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| 1 | A Novel Coronavirus Genome Identified in a Cluster of Pneumonia Cases--Wuhan,China 2019−2020显示文摘Emerging and re-emerging pathogens are great challenges to the public health(1).A cluster of pneumonia cases with an unknown cause occurred in Wuhan starting on December 21,2019.As of January 20,2020,a total of 201 cases of pneumonia in China have been confirmed.A team of professionals from the National Health Commission and China CDC conducted epidemiological and etiological investigations.On January 3,2020,the first complete genome of the novelβgenus coronaviruses(2019-nCoVs)was identified in samples of bronchoalveolar lavage fluid(BALF)from a patient from Wuhan by scientists of the National Institute of Viral Disease Control and Prevention(IVDC)through a combination of Sanger sequencing,Illumina sequencing,and nanopore sequencing.Three distinct strains have been identified,the virus has been designated as 2019-nCoV,and the disease has been subsequently named novel coronavirus-infected pneumonia(NCIP). | Wenjie Tan Xiang Zhao Xuejun Ma Wenling Wang Peihua Niu Wenbo Xu George F.Gao Guizhen Wu | 2020 | China CDC weekly2020，2，4： | 95 |
| 2 | Grhl3 induces human epithelial tumor cell migration and invasion via downregulation of E-cadherin显示文摘Grainyhead 基因涉及愈合弯屈和发展神经试管闭合。转移在细胞从主要肿瘤的地点传播哪个癌症并且在远器官建立第二等的肿瘤期间是一个 multistep 过程。粘附蛋白质 E-cadherin 在转移起一个必要作用。考虑到在在皮或乳癌发生在侵略的获得期间的愈合创伤的过程和 EMT 发生的 epithelialmesenchymal 转变(EMT ) 的类似的高度,我们在癌症侵略调查了 Grainyhead 基因的角色。这里,我们证明在象 Grainyhead 一样之间有一种反的关系 3 (Grhl3 ) 并且在某上皮的肿瘤房间的 E-cadherin 表示排队。在 E-cadherin-positive 上皮的肿瘤房间线的 Grhl3 的 Overexpression,由更少的侵略描绘了,产生了 E-cadherin 基因的 transcriptional 阻塞并且支持了房间移植和房间侵略。相反地, Grhl3 弄空禁止了房间移植和房间侵略并且与 E-cadherin 表示的获得被联系。为了推进,探索 Grhl3 由调整了 E-cadherin 表示的机制, E-cadherin 倡导者报告分析被表现,结果出现了那 Grhl3 镇压 E-cadherin 基因表示由对在近似 E-cadherin 倡导者在场的电子盒子直接或间接地有约束力。一起拿,我们的调查结果在癌症房间由 E-cadherin 的 downregulation 在移植和侵略的正式就职为 Grhl3 定义一个主要角色。 | Pan Zhao Sijia Guo Zhenzhen Tu Lijun Di Xiaoiun Zha Haisheng Zhou Xuejun Zhang | 2016 | Acta Biochimica et Biophysica Sinica2016，0，3： | 9 |
| 3 | Investigation on a vertical radial flow adsorber designed by a novel parallel connection method显示文摘Due to the increasing global demand for industrial gas, the development of large-scale cryogenic air separation systems has attracted considerable attention in recent years. Increasing the height of the adsorption bed in a vertical radial flow adsorber used in cryogenic air separation systems may efficiently increase the treatment capacity of the air in the adsorber. However, uniformity of the flow distribution of the air inside the adsorber would be deteriorated using the height-increasing method. In order to reduce the non-uniformity of the flow distribution caused by the excessive height of adsorption bed in a vertical radial flow adsorber, a novel parallel connection method is proposed in the present work. The experimental apparatus is designed and constructed; the Computational Fluid Dynamics(CFD) technique is used to develop a CFD-based model, which is used to analyze the flow distribution, the static pressure drop and the radial velocity in the newly designed adsorber. In addition, the geometric parameters of annular flow channels and the adsorption bed thickness of the upper unit in the parallelconnected vertical radial flow adsorber are optimized, so that the upper and lower adsorption units could be penetrated by air simultaneously. Comparisons are made between the height-increasing method and the parallel connection method with the same adsorber height. It is shown that using the parallel connection method could reduce the difference between the maximum and minimum radial static pressure drop by 86.2% and improve the uniformity by 80% compared with those of using the height-increasing method. The optimal thickness ratio of the upper and lower adsorption units is obtained as 0.966, in which case the upper and lower adsorption units could be penetrated by air simultaneously, so that the adsorbents in adsorption space could be used more efficiently. | Zhengshu Dai Meng Yu Daozhe Rui Xuejun Zhang Yang Zhao | 2018 | Chinese Journal of Chemical Engineering2018，26，3： | 9 |
