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| 1 | The material and biological characteristics of osteoinductive calcium phosphate ceramics显示文摘The discovery of osteoinductivity of calcium phosphate(Ca-P)ceramics has set an enduring paradigm of conferring biological regenerative activity to materials with carefully designed structural characteristics.The unique phase composition and porous structural features of osteoinductive Ca-P ceramics allow it to interact with signaling molecules and extracellular matrices in the host system,creating a local environment conducive to new bone formation.Mounting evidence now indicate that the osteoinductive activity of Ca-P ceramics is linked to their physicochemical and three-dimensional structural properties.Inspired by this conceptual breakthrough,many laboratories have shown that other materials can be also enticed to join the rank of tissue-inducing biomaterials,and besides the bones,other tissues such as cartilage,nerves and blood vessels were also regenerated with the assistance of biomaterials.Here,we give a brief historical recount about the discovery of the osteoinductivity of Ca-P ceramics,summarize the underlying material factors and biological characteristics,and discuss the mechanism of osteoinduction concerning protein adsorption,and the interaction with different types of cells,and the involvement of the vascular and immune systems. | Zhurong Tang Xiangfeng Li Yanfei Tan Hongsong Fan Xingdong Zhang | 2018 | Regenerative Biomaterials2018，5，1： | 20 |
| 2 | Development and utilization of a new chemically-induced soybean library with a high mutation density显示文摘Mutagenized populations have provided important materials for introducing variation and identifying gene function in plants. In this study, an ethyl methanesulfonate(EMS)-induced soybean(Glycine max) population,consisting of 21,600 independent M_2 lines, was developed.Over 1,000 M_(4(5))families, with diverse abnormal phenotypes for seed composition, seed shape, plant morphology and maturity that are stably expressed across different environments and generations were identified. Phenotypic analysis of the population led to the identification of a yellow pigmentation mutant, gyl, that displayed significantly decreased chlorophyll(Chl) content and abnormal chloroplast development. Sequence analysis showed that gyl is allelic to Minn Gold, where a different single nucleotide polymorphism variation in the Mg-chelatase subunit gene(ChlI1a) results in golden yellow leaves. A cleaved amplified polymorphic sequence marker was developed and may be applied to marker-assisted selection for the golden yellow phenotype in soybean breeding. We show that the newly developed soybean EMS mutant population has potential for functional genomics research and genetic improvement in soybean. | Zhongfeng Li Lingxue Jiang Yansong Ma Zhongyan Wei Huilong Hong Zhangxiong Liu Jinhui Lei Ying Liu Rongxia Guan Yong Guo Longguo Jin Lijuan Zhang Yinghui Li Yulong Ren Wei He Ming Liu Nang Myint Phyu Sin Htwe Lin Liu Bingfu Guo Jian Song Bing Tan Guifeng Liu Maiquan Li Xianli Zhang Bo Liu Xuehui Shi Sining Han Sunan Hua Fulai Zhou Lili Yu Yanfei Li Shuang Wang Jun Wang Ruzhen Chang Lijuan Qiu | 2017 | Journal of Integrative Plant Biology2017，59，1： | 6 |
| 3 | Remediation Technology for Combined Pollution of Lead and Cadmium in Farmland Soil显示文摘At present,the problem of heavy metal pollution in farmland in southern China is serious. Especially,the cadmium and lead are two heavy metal elements with serious pollution and great harm to human body. This paper reviewed some common methods and materials used in the control of cadmium and lead pollution in farmland soil. Then,it discussed the problems in the repair of cadmium and lead pollution in farmland soil. It came up with the future research direction,to provide references for remediation of lead and cadmium pollution in farmland soil. | Jun TAN Yongxian LIU Xiangfeng WEI Yanfei HUANG Liumei XIONG Liping PAN Jinping CHEN Bin LIU Chaolan ZHANG | 2018 | Asian Agricultural Research2018，10，9： | 3 |
| 4 | Immobilization of RGD Peptide onto the Surface of Apatite-Wollastonite Ceramic for Enhanced Osteoblast Adhesion and Bone Regeneration显示文摘The arginine-glycine-aspartic(RGD) acid peptide was grafted to the surface of apatitewollastonite(AW) ceramic in an effort to improve its cell adhesion, proliferation and osteoinduction. RGD peptide was covalently immobilized onto the surface of AW ceramic via the synthetic cross linker AAPTS-E and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide(EDC). The modified surfaces were characterized by attenuated total reflectance Fourier transform infrared spectroscopy(ATR-FTIR) and X-ray photoelectron spectroscopy(XPS). The chemical analysis indicated that RGD peptide had been immobilized onto the AW surface successfully. The growth of osteoblast-like cells(MG63) showed that modifying the AW surface with RGD peptide enhanced the cell adhesion and proliferation. And the histological evaluation of RGD-AW showed that the bone regeneration and remodeling process were signifi cantly enhanced compared to the original AW ceramics after 2, 4 and 8 weeks implantation in rabbit's femoral condyles. | 张翔 GU Jianwen ZHANG Yue TAN Yanfei ZHOU Jiabei 周大利 | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，3： | 2 |
| 5 | BLIND IDENTIFICATION OF A CLASS OF NONLINEAR SYSTEMS WITH CYCLOSTATIONARY INPUT显示文摘This letter deals with blind identification of nonlinear discrete Hammerstein system under the input signal that is cyclostationary. The first-order moment of the specific input as well as the inverse nonlinear mapping of the Hammerstein model are combined to establish a relationship between the system output and the system parameters, which implies an approach to identifying the system blindly. Simulation results demonstrate the effectiveness of this approach to blind identification of a class of nonlinear systems. | Fu Jian Zhu Yanfei Li Xiaodong Tan Hongzhou | 2008 | Journal of Electronics(China)2008，25，6： | 0 |
