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| 1 | FADD and TRADD expression and apoptosis in primary hepatocellular carcinoma显示文摘AIM To investigate the clinical features ofFADD and TRADD expressions in primaryhepatocellular carcinoma(HCC)and todetermine their relationship with hepaticapoptosis.METHODS FADD and TRADD expressions weredetected by immunohistochemistry and hepaticapoptosis were determined by in situ end-labeling(ISEL).RESULTS Ten(25.6%)cases of HCC weredetected to express FADD protein.The positiverate in HCC is lower than that in non-cancerousadjacent liver tissues(62.5%)(P<0.05).Inthose of grade Ⅰ-Ⅱ,8(38.1%)cases wereFADD positive,while only 2/18(11.1%)casesof grade Ⅲ-Ⅳ had detectable FADD protein(P<0.05).No relationship was found betweenFADD expression and other clinical features,such as gender,age,tumor size,differentiationor metastasis.ISEL positive cells can be seen inall cases of HCC.The hepatic apoptosis wasassociated with FADD expression as moreapoptotic cells were detected in those caseswhich had moderately to strongly positiveFADD,as compared with negative or weakpositive FADD cases(P<0.05).No relationshipwas found between FADD expression and hepaticapoptosis in non-cancerous adjacent livertissues.Fifteen of 39(38.5%)cases of HCCwere found positive for TRADD protein,andsimilar positive rate(37.5%)in non-cancerousadjacent liver tissues(P>0.05).The expressionof TRADD is correlated with HCC differentiation, as only 22.2% of moderately to highlydifferentiated HCC showed positive TRADDprotein,while as high as 52.4% of poorlydifferentiated HCC had TRADD(P<0.05),Norelationship was found between TRADDexpression and gender,age,tumor size or gradeor metastasis,although 42.9% of HCC of gradeⅠ/Ⅱ showed positive TRADD which wasslightly higher than that of grade Ⅲ/Ⅳ(33.3%,P>0.05).Hepatic apoptosis was not related toTRADD expression in HCC or non-cancerousadjacent liver tissues.CONCLUSION Loss of FADD expression playsan important role in HCC carcinogenesis,andexpression of TRADD also contributes to HCCdevelopment.The cell apoptosis in HCC isassociated with FADD expression.However,theexpression of TRADD does not correlate wellwith hepatic apoptosis in HCC. | Sun BH Zhao XP Wang BJ Yang DL Hao LJ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | Overexpression of P-glycoprotein in hepatocellular carcinoma and its clinical implication显示文摘INTRODUCTIONMost advanced hepatocellular garcinoma (HCC) isinsensitive to most anticancer drugs which might berelated to the high frequency of expression of themultidrug resistance-1(MDR1) gene and itsproduct,P-glycoprotein (p-gp).p-gp expressionmay also be concerned with tumor progression anddifferentiation.In the present study。 | Kong XB Yang ZK Liang LJ Huang JF Lin HL | 2000 | World Journal of Gastroenterology2000，6，1： | 13 |
| 3 | Noninvasive diagnosis of bron- chial artery aneurysm using dual-source computed tomography angiography 显示文摘 | Zhang LJ Yang GF Lu GM | 2008 | Acta Radiol2008，49，3： | 1 |
| 4 | Improved genome annotation for Zymomonasmobilis 显示文摘 | Yang S Pappas KM Hauser LJ Land ML Chen GL Hurst GB PanC Kouvelis VN Typas MA Pelletier DA Klinqeman DM Chanq YJ Samatova NF Brown SD | 2009 | Nat Biotechnol2009，27，10： | 1 |
| 5 | A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits显示文摘 | Presky DH Yang H Minetti LJ | 1996 | Proc Natl Acad Sci USA1996，93，14： | 1 |
| 6 | The accuracy of endoscopic ultrasound,endoscopic retrograde cholangiopancreatography,computed tomography,and transabdominal ultrasound in the detection and staging of primary ampullary tumours显示文摘 | Chen CH Tseng LJ Yang CC | 2001 | Hepatogastroenterology2001，48，42： | 1 |
| 7 | Heparan sulfate proteoglycans and heparanase--partners in osteolytic tumer growth and metastasis 显示文摘 | Sanderson RD Yang Y Suva LJ | 2004 | Matrix Biol2004，23，6： | 1 |
| 8 | Levels of intracellular adhesion molecule-1 and vascular cell adhesion molecule-1 in children with Henoch-Schonlein purpura显示文摘 | Yang YH Lin YT | 2006 | J Microbiol Immunol Infect2006，39，2： | 1 |
| 9 | Hyperchaos from two coupled Wien-bridge oscillators显示文摘 | Lj Q Yang X | 2008 | International Journal of Circuit Theory and Applications2008，36，1： | 1 |
| 10 | Generalized granuloma annulare associated with granulomatous mycosis fungoides显示文摘 | Wong WR Yang LJ Kuo TT | 2000 | Dermatology2000，200，1： | 1 |
| 11 | Factors associated with a failed closed reduction for supracondylar fractures in children显示文摘 | Sun LJ Wu ZP Yang J | 2014 | Orthop Traumatol Surg Res2014，100，6： | 1 |
| 12 | Targeted delivery of antisense oligodeoxynueleotides to folate reeeptor-overexpressing tumor cells 显示文摘 | Yang LJ Li J Zhou W | 2004 | J Control Release2004，95，： | 1 |
| 13 | Evaluation of TCR Vb subfamily T cell expansion in NOD/SCID mice transplanted with human cord blood hematopoietic stem cells显示文摘 | Lin C Chen SH Yang LJ | 2007 | Hematology2007，12，4： | 1 |
| 14 | Downregulation of expression of transporters associated with antigen processing 1and 2 and human leukocyte antigen I and its effect on immunity in nasopharyngeal carcinoma patients显示文摘 | REN YX YANG J ZHANG LJ | 2014 | Mol Clin Oncol2014，2，1： | 1 |
| 15 | Hydrolysis of soybean isoflavone gly- cosides by a thermostable β - glucosidase from Paecilomyces ther- mophila 显示文摘 | Yang SQ Wang LJ Yan Q J | 2009 | Food Chemistry2009，115，4： | 1 |
| 16 | 显示文摘 | Yang LJ Li SW Hatch H | 2002 | PNAS2002，11，99： | 1 |
| 17 | Preoperative evaluation of periampullary tumors by endoscopic sonography,transabdominal sonography and computed tomography显示文摘 | Chen CH Tseng LJ Yang CC | 2001 | J Clin Ultrasound2001，29，6： | 1 |
| 18 | Retardation of atheroscleros is by overexpression of catalase or both Cu/Zn-superoxile dismutase and catalase in mice lacking apolipoprotein E显示文摘 | Yang H Roberts LJ Sh IM J | | 0，，11： | 1 |
| 19 | SATBI is overexptssed in metastatic prostate cancer and promotesprostate cancer cell growth and invasion显示文摘 | MAO LJ YANG CH WANG JQ | 2013 | Transl Med2013，，： | 1 |
| 20 | Liver stem cell-derivedβ-cell surrogates for treatment of type 1 diabetes显示文摘 | Yang LJ | 2006 | Autoimmun Rev2006，5，： | 1 |
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