuhui Yang Shaojian Cai Xiaoqian Wu Yong Zhang Dong Li Yahong Chen Qianjing Chen Shuangli Zhu Dongmei Yan Wenbo Xu Hairong Zhang Zhifei Chen Suhan Zhang Yong Zhou Mengping Zhang Ningxuan Zheng Na You | 2023 | Biosafety and Health2023，5，4： | 0 |
| 11 | Estimation of inverse Compton peak frequency for 4FGL Blazars显示文摘This study uses a parabolic equation to fit the Inverse Compton (IC) spectral component of 3743 blazars (794 FSRQs,1432 BLLacs,and 1517 BCUs) from the 4FGL-DR3 catalog.Some mutual correlations are investigated,and a Bayesian classification is performed to the IC peak frequencies.Our analyses draw the following conclusions:(1) The Bayesian classification shows two components with a dividing boundary of log(v_(p)^(IC)/Hz)pIC=22.9.Therefore,the 3743 blazars are divided into low IC peak frequency(LCP) blazars and high IC peak frequency (HCP) blazars.(2) A strong linear correlation exists between IC peak frequency(logv_(p)^(IC)) and γ-ray photon spectral index (Γ).The IC peak frequency can be estimated by an empirical relation logv_(p)^(IC)=–4.5·Γ+32.8 for BL Lacs and logv_(p)^(IC)=4.0+31.4pICfor FSRQs,which is consistent with the result by Abdo et al.(3) The ICspectral curvature and IC peak frequency are not as closely related as the synchrotron curvature and the synchrotron peak frequency.(4) An anti-correlation exists between IC peak frequency and IC peak luminosity,implying that as the IC peak frequency in the γ-ray band decreases,the source becomes more luminous.The beaming effect is stronger for the source with a lower IC peak frequency.(5) Positive correlations exist between IC and synchrotron components for both peak frequencies and peak fluxes,but no clear correlation exists between IC curvature and synchrotron curvature. | JiangHe Yang JunHui Fan Yi Liu ManXian Tuo ZhiYuan Pei WenXin Yang YuHai Yuan SiLe He ShengHui Wang XiaoHai Qu YueLian Zhang JianJun Nie XiuHui Chen | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，4： | 0 |
| 12 | Enlarged fins of Tibetan catfish provide new evidence of adaptation to high plateau显示文摘The uplift of the Tibetan Plateau significantly altered the geomorphology and climate of the Euroasia by creating large mountains and rivers.Fishes are more likely to be affected relative to other organisms,as they are largely restricted to river systems.Faced with the rapidly flowing water in the Tibetan Plateau,a group of catfish has evolved greatly enlarged pectoral fins with more numbers of fin-rays to form an adhesive apparatus.However,the genetic basis of these adaptations in Tibetan catfishes remains elusive.In this study,we performed comparative genomic analyses based on the chromosome-level genome of Glyptosternum maculatum in family Sisoridae and detected some proteins with conspicuously high evolutionary rates in particular in genes involved in skeleton development,energy metabolism,and hypoxia response.We found that the hoxd12a gene evolved faster and a loss-of-function assay of hoxd12a supports a potential role for this gene in shaping the enlarged fins of these Tibetan catfishes.Other genes with amino acid replacements and signatures of positive selection included proteins involved in low temperature(TRMU)and hypoxia(VHL)responses.Functional assays reveal that the G.maculatum TRMU allele generates more mitochondrial ATP than the ancestral allele found in low-altitude fishes.Functional assays of VHL alleles suggest that the G.maculatum allele has lower transactivation activity than the low-altitude forms.These findings provide a window into the genomic underpinnings of physiological adaptations that permit G.maculatum to survive in the harsh environment of the Tibetan Himalayas that mirror those that are convergently found in other vertebrates such as humans. | Liandong Yang Ning Sun Honghui Zeng Ying Wang Wenjun Chen Zufa Ding Yang Liu Jing Wang Minghui Meng Yanjun Shen Jingliang Kang Xiuhui Ma Wenqi Lv Juan Chen Axel Meyer Baocheng Guo Shunping He | 2023 | Science China(Life Sciences)2023，66，7： | 0 |
| 13 | Non-Relativistic and Low Mach Number Limits of a Compressible Full MHD-P1 Approximate Model Arising in Radiation Magnetohydrodynamics显示文摘In this paper we study the non-relativistic and low Mach number limits of strong solutions to a full compressible MHD-P1 approximate model arising in radiation magnetohydrodynamics.We prove that,as the parameters go to zero,the solutions of the primitive system converge to that of the classical incompressible magnetohydrodynamic equations. | Xiuhui Yang | 2017 | Journal of Mathematical Study2017，50，4： | 0 |