| 4 | In situ plasmonic optical fiber detection of the state of charge of supercapacitors for renewable energy storage显示文摘In situ and continuous monitoring of electrochemical activity is key to understanding and evaluating the operation mechanism and efficiency of energy storage devices.However,this task remains challenging.For example,the present methods are not capable of providing the real-time information about the state of charge(SOC)of the energy storage devices while in operation.To address this,a novel approach based on an electrochemical surface plasmon resonance(SPR)optical fiber sensor is proposed here.This approach offers the capability of in situ comprehensive monitoring of the electrochemical activity(the electrode potential and the SOC)of supercapacitors(used as an example).The sensor adopted is a tilted fiber Bragg grating imprinted in a commercial single-mode fiber and coated with a nanoscale gold film for high-efficiency SPR excitation.Unlike conventional“bulk”detection methods for electrode activity,our approach targets the“localized”(sub-μm-scale)charge state of the ions adjacent to the electrode interface of supercapacitors by monitoring the properties of the SPR wave on the fiber sensor surface located adjacent to the electrode.A stable and reproducible correlation between the real-time charge–discharge cycles of the supercapacitors and the optical transmission of the optical fiber has been found.Moreover,the method proposed is inherently immune to temperature cross-talk because of the presence of environmentally insensitive reference features in the optical transmission spectrum of the devices.Finally,this particular application is ideally suited to the fundamental qualities of optical fiber sensors,such as their compact size,flexible shape,and remote operation capability,thereby opening the way for other opportunities for electrochemical monitoring in various hard-to-reach spaces and remote environments. | Jiajie Lao Peng Sun Fu Liu Xuejun Zhang Chuanxi Zhao Wenjie Mai Tuan Guo Gaozhi Xiao Jacques Albert | 2018 | Light(Science & Applications)2018，7，1： | 8 |
| 5 | Spatial and vertical variations of perfluoroalkyl substances in sediments of the Haihe River,China显示文摘The levels of six perfluoroalkyl substances(PFASs) in surface sediment and their vertical variations in dated sediment cores from the Haihe River were investigated; studied substances included perfluorooctanoic acid(PFOA),perfluorononanoic acid(PFNA),perfluorooctane sulfonate(PFOS),perfluorodecanoic acid(PFDA),perfluoroundecanoic acid(PFUnA),and perfluorododecanoic acid(PFDoA). Results showed that the total PFAS concentration in surface sediment ranged between 0.52 and 16.33 ng/g dry weight(dw) with an average of3.47 ng/g dw,with PFOS and PFOA as the dominant PFASs. In general,the PFAS concentrations in the mainstream increased from the upper to the lower reaches,except that a drop occurred downstream of the Erdao dam. Although the PFASs in the sediment cores did not show a clear decreasing or increasing trend with depth,the three cores had a similar vertical variation.The PFAS levels were relatively low in the surface sediment,and reached the first high point at8–20 cm as a result of the wide use of PFASs from 1990 to 2000. After that the PFAS levels decreased,and then