| 6 | Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma显示文摘Detailed characterizations of genomic alterations have not identified subtype-specific vulnerabilities in adult gliomas. Mapping gliomas into developmental programs may uncover new vulnerabilities that are not strictly related to genomic alterations. After identifying conserved gene modules co-expressed with EGFR or PDGFRA (EM or PM), we recently proposed an EM/PM classification scheme for adult gliomas in a histological subtype- and grade-independent manner. By using cohorts of bulk samples, paired primary and recurrent samples, multi-region samples from the same glioma, single-cell RNA-seq samples, and clinical samples, we here demonstrate the temporal and spatial stability of the EM and PM subtypes. The EM and PM subtypes, which progress in a subtype-specific mode, are robustly maintained in paired longitudinal samples. Elevated activities of cell proliferation, genomic instability and microenvironment, rather than subtype switching, mark recurrent gliomas. Within individual gliomas, the EM/PM subtype was preserved across regions and single cells. Malignant cells in the EM and PM gliomas were correlated to neural stem cell and oligodendrocyte progenitor cell compartment, respectively. Thus, while genetic makeup may change during progression and/or within different tumor areas, adult gliomas evolve within a neurodevelopmental framework of the EM and PM molecular subtypes. The dysregulated developmental pathways embedded in these molecular subtypes may contain subtype-specific vulnerabilities. | Jing Feng Zheng Zhao Yanfei Wei Zhaoshi Bao Wei Zhang Fan Wu Guanzhang Li Zhiyan Sun Yanli Tan Jiuyi Li Yunqiu Zhang Zejun Duan Xueling Qi Kai Yu Zhengmin Cong Junjie Yang Yaxin Wang Yingyu Sun Fuchou Tang Xiaodong Su Chuan Fang Tao Jiang Xiaolong Fan | 2023 | Frontiers of Medicine2023，17，2： | 0 |
| 7 | Identification of Tibetan Medical Material Dracocephalum tanguticum Maxim.显示文摘[Objectives]To explore morphological identification,macroscopical identification,microscopic identification,thin layer chromatography(TLC)identification of Tibetan medical material Dracocephalum tanguticum Maxim.,and provide experimental data for its identification and application.[Methods]The Tibetan medical material was identified by means of original plant,characters,powder,paraffin section and thin layer chromatography(TLC).[Results]Tibetan medical material D.tanguticum Maxim.was obviously distinguished in character identification and microscopic identification,and the TLC method was simple and feasible.[Conclusions]The results will provide the source work foundation for the formulation of the quality standard of Sichuan Province(draft)for Tibetan medicinal material'D.tanguticum Maxim.'and the development of pharmaceutical preparations for medical institutions. | Ling TAN Pei QUN Hongna SU Xuelian ZHAO Yisong LI Yanfei HUANG Yuan LIU | 2021 | Medicinal Plant2021，12，5： | 0 |
| 8 | Evolutionary PSO-based emergency monitoring geospatial edge service chain in the emergency communication network显示文摘Emergency communication networks play a vital role in disaster monitoring,transmission,and application during disaster emergency response(DER),however,the performance and stability of edge nodes in the emergency communication networks are often weak due to limited communication and computation resources.This weakness directly affects the quality,of service(Qos)of the geospatial edge service(GES)chains involved in emergency monitoring.Existing research predominantly addresses service compositions in stable environments,neglecting the aggregation of efficient and robust GES chains in emergency communication networks.This study proposes an evolutionary_particie swarm optimization(EPSO)-based emergency monitoring GES chain in an_emergency communication network.it includes a GES chain model of emergency environment monitoring for tailing areas,as well as the designs of the particle chromosome encoding method,fitness evaluation model,and particle chromosome swarm update operators of the EPSO-based GES chain.Finally,the study conducts emergency environment monitoring experiments for tailing areas using the proposed method.Experiments results demonstrate that the proposed method significantly enhances the efficiency,stability,and reliability of emergency monitoring GEs chains in the emergency communication network.This is crucial to providing fast and reliable services for DER during natural disasters. | Sheng He Xicheng Tan Yanfei Zhong Meng Huang Zhiyuan Mei You Wan Huaming Wang | 2023 | International Journal of Digital Earth2023，16，1： | 0 |
| 9 | GACS:Generative Adversarial Imitation Learning Based on Control Sharing显示文摘Generative adversarial imitation learning(GAIL)directly imitates the behavior of experts from human demonstration instead of designing explicit reward signals like reinforcement learning.Meanwhile,GAIL overcomes the defects of traditional imitation learning by using a generative adversary network framework and shows excellent performance in many fields.However,GAIL directly acts on immediate rewards,a feature that is reflected in the value function after a period of accumulation.Thus,when faced with complex practical problems,the learning efficiency of GAIL is often extremely low and the policy may be slow to learn.One way to solve this problem is to directly guide the action(policy)in the agents'learning process,such as the control sharing(CS)method.This paper combines reinforcement learning and imitation learning and proposes a novel GAIL framework called generative adversarial imitation learning based on control sharing policy(GACS).GACS learns model constraints from expert samples and uses adversarial networks to guide learning directly.The actions are produced by adversarial networks and are used to optimize the policy and effectively improve learning efficiency.Experiments in the autonomous driving environment and the real-time strategy game breakout show that GACS has better generalization capabilities,more efficient imitation of the behavior of experts,and can learn better policies relative to other frameworks. | Huaiwei SI Guozhen TAN Dongyu LI Yanfei PENG | 2023 | Journal of Systems Science and Information2023，11，1： | 0 |
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