| 14 | Free radicals induced ultra-rapid synthesis of N-doped carbon sphere catalyst with boosted pyrrolic N active sites for efficient acetylene hydrochlorination显示文摘Activated carbon-supported HgCl2 catalysts have seriously impeded the development of the polyvinyl chloride(PVC)industry due to the sublimation of Hg species and environmental pollution problems.Herein,the template-free and organic solvent-free strategy was devised to synthesize non-metallic based nitrogen-doped carbon(U-NC)sphere catalyst for acetylene hydrochlorination.This green strategy via ultrasonic chemistry initiates resin crosslinking reactions between aminophenol and formaldehyde resin by free radicals,leading to the ultra-rapid formation of U-NC with remarkably high pyrrolic N content in only 5 min.This U-NC catalyst exhibited an outstanding space-time-yield(1.6 gVCM·gcat^(−1)·h^(−1)),even comparable to the reported metallic catalyst.By combining kinetic analysis,advanced characterizations,density functional theory,it is found that the amount of pyrrolic N is in linear with C_(2)H_(2)conversion,pyrrolic N in U-NC can effectively improve acetylene hydrochlorination performance by mediating HCl adsorption.This work sheds new light on rationally constructing metal-free catalyst for acetylene hydrochlorination. | Yuxiang Bao Xiuhui Zheng Jianlin Cao Shuo Li Yongxiao Tuo Xiang Feng Mingyuan Zhu Bin Dai Chaohe Yang De Chen | 2023 | Nano Research2023，16，5： | 0 |
| 15 | The missing base molecules in atmospheric acid–base nucleation显示文摘Transformation of low-volatility gaseous precursors to new particles affects aerosol number concentration,cloud formation and hence the climate.The clustering of acid and base molecules is a major mechanism driving fast nucleation and initial growth of new particles in the atmosphere.However,the acid–base cluster composition,measured using state-of-the-art mass spectrometers,cannot explain the measured high formation rate of new particles.Here we present strong evidence for the existence of base molecules such as amines in the smallest atmospheric sulfuric acid clusters prior to their detection by mass spectrometers.We demonstrate that forming(H_(2)SO_(4))1(amine)1 is the rate-limiting step in atmospheric H_(2)SO_(4)-amine nucleation and the uptake of(H_(2)SO_(4))1(amine)1 is a major pathway for the initial growth of H_(2)SO_(4)clusters.The proposed mechanism is very consistent with measured new particle formation in urban Beijing,in which dimethylamine is the key base for H_(2)SO_(4)nucleation while other bases such as ammonia may contribute to the growth of larger clusters.Our findings further underline the fact that strong amines,even at low concentrations and when undetected in the smallest clusters,can be crucial to particle formation in the planetary boundary layer. | Runlong Cai Rujing Yin Chao Yan Dongsen Yang Chenjuan Deng Lubna Dada Juha Kangasluoma Jenni Kontkanen Roope Halonen Yan Ma Xiuhui Zhang Pauli Paasonen Tuukka Petaja Veli-Matti Kerminen Yongchun Liu Federico Bianchi Jun Zheng Lin Wang Jiming Hao James N.Smith Neil M.Donahue Markku Kulmala Douglas R.Worsnop Jingkun Jiang | 2022 | National Science Review2022，9，10： | 0 |
| 16 | Stability of the Equilibrium to the Boltzmann Equation with Large Potential Force显示文摘The Boltzmann equation with external potential force exists a unique equilibrium—local Maxwellian. The author constructs the nonlinear stability of the equilibrium when the initial datum is a small perturbation of the local Maxwellian in the whole space R^3. Compared with the previous result [Ukai, S., Yang, T. and Zhao, H.-J.,Global solutions to the Boltzmann equation with external forces, Anal. Appl.(Singap.), 3,2005, 157–193], no smallness condition on the Sobolev norm H^1 of the potential is needed in our arguments. The proof is based on the entropy-energy inequality and the L^2-L~∞ estimates. | Xiuhui YANG | 2018 | Chinese Annals of Mathematics,Series B2018，39，5： | 0 |
| 17 | A local discontinuous Galerkin method for the pattern formation dynamical model in polymerizing action flocks显示文摘In this paper,we apply local discontinuous Galerkin methods to the pattern formation dynamical model in polymerizing action flocks.Optimal error estimates for the density and filament polarization in different norms are established.We use a semi-implicit spectral deferred correction time method for time discretization,which allows a relative large time step and avoids computation of a Jacobian matrix.Numerical experiments are presented to verify the theoretical analysis and to show the capability for simulations of action wave formation. | Lulu Tian Xiuhui Guo Hui Guo Maosheng Jiang Yang Yang Jiansong Zhang | 2022 | Science China Mathematics2022，65，4： | 0 |
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