increased to a second high point at about 40–48 cm,which might be caused by the leaching of PFASs in sediment. Because PFASs have hydrophilic groups and relatively high solubility,the PFASs will transfer from the upper to lower layers of sediment when water infiltration occurs,leading to the fluctuation of PFAS levels in sediment cores. This study suggests that both the temporal variation of sources and transfer processes of PFASs in sediments are important factors influencing the vertical variation of PFASs in sediment cores. | Xiuli Zhao Xinghui Xia Shangwei Zhang Qiong Wu Xuejun Wang | 2014 | Journal of Environmental Sciences2014，26，8： | 8 |
| 6 | Cloning and functional characterization of Rht8,a“Green Revolution”replacement gene in wheat显示文摘Dear Editor,Wheat(Triticum aestivum)is a major staple crop in the world and provides~20%of the food calories for human consumption(Appels et al.,2018).During the 1960s and 1970s,the introduction of two semi-dwarfing genes Rht-B1b and Rht-D1b in wheat varieties strikingly improved lodging resistance and harvest index,and therefore substantially increased grain yield,resulting in the well-known'Green Revolution'(Peng et al.,1999).However,plants carrying Rht-B1b and Rht-D1b suffer from several drawbacks. | Hongchun Xiong Chunyun Zhou Meiyu Fu Huijun Guo Yongdun Xie Linshu Zhao Jiayu Gu Shirong Zhao Yuping Ding Yuting Li Jiazi Zhang Ke Wang Xuejun Li Luxiang Liu | 2022 | Molecular Plant2022，15，3： | 7 |
| 7 | Industrial and Agricultural Effects on Water Environment and Its Optimization in Heavily Polluted Area in Taihu Lake Basin, China显示文摘The deteriorating water quality in the Taihu Lake Basin has attracted widespread attention for many years, and is correlated with a sharp increase in the quantity of pollutant discharge such as agricultural fertilizers and industrial wastewater. In this study, several factors were selected for evaluating and regionalizing the water environmental capacity by ArcGIS spatial analysis, including geomorphologic characteristics, water quality goals, water body accessibility, water-dilution channels, and current water quality. Then, the spatial optimization of agriculture and industry was adjusted through overlay analysis, based on the balance between industrial space and water environmental capacity. The results show that the water environmental capacity gradually decreases from the west to the east, in contrast, the pollution caused by industrial and agricultural clustering is distributes along Taihu Lake, Gehu Lake and urban districts. The analysis of the agricultural space focuses on optimizing key protected areas of the Taihu Lake Basin, and the shores of Gehu Lake, optimally adjusting the second protected areas of the Taihu Lake Basin, and generally adjusting the urban areas of Changzhou and Wuxi cities. The analysis of industrial space focuses on optimizing the downtowns of Changzhou and Wuxi cities, optimally adjusting key protected areas and second protected areas of the Taihu Lake Basin, and generally adjusting the south and southwest of Gehu Lake. Lastly, some schemes of industrial and agricultural layouts and policies for the direction of industrial and agricultural development were proposed, reflecting a correlation between industry and agriculture and the water environment. | ZHAO Haixia YOU Bensheng DUAN Xuejun Stewart BECKY JIANG Xiaowei | 2013 | Chinese Geographical Science2013，23，2： | 7 |
| 8 | Characterization of particulate products for aging of ethylbenzene secondary organic aerosol in the presence of ammonium sulfate seed aerosol显示文摘Aging of secondary organic aerosol(SOA) particles formed from OH– initiated oxidation of ethylbenzene in the presence of high mass(100–300 μg/m^3) concentrations of(NH_4)_2SO_4seed aerosol was investigated in a home-made smog chamber in this study.The chemical composition of aged ethylbenzene SOA particles was measured using an aerosol laser time-of-flight mass spectrometer(ALTOFMS) coupled with a Fuzzy C-Means(FCM) clustering algorithm.Experimental results showed that nitrophenol,ethyl-nitrophenol,2,4-dinitrophenol,methyl glyoxylic acid,5-ethyl-6-oxo-2,4-hexadienoic acid,2-ethyl-2,4-hexadiendioic acid,2,3-dihydroxy-5-ethyl-6-oxo-4-hexenoic acid,1H-imidazole,hydrated N-glyoxal substituted1H-imidazole,hydrated glyoxal dimer substituted imidazole,1H-imidazole-2-carbaldehyde,N-glyoxal substituted hydrated 1H-imidazole-2-carbaldehyde and high-molecular-weight(HMW) components were the predominant products in the aged particles.Compared to the previous aromatic SOA aging studies,imidazole compounds,which can absorb solar radiation effectively,were newly detected in aged ethylbenzene SOA in the presence of high concentrations of(NH_4)_2SO_4seed aerosol.These findings provide new information for discussing aromatic SOA aging mechanisms. | Mingqiang Huang Jiahui Zhang Shunyou Cai Yingmin Liao Weixiong Zhao Changjin Hu Xuejun Gu Li Fang Weijun Zhang | 2016 | Journal of Environmental Sciences2016，28，9： | 6 |
| 9 | Bushen Qiangjin capsule(补肾强筋胶囊) inhibits the Wnt/β-catenin pathway to ameliorate papain-induced knee osteoarthritis in rats显示文摘OBJECTIVE:To evaluate the molecular mechanism underlying the beneficial effect of Bushen Qiangjin capsule(补肾强筋胶囊,BSQJ),a Traditional Chinese Medicine,on knee osteoarthritis(KOA).METHODS:In the present study,32 female Sprague-Dawley rats were randomly divided into four groups:control,KOA,high-dose BSQJ(H-BSQJ),and low-dose BSQJ(L-BSQJ).After successfully establishing the KOA model by intra-articular injection of papain,H-BSQJ and L-BSQJ groups were intragastrically administered 0.243 and 0.122 g/kg BSQJ,respectively,daily for 6 weeks.At the end of the experiment,knee articular cartilage tissues of rats were collected for evaluation by hematoxylin and eosin staining,Safranin O-Fast Green staining,and terminal deoxynucleotidyl transferase-mediated d UTP nick-end labeling assay.Serum interleukin-1βand tumor necrosis factor-αlevels of rats were detected with an enzyme-linked immunosorbent assay method.Gene expression of Wnt-4,β-catenin,Frizzled-2,glycogen synthase kinase-3β(GSK-3β),cysteinyl aspartate-specific proteinases 3 and 9(caspases 3 and 9),collagen typeⅡalpha 1(Col2 a1),and matrix metalloproteinases 1 and 13(MMP-1 and MMP-3)of rat knee articular cartilage was quantified by reverse transcription-quantitative polymerase chain reaction analysis.Wnt-4,β-catenin,Frizzled-2,GSK-3β,cleaved caspase-3,and cleaved caspase-9 protein expression in rat knee articular cartilage was determined by western blot analysis.RESULTS:BSQJ obviously reduced pathological damage and matrix degradation of articular cartilage in KOA rats.Compared with the KOA group,H-BSQJ rats exhibited downregulated m RNA and protein expression of Wnt-4,β-catenin,Frizzled-2,and caspase-3,as well as upregulated m RNA and protein expression of GSK-3β.In addition,H-BSQJ significantly increased m RNA expression of Col2 a1 and decreased m RNA expression of MMP-1 and MMP-13.CONCLUSION:BSQJ exerted a beneficial effect on KOA by a mechanism involving downregulation of the Wnt/β-catenin pathway,which inhibited both cartilage extracellular matrix degradation and chondrocyte apoptosis to ameliorate KOA in rats. | YAO Nan CHEN Guocai LU Yanyan XU Xuemeng ZHAO Chuanxi HUANG Xuejun LIU Wengang PENG Sha WU Huai | 2021 | Journal of Traditional Chinese Medicine2021，41，6： | 5 |
| 10 | Phase Ⅱ open-label study of recombinant circularly permuted TRAIL as a single-agent treatment for relapsed or refractory multiple myeloma显示文摘Background: Despite the recent development of new therapies, multiple myeloma(MM) remains an incurable disease. Thus, new, efective treatments are urgently needed, particularly for relapsed or refractory MM(RRMM). In an earlier phase I study, a novel form of recombinant human Apo2L/tumor necrosis factor-related apoptosis-inducing ligand(TRAIL) that is currently in clinical development for the treatment of hematologic malignancies, i.e., circularly permuted TRAIL(CPT), was well tolerated at a dose of 2.5 mg/kg per day and showed promising preliminary activity in patients with RRMM. This phase II, open-label, multicenter study further investigated the eicacy and safety of 2.5-mg/kg per day CPT as single-agent therapy for patients with RRMM.Methods: Patients with RRMM were treated once daily with CPT(2.5 mg/kg, intravenously) for 14 consecutive days for each 21-day cycle. Clinical response and toxicity were assessed after each treatment cycle.Results: Twenty-seven patients received CPT. Using the European Group for Blood and Marrow Transplantation criteria, we calculated the overall response rate of 33.3% with 1 near-complete response(n CR) and 8 partial responses(PRs). The clinical beneit rate(48.1%) included 1 nCR, 8 PRs, and 4 minimal responses. The most common treatmentrelated adverse events(TRAEs) were fever, aspartate aminotransferase elevation, alanine aminotransferase elevation, leucopenia, rash, neutropenia, and thrombocytopenia. We graded toxicity using the Common Toxicity Criteria for Adverse Events, version 3.0, and determined that 37.0% of patients had at least 1 grade 3–4 TRAE.Conclusions: CPT as a single agent can elicit a response in patients with RRMM and is well tolerated. Further clinical investigation is warranted. | Yun Leng Lugui Qiu Jian Hou Yaozhong Zhao Xuejun Zhang Shifang Yang Hao Xi Zhongxia Huang Ling Pan Wenming Chen | 2016 | Chinese Journal of Cancer2016，35，12： | 4 |
| 11 | Mechanism and effect of Shijueming (Concha Haliotidis) on serum calcium in spontaneously hypertensive rats显示文摘OBJECTIVE: To observe the impact of Shijueming (Concha Haliotidis) on spontaneously hypertensive rats via blood pressure, serum calcium, vascular smooth muscle membrane L-type calcium channel α1 C subunit (CaL-α1C), plasma membrane calcium-ATPase (PMCA) mRNA expression, and the L-type calcium channel in vascular smooth muscle cells. METHODS:Twelve-week-old male rats with spontaneous hypertension were divided into three groups: a Shijueming (Concha Haliotidis) group (group 1), a nifedipine group (group 2), and a distilled water group (group 3). All were given a four-week treatment. Blood pressure and dissociative serum calcium were examined before treatment. Blood pressure was taken every week during treatment. Atomic absorption spectrometry was used to examine dissociative serum calcium. Re-verse transcription-polymerase chain reaction was used to examine the expression of CaL-α1C and PM-CA1 mRNA. The patch clamp technique was used to examine the electrophysiological characteristics of the vascular smooth muscle cell calcium channels. RESULTS: After treatment, blood pressure of the Shijueming (Concha Haliotidis) group lowered but not significantly (P>0.05). Blood pressure of the nifedipine group lowered significantly (P<0.05). Blood pressure of the distilled water group remained high. The concentration of serum calcium in the Shijueming (Concha Haliotidis) and the distilled water groups lowered (P<0.05). Expression of CaL-α1C mRNA in the nifedipine group decreased compared with the distilled water group (P<0.01). There was the decreasing trend in the Shijueming (Concha Haliotidis) group, but it was not statistically significant. Shijueming (Concha Haliotidis) also had effects on the expression of PMCA1 mRNA but with- out statistical significance. However, there was a significant decreasing effect on vascular smooth muscle cell I Ca-L flow. CONCLUSION: This study indicated that Shijueming (Concha Haliotidis) could increase serum calcium and decrease blood pressure. It may work by influencing calcium channels, expression of PMCA1 mRNA, and regulating ion calcium channels and calcium-ATPase. | Chao Chen Changlin Zhao Xuejun Wang Weili Li Xiaoyin Chen | 2013 | Journal of Traditional Chinese Medicine2013，33，3： | 4 |
| 12 | Further results on state feedback stabilization of stochastic high-order nonlinear systems显示文摘In this paper,a combined homogeneous domination and sign function design approach is presented to state feedback control for a class of stochastic high-order nonlinear systems with time-varying delay.The use of the combined approach relaxes the restriction on nonlinear functions and makes the closed-loop system globally asymptotically stable in probability. | XIE XueJun ZHAO CongRan DUAN Na | 2014 | Science China(Information Sciences)2014，57，7： | 4 |
| 13 | Development of an innovative one-step nested PCR strategy for virus detection using the LNA technique显示文摘Dear Editor,Polymerase chain reaction(PCR)is a molecular diagnostic technique that has been widely used for diagnosing viral diseases.Nested PCR(N-PCR)is a variation on the standard PCR technique that involves two amplification steps,yielding greater sensitivity and specificity.But there are two main disadvantages:the protocol is more complex than conventional PCR,and the risk of cross-contamination is relatively high.One-step nested PCR(OSN-PCR)enables conventional N-PCR to be performed as a closed reaction in a single tube that contains both outer and inner primers.This strategy makes OSN-PCR more rapid than N-PCR,lowers the probability of cross-contamination,and requires a smaller amount of reagents. | Ji Wang Li Zhao Zhihua Sun Guixia Li Peihua Niu DANDi Li Lianjun Wang Yi Zhang Zhishan Feng Xuejun Ma | 2019 | Science China(Life Sciences)2019，62，3： | 4 |
| 14 | Physiological levels of ATP negatively regulate proteasome function显示文摘由 ubiquitin-proteasome 系统的细胞内部的蛋白质降级是 ATP 依赖者,和最佳的 ATP 集中激活 proteasome 在 vitro 的功能是 ~ 100 渭 M。细胞内部的 ATP 层次在在这个范围以内的水平通常在低 millimolar 范围,而是 ATP 被显示在 vitro 禁止 proteasome peptidase 活动。这里,我们报导支持在生理的层次的细胞内部的 ATP 双向地调整的一个假设的新证据 26S proteasome 在房间的解朊的功能。首先,我们证实 ATP 在 vitro 在 26S proteasome 上施加了双向规定,与最佳的 ATP 集中(在 50 和 100 渭 M 之间) 刺激 proteasome 像糜蛋白酶的活动。第二,我们发现操作细胞内部的 ATP 层次也在有教养的房间在 proteasome 特定的蛋白质底层的层次导致了双向变化。最后,测量增加提高的细胞内部的 ATP,当减少的细胞内部的 ATP 稀释了导致房间死亡的 proteasome 抑制的能力时。这些数据强烈建议在生理的集中范围以内的内长的 ATP 能在 proteasome 活动施加否定影响,允许房间到很快,在应力下面的 ATP 减小上的 upregulate proteasome 活动调节。 | Hongbiao Huang Xiaoyan Zhang Shujue Li Ningning Liu Wen Elan Emily McDowell Ping Zhou Canguo Zhao Haiping Guo Change Zhang Changshan Yang Guangmei Wen Xiaoxian Dong Li Lu Ningfang Ma Weihua Dong Q Ping Dou Xuejun Wang Jinbao Liu | 2010 | Cell Research2010，20，12： | 4 |
| 15 | Hydrocarbon accumulation principles in troughs within faulted depressions and their significance in exploration显示文摘以前,在指责的消沉通常是的大陆人的马槽为烃累积看作了烃产生和逐出的一个地区而非一个地区。如果他们被证实是来源厨房,他们能组成潜在的戏的可能性将在随后的探索程序被俯看。在过去的几年里基于 Jizhong 消沉和 Erlian 盆的烃探索实践,这份报纸讨论水库分发被多重因素控制, lithological 累积是更可能的在马槽区域形成的新理解。在马槽区域控制大 lithological 烃累积的形成进一步记录三个主要因素。纸也讨论新概念结构并且 lithological 累积不仅共存而且补充对方。我们建议那个扇子三角洲在轻轻的斜坡上的马槽,三角洲前面和 sublacustrine 扇子的转换陡峭的斜坡上的前面,沿着差错陡坡的脚趾的隧道沙是为新油的发现的有利地点累积。这个概念的申请在 Jizhong 消沉和 Erlian 盆在马槽区域在地方导致了油的几百百万公吨的发现。 | Zhao Xianzheng Jin Fengming Wang Quan Lu Xuejun | 2011 | Petroleum Science2011，8，1： | 4 |
| 16 | Size distribution and chemical composition of secondary organic aerosol formed from Cl-initiated oxidation of toluene显示文摘Secondary organic aerosol (SOA) formed from Cl-initiated oxidation of toluene was investigated in a home-made smog chamber. The size distribution and chemical composition of SOA particles were measured using aerodynamic particle sizer spectrometer and the aerosol laser time-of-flight mass spectrometer (ALTOFMS), respectively. According to a large number of single aerosol diameter and mass spectra, the size distribution and chemical composition of SOA were obtained statistically. Experimental results showed that SOA particles created by Cl-initiated oxidation of toluene is predominantly in the form of fine particles, which have diameters less than 2.5 μm (i.e., PM2.5), and glyoxal, benzaldehyde, benzyl alcohol, benzoquinone, benzoic acid, benzyl hydroperoxide and benzyl methyl nitrate are the major products components in the SOA. The possible reaction mechanisms leading to these products are also proposed. | Mingqiang Huang Weijun Zhang Xuejun Gu Changjin Hu Weixiong Zhao Zhenya Wang Li Fang | 2012 | Journal of Environmental Sciences2012，24，5： | 3 |
| 17 | Identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge, Guyana显示文摘Here,we report the identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge,Guyana.In March 2019,14 employees of Chongqing Bosai Mining Company,China,working in a manganese mining of Guyana,had unexplained fever,and two of them died.We obtained lung and brain tissues as well as the blood samples from the two deceased cases(patient No.1 and 2),and bronchoscopy lavages and cerebrospinal fluid samples from one severe case(patient No.3),respectively.All samples were tested by pathological examination,high-throughput sequencing,and real-time PCR.Pathological detection showed the presence of spore-like structures in the lung tissue of patient No.1,indicating a fungal infection in this patient.Nanopore sequencing identified the existing of H.capsulatum in the lung tissue sample within 13 h.Next-generation sequencing identified specific fragments of H.capsulatum in all of the samples tested(lung,brain and blood serum from the deceased cases,and plasma from the severe case).Real-time PCR assays did not reveal any viral infection related to transmission from bat feces.We conclude that H.capsulatum was the causative pathogen of this disease cluster based on epidemiologic,clinical,pathological and nucleic acid evidence. | Ji Wang Weimin Zhou Hua Ling Xiaoping Dong Yi Zhang Jiandong Li Yong Zhang Jingdong Song William J.Liu Yang Li Ruiqing Zhang Wei Zhen Kun Cai Shuangli Zhu Dongyan Wang Jinbo Xiao Yigang Tong Wenli Liu Lihua Song Wei Wu Yang Liu Xiang Zhao Ruihuan Wang Sheng Ye Jing Wang Roujian Lu Baoying Huang Fei Ye Wenwen Lei Rongbao Gao Qi Shi Cao Chen Jun Han Wenbo Xu George F.Gao Xuejun Ma Guizhen Wu | 2019 | Biosafety and Health2019，1，3： | 3 |
| 18 | Challenges and strategies in high-accuracy manufacturing of the world’s largest SiC aspheric mirror显示文摘In the process of manufacturing the world’s largest silicon carbide(SiC)aspheric mirror,the primary difficulties are mirror blank preparation,asphere fabrication,and testing,as well as cladding and coating.Specifically,the challenges include the homogeneity of the complicated structure casting,accuracy and efficiency of the fabrication process,print-through effect,fidelity and precision of test procedure,stress and denseness of cladding process,the dynamic range of interferometric measurement,and air turbulence error due to the long optical path.To break through such a barrier of difficulties,we proposed the water-soluble room temperature vanishing mold and gel casting technology,homogeneous microstructure reaction-formed joint technology,nano-accuracy efficient compound fabrication,gravity unloading technology,high-denseness low-defect physical vapor deposition(PVD)Si-cladding technology,test data fusion method,and time-domain averaging method,etc.Based on the proposed technologies and methods,we have accomplished the world’s largest SiC aspheric mirror with a size of φ4.03 m.The impressive performance of the SiC aspheric mirror is validated by the characteristics of the fabricated SiC aspheric mirror.The aerial density of the SiC blank is less than 120 kg/m^(2),surface shape test accuracy is better than 6 nm RMS,thickness inhomogeneity of the cladding layer is less than 5%,and the final surface figure error and roughness are 15.2 nm RMS and 0.8 nm RMS,respectively. | Xuejun Zhang Haixiang Hu Xiaokun Wang Xiao Luo Ge Zhang Wenxing Zhao Xiaoyi Wang Zhenyu Liu Ling Xiong Erhui Qi Congcong Cui Yanchao Wang Yingjie Li Xu Wang Longxiang Li Yang Bai Qiang Cheng Zhiyu Zhang Ruigang Li Wa Tang Xuefeng Zeng Weijie Deng Feng Zhang | 2022 | Light(Science & Applications)2022，11，12： | 3 |
| 19 | Adenovirus-mediated LIGHT gene modification in murine B-cell lymphoma elicits a potent antitumor effect显示文摘Here,we investigated the antitumor effect of adenovirus-mediated gene transfer of LIGHT,the tumor-necrosis factor(TNF)superfamily member also known as TNFSF14,in the murine A20 B-cell lymphoma.LIGHT gene modification resulted in upregulated expression of Fas and the accessory molecule-intercellular adhesion molecule-1(ICAM-1)on A20 cells and led to enhanced A20 cell apoptosis.LIGHT-modified A20 cells effectively stimulated the proliferation of T lymphocytes and interferon(IFN)-c production in vitro.Immunization of BALB/c mice with a LIGHT-modified A20 cell vaccine efficiently elicited protective immunity against challenge with the parental tumor cell line.Adenovirus-mediated gene transfer of LIGHT by intratumoral injection exerted a very potent antitumor effect against pre-existing A20 cell lymphoma in BALB/c mice.This adenovirus-mediated LIGHT therapy induced substantial splenic natural killer(NK)and cytotoxic T lymphocyte(CTL)activity,enhanced tumor infiltration by inflammatory cells and increased chemokine expression of CC chemokine ligand 21(CCL21),IFN-inducible protein-10(IP-10)and monokine induced by IFN-c(Mig)from tumor tissues.Thus,adenovirus-mediated LIGHT therapy might have potential utility for the prevention and treatment of B-cell lymphoma. | Guili Hu Yang Liu Hong Li Dekuang Zhao Liuqing Yang Jiangen Shen Xuejun Hong Xuetao Cao Qingqing Wang | 2010 | Cellular & Molecular Immunology2010，7，4： | 3 |
| 20 | A real-time abnormal operation pattern detection method for building energy systems based on association rule bases显示文摘Expert systems are effective for anomaly detection in building energy systems.However,it is usually inefficient to establish comprehensive rule bases manually for complex building energy systems.Association rule mining is available to accelerate the establishment of the rule bases due to its powerful capability of discovering rules from numerous data.This paper proposes a real-time abnormal operation pattern detection method towards building energy systems.It can benefit from both expert systems and association rule mining.Association rules are utilized to establish association rule bases of abnormal and normal operation patterns.The established rule bases are then utilized to develop an expert system for real-time detection of abnormal operation patterns.The proposed method is applied to an actual chiller plant for evaluating its performance.Results show that 15 types of known abnormal operation patterns and 11 types of unknown abnormal operation patterns are detected successfully by the proposed method. | Chaobo Zhang Yang Zhao Yangze Zhou Xuejun Zhang Tingting Li | 2022 | Building Simulation2022，15，1： | 3 